fail

[Shirobon]

sds

 

[Zurrz]

Prerequisites to this guide:​

This is literally my first guide so cut me some slack when it comes to formatting and overall reading comprehension there might be some oversimplifications in this thread im srry im not very high iq, anyways enjoy reading ​

Spoiler: Thread Song:

Glossary:
​

Explanation of SIK

Melanogenesis Overview & Relation to SIK

SIK Inhibition

Trials & Findings

Topical Formulation

Salt-inducible kinases:
​

Salt-inducible kinases(SIK) Are a family of Serine/threonine Proteins that regulate innumerable cellular processes, including metabolic responses to feeding/fasting, cell division and oncogenesis(Initiation of cancer), inflammation, sleep and circadian rhythms, along with various other important roles in the endocrine system. the SIK family consists of three members; SIK1, SIK2, and SIK3. Although they share similar structures each perform diverse physiological functions by regulating numerous pathways in the body, and are highly important in overall homeostasis. For the purposes of this guide, the primary focus is SIK2, as it plays a vital role in the regulation of Melanogenesis. View attachment 5354455 View attachment 5354990 ​

TL;DR:
SIK is a family of proteins found in our bodies that regulates lots of stuf including SIK2's regulation of tanning proccess luh bruh

Process of Melanogenesis:
​

Melanogenesis is a complex biological process where Melanocytes(Specialized cells) synthesize two types of melanin, Eumelanin(brown-black) and pheomelanin(yellow-red). Melanin plays a key role in absorbing Ultra-violet Radiation, this limits the damaging effects of UV cellular macromolecules(DNA and RNA put simply) and aids in prevention of photoaging skin. Beyond this important role, the added benefit of Increased Melanin production is it's Aesthetic value in the Looks space. It's generally conceded that a Tan is far more attractive than being pale and signals youth and vitality. View attachment 5354604View attachment 5355002 The Melanocortin 1 receptor(MC1R) is a essential regulator of skin pigmentation and acts as a biological response to the exposure of Ultraviolet Radiation, once skin is exposed to UV Radiation, MC1R activates and begins signaling. The signaling pathways primarily involved are cAMP, PKA, CREB. These pathways regulate the MITF transcription factor and activation, which controls the expression of Tyrosinase and its related proteins(TYRP-1, TYRP-2), the vital enzymes responsible for melanin synthesis.​

TL;DR:
melanogenesis is process that make u tan



Now that you understand the basic overview of Salt-inducible kinases(SIK) and the process of melanin production,
how does SIK2 factor into the regulation of Melanogenesis and how can we influence it to achieve a mogger tan?
SIK2 Inhibition:​

View attachment 5364422 To Start, SIK Inhibitors were originally developed to explore the biological functions of the SIK family without the need of Gene Manipulation, A notable Inhibitor like HG-9-91-01 was first deployed to inhibit all three isoforms of the family, with differentiating levels of inhibition, Many others were developed after with the same goal in mind. An interesting use case of a separate SIK inhibitor, specifically YKL-05-099(Derived from HG-9-91-09) in a study was shown to have an effect on osteocytes due to it's higher selectivity, yielding better bone formation and bone mass. ​

Conclusion and Extra:
SIK Inhibitors have shown great promise in changing skin pigmentation for extended periods of time, up to 4 weeks potentially more. This mogs Molonten in my opinion heavily because of its ease of use(It's topical) and lasting effects in trial, other benefits that have been observed is it's ability to enhance DNA repair in keratinocytes and fibroblasts, and decrease expression of the MMP-1; a key marker for photoaging. Overall with no worrisome side effects brought to light, SIK inhibitors are a great alternative to Melontan I/II

As i said in the beginning this is my first guide but this is also likely my last, this was something i hadn't hear much of anyone talk about nor did i see any formulations so i took the opportunity to actually make something useful for the comm, just about everything has mostly already been covered by other users so i don't rlly see a point in making regurgitated guides. I had planned to do a Topical Rosiglitazone guide but unfortuntaly someone beat me to making it and did far better than i prolly could've, im aware some of you were waiting on me to make that one so soz @Paul.jnxy and others
You can find their guide on tiktok here:

Spoiler: Guide Link:

Hymen

 

[Shirobon]

FUCK BRO

 

[ZyzzReincarnate]

Whats wrong with just using Melanotan 2 for this though? It also has a very noticeable positive influence on insulin sensitivity and fat oxidation

 

[Shirobon]

Whats wrong with just using Melanotan 2 for this though? It also has a very noticeable positive influence on insulin sensitivity and fat oxidation

please ignore i accidentally fucking pressed enter
thread isnt even done FUCK this pissed me off

 

[Shirobon]

Whats wrong with just using Melanotan 2 for this though? It also has a very noticeable positive influence on insulin sensitivity and fat oxidation

But to answer your question nothing wrong with it just an interesting alternative with some extra benefits


deadass just lost all my fucking formatting because of my fat fingers
broooo

 

[ZyzzReincarnate]

But to answer your question nothing wrong with it just an interesting alternative with some extra benefits

good thread re-do it

 

[FueledByStims]

wow

 

[Paul.jnxy]

sds

You deleted the thread . It looks good tho. Can you redo it? Also DWBI for the topical rosiglitazone thread. I don’t think anybody did it tho?

 

[Shirobon]

You deleted the thread . It looks good tho. Can you redo it? Also DWBI for the topical rosiglitazone thread. I don’t think anybody did it tho?

accidentally posted it
was including formulation and way more info and stuff tmrrw ill finish it