Finasteride vs Dutasteride

[Deleted member 110398]

Which should i get

 

[Deleted member 110398]

bump i need this right now

 

[Mainlander]

Duta

100%

 

[VinnyH]

Which should i get

Dutasteride ofc

 

[Deleted member 110398]

Duta

100%

Why

 

[j3nx]

Why

Dutasteride and Finasteride both blocks enzyme 5-alpha reductase but dutasteride blocks type 1 and 2,
while Finasteride only blocks type 2 which makes dutasteride better. (5-alpha reductase is the enzyme that converts test into dht)

 

[Deleted member 101844]

either or is fine for becoming a tranny

 

[Deleted member 110398]

either or is fine for becoming a tranny

I just want to keep my hair dude

 

[davinci]

Which should i get

Dutasteride and Finasteride both blocks enzyme 5-alpha reductase but dutasteride blocks type 1 and 2,
while Finasteride only blocks type 2 which makes dutasteride better. (5-alpha reductase is the enzyme that converts test into dht)

i would start with finasteride for this reason since type 1 5ars are responsible for ALLO production in the brain.
Or is it bs? @chadbeingmade @Jonasㅤㅤ⠀ @Hexmask

 

[piec]

@optimisticzoomer which one would u recommend bud

 

[Kroker]

Start with fin, most do fine and preserve their hair, even doing it every other day with only 0.25 can do the job, cuz everyone need is different in terms of how much 5ar enzyme blockage, also you don't want to exhaust all of your arsenal, keep some space for extra options that you might need to throw in later on that if it is needed in the first place.

 

[Chad]

@optimisticzoomer which one would u recommend bud

“Dutasteride is the same as Finasteride just more expensive”

i would start with finasteride for this reason since type 1 5ars are responsible for ALLO production in the brain.
Or is it bs? @chadbeingmade @Jonasㅤㅤ⠀ @Hexmask

Largely cope. Just take Dut. No reason to start with Fin. I don’t see the point if seeing if Fin is enough when you can just take Dut and be certain.

 

[optimisticzoomer]

“Dutasteride is the same as Finasteride just more expensive”

You told me you take Chinese dut powder
In what form? You're not even taking a bioavailable form

 

[optimisticzoomer]

@optimisticzoomer which one would u recommend bud

Fin

 

[optimisticzoomer]

Duta

100%

Dutasteride ofc

People always say this and then there's never any photos of regrowth on Reddit
The ones that do always use min

 

[pusk]

dut works best

 

[Chad]

You told me you take Chinese dut powder
In what form? You're not even taking a bioavailable form

What do you think is in a Dut capsule bud? LOL.

Having Dut with fat (because it’s fat soluble) increases its absorption.

It’s no different than taking Avodart.

 

[piec]

Fin

 

[optimisticzoomer]

What do you think is in a Dut capsule bud? LOL.

Having Dut with fat (because it’s fat soluble) increases its absorption.

It’s no different than taking Avodart.

Brutal moment u realise you've been absorbing none of the dut

I don't even really trust dut tablets

 

[Chad]

View attachment 3812173
Brutal moment u realise you've been absorbing none of the dut

I don't even really trust dut tablets

You are a fucking retard, aren’t you?

Do you realise what you sent just now?

Fucking LOL. Bro just outed himself as a complete retard.


@Jonasㅤㅤ⠀

 

[davinci]

Largely cope. Just take Dut. No reason to start with Fin. I don’t see the point if seeing if Fin is enough when you can just take Dut and be certain.

then maybe the body finds other ways to compensate for the lack of it since there are is no scientific link between dut use and negative mental effects, but maybe it's better to not suppress it greatly by starting with fin and moving to dut only if really needed, no?

 

[optimisticzoomer]

Bro just outed himself as a complete retard.

- guy who thinks he's absorbing any of his dutasteride powder

 

[itssooverropecope]

Which should i get

dut

 

[optimisticzoomer]

Dutasteride is dissolved in fat, to put it in retard terms for you, is basically what you just sent a screen shot of. Fucking imbecile.

Yeah bro just formulate your own bioavailable delivery

Even a hard capsule was shown to have like 70% bioavailability of a softgel. And u think you're getting any without some sort of delivery system

Absolute moron. Cagefuel

 

[optimisticzoomer]

People always say this and then there's never any photos of regrowth on Reddit
The ones that do always use min

 

[davinci]

View attachment 3812164
then maybe the body finds other ways to compensate for the lack of it since there are is no scientific link between dut use and negative mental effects, but maybe it's better to not suppress it greatly by starting with fin and moving to dut only if really needed, no?

@chadbeingmade

 

[got.daim]

dut

 

[piec]

People always say this and then there's never any photos of regrowth on Reddit
The ones that do always use min

reddit > clinical trials

 

[SlayerJonas]

Yeah bro just formulate your own bioavailable delivery

Even a hard capsule was shown to have like 70% bioavailability of a softgel. And u think you're getting any without some sort of delivery system

Absolute moron. Cagefuel

Both of these compounds are lipophilic.

"0.5 mg of dutasteride dissolved in a mixture of mono-di-glycerides of caprylic/capric acid and butylated hydroxytoluene."

You can literally just take the dut with a meal.

@chadbeingmade @imontheloose

View attachment 3812164
then maybe the body finds other ways to compensate for the lack of it since there are is no scientific link between dut use and negative mental effects, but maybe it's better to not suppress it greatly by starting with fin and moving to dut only if really needed, no?

DHT and 5AR don't have a major impact on neurosteroids.

Even if they did: Hair is life, why risk dying?

 

[optimisticzoomer]

reddit > clinical trials

The point is it's not a noticeable difference. And yes, you would expect a subreddit with thousands of users taking dut to have some promising results. (Oral) min truly is law for regrowth, and fin stops loss

 

[optimisticzoomer]

Both of these compounds are lipophilic.

You can literally just take the dut with a meal.

@chadbeingmade @imontheloose

DHT and 5AR don't have a major impact on neurosteroids.

Even if they did: Hair is life, why risk dying?

Release time matters for a start. Which is why softgels and hard capsules have a difference

 

[imontheloose]

Both of these compounds are lipophilic.

You can literally just take the dut with a meal.

@chadbeingmade @imontheloose

DHT and 5AR don't have a major impact on neurosteroids.

Even if they did: Hair is life, why risk dying?

Love the sig, son. We are matching.

 

[piec]

The point is it's not a noticeable difference. And yes, you would expect a subreddit with thousands of users taking dut to have some promising results. (Oral) min truly is law for regrowth, and fin stops loss

took me 20 seconds

 

[SlayerJonas]

Release time matters for a start. Which is why softgels and hard capsules have a difference

I started my 5ARi journey with sublingual dutasteride literally.

The only thing that matters is blood serum concentration.

Taking your dut with a meal is enough for full absorption.

Love the sig, son. We are matching.

PAT PAT!

@chadbeingmade

 

[imontheloose]

PAT PAT!

PAT PAT!

 

[davinci]

5AR don't have a major impact on neurosteroids

sorry but don't 5ars (type 1) produce neurosteroids like ALLO?

 

[optimisticzoomer]

I started my 5ARi journey with sublingual dutasteride literally.

The only thing that matters is blood serum concentration.

Taking your dut with a meal is enough for full absorption.

PAT PAT!

@chadbeingmade

At work rn and can't really use my phone
But one thing is for sure. If you're just swallowing 2.5 mg as a powder with some fat, you're not getting close to 2.5 mg absorption

 

[imontheloose]

Release time matters for a start. Which is why softgels and hard capsules have a difference

This is very true. I mean. This is worse for dutasteride specifically. It’s pretty unreliable unless it’s in a soft-gel. You’d have to have a decent fat load to compensate for it. Finasteride is not so bad, however. Pretty forgiving.

PAT PAT!

 

[optimisticzoomer]

took me 20 seconds

 

[piec]

View attachment 3813698

ru is an anti androgen lil bro doubt it even did anything since dut makes dht practically nonexistant in hair follicles

 

[optimisticzoomer]

ru is an anti androgen lil bro doubt it even did anything since dut makes dht practically nonexistant in hair follicles

Yes?
Point was dude said he didn't notice anything for 2 years on dut alone

 

[piec]

Yes?
Point was dude said he didn't notice anything for 2 years on dut alone

when bro finds out hair doesnt go from subhuman to norwood 2.5 in 4 weeks

 

[Deleted member 91663]

This is very true. I mean. This is worse for dutasteride specifically. It’s pretty unreliable unless it’s in a soft-gel. You’d have to have a decent fat load to compensate for it. Finasteride is not so bad, however. Pretty forgiving.

PAT PAT!

What about using MCT as a solvent?
The half life of Dutasteride so long that surely after a few weeks of daily intake, your systemic DHT levels with tank - even in non capsule form.

 

[One Rep Max]

Fin works but it’s a half measure
Dut is as good of a protection modern pharma can give you

 

[Deleted member 91663]

What do you think is in a Dut capsule bud? LOL.

Having Dut with fat (because it’s fat soluble) increases its absorption.

It’s no different than taking Avodart.

Even if you accept the point that absorption is inferior in tablet vs powdered form, DUT's long half life coupled with daily intake will surely crush systemic DHT levels after a month.

 

[Deleted member 17578]

Fin works but it’s a half measure
Dut is as good of a protection modern pharma can give you

dut mogs but fin will get u like 80+% of the results. it's not a 'half measure'.

im on fin rn but ill go on dut in the future. i dont think the difference between fin/dut is significant. the most important part is being on a dht-blocker in general whether its fin or dut, both are good options as long as u block that fucking DHT

 

[One Rep Max]

dut mogs but fin will get u like 80+% of the results. it's not a 'half measure'.

im on fin rn but ill go on dut in the future. i dont think the difference between fin/dut is significant. the most important part is being on a dht-blocker in general whether its fin or dut, both are good options as long as u block that fucking DHT

yea but if you wanted to preserve as much hair as u can long term wouldn’t u prefer the stronger option

I guess it makes sense if ur concerned about sides

 

[imontheloose]

What about using MCT as a solvent?

It would dissolve essentially entirely in MCT. Just use a gentle water bath of like, meh, 50degC? You'll be fine. MCT forms micelles itself, but you might wanna have about 5g-10g of fat with it. Basically, you could take it with any meal, really. Instead of needing 30g+. Just make sure you have a 1mL syringe when dosing, there's like a +-10% of an error in other cases and that'll be very common.

The half life of Dutasteride so long that surely after a few weeks of daily intake, your systemic DHT levels with tank - even in non capsule form.

Correct. 4-5wks is the half-life. You'll reach steady state (practically a plateau) at 4-5mths. Granted by month 2, the curve is practically horizontal. With MCT the difference will be basically be non-existent. However, using powder only, and a meal of high fat (30g+) can not only be inconvenient, but you'll also be about 10% less in serum-DHT suppression. But that isn't much a concern for most.

 

[Deleted member 91663]

It would dissolve essentially entirely in MCT. Just use a gentle water bath of like, meh, 50degC? You'll be fine. MCT forms micelles itself, but you might wanna have about 5g-10g of fat with it. Basically, you could take it with any meal, really. Instead of needing 30g+. Just make sure you have a 1mL syringe when dosing, there's like a +-10% of an error in other cases and that'll be very common.


Correct. 4-5wks is the half-life. You'll reach steady state (practically a plateau) at 4-5mths. Granted by month 2, the curve is practically horizontal. With MCT the difference will be basically be non-existent. However, using powder only, and a meal of high fat (30g+) can not only be inconvenient, but you'll also be about 10% less in serum-DHT suppression. But that isn't much a concern for most.

Thanks. This was informative. I haven’t gone down the importing powder route because I don’t trust the foreign (Chinese) suppliers of it.

I am in contact with a compounding pharmacy who are offering to do 2.5mg DUT liquid capsules using olive oil as the solvent.

Ignoring the inconvenience factor, do you think I am better off just taking 5 Avodart tablets a day instead? Or will the difference in bioavailability be marginal at best?

 

[imontheloose]

Thanks. This was informative. I haven’t gone down the importing powder route because I don’t trust the foreign (Chinese) suppliers of it.

I am in contact with a compounding pharmacy who are offering to do 2.5mg DUT liquid capsules using olive oil as the solvent.

Ignoring the inconvenience factor, do you think I am better off just taking 5 Avodart tablets a day instead? Or will the difference in bioavailability be marginal at best?

Avodart tabs are like 60%-70% bio-available fasted. It can reach 80%-ish if consumed with some fat in a meal. Compounded formulations in olive oil are going to be pretty much the same. Effectively and physiologically immeasurable. You should note that lipophilic solubilisation is gonna be king. Dut's K_0w is roughly 5, so being pre-dissolved in any long-chain triglyceride (can be olive, MCT, mono-/di-glyceride) raises its intestinal lymph uptake about 30% vs. any old dry powder.

Also, you'll know that dosing is essentially logarithmic generally. Going from 0.5mg to 2.5mg pushes scalp DHT suppression from like 60%-ish to about 90%, but that final 0.5mg from 2mg-2.5mg is doing fuck all. The +-10% error that can be made by them capsules (and often are) is physiologically irrelevant hence why it isn't 2mg, so the error by them is mostly forgettable. Not to mention, even if we took the differences between triglyceride vehicles as marginal or perhaps more, consistent usage of even a couple months effectively chases the same horizontal peak.

It's more cost efficient, as long as you trust the compounder, to run the olive oil formulations. You can do this stuff DIY for some fun, but you'll spend much more effort weighing, heating, and timing fat meals for like 10% less suppression. Just skip it unless your budget is THAT tight. Worst case, go pick up some dropped fivers in Old Quad.

You can take some fat with your formulations if you wanna make it more similar to Avodart too if you wish. The choice is yours. It's totally based on cost, the burden, and trust.