Finasteride vs Dutasteride

[imontheloose]

What about using MCT as a solvent?

It would dissolve essentially entirely in MCT. Just use a gentle water bath of like, meh, 50degC? You'll be fine. MCT forms micelles itself, but you might wanna have about 5g-10g of fat with it. Basically, you could take it with any meal, really. Instead of needing 30g+. Just make sure you have a 1mL syringe when dosing, there's like a +-10% of an error in other cases and that'll be very common.

The half life of Dutasteride so long that surely after a few weeks of daily intake, your systemic DHT levels with tank - even in non capsule form.

Correct. 4-5wks is the half-life. You'll reach steady state (practically a plateau) at 4-5mths. Granted by month 2, the curve is practically horizontal. With MCT the difference will be basically be non-existent. However, using powder only, and a meal of high fat (30g+) can not only be inconvenient, but you'll also be about 10% less in serum-DHT suppression. But that isn't much a concern for most.

 

[Deleted member 91663]

It would dissolve essentially entirely in MCT. Just use a gentle water bath of like, meh, 50degC? You'll be fine. MCT forms micelles itself, but you might wanna have about 5g-10g of fat with it. Basically, you could take it with any meal, really. Instead of needing 30g+. Just make sure you have a 1mL syringe when dosing, there's like a +-10% of an error in other cases and that'll be very common.


Correct. 4-5wks is the half-life. You'll reach steady state (practically a plateau) at 4-5mths. Granted by month 2, the curve is practically horizontal. With MCT the difference will be basically be non-existent. However, using powder only, and a meal of high fat (30g+) can not only be inconvenient, but you'll also be about 10% less in serum-DHT suppression. But that isn't much a concern for most.

Thanks. This was informative. I haven’t gone down the importing powder route because I don’t trust the foreign (Chinese) suppliers of it.

I am in contact with a compounding pharmacy who are offering to do 2.5mg DUT liquid capsules using olive oil as the solvent.

Ignoring the inconvenience factor, do you think I am better off just taking 5 Avodart tablets a day instead? Or will the difference in bioavailability be marginal at best?

 

[imontheloose]

Thanks. This was informative. I haven’t gone down the importing powder route because I don’t trust the foreign (Chinese) suppliers of it.

I am in contact with a compounding pharmacy who are offering to do 2.5mg DUT liquid capsules using olive oil as the solvent.

Ignoring the inconvenience factor, do you think I am better off just taking 5 Avodart tablets a day instead? Or will the difference in bioavailability be marginal at best?

Avodart tabs are like 60%-70% bio-available fasted. It can reach 80%-ish if consumed with some fat in a meal. Compounded formulations in olive oil are going to be pretty much the same. Effectively and physiologically immeasurable. You should note that lipophilic solubilisation is gonna be king. Dut's K_0w is roughly 5, so being pre-dissolved in any long-chain triglyceride (can be olive, MCT, mono-/di-glyceride) raises its intestinal lymph uptake about 30% vs. any old dry powder.

Also, you'll know that dosing is essentially logarithmic generally. Going from 0.5mg to 2.5mg pushes scalp DHT suppression from like 60%-ish to about 90%, but that final 0.5mg from 2mg-2.5mg is doing fuck all. The +-10% error that can be made by them capsules (and often are) is physiologically irrelevant hence why it isn't 2mg, so the error by them is mostly forgettable. Not to mention, even if we took the differences between triglyceride vehicles as marginal or perhaps more, consistent usage of even a couple months effectively chases the same horizontal peak.

It's more cost efficient, as long as you trust the compounder, to run the olive oil formulations. You can do this stuff DIY for some fun, but you'll spend much more effort weighing, heating, and timing fat meals for like 10% less suppression. Just skip it unless your budget is THAT tight. Worst case, go pick up some dropped fivers in Old Quad.

You can take some fat with your formulations if you wanna make it more similar to Avodart too if you wish. The choice is yours. It's totally based on cost, the burden, and trust.

 

[gooner23]

was on both fin for 4-5 years kinda intermittent in the first year and then tried loading onto dut basically once a week while i was still using fin until 6 months where i went onto dut 3 times a week for 3 months and i honestly couldnt handle the sides PERSONALLY.

The general consensus is that dut is probably not saving you if you weren't at least able to maintain with fin and note that some people experience shedding switching like this dude got obliterated by dutasteride for some reason

 

[Deleted member 91663]

Avodart tabs are like 60%-70% bio-available fasted. It can reach 80%-ish if consumed with some fat in a meal. Compounded formulations in olive oil are going to be pretty much the same. Effectively and physiologically immeasurable. You should note that lipophilic solubilisation is gonna be king. Dut's K_0w is roughly 5, so being pre-dissolved in any long-chain triglyceride (can be olive, MCT, mono-/di-glyceride) raises its intestinal lymph uptake about 30% vs. any old dry powder.

Thanks, this is very useful. I think I'll opt for compounded meds based on that information.

Not to mention, even if we took the differences between triglyceride vehicles as marginal or perhaps more, consistent usage of even a couple months effectively chases the same horizontal peak.

Right, medium term usage and we reach similar levels of DHT suppression, even without surfacants.

It's more cost efficient, as long as you trust the compounder, to run the olive oil formulations. You can do this stuff DIY for some fun, but you'll spend much more effort weighing, heating, and timing fat meals for like 10% less suppression.

Yes I don't want the bother or the risk of importing Dutasteride from dubious foreign suppliers without proper quality assurance.

Just skip it unless your budget is THAT tight. Worst case, go pick up some dropped fivers in Old Quad.

Old Quad isn't that cheap! Expect to hear from the moderators soon.

 

[imontheloose]

Old Quad isn't that cheap!

Definitely not. I was in fact implying that residents are so abundant in free cash that dropping £5 is insignificant to their care.

 

[Deleted member 91663]

Definitely not. I was in fact implying that residents are so abundant in free cash that dropping £5 is insignificant to their care.

I know. I was joking!

 

[imontheloose]

Expect to hear from the moderators soon.

Hopefully my spot at Oxford is replaced by a Somali migrant. Diversity is Oxford’s strength.