Found niche pharma source. Is it legit?

[LGG]

yo so found this seller from a friend, that sells a bunch of niche pharmaceuticals such as infigratinib, etc, im still awaiting a pricelist so i dont have all the details.

his profile pic says CORE so let me know if anyone has heard of this guy or group cause im not sure if this legit and i dont wanna get scammed. It has testing but not janoshik. im not gonna send the number cause i dont want anyone to think im promoting a source or something (name is steven here cause its what i named him as a contact ignore that.)

 

[mtbslayr]

hello steven

 

[soapbubble]

hi steven

 

[birthdefect]

yo so found this seller from a friend, that sells a bunch of niche pharmaceuticals such as infigratinib, etc, im still awaiting a pricelist so i dont have all the details.

his profile pic says CORE so let me know if anyone has heard of this guy or group cause im not sure if this legit and i dont wanna get scammed. It has testing but not janoshik. im not gonna send the number cause i dont want anyone to think im promoting a source or something (name is steven here cause its what i named him as a contact ignore that.)View attachment 4647606

infig is useless if you dont have the mutation
it inhibits an fgf thats needed for growth as well
kind soul told me this on my thread

 

[LGG]

infig is useless if you dont have the mutation
it inhibits an fgf thats needed for growth as well
kind soul told me this on my thread

ive not heard about the other fgfr type needed for growth, but on regard to the other point, atleast in mice fgfr3 inhibition grew longer bones, it was with TYRA 300, but we can assume the same with infigratinib:

TYRA-300 increases growth velocity and long bone growth in wild-type mice. To determine the in vivo effect of FGFR3 inhibition under normal physiologic conditions, TYRA-300 was tested in a growth velocity assay in wild-type mice (32). In this study, wild-type C57BL/6J mice were dosed orally with TYRA-300 once daily from 4 to 8 weeks of age. Previous work has demonstrated efficacy with TYRA-300 up to 18 mg/kg in oncology models (31). Based on the doses evaluated for infigratinib in oncology and ACH, a lower dose was thought to be more appropriate for long-term treatment of pediatric growth–related conditions. We therefore initially explored doses in the 8 to 14 mg/kg range in this model. Compared with the vehicle-treated group, there was a statistically significant increase in nasoanal length after treatment with 14 mg/kg TYRA-300 once daily (+7.3%, Figure 1A). Tail length and tibia and femur length also increased significantly and dose-dependently with both 12 mg/kg and 14 mg/kg TYRA-300 compared with vehicle treatment after 4 weeks of treatment (Figure 1, B–D). Specifically, after treatment with 12 mg/kg TYRA-300, the tibias were on average 3.9% longer than the tibias of mice that received treatment with vehicle, and the femurs were on average 5.0% longer after treatment; additionally, with 14 mg/kg TYRA-300, the tibias were 6.4% longer and the femurs were 8.2% longer. There was no difference in body weight among the treatment groups (data not shown). In addition, significant increases in nasoanal length and tibia and femur length were observed after treatment with 8 mg/kg and 10 mg/kg TYRA-300 (data not shown; P < 0.05). These results indicate that inhibition of wild-type FGFR3 signaling can effectively enhance growth velocity in a dose-dependent manner. While this model does not recapitulate any genetic growth disorder it does represent an accessible and facile tool for preliminary screening of compounds or treatments relative to the genetically modified models.

 

[birthdefect]

ive not heard about the other fgfr type needed for growth, but on regard to the other point, atleast in mice fgfr3 inhibition grew longer bones, it was with TYRA 300, but we can assume the same with infigratinib:

TYRA-300 increases growth velocity and long bone growth in wild-type mice. To determine the in vivo effect of FGFR3 inhibition under normal physiologic conditions, TYRA-300 was tested in a growth velocity assay in wild-type mice (32). In this study, wild-type C57BL/6J mice were dosed orally with TYRA-300 once daily from 4 to 8 weeks of age. Previous work has demonstrated efficacy with TYRA-300 up to 18 mg/kg in oncology models (31). Based on the doses evaluated for infigratinib in oncology and ACH, a lower dose was thought to be more appropriate for long-term treatment of pediatric growth–related conditions. We therefore initially explored doses in the 8 to 14 mg/kg range in this model. Compared with the vehicle-treated group, there was a statistically significant increase in nasoanal length after treatment with 14 mg/kg TYRA-300 once daily (+7.3%, Figure 1A). Tail length and tibia and femur length also increased significantly and dose-dependently with both 12 mg/kg and 14 mg/kg TYRA-300 compared with vehicle treatment after 4 weeks of treatment (Figure 1, B–D). Specifically, after treatment with 12 mg/kg TYRA-300, the tibias were on average 3.9% longer than the tibias of mice that received treatment with vehicle, and the femurs were on average 5.0% longer after treatment; additionally, with 14 mg/kg TYRA-300, the tibias were 6.4% longer and the femurs were 8.2% longer. There was no difference in body weight among the treatment groups (data not shown). In addition, significant increases in nasoanal length and tibia and femur length were observed after treatment with 8 mg/kg and 10 mg/kg TYRA-300 (data not shown; P < 0.05). These results indicate that inhibition of wild-type FGFR3 signaling can effectively enhance growth velocity in a dose-dependent manner. While this model does not recapitulate any genetic growth disorder it does represent an accessible and facile tool for preliminary screening of compounds or treatments relative to the genetically modified models.

yea no way im reading all that, how did you not realise that i said it doesnt work BECAUSE of it inhibiting another fgf
tyra 300 is legit tho

 

[infrainfra]

yea no way im reading all that, how did you not realise that i said it doesnt work BECAUSE of it inhibiting another fgf
tyra 300 is legit tho

fgf1 and 2 arent needed for growth? correct me if jm wrong

 

[js.rm.atp]

yo so found this seller from a friend, that sells a bunch of niche pharmaceuticals such as infigratinib, etc, im still awaiting a pricelist so i dont have all the details.

his profile pic says CORE so let me know if anyone has heard of this guy or group cause im not sure if this legit and i dont wanna get scammed. It has testing but not janoshik. im not gonna send the number cause i dont want anyone to think im promoting a source or something (name is steven here cause its what i named him as a contact ignore that.)View attachment 4647606

Not tagging me even tho I gave you the source is criminal nigga

 

[LGG]

Not tagging me even tho I gave you the source is criminal nigga

how was i supposed to know ur .org

 

[js.rm.atp]

how was i supposed to know ur .org

Bhai you literally asked for a source on org

 

[LGG]

Bhai you literally asked for a source on org

i cant find our convo i got this from some guy on gaycord

 

[js.rm.atp]

i cant find our convo i got this from some guy on gaycord

https://looksmax.org/threads/infigratinib-source.1862073/

 

[LGG]

https://looksmax.org/threads/infigratinib-source.1862073/

i still dont see our dm but anyways u purchased from this guy?

 

[js.rm.atp]

i still dont see our dm but anyways u purchased from this guy?

Ye

 

[LGG]

Ye

whered u find this source from im curious

 

[js.rm.atp]

whered u find this source from im curious

Inquiries bhai. Wont say where tho

 

[birthdefect]

fgf1 and 2 arent needed for growth? correct me if jm wrong

fgf2 acts to hypertrophy the chondrocytes later, which you kinda need tbh at some point

 

[infrainfra]

fgf2 acts to hypertrophy the chondrocytes later, which you kinda need tbh at some point

is there any drug that inhibits only fgfr3? prolly not. our best option by far is infigatinib ?

 

[birthdefect]

is there any drug that inhibits only fgfr3? prolly not. our best option by far is infigatinib ?

tyra 300

 

[LGG]

fgf2 acts to hypertrophy the chondrocytes later, which you kinda need tbh at some point

we dont even want chondrocyte hypertrophy much, and even while inhibiting fgfr2 so it obviously works in achondroplasia people still

 

[infrainfra]

tyra 300

is this even sourcable? if so have you got a source?

 

[ascendrx]

yo so found this seller from a friend, that sells a bunch of niche pharmaceuticals such as infigratinib, etc, im still awaiting a pricelist so i dont have all the details.

his profile pic says CORE so let me know if anyone has heard of this guy or group cause im not sure if this legit and i dont wanna get scammed. It has testing but not janoshik. im not gonna send the number cause i dont want anyone to think im promoting a source or something (name is steven here cause its what i named him as a contact ignore that.)View attachment 4647606

Yo that’s my boy Steven

 

[LGG]

is this even sourcable? if so have you got a source?

yeah my source has it but its like hella expensive, as in not worth it right now, just use infig or high inhib

 

[LGG]

Inquiries bhai. Wont say where tho

shlould i be low inhib and order rn? icl im just skeptical no one else has heard of this seller

 

[hardstucklmtn]

ive not heard about the other fgfr type needed for growth, but on regard to the other point, atleast in mice fgfr3 inhibition grew longer bones, it was with TYRA 300, but we can assume the same with infigratinib:

TYRA-300 increases growth velocity and long bone growth in wild-type mice. To determine the in vivo effect of FGFR3 inhibition under normal physiologic conditions, TYRA-300 was tested in a growth velocity assay in wild-type mice (32). In this study, wild-type C57BL/6J mice were dosed orally with TYRA-300 once daily from 4 to 8 weeks of age. Previous work has demonstrated efficacy with TYRA-300 up to 18 mg/kg in oncology models (31). Based on the doses evaluated for infigratinib in oncology and ACH, a lower dose was thought to be more appropriate for long-term treatment of pediatric growth–related conditions. We therefore initially explored doses in the 8 to 14 mg/kg range in this model. Compared with the vehicle-treated group, there was a statistically significant increase in nasoanal length after treatment with 14 mg/kg TYRA-300 once daily (+7.3%, Figure 1A). Tail length and tibia and femur length also increased significantly and dose-dependently with both 12 mg/kg and 14 mg/kg TYRA-300 compared with vehicle treatment after 4 weeks of treatment (Figure 1, B–D). Specifically, after treatment with 12 mg/kg TYRA-300, the tibias were on average 3.9% longer than the tibias of mice that received treatment with vehicle, and the femurs were on average 5.0% longer after treatment; additionally, with 14 mg/kg TYRA-300, the tibias were 6.4% longer and the femurs were 8.2% longer. There was no difference in body weight among the treatment groups (data not shown). In addition, significant increases in nasoanal length and tibia and femur length were observed after treatment with 8 mg/kg and 10 mg/kg TYRA-300 (data not shown; P < 0.05). These results indicate that inhibition of wild-type FGFR3 signaling can effectively enhance growth velocity in a dose-dependent manner. While this model does not recapitulate any genetic growth disorder it does represent an accessible and facile tool for preliminary screening of compounds or treatments relative to the genetically modified models.

Dnr

 

[birthdefect]

is this even sourcable? if so have you got a source?

kind soul taught me that its fairly simple to source chemicals like this, just not with names

 

[js.rm.atp]

shlould i be low inhib and order rn? icl im just skeptical no one else has heard of this seller

I mean I can show you that I ordered but idrc wheter u think theyre legit or not