Found niche pharma source. Is it legit?

LGG

LGG

LDAR is law
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yo so found this seller from a friend, that sells a bunch of niche pharmaceuticals such as infigratinib, etc, im still awaiting a pricelist so i dont have all the details.

his profile pic says CORE so let me know if anyone has heard of this guy or group cause im not sure if this legit and i dont wanna get scammed. It has testing but not janoshik. im not gonna send the number cause i dont want anyone to think im promoting a source or something (name is steven here cause its what i named him as a contact ignore that.)
IMG 3578
 
hello steven
 
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hi steven
 
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LGG said:
yo so found this seller from a friend, that sells a bunch of niche pharmaceuticals such as infigratinib, etc, im still awaiting a pricelist so i dont have all the details.

his profile pic says CORE so let me know if anyone has heard of this guy or group cause im not sure if this legit and i dont wanna get scammed. It has testing but not janoshik. im not gonna send the number cause i dont want anyone to think im promoting a source or something (name is steven here cause its what i named him as a contact ignore that.)View attachment 4647606
Click to expand...
infig is useless if you dont have the mutation
it inhibits an fgf thats needed for growth as well
kind soul told me this on my thread
 
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birthdefect said:
infig is useless if you dont have the mutation
it inhibits an fgf thats needed for growth as well
kind soul told me this on my thread
Click to expand...
ive not heard about the other fgfr type needed for growth, but on regard to the other point, atleast in mice fgfr3 inhibition grew longer bones, it was with TYRA 300, but we can assume the same with infigratinib:

TYRA-300 increases growth velocity and long bone growth in wild-type mice. To determine the in vivo effect of FGFR3 inhibition under normal physiologic conditions, TYRA-300 was tested in a growth velocity assay in wild-type mice (32). In this study, wild-type C57BL/6J mice were dosed orally with TYRA-300 once daily from 4 to 8 weeks of age. Previous work has demonstrated efficacy with TYRA-300 up to 18 mg/kg in oncology models (31). Based on the doses evaluated for infigratinib in oncology and ACH, a lower dose was thought to be more appropriate for long-term treatment of pediatric growth–related conditions. We therefore initially explored doses in the 8 to 14 mg/kg range in this model. Compared with the vehicle-treated group, there was a statistically significant increase in nasoanal length after treatment with 14 mg/kg TYRA-300 once daily (+7.3%, Figure 1A). Tail length and tibia and femur length also increased significantly and dose-dependently with both 12 mg/kg and 14 mg/kg TYRA-300 compared with vehicle treatment after 4 weeks of treatment (Figure 1, B–D). Specifically, after treatment with 12 mg/kg TYRA-300, the tibias were on average 3.9% longer than the tibias of mice that received treatment with vehicle, and the femurs were on average 5.0% longer after treatment; additionally, with 14 mg/kg TYRA-300, the tibias were 6.4% longer and the femurs were 8.2% longer. There was no difference in body weight among the treatment groups (data not shown). In addition, significant increases in nasoanal length and tibia and femur length were observed after treatment with 8 mg/kg and 10 mg/kg TYRA-300 (data not shown; P < 0.05). These results indicate that inhibition of wild-type FGFR3 signaling can effectively enhance growth velocity in a dose-dependent manner. While this model does not recapitulate any genetic growth disorder it does represent an accessible and facile tool for preliminary screening of compounds or treatments relative to the genetically modified models.
 
LGG said:
ive not heard about the other fgfr type needed for growth, but on regard to the other point, atleast in mice fgfr3 inhibition grew longer bones, it was with TYRA 300, but we can assume the same with infigratinib:

TYRA-300 increases growth velocity and long bone growth in wild-type mice. To determine the in vivo effect of FGFR3 inhibition under normal physiologic conditions, TYRA-300 was tested in a growth velocity assay in wild-type mice (32). In this study, wild-type C57BL/6J mice were dosed orally with TYRA-300 once daily from 4 to 8 weeks of age. Previous work has demonstrated efficacy with TYRA-300 up to 18 mg/kg in oncology models (31). Based on the doses evaluated for infigratinib in oncology and ACH, a lower dose was thought to be more appropriate for long-term treatment of pediatric growth–related conditions. We therefore initially explored doses in the 8 to 14 mg/kg range in this model. Compared with the vehicle-treated group, there was a statistically significant increase in nasoanal length after treatment with 14 mg/kg TYRA-300 once daily (+7.3%, Figure 1A). Tail length and tibia and femur length also increased significantly and dose-dependently with both 12 mg/kg and 14 mg/kg TYRA-300 compared with vehicle treatment after 4 weeks of treatment (Figure 1, B–D). Specifically, after treatment with 12 mg/kg TYRA-300, the tibias were on average 3.9% longer than the tibias of mice that received treatment with vehicle, and the femurs were on average 5.0% longer after treatment; additionally, with 14 mg/kg TYRA-300, the tibias were 6.4% longer and the femurs were 8.2% longer. There was no difference in body weight among the treatment groups (data not shown). In addition, significant increases in nasoanal length and tibia and femur length were observed after treatment with 8 mg/kg and 10 mg/kg TYRA-300 (data not shown; P < 0.05). These results indicate that inhibition of wild-type FGFR3 signaling can effectively enhance growth velocity in a dose-dependent manner. While this model does not recapitulate any genetic growth disorder it does represent an accessible and facile tool for preliminary screening of compounds or treatments relative to the genetically modified models.
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yea no way im reading all that, how did you not realise that i said it doesnt work BECAUSE of it inhibiting another fgf
tyra 300 is legit tho
 
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birthdefect said:
yea no way im reading all that, how did you not realise that i said it doesnt work BECAUSE of it inhibiting another fgf
tyra 300 is legit tho
Click to expand...
fgf1 and 2 arent needed for growth? correct me if jm wrong
 
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LGG said:
yo so found this seller from a friend, that sells a bunch of niche pharmaceuticals such as infigratinib, etc, im still awaiting a pricelist so i dont have all the details.

his profile pic says CORE so let me know if anyone has heard of this guy or group cause im not sure if this legit and i dont wanna get scammed. It has testing but not janoshik. im not gonna send the number cause i dont want anyone to think im promoting a source or something (name is steven here cause its what i named him as a contact ignore that.)View attachment 4647606
Click to expand...
Not tagging me even tho I gave you the source is criminal nigga
 
infrainfra said:
fgf1 and 2 arent needed for growth? correct me if jm wrong
Click to expand...
fgf2 acts to hypertrophy the chondrocytes later, which you kinda need tbh at some point
 
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birthdefect said:
fgf2 acts to hypertrophy the chondrocytes later, which you kinda need tbh at some point
Click to expand...
is there any drug that inhibits only fgfr3? prolly not. our best option by far is infigatinib ?
 
birthdefect said:
fgf2 acts to hypertrophy the chondrocytes later, which you kinda need tbh at some point
Click to expand...
we dont even want chondrocyte hypertrophy much, and even while inhibiting fgfr2 so it obviously works in achondroplasia people still
 
Last edited:
LGG said:
yo so found this seller from a friend, that sells a bunch of niche pharmaceuticals such as infigratinib, etc, im still awaiting a pricelist so i dont have all the details.

his profile pic says CORE so let me know if anyone has heard of this guy or group cause im not sure if this legit and i dont wanna get scammed. It has testing but not janoshik. im not gonna send the number cause i dont want anyone to think im promoting a source or something (name is steven here cause its what i named him as a contact ignore that.)View attachment 4647606
Click to expand...
Yo that’s my boy Steven
 
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infrainfra said:
is this even sourcable? if so have you got a source?
Click to expand...
yeah my source has it but its like hella expensive, as in not worth it right now, just use infig or high inhib
 
LGG said:
ive not heard about the other fgfr type needed for growth, but on regard to the other point, atleast in mice fgfr3 inhibition grew longer bones, it was with TYRA 300, but we can assume the same with infigratinib:

TYRA-300 increases growth velocity and long bone growth in wild-type mice. To determine the in vivo effect of FGFR3 inhibition under normal physiologic conditions, TYRA-300 was tested in a growth velocity assay in wild-type mice (32). In this study, wild-type C57BL/6J mice were dosed orally with TYRA-300 once daily from 4 to 8 weeks of age. Previous work has demonstrated efficacy with TYRA-300 up to 18 mg/kg in oncology models (31). Based on the doses evaluated for infigratinib in oncology and ACH, a lower dose was thought to be more appropriate for long-term treatment of pediatric growth–related conditions. We therefore initially explored doses in the 8 to 14 mg/kg range in this model. Compared with the vehicle-treated group, there was a statistically significant increase in nasoanal length after treatment with 14 mg/kg TYRA-300 once daily (+7.3%, Figure 1A). Tail length and tibia and femur length also increased significantly and dose-dependently with both 12 mg/kg and 14 mg/kg TYRA-300 compared with vehicle treatment after 4 weeks of treatment (Figure 1, B–D). Specifically, after treatment with 12 mg/kg TYRA-300, the tibias were on average 3.9% longer than the tibias of mice that received treatment with vehicle, and the femurs were on average 5.0% longer after treatment; additionally, with 14 mg/kg TYRA-300, the tibias were 6.4% longer and the femurs were 8.2% longer. There was no difference in body weight among the treatment groups (data not shown). In addition, significant increases in nasoanal length and tibia and femur length were observed after treatment with 8 mg/kg and 10 mg/kg TYRA-300 (data not shown; P < 0.05). These results indicate that inhibition of wild-type FGFR3 signaling can effectively enhance growth velocity in a dose-dependent manner. While this model does not recapitulate any genetic growth disorder it does represent an accessible and facile tool for preliminary screening of compounds or treatments relative to the genetically modified models.
Click to expand...
Dnr
 
infrainfra said:
is this even sourcable? if so have you got a source?
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kind soul taught me that its fairly simple to source chemicals like this, just not with names
 
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LGG said:
shlould i be low inhib and order rn? icl im just skeptical no one else has heard of this seller
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I mean I can show you that I ordered but idrc wheter u think theyre legit or not
 
IMG 0370
 
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LGG said:
yeah my source has it but its like hella expensive, as in not worth it right now, just use infig or high inhib
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yeah but infig is like almost impossible to source and the corelabsguy is super sketchy. only grays recommended him which sounds like a scam. can you please pm me your source for tyra?
 
infrainfra said:
yeah but infig is like almost impossible to source and the corelabsguy is super sketchy. only grays recommended him which sounds like a scam. can you please pm me your source for tyra?
Click to expand...
the source was the core guy and it was apprently like in the thousands in price so its really not affordable rn, u would have better luck finding infig source than tyra
 
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LGG said:
yo so found this seller from a friend, that sells a bunch of niche pharmaceuticals such as infigratinib, etc, im still awaiting a pricelist so i dont have all the details.

his profile pic says CORE so let me know if anyone has heard of this guy or group cause im not sure if this legit and i dont wanna get scammed. It has testing but not janoshik. im not gonna send the number cause i dont want anyone to think im promoting a source or something (name is steven here cause its what i named him as a contact ignore that.)View attachment 4647606
Click to expand...
Those who inhibit fgfr3 😭
 

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Thatfish said:
Those who inhibit fgfr3 😭
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The guy added flour to the jar and printed a sticker with the name Infragratinib, and also created an account on Tiktok:lul::lul::lul::lul:
 
rzazeynlov777 said:
The guy added flour to the jar and printed a sticker with the name Infragratinib, and also created an account on Tiktok:lul::lul::lul::lul:
Click to expand...
It’s real brotato chip 🙏
 
Foidmaxxer said:
3 acts but inhibiting 1 and 2 hinders skull growth
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no actually inhibiting fgfr2 in mice resulted in wider skull and better shaped bones. fgfr1 inhibited is the only problem. the only flaw of infigatinib. a pretty serious one
 
Tales from Steven
 
LGG said:
yo so found this seller from a friend, that sells a bunch of niche pharmaceuticals such as infigratinib, etc, im still awaiting a pricelist so i dont have all the details.

his profile pic says CORE so let me know if anyone has heard of this guy or group cause im not sure if this legit and i dont wanna get scammed. It has testing but not janoshik. im not gonna send the number cause i dont want anyone to think im promoting a source or something (name is steven here cause its what i named him as a contact ignore that.)View attachment 4647606
Click to expand...
Can you give me his number?
 
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