Full skin guide

[Rayzo]

---

Isotretinoin​

Starting of with a personal favourite

Isotretinoin works by-​

• Reducing size and activity of Sebaceous glands*, drastically cutting sebum* production, also indirectly killing bacteria
• Induces keratinization*, reduce formation of microcomedones*
• Lowers inflammation, reducing irritation and future scarring

What else does it do ?-​

In areas where this glandular density is high (nose, nasolabial folds, central face), this reduces volume and surface oiliness, making contours appear sharper.

Modifies keratinization and barrier function in the lips. The vermilion becomes drier, but also thinner in the stratum corneum, which can make vascularity more visible and appear as bigger, fuller lips

Side effects -​

Dry skin-​

The gaint drop in sebum production means the skins main natural hydrator is lowered, dry skin then causes breaks, flaky skin and it just looks bad

Dry lips-​

Again, the drop in sebum elimates that natural layer, lips crack and become raw.
This looks unhygienic

Dry eyes-​

Something really bad for myself, meibomian glands in the eyelids are shrunk, meaning that the protective oil layer is reduced

Photosensitivity-​

Isotretinoin makes the skin very sensitive to ultraviolet rays (the sun), your skin burns twice as easily

Initial acne flare ("purge")​

accelerated turnover and normalization of the follicular epithelium* meaning Microcomedones and existing clogged follicles are pushed through the skin

Tips and fixes-​

Taking Isotretinoin with a fatty food-​

Isotretinoin is fat soluble, meaning a higher absorption rate when digesting with a fat.

Antihistamines during the purge-​

This drastically lowers inflammation and the potential runny noses

Sunscreen-​

Due to the increased Photosensitivity, sunscreen is an absolute MUST, "muuhh goatis said.. " , you will burn, you will burn horribly, you will get skin cancer

Copious amount of vaseline and moisturiser-​

The skin and lips completely lack oil, you need to be carrying both things with you at all times

Dosing-​

0.5 mg/kg/day

Do not go above
1mg/kg

The traditional goal is a cumulative dose of about 120 to 150 mg/kg over the entire course

Rating​

I give it a 9/10

---

Topical estrogen​

Femboymaxxing

how does it work ?-​

• activates fibroblast estrogen receptors, increasing collagen gene expression and reducing collagen breakdown via MMP* inhibition
• Upregulates hyaloronic acid synthase enzymes in fibroblasts and keratinocytes, increasing dermal water binding
• Reduces transepidermal water loss
• Enhances keratinocyte* proliferation and differentiation and supports growth factor signalin in dermal regeneration.

Resulting in-​

• Improved elasticity
• Improved skin hydration
• Thicker dermis
• "Youthful" skin

side effects-​

really not much, some skin irritation upon application
Haven't tried it myself so im not sure

Just avoid systemic absorption..

:headpain:

Rating​

I give it a 7.5/10

---

Topical minoxidil​

Started using this recently js to test, less of a "aggressive" acne look, less redness

how it works-​

• Opens ATP sensitive potassium chanels, promoted blood flow and hyperpolarization* in the dermal
• Increases vascular endothelial growth factor expression in dermal papella and surrounding skin
• Minor modulation of dermal fibroblast activity

Side notes-​

May cause unwanted hair growth
Not the most effective on this

Rating​

I give it a 4.5/10

---

Botox​

Commonly used in a cosmetic sense (mesobotox, microbitox)
Temporary (<6 months)

how it works-​

• Blocks acetylcholine* release at neuromuscular nerve endings
• Decreases acetylcholine caused sebum production
• paralysis of dermal muscles and reduced sebum output leads to decreased pore visibility and smoother surface
• Inhibits sweat gland activity, leading into reduces swelling and oil mixing
• reduction of neurogenic inflammation via decreased release of substance P and CGRP*

side effects-​

• Pain, burning, or stinging at injection sites
• Dermal muscles paralysis
• Repeated use can cause slower facial wound healing and infection response

Rating​

I give it a 7/10

---

Topical metformin​

topcial metformin

Not sold, ill try think of a way to make it

how does it work-​

• Reduced lipogenesis and triglyceride synthesis* through AMPK inhibition
• Downregulation of NF-κB* activity, lowering pro-inflammatory cytokine production

how to make-​

you will need-

• Raw metformin (as fine as possible)
• water

Mix at a 1:8 ratio

Incorporate some type of skin safe gel (moisturiser)
Mix with water solution

Dermaneedle mixture into skin

side effects-​

• Temporary Irritation and redness
• Barrier disruption
• Peeling (keratinocyte turnover)

Rating​

I rate it a 6/10
(Need more info, pro:Con isnt great)

---

Tazarotene​

how it works-​

• Selective retinoic acid receptor RARβ/RARγ agonist*
• Normalizes keratinocyte life cycle (proliferation and differentiation)
• Increases dermal cell turnover
• Reduces inflammatory signaling in acne lesions
• improvemnt in dermal collagen synthesis and mediated MMP collagen loss

results-​

• reduced comedones
• Reduced inflammation
• Smoother skin
• Improved scarring pigment

side effects-​

• dry skin
• Redness
• peeling
• Photosensitivity

Rating​

I rate it a 8/10
very nice

---

Azelaic acid​

10% or more

how its works-​

• Inhibits mitochondrial oxidoreductase* enzymes, reducing cellular proliferation in hyperactive keratinocytes.
• Normalizes keratinization within the follicle
• antimicrobial activity against Cutibacterium acnes
• Inhibits tyrosinase activity in melanocytes* reducing excess melanin production
• Reduces inflammatory cytokine production

results-​

• Reduced acne and comedones
• Reduced facial redness
• Even skin tone and texture

sides-​

• Burning upon application
• Dry skin
• Overall Temporary Irritation

Rating​

I rate it a 8.5/10
Easily one of the best Topicals
Arguably mogs tret

And speaking of....

---

Tretinoin​

Hold the iso

how it works-​

• Binds to retinoic acid receptors, aaltering the gene expression
• Accelerates dermal cell turnover
• Increases collagen synthesis and reduces MMP mediated collagen loss

results-​

• reduced comedomes
• Reduced inflammation
• Smoother skin brev
• Great healing factor

sides-​

• Dry skin
• Peeling
• Redness
• Photosensitivity
• "Purge"

Rating​

I rate it a 6.5/10
Its not bad but very overhyped

"Mmuuuhh u rate iso higher"
Suck my dick faggot

---

Clascoterone​

Aas protection for @includings

how it works-​

• Topical anti-androgen
• competing with DHT and testosterone for androgen receptor binding in the skin
• Reduces androgen driven sebum production
• Decreases androgen driven inflammatory signaling
• Acts locally in the skin with minimal systemic exposure.

Near completely corrects and stops all androgen driven skin issues

side effects-​

same as most topicals

• Redness
• Burning
• Irritation

Rating​

I give it a 4/10 for avg use
On AAS I give it a 8.5/10

---

Topical calcitriol​

How it works-​

• Activates the vitamin D receptor in keratinocytes
• keratinocyte proliferation, reducing excessive dermal cell growth
• promotes proper keratinocyte maturation and differentiation
• Modulates immune signaling by reducing production of pro inflammatory cytokines

Resulting in-​

• Reduced scaling and plaque formation
• improved skin barrier function
• reduced inflammation
• More dermal turnover

Rating​

I give it a 5/10
Simply js improves skin structure and barrier

---

Dictionary*​

Copied directly of studies

Sebum-​

The oily substance naturally produced by the skin. It helps lubricate and protect the skin and hair.

Sebaceous glands-​

Small glands attached to hair follicles that produce and release sebum.

Keratinization-​

The process by which skin cells mature, harden, and move toward the skin surface before being shed.

Follicular epithelium-​

The layer of skin cells lining the inside of a hair follicle.

MMP (Matrix Metalloproteinase)-​

A group of enzymes that break down collagen and other structural proteins in the skin.

Keratinocyte-​

The main cell type found in the epidermis. These cells produce keratin and make up most of the skin's outer layer.

Hyperpolarization-​

A change in a cell's electrical charge that makes it less likely to become activated.

Acetylcholine-​

A neurotransmitter used by nerves to communicate with muscles, sweat glands, sebaceous glands

Substance P and CGRP-​

Signaling molecules released by nerves that promote inflammation, redness, pain, and blood vessel dilation.

Triglyceride synthesis-​

The process by which cells produce triglycerides, the main fats stored in tissues and found within sebum.

NF κB-​

A protein complex that acts as a master switch for inflammation, turning on genes involved in immune and inflammatory responses.

RARβ/RARγ agonist-​

A compound that activates retinoic acid receptors beta and gamma, altering gene expression involved in skin cell growth and differentiation

Oxidoreductase-​

An enzyme that helps transfer electrons between molecules during metabolic reactions.

Melanocytes-​

Specialized skin cells that produce melanin, the pigment responsible for skin, hair and eye colour.

 

[bpkai]

Awesome thread bro mirin

 

[Rayzo]

my images are fucked one sec

Awesome thread bro mirin

 

[AbelMakkonenTesfa]

the rep farm has to be studied

 

[Rayzo]

the rep farm has to be studied

sorry im not to ur standards baby

 

[bluebandz]

---

Isotretinoin​

Starting of with a personal favourite

Isotretinoin works by-​

• Reducing size and activity of Sebaceous glands*, drastically cutting sebum* production, also indirectly killing bacteria
• Induces keratinization*, reduce formation of microcomedones*
• Lowers inflammation, reducing irritation and future scarring

What else does it do ?-​

In areas where this glandular density is high (nose, nasolabial folds, central face), this reduces volume and surface oiliness, making contours appear sharper.

Modifies keratinization and barrier function in the lips. The vermilion becomes drier, but also thinner in the stratum corneum, which can make vascularity more visible and appear as bigger, fuller lips

Side effects -​

Dry skin-​

The gaint drop in sebum production means the skins main natural hydrator is lowered, dry skin then causes breaks, flaky skin and it just looks bad

Dry lips-​

Again, the drop in sebum elimates that natural layer, lips crack and become raw.
This looks unhygienic

Dry eyes-​

Something really bad for myself, meibomian glands in the eyelids are shrunk, meaning that the protective oil layer is reduced

Photosensitivity-​

Isotretinoin makes the skin very sensitive to ultraviolet rays (the sun), your skin burns twice as easily

Initial acne flare ("purge")​

accelerated turnover and normalization of the follicular epithelium* meaning Microcomedones and existing clogged follicles are pushed through the skin

Tips and fixes-​

Taking Isotretinoin with a fatty food-​

Isotretinoin is fat soluble, meaning a higher absorption rate when digesting with a fat.

Antihistamines during the purge-​

This drastically lowers inflammation and the potential runny noses

Sunscreen-​

Due to the increased Photosensitivity, sunscreen is an absolute MUST, "muuhh goatis said.. " , you will burn, you will burn horribly, you will get skin cancer

Copious amount of vaseline and moisturiser-​

The skin and lips completely lack oil, you need to be carrying both things with you at all times

Dosing-​

0.5 mg/kg/day

Do not go above
1mg/kg

The traditional goal is a cumulative dose of about 120 to 150 mg/kg over the entire course

Rating​

I give it a 9/10

---

Topical estrogen​

Femboymaxxing

how does it work ?-​

• activates fibroblast estrogen receptors, increasing collagen gene expression and reducing collagen breakdown via MMP* inhibition
• Upregulates hyaloronic acid synthase enzymes in fibroblasts and keratinocytes, increasing dermal water binding
• Reduces transepidermal water loss
• Enhances keratinocyte* proliferation and differentiation and supports growth factor signalin in dermal regeneration.

Resulting in-​

• Improved elasticity
• Improved skin hydration
• Thicker dermis
• "Youthful" skin

side effects-​

really not much, some skin irritation upon application
Haven't tried it myself so im not sure

Just avoid systemic absorption..

:headpain:

Rating​

I give it a 7.5/10

---

Topical minoxidil​

Started using this recently js to test, less of a "aggressive" acne look, less redness

how it works-​

• Opens ATP sensitive potassium chanels, promoted blood flow and hyperpolarization* in the dermal
• Increases vascular endothelial growth factor expression in dermal papella and surrounding skin
• Minor modulation of dermal fibroblast activity

Side notes-​

May cause unwanted hair growth
Not the most effective on this

Rating​

I give it a 4.5/10

---

Botox​

Commonly used in a cosmetic sense (mesobotox, microbitox)
Temporary (<6 months)

how it works-​

• Blocks acetylcholine* release at neuromuscular nerve endings
• Decreases acetylcholine caused sebum production
• paralysis of dermal muscles and reduced sebum output leads to decreased pore visibility and smoother surface
• Inhibits sweat gland activity, leading into reduces swelling and oil mixing
• reduction of neurogenic inflammation via decreased release of substance P and CGRP*

side effects-​

• Pain, burning, or stinging at injection sites
• Dermal muscles paralysis
• Repeated use can cause slower facial wound healing and infection response

Rating​

I give it a 7/10

---

Topical metformin​

topcial metformin

Not sold, ill try think of a way to make it

how does it work-​

• Reduced lipogenesis and triglyceride synthesis* through AMPK inhibition
• Downregulation of NF-κB* activity, lowering pro-inflammatory cytokine production

how to make-​

you will need-

• Raw metformin (as fine as possible)
• water

Mix at a 1:8 ratio

Incorporate some type of skin safe gel (moisturiser)
Mix with water solution

Dermaneedle mixture into skin

side effects-​

• Temporary Irritation and redness
• Barrier disruption
• Peeling (keratinocyte turnover)

Rating​

I rate it a 6/10
(Need more info, pro:Con isnt great)

---

Tazarotene​

how it works-​

• Selective retinoic acid receptor RARβ/RARγ agonist*
• Normalizes keratinocyte life cycle (proliferation and differentiation)
• Increases dermal cell turnover
• Reduces inflammatory signaling in acne lesions
• improvemnt in dermal collagen synthesis and mediated MMP collagen loss

results-​

• reduced comedones
• Reduced inflammation
• Smoother skin
• Improved scarring pigment

side effects-​

• dry skin
• Redness
• peeling
• Photosensitivity

Rating​

I rate it a 8/10
very nice

---

Azelaic acid​

10% or more

how its works-​

• Inhibits mitochondrial oxidoreductase* enzymes, reducing cellular proliferation in hyperactive keratinocytes.
• Normalizes keratinization within the follicle
• antimicrobial activity against Cutibacterium acnes
• Inhibits tyrosinase activity in melanocytes* reducing excess melanin production
• Reduces inflammatory cytokine production

results-​

• Reduced acne and comedones
• Reduced facial redness
• Even skin tone and texture

sides-​

• Burning upon application
• Dry skin
• Overall Temporary Irritation

Rating​

I rate it a 8.5/10
Easily one of the best Topicals
Arguably mogs tret

And speaking of....

---

Tretinoin​

Hold the iso

how it works-​

• Binds to retinoic acid receptors, aaltering the gene expression
• Accelerates dermal cell turnover
• Increases collagen synthesis and reduces MMP mediated collagen loss

results-​

• reduced comedomes
• Reduced inflammation
• Smoother skin brev
• Great healing factor

sides-​

• Dry skin
• Peeling
• Redness
• Photosensitivity
• "Purge"

Rating​

I rate it a 6.5/10
Its not bad but very overhyped

"Mmuuuhh u rate iso higher"
Suck my dick faggot

---

Clascoterone​

Aas protection for @includings

how it works-​

• Topical anti-androgen
• competing with DHT and testosterone for androgen receptor binding in the skin
• Reduces androgen driven sebum production
• Decreases androgen driven inflammatory signaling
• Acts locally in the skin with minimal systemic exposure.

Near completely corrects and stops all androgen driven skin issues

side effects-​

same as most topicals

• Redness
• Burning
• Irritation

Rating​

I give it a 4/10 for avg use
On AAS I give it a 8.5/10

---

Topical calcitriol​

How it works-​

• Activates the vitamin D receptor in keratinocytes
• keratinocyte proliferation, reducing excessive dermal cell growth
• promotes proper keratinocyte maturation and differentiation
• Modulates immune signaling by reducing production of pro inflammatory cytokines

Resulting in-​

• Reduced scaling and plaque formation
• improved skin barrier function
• reduced inflammation
• More dermal turnover

Rating​

I give it a 5/10
Simply js improves skin structure and barrier

---

Dictionary*​

Copied directly of studies

Sebum-​

The oily substance naturally produced by the skin. It helps lubricate and protect the skin and hair.

Sebaceous glands-​

Small glands attached to hair follicles that produce and release sebum.

Keratinization-​

The process by which skin cells mature, harden, and move toward the skin surface before being shed.

Follicular epithelium-​

The layer of skin cells lining the inside of a hair follicle.

MMP (Matrix Metalloproteinase)-​

A group of enzymes that break down collagen and other structural proteins in the skin.

Keratinocyte-​

The main cell type found in the epidermis. These cells produce keratin and make up most of the skin's outer layer.

Hyperpolarization-​

A change in a cell's electrical charge that makes it less likely to become activated.

Acetylcholine-​

A neurotransmitter used by nerves to communicate with muscles, sweat glands, sebaceous glands

Substance P and CGRP-​

Signaling molecules released by nerves that promote inflammation, redness, pain, and blood vessel dilation.

Triglyceride synthesis-​

The process by which cells produce triglycerides, the main fats stored in tissues and found within sebum.

NF κB-​

A protein complex that acts as a master switch for inflammation, turning on genes involved in immune and inflammatory responses.

RARβ/RARγ agonist-​

A compound that activates retinoic acid receptors beta and gamma, altering gene expression involved in skin cell growth and differentiation

Oxidoreductase-​

An enzyme that helps transfer electrons between molecules during metabolic reactions.

Melanocytes-​

Specialized skin cells that produce melanin, the pigment responsible for skin, hair and eye colour.

great, wish u added coloring but great other than that

 

[Rayzo]

great, wish u added coloring but great other than that

that varries person by person too much i would not be able to cover it all

 

[bluebandz]

that varries person by person too much i would not be able to cover it all

Fair