Furosemide and Diuretic Adaptation- Why You still look like a Chud after 80mg Furosemide.

[Genio]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium

Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

 

[Genio]

@Sayori @Orka @Veridic @Whiteboard7 @egyptiansub5

 

[Navity]

Thoughts? @6footislaw

 

[Genio]

@polonaecel @tuberculosisinmybal

 

[Genio]

Wtf I had so much people in mind to mention but now im blanking like fuck

 

[Genio]

@SlayerJonas IIRC you had the Furo Thread in BOTB, Wishing to hear your thoughts.

 

[polonaecel]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

My mom has prescription lisinopril

 

[Genio]

My mom has prescription lisinopril

Planning to take a pack of hers? It's fairly cheap, all in all I dont think Im spending over 30 USD total monthly on this.

 

[Navity]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

Great thread, Every molecule.
Thought's on teens using this?

 

[polonaecel]

Planning to take a pack of hers? It's fairly cheap, all in all I dont think Im spending over 30 USD total monthly on this.

nah
when i eventually roid ill use telmisartan (for BP)
cuz my mom has lisinpril prescirbed for high BP

 

[Genio]

@Histism Egyptians always hook eachother up (plz rep)
@Sadist

 

[Genio]

Great thread, Every molecule.
Thought's on teens using this?

I'm a teen using it, Aslong as you can get test's I don't think there's much risk, I am planning to make a thread in a month regarding experience's (hoping to get additional test's aswell) to show that it's fairly low risk.

The only issue I can name is High Potassium, Low-Dose Thia shouldnt cause a problem though.

 

[Genio]

nah
when i eventually roid ill use telmisartan (for BP)
cuz my mom has lisinpril prescirbed for high BP

All the best mate

 

[Navity]

I'm a teen using it, Aslong as you can get test's I don't think there's much risk, I am planning to make a thread in a month regarding experience's (hoping to get additional test's aswell) to show that it's fairly low risk.

The only issue I can name is High Potassium, Low-Dose Thia shouldnt cause a problem though.

Could I PM you for some doubts I have? Also Tag me

 

[Whiteboard7]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

I don't use this kind of stuff but thanks for pinging me bhai

 

[polonaecel]

I'm a teen using it, Aslong as you can get test's I don't think there's much risk, I am planning to make a thread in a month regarding experience's (hoping to get additional test's aswell) to show that it's fairly low risk.

The only issue I can name is High Potassium, Low-Dose Thia shouldnt cause a problem though.

b- b- but clav said its dangerous

 

[Genio]

Could I PM you for some doubts I have? Also Tag me

For sure bro, Dm's are always open.

 

[Histy]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

Showing my presence of admiration on this guide.
Well done and simply written.
Shall this taste in music spread everywhere.​

 

[Genio]

b- b- but clav said its dangerous

Same dude who cried over his cheeseburger having cheese

 

[Genio]

I don't use this kind of stuff but thanks for pinging me bhai

All the best mate, more thread's to come, investment will be godly.

 

[alexias]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

Good thread, I'll be starting eplerenone after I get a job it's very expensive. Furo always kind of sucked

 

[Genio]

Good thread, I'll be starting eplerenone after I get a job it's very expensive. Furo always kind of sucked

Wishing you all the best, It'll take a few week's for visible result's as far as I have heard, Please let me know your experiences with it, Maybe there can be some additions to this thread.

 

[Boyoshutup]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

Just methmax at this point
Good thread btw

 

[Genio]

mayne i had BOTB vision writing this thread, plz rep
bump

 

[Genio]

@Zagro @forestanon @fazehamster Dudes were here from the beginning lol

 

[Genio]

@Gaia262 I don't know if youre interested in this, hope its of any use to you

 

[Zagro]

Bump

 

[Genio]

Bump.

 

[Sayori]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

amazing thread bhai holy

 

[Genio]

amazing thread bhai holy

you think BOTB worthy with some refinements?

 

[Genio]

Bump

 

[goku21]

Good thread

 

[Genio]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

@Hernan Hey man, sorry to disturb you but I made a Spelling Error in the Conclusion (I stopped looking as bloated as when I first took 40mg Lasix) and I don't think I can edit anymore, is it that you can only edit once and after that editing perm's are gone? Is there a way to fix this?

Thank's for any Information.

 

[Sayori]

you think BOTB worthy with some refinements?

Its already been talked about in a botb so I dont think so

But it's a top tier thread

 

[Genio]

Its already been talked about in a botb so I dont think so

But it's a top tier thread

Diuretic Adaptations? No shot I legit came when I found out why I wasnt as debloated as before

 

[Sayori]

Diuretic Adaptations? No shot I legit came when I found out why I wasnt as debloated as before

ill be seeing this in botb

 

[Genio]

ill be seeing this in botb

Uncle did you even read the thread

 

[Sayori]

Uncle did you even read the thread

No a nga was filtering test

Ill read in a bit

 

[Genio]

No a nga was filtering test

Ill read in a bit

Filtering test

Wallahi Billahi Tillahi not a single person was filtering their testosterone before that tiktok came up, fucks up with purity aswell.

 

[Sayori]

Filtering test

Wallahi Billahi Tillahi not a single person was filtering their testosterone before that tiktok came up, fucks up with purity aswell.

I got my filtering from goo jfl

people have been filtering for a while on meso rx I prefer not to inject those black specs

 

[Genio]

I got my filtering from goo jfl

people have been filtering for a while on meso rx I prefer not to inject those black specs

Yeah but there's not much use, if your Testosterone is from a good source then filtering wont do much else, Bodybuilder's in the 90s proved this, plus it can fuck up with purity if your filteration system isn't clean.

plus we all know you only scared of those spec's cause they black smh

 

[norwoodingmanlet]

I got my filtering from goo jfl

people have been filtering for a while on meso rx I prefer not to inject those black specs

some say it makes their cycle feel smoother

would u say it does?

 

[Sayori]

Yeah but there's not much use, if your Testosterone is from a good source then filtering wont do much else, Bodybuilder's in the 90s proved this, plus it can fuck up with purity if your filteration system isn't clean.

plus we all know you only scared of those spec's cause they black smh

I got a good filtering system + my wwb gear had specs nga

I only filter if I'm feeling motivated tho if not idc

 

[norwoodingmanlet]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

dont even need to read to tell its a good thread LOL

keep it up

 

[Sayori]

some say it makes their cycle feel smoother

would u say it does?

idk im new it's not much dif

 

[norwoodingmanlet]

I got a good filtering system + my wwb gear had specs nga

I only filter if I'm feeling motivated tho if not idc

In a couple weeks I could slang u a homebrew source that doesnt use any ethyl

gimme a min tho

 

[Genio]

I got a good filtering system + my wwb gear had specs nga

I only filter if I'm feeling motivated tho if not idc

I mean uncle its WWB, their shit is either underdosed or over-drugged with Chinese Circle-Jerk cum

either way, up to you, i just dont really see the point. keep it up bhai can't wait for the slay stories in 2 years

 

[whodoievenbelieve]

Even if I'm not on furosemide can I still take those 3 drugs daily to stay more debloated for life? (epleronone, lisinopril, metolazone eod). Currently I was just using 100mg epleronone daily and all ts seems confusing

 

[Genio]

dont even need to read to tell its a good thread LOL

keep it up

Thank you man, spent an hour on it and was feeling unmotivated, I have alot more threads I wanna write but I keep Procrastinating + my GCSE's are in a few week's.

 

[norwoodingmanlet]

Thank you man, spent an hour on it and was feeling unmotivated, I have alot more threads I wanna write but I keep Procrastinating + my GCSE's are in a few week's.

yeah i like the photographs makes shit easier for us id say only critique is add a spoiler or 2 and a little smaller text but even then still good thread bro im investing hold up