Furosemide and Diuretic Adaptation- Why You still look like a Chud after 80mg Furosemide.

[Genio]

Even if I'm not on furosemide can I still take those 3 drugs daily to stay more debloated for life? (epleronone, lisinopril, metolazone eod). Currently I was just using 100mg epleronone daily and all ts seems confusing

For sure, I would say their slightly better since they are compatible to be taken ED while Furo is only once per week.

Furo is stronger though, if you can't get it then Epl + Metolazone + Lisino is great.
all the best.

 

[Sayori]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

So, if I read this right loop diuretics cause your body to become a bloat cell after them because of RAAS

your counter is "Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily."

Honestly amazing thread bhai I expect to see this in the botb as its pharma

 

[Genio]

yeah i like the photographs makes shit easier for us id say only critique is add a spoiler or 2 and a little smaller text but even then still good thread bro im investing hold up

Yeah i wanted to add a Before Lisino+Metalozone Pic while on Lasix and 2 weeks post Lisino+Metalozone with Lasix but I got lazy.

The change's are definently there though, you can steer clear of these pharmaceuticals if Lasix intake is once like every 1 or 2 month's since RAAS doesnt get desensitized to it as much, this is just a solution for those who wanna go back to their first Lasix Dosage while taking it Every Week.

Next thread will hopefully be Injectable Furo vs Oral Furo (since a percentage of Oral doesn't get absorbed and instead is digested).

 

[whodoievenbelieve]

For sure, I would say their slightly better since they are compatible to be taken ED while Furo is only once per week.

Furo is stronger though, if you can't get it then Epl + Metolazone + Lisino is great.
all the best.

Goated bro I def will be scoring those other 3 drugs from Indiamart immediately

 

[norwoodingmanlet]

Yeah i wanted to add a Before Lisino+Metalozone Pic while on Lasix and 2 weeks post Lisino+Metalozone with Lasix but I got lazy.

The change's are definently there though, you can steer clear of these pharmaceuticals if Lasix intake is once like every 1 or 2 month's since RAAS doesnt get desensitized to it as much, this is just a solution for those who wanna go back to their first Lasix Dosage while taking it Every Week.

Next thread will hopefully be Injectable Furo vs Oral Furo (since a percentage of Oral doesn't get absorbed and instead is digested).

woww injectable furo

dk how youd even source that but high iq ngl bro

yo so with me having past atrial fibrilation events im worried about lasix, would you say for minor bloat HCTZ could suffice? dm me bro itd mean alot

 

[Genio]

So, if I read this right loop diuretics cause your body to become a bloat cell after them because of RAAS

your counter is "Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily."

Honestly amazing thread bhai I expect to see this in the botb as its pharma

Coorect, Loop Diuretic's have a Sad Rebound since Minerals either get trapped or get excreted, Taking Eplerenone and Metalozone Daily rid's that effect (whenever you do go on lasix)

 

[Genio]

woww injectable furo

dk how youd even source that but high iq ngl bro

yo so with me having past atrial fibrilation events im worried about lasix, would you say for minor bloat HCTZ could suffice? dm me bro itd mean alot

fs bro, my pm's are always open.

 

[Sayori]

Coorect, Loop Diuretic's have a Sad Rebound since Minerals either get trapped or get excreted, Taking Eplerenone and Metalozone Daily rid's that effect (whenever you do go on lasix)

Nigger rep me

 

[Genio]

Nigger rep me

View attachment 4907115

Nop betraying my Day 1's

 

[Sayori]

Nop betraying my Day 1's

nga made it! with this fire thread and shot his day one

 

[Genio]

nga made it! with this fire thread and shot his day one

Got my first 50 USD from my 9-5 and unfollowed ALL my day 1's

 

[Genio]

BUMPPPPP

 

[Genio]

Bump

 

[Genio]

@NoxInfernum @Verdam

 

[Verdam]

@NoxInfernum @Verdam

nigga tagged me like ik anything abt ts

 

[Genio]

nigga tagged me like ik anything abt ts

I NEED the rep's

 

[egyptiansub5]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

high iq
repped
bookmarked
kised

 

[Genio]

Yall got me fucked up, Reeves shrugs can get into BOTB but i have to keep bumping this shit?

BUMP FAGGOTS

 

[Genio]

Bump

 

[Genio]

@Grilldaddy❤️ @neurodivergent @Jager any nigga from GDS atp just ffs rep so that I can get to BOTB req.

 

[forestanon]

@Zagro @forestanon @fazehamster Dudes were here from the beginning lol

hi whatsup

 

[Hernan]

@Hernan Hey man, sorry to disturb you but I made a Spelling Error in the Conclusion (I stopped looking as bloated as when I first took 40mg Lasix) and I don't think I can edit anymore, is it that you can only edit once and after that editing perm's are gone? Is there a way to fix this?

Thank's for any Information.

you can edit all you want in a timewindow.

 

[Aoki33]

mirin nigga

 

[tripletungsahur67]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

---

2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

---

3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

---

4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

---

If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

Dance to pay le respect

 

[Genio]

you can edit all you want in a timewindow.

Thank's for the info, do u have any BOTB tip's? I thought this was good but clearly not BOTB-worthy

 

[Hernan]

Thank's for the info, do u have any BOTB tip's? I thought this was good but clearly not BOTB-worthy

None.

 

[Genio]

None.

What are the step's I can take to check if it is BOTB worthy? I don't find any thread talking about Diuretic Adaptations, my thread officially has 20 Rep's and helped a few people, I believe it can be structured a bit better. Any Information would be appreciated.

Thank's again for your time, I saw your BSSO thread, Wishing you all the best.

 

[Hernan]

What are the step's I can take to check if it is BOTB worthy? I don't find any thread talking about Diuretic Adaptations, my thread officially has 20 Rep's and helped a few people, I believe it can be structured a bit better. Any Information would be appreciated.

@Chad what do you think?

Thank's again for your time, I saw your BSSO thread, Wishing you all the best.

Thanks a lot I’m recovering well.

 

[Genio]

@Chad what do you think?

Thanks a lot I’m recovering well.

Wishing you a speedy recovery! Any other Surgeries in mind? I am trying to save enough fund's right now so that once I turn 18 I am able to get a Bone-Graft Augmented Rhinoplasty and L-Shaped Paranasal Implant's.

 

[Genio]

Bumbbumb, the more rep's the better.

 

[smartstyle]

Song for the Thread (Highly Recommend)

Spoiler: Yearly Music

WARNING
Everything mentioned in this thread is purely Theoretical, Consult with a Medical Profession before taking any action in regard's to your Health and Diuretic's, I am NOT Responsible for any Health Problem's that may occur.​

---

Table of Introduction
1. How Furosemide Work's in Pathways
2. How Diuretic Adaptation Work's inside the Body and it's Effects.
3. How to Inhibit Diuretic Adaptation to the Fullest Potential
4. My Schedule and Effect's​

---

1. How Furosemide Work's in Pathway's
Furosemide (Brand Name Lasix) is a Loop Diuretic that is used in the Medical Scene for Prevention of Fluid Retention, Edema, Heart Failure, and High Blood Pressure. a Loop Diuretic is differentiated from other Diuretic's due to it's effect on Excretion of all the Mineral's inside your Body, While other Diuretics can be used to Excrete only Sodium and Keep Potassium, Loop Diuretic's rids your body of all the Mineral's it contains over the span of 3-6 Hour's (in my experience).
Furosemide acts by inhibiting sodium reabsorption in the thick ascending limb of the loop of Henle within the nephron. This segment is characterized by the presence of the NKCC2 cotransporter, which normally mediates the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream.
Na+ + K+ + 2Cl- -----> Aggressive Reabsorption of Sodium
View attachment 4905825
Furosemide work's to inhibit the NKCC2 Transporter by Binding to it in the Ascending Limb of the Henle Loop, and prevents Sodium from being Transported into the Blood-stream. Sodium, Potassium, and all other Mineral's are kept inside the Tubular Fluid.
The Existing Sodium and Potassium in the Bloodstream are Followed by Water and Bond Together, where they are Excreted through Urine (Which result's in an increase of Diuresis).

Lasix is regularly taken at dose's of 80-120MG, However I believe 40mg is Enough for Visible Result's.
Do not exceed Absorption of Lasix more than Twice per week.​

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2. How Diuretic Adaptation Work's Inside the Body and it's Effect's.
The Body hates losing fluid volume, Once Blood fluid drop's, the Body panic's, and activate's Renin-Angiotestin-Aldosterone-System (RAAS) and Anti-Diuretic Hormone (ADH-Vasopressin), Both of these Product's do their best to reduce Fluid loss.

Renin-Angiotestin-Aldosterone-System (RAAS)
This System is what induce's Diuretic Adaptation the Most.

Renin
Renin (Juxtaglomerular Cell) is an Enzyme released by the Kidney when the Kidney sense's Low Sodium, Renin Triggers Angiotestin I as a Precursor to Trigger Angiotestin II
Angiotestinogen ----> Angiotestin I Via Renin.

Angiotestin I
Angiotestin I is mostly an Inactive form of Angiotestin, It's main role is to Circulate in the Blood until it reaches the Lung's, Where Angiotestin-Converting Enzyme (ACE) convert's Angiotestin I to Angiotestin II.
Angiotestin I -----> Angiotestin II Via Angiotestin Converting Enzyme (ACE)

Angiotestin II
Angiotestin II Upregulates Vasoconstriction, Which directly increases Blood Pressure and counter-act's Furo's Effect by reducing the need of Fluid Excretion. Kidney perfusion pressure improve's, and the Body stop's excretion.
Angiotestin II ----> Blood Pressure via Upregulating Vasoconstriction.
Angiotestin II Additionally Activate's Aldosterone Release by the Adrenal Cortex (Zona Glomerulosa)
Angiotestin II -----> Aldosterone by Release of Adrenal Cortex

Aldosterone
Aldosterone is triggered by Angiotestin II and can occasionally be triggered by High Potassium Level's (Must read for Potassium Sparing Diuretic User's), Aldosterone directly increases Sodium Reabsorption by acting on the distal tubule and collecting duct, It act's on the ENaC Channel which allow's Sodium to enter the Kidney Cell's and be transported in the Blood System, Directly Countering Furo's Effect

Overtime, RAAS become's stronger due to Constant Use of Furosemide (and Potassium Sparring Diuretic's), and lead's Furosemide becoming Useless.

Anti-Diuretic Hormone (ADH)
ADH is a Hormone that work's by noticing when the Blood is too concentrated, it reabsorbs Water from Urine by Activating Aquaporin II Channel's, Water is then Transported into the Blood System, as if nothing ever happened.​

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3. How to Inhibit Diuretic Adaptation
To Inhibit Diuretic Adaptation, We would have to Manipulate part's of the RAAS System and ADH, Specifically, the Part's which cause Reabsorption and Counter-acting Excretion.

Aldosterone Inhibitor's
By Inhibiting Aldosterone through Aldosterone Inhibitor's, Sodium cannot be Re-absorbed. This can be Achieved through Aldosterone Inhibitor's such as Eplerenone or Spirolactone. Inhibiting Aldosterone has good Heart benefit's, since Aldosterone is known for Tissue-Scarring. Risk's Include Gyno (Man-boob's) when taking Spironolactone since it isn't selective and reduce's AR Sensitivity, Eplerenone has no effect's on AR, Can still cause Gyno but risk is much lower.
Spironolactone can be taken 12.5 - 25mg daily, Eplerenone can be taken at 50-100mg daily.

Angiotestin-Conversion Enzyme Blocker's
Blocking ACE can be achieved through a Pharmaceutical known as Lisinoprol. Inhibiting ACE long-term can have Great Health Benefit's such as lowering Blood-Pressure and Slowing Kidney Disease Progression, Fainting/Dizziness can occur at time's. If any Health Problem's arise (Which I doubt will happen), You can stop taking it, and ACE can return in the span of a couple of day's.
I take 5mg of Lisinopril daily.

Thiazide Diuretic's
Thiazide Diuretics counter-act Sodium Re-Absorption after the Loop of Henle in the Distal Tubule, Meaning even after Lasix wears off, the Nephron cannot Reabsorb Sodium efficiently. Thiazide Diuretic's were made to be taken life-long, so Side-Effect's are low. They can reduce Kidney Stone's due to High Absorption of Calcium in the blood. I highly recommend Metolazone.
2.5mg of Metolazone every other-day is more than enough (Due to Effect on Potassium)​

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4. My Schedule and Effect's of Supplementing in Metolazone and Lisinopril.
I have been taking Lasix for over a year and a half so far, I haven't entered any Health Problem's, my EGFR is >100 and my Creatinine Level's were Ideal. But I realized I stopped looking as bloated as when I first took 40mg Lasix, Once I started supplementing Lisinopril and Metolazone Daily, I noticed great effect's with Aqualyx after two week's, I have never seen myself as debloated as then. I haven't really felt dizzy at all. I recommend keeping Potassium Low (Not zero) when on Lisinopril. Long-term both Compound's can be really beneficial to Health.​

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If you have any Question's, feel free to ask and I will do my best to answer them down below
Please get Test's while on Diuretic's just to be safe, even if risk is low.
Praying for an Ascension for all of you.

Your's truly,
Genio.

Edit: I am planning to start on Eplerenone soon aswell, Just need to wait a bit or else my local pharmacy might report me (douchebags)​

Ain't using furo daily would rape your liver and health? I use it only on really special occasions since pissing like 3 liters of liquid terrifies me.

 

[Genio]

Ain't using furo daily would rape your liver and health? I use it only on really special occasions since pissing like 3 liters of liquid terrifies me.

Kidney*

Nobody should be taking it daily, This is why I recommend twice a week top's, I know a few people on here who took 120mg continuously and they are fine though, The Pharma's i'm taking are daily since RAAS can't be desensitized day of Furo, it has to be continuously desensitized iykwim, this is just so when I need to use Furo it can work perfectly well without it being counter-acted.

 

[smartstyle]

Wh

Kidney*

Nobody should be taking it daily, This is why I recommend twice a week top's, I know a few people on here who took 120mg continuously and they are fine though, The Pharma's i'm taking are daily since RAAS can't be desensitized day of Furo, it has to be continuously desensitized iykwim, this is just so when I need to use Furo it can work perfectly well without it being counter-acted.

At you think about Eplerenone

 

[Genio]

Wh

At you think about Eplerenone

It's great, planning to get on it soon.

+please rep, hoping this could get BOTB.

 

[Sayori]

Bump this fire thread

 

[Sayori]

It's great, planning to get on it soon.

+please rep, hoping this could get BOTB.

Don't forget to apply for the botb

 

[Genio]

Don't forget to apply for the botb

How can I apply for BOTB?

 

[Sayori]

How can I apply for BOTB?

Im missing two reps

Best of the Best Submissions & Eligibility Rubric Thread

Dear forum members, As a newly appointed moderator of this website, my primary objective is to identify outstanding threads and give justice to the rotting gems on the looksmaxing section, and promote them to the "Best of the Best" section. Having assumed my role just a few hours ago, I am...

looksmax.org

 

[goku21]

I’ve already ordered floursmide n I dnrd ts, tldr pls

 

[Genio]

I’ve already ordered floursmide n I dnrd ts, tldr pls

Take it once per month or hop on Lisinopril + Eplerenone daily.

And rep uncle

 

[goku21]

Take it once per month or hop on Lisinopril + Eplerenone daily.

And rep uncle

I did rep

 

[Genio]

Im missing two reps

Best of the Best Submissions & Eligibility Rubric Thread

Dear forum members, As a newly appointed moderator of this website, my primary objective is to identify outstanding threads and give justice to the rotting gems on the looksmaxing section, and promote them to the "Best of the Best" section. Having assumed my role just a few hours ago, I am...

looksmax.org

Uncle my thread has 20 reactions now, regard this as me ABANDONING and SHOOTING my day 1's

 

[Genio]

I did rep

thnx pooks

 

[Hernan]

Wishing you a speedy recovery! Any other Surgeries in mind?

Genio for sure, I don’t think rhino is needed but if someone gifts me it I’ll take it.

 

[The Dire]

I noticed great effect's with Aqualyx after two week's

What's your experience with Aqualyx?

 

[LackEmpathyTherefor]

broski, for a first time diuretic user looking to counteract minoxidil bloat mainly and for dates:
What do you think of HCTZ, and occasional Eplerone usage, and 1-2x month lasix.

Also can you confortably use those while slaying or will it endure sexual performance ?
I really lack pharma knowledge on ts tbh

 

[Genio]

What's your experience with Aqualyx?

My bad I was running on 4 hours of sleep at 2 AM in the morning, I meant Lasix.

Lasix kind of sounds similiar to Aqualyx in a way iykwim, my bad.

 

[Genio]

broski, for a first time diuretic user looking to counteract minoxidil bloat mainly and for dates:
What do you think of HCTZ, and occasional Eplerone usage, and 1-2x month lasix.

Also can you confortably use those while slaying or will it endure sexual performance ?
I really lack pharma knowledge on ts tbh

If youre able to get Eplerenone then no need for HCTZ (though it is really mogger), Since youre gonna be taking Lasix only once or twice a month, RAAS wont be able to get adapted really quickly, you would have more than enough time before entering into Diuretic Adaptation.

Eplerenone Daily + Lasix on special Occasions will do wonders

 

[Genio]

Bump

 

[Genio]

Bump