currycel67
Bronze
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Total E2 wipeout :
Aromatese inhibitors are not enough
They does not do anything for :
Direct testicular secretion -Als CANNOT penetrate your balls which create 15-25% estradiol
Local bone aromatase Growth plates make their own estrogen from circulating testosterone
Adrenal sources-DHEA converting to estrone in peripheral tissues, contributes 20-40% estrogen
Why estrogen receptor degrading is also not optimal
Fulvestrant which degrades ERa directly we may think it's the meta but it's not ideal
in girls it only brought bone age back to NORMAL progression + no tests in human males
Nonetheless, Estrogen Receptor degradation has FAR worse side effects than nuking e2.
Degrading Hepatic ER-alpha→ metabolic chaos, insulin resistance, NAFLD
Vascular ERa→endothelial dysfunction, premature atherosclerosis
Bone maintenance ERa-paradoxically causing the
osteoporosis
Als spare cognition because ER-beta provides e2 independent support. Although Fulv doesn't affect ERb, this still proves our ER theory
Now let's get into how to optimally get rid of e2
GONADAL
Testes produce 15-25% of male estrogen directly, plus
massive local aromatization
C-Met
Solution:
ZERO serum testosterone
Minimal ITT
(intratesticular testosterone maintained at 20-40ng/dl via micro-dose HCG
Leydi
S IU EOD, or better-FSH-only
stimulation at ~75 1U/week to preserve fertility without g activation)
ADRENAL GLANDS
Adrenal androgens (DHEA, androstenedione) convert
peripherally to estrogen and account up to 30%
This is a bit more trickly to manipulate as some of these
are pretty important
My best Solution would be:
A Glucocorticoid antagonist such as tren or
Mifepristone (I would do tren for this effect + bones)
2. 20mg Melatonin blunts DHEA-S 15-20%, cheap & safe
3. Sensitizing Insulin receptors
4. Reducing Cortisol
5. Lowering Body Fat
6. STA Very Low testosterone levels
Extras:
DHED
What it is :
A prodrug of estradiol (E2) designed to convert preferentially in the brain.
We could potentially use this to get rid of the brain related sides (brain related sides are overly exaggerated and not that big of a deal)
Summary
Our goal is to create a near-zero estrogen environment via manipulation aromatese, aromitizable androgen abscence, and adrenals
Crash testosterone with AAS, replace androgen needs with dht-deriv or tren + allopregnenolone
Micro-dose 5iu HCG EOD to prevent full testes atrophy while keeping ITT minimal for less estrogen
Supress Adrenal estrogen with Tren or Misprefistone (GR antagonistic), 20mg ogenes Melatonin, Metformin
Mop up remaining aromatese derived estrogen by maintaining a low body fat + 25mg aromasin or 1mg Anastrozole
Optional:
Way200070 for ERb activation (doesn't contribute to fusion much) and prevention of most low-estrogen side effects if needed
@Sayori, @Disturbed @0ptimized, @eyezen, @Revan
Aromatese inhibitors are not enough
They does not do anything for :
Direct testicular secretion -Als CANNOT penetrate your balls which create 15-25% estradiol
Local bone aromatase Growth plates make their own estrogen from circulating testosterone
Adrenal sources-DHEA converting to estrone in peripheral tissues, contributes 20-40% estrogen
Why estrogen receptor degrading is also not optimal
Fulvestrant which degrades ERa directly we may think it's the meta but it's not ideal
in girls it only brought bone age back to NORMAL progression + no tests in human males
Nonetheless, Estrogen Receptor degradation has FAR worse side effects than nuking e2.
Degrading Hepatic ER-alpha→ metabolic chaos, insulin resistance, NAFLD
Vascular ERa→endothelial dysfunction, premature atherosclerosis
Bone maintenance ERa-paradoxically causing the
osteoporosis
Als spare cognition because ER-beta provides e2 independent support. Although Fulv doesn't affect ERb, this still proves our ER theory
Now let's get into how to optimally get rid of e2
GONADAL
Testes produce 15-25% of male estrogen directly, plus
massive local aromatization
C-Met
Solution:
ZERO serum testosterone
Minimal ITT
(intratesticular testosterone maintained at 20-40ng/dl via micro-dose HCG
Leydi
S IU EOD, or better-FSH-only
stimulation at ~75 1U/week to preserve fertility without g activation)
ADRENAL GLANDS
Adrenal androgens (DHEA, androstenedione) convert
peripherally to estrogen and account up to 30%
This is a bit more trickly to manipulate as some of these
are pretty important
My best Solution would be:
A Glucocorticoid antagonist such as tren or
Mifepristone (I would do tren for this effect + bones)
2. 20mg Melatonin blunts DHEA-S 15-20%, cheap & safe
3. Sensitizing Insulin receptors
4. Reducing Cortisol
5. Lowering Body Fat
6. STA Very Low testosterone levels
Extras:
DHED
What it is :
A prodrug of estradiol (E2) designed to convert preferentially in the brain.
We could potentially use this to get rid of the brain related sides (brain related sides are overly exaggerated and not that big of a deal)
Summary
Our goal is to create a near-zero estrogen environment via manipulation aromatese, aromitizable androgen abscence, and adrenals
Crash testosterone with AAS, replace androgen needs with dht-deriv or tren + allopregnenolone
Micro-dose 5iu HCG EOD to prevent full testes atrophy while keeping ITT minimal for less estrogen
Supress Adrenal estrogen with Tren or Misprefistone (GR antagonistic), 20mg ogenes Melatonin, Metformin
Mop up remaining aromatese derived estrogen by maintaining a low body fat + 25mg aromasin or 1mg Anastrozole
Optional:
Way200070 for ERb activation (doesn't contribute to fusion much) and prevention of most low-estrogen side effects if needed
@Sayori, @Disturbed @0ptimized, @eyezen, @Revan
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