GH peptides for Local IGF-1

[kise]

Introduction​

I see many people on this forum do not know the difference between chondrocytic igf1 and serum. They wonder how come most ISS studies on GH don’t show much or any increase in FAH? It’s because HGH (semi-continuous exposure) is not a viable option for Local IGF-1. My thread will go over the most viable option (GH pathway) for Local IGF-1. (I will have thread on local IGF-1 vs Serum soon)​

​

​

Summary​

A highly effective approach for enhancing local IGF-1 signaling involves combining GHRP-2, CJC-1295 (no DAC), and a somatostatin (SST) inhibitor such as melatonin.
For optimal results, injections should be performed after at least 3 hours of fasting, followed by a carbohydrate intake 30 minutes post-injection to support the GH → IGF-1 conversion.

Reasoning

The most reliable way to stimulate local IGF-1 is to amplify your body’s natural GH pulse rather than forcing a prolonged, artificial elevation. GHRP-2 and CJC-1295 (no DAC) do exactly that.

They avoid issues such as STAT5b resistance, which can blunt GH → IGF-1 signaling.
(As referenced in “Regular Meals Matter: Bone Growth and Beyond,” disturbances in STAT5b severely impair IGF-1–dependent growth.)

• GHRP-2 → GHS-R1a (ghrelin receptor)
• CJC-1295 (no DAC) → GHRH receptor

By activating both pathways, they enhance GH secretion far more than either alone.
This dual-pathway synergy is repeatedly supported in GH-stimulation research. ( Lol they grew from GHRP nasal spray as well ).

SST Inhibition


Somatostatin is one of the body’s strongest GH-inhibiting hormones. It works directly against GHRH and suppresses pituitary GH release.

To get the highest possible GH peak, lowering somatostatin is essential. Melatonin has been shown in studies to increase GH lower SST. For example, one study shows dosages up to 5mg melatonin increased GH and decreased SST compared to placebo both prior and after exercise.



References : Nassar E, Mulligan C, Taylor L, Kerksick C, Galbreath M, Greenwood M, Kreider R, Willoughby DS. Effects of a single dose of N-Acetyl-5-methoxytryptamine (Melatonin) and resistance exercise on the growth hormone/IGF-1 axis in young males and females. J Int Soc Sports Nutr. 2007 Oct 23;4:14. doi: 10.1186/1550-2783-4-14. PMID: 17956623; PMCID: PMC2174513.

https://journals.physiology.org/doi/full/10.1152/ajpendo.00513.2001

Pihoker C, Badger TM, Reynolds GA, Bowers CY. Treatment effects of intranasal growth hormone releasing peptide-2 in children with short stature. J Endocrinol. 1997 Oct;155(1):79-86. doi: 10.1677/joe.0.1550079. PMID: 9390009.

 

[Stacyslayerᛉ]

Thread ok, just water information.

 

[CertifiedGoy]

Exogenous gh will still be more useful nevertheless

 

[kise]

Thread ok, just water information.

first thread idk what to post. and surprisingly ngas dk what chondrocytic igf1 is

 

[kise]

Exogenous gh will still be more useful nevertheless

maybe in high doses yes ( 15-20iu + )

 

[Stacyslayerᛉ]

first thread idk what to post. and surprisingly ngas dk what chondrocytic igf1 is

yeah, Thread is good, but should be common knowledge.

 

[kise]

Thread ok, just water information.

what should i post tbh like i have info on each pathway or trans factor

 

[kise]

yeah, Thread is good, but should be common knowledge.

true, I will probably post abt how to inhib sost without any drugs or sum shi unless you think its all water 2.

 

[Stacyslayerᛉ]

true, I will probably post abt how to inhib sost without any drugs or sum shi unless you think its all water 2.

I mean its usefull info.
But id say post about sox9 and runx 2 would be interesting.
maybe some method on how to optimise them.
Also HDAC inhibition would be interesting to see.

 

[kise]

I mean its usefull info.
But id say post about sox9 and runx 2 would be interesting.
maybe some method on how to optimise them.
Also HDAC inhibition would be interesting to see.

sure, i already got sox9 and run down in my docs but ive been looking into hdaci more ( not some vorinostat cope )

 

[Stacyslayerᛉ]

sure, i already got sox9 and run down in my docs but ive been looking into hdaci more ( not some vorinostat cope )

nice, tag me fs

 

[kise]

nice, tag me fs

fs

 

[Leo]

nice, tag me fs

fs

Tag me too, i also wanna know

 

[kise]

nice, tag me fs

whats your disc you sound like sum1 from users fg

 

[Stacyslayerᛉ]

_kxnsti_

 

[Zagro]

sure, i already got sox9 and run down in my docs but ive been looking into hdaci more ( not some vorinostat cope )

Vorinostat is almost the best possible one lol

 

[kise]

Vorinostat is almost the best possible one lol

hdac6i and hdac4i is best for bone pan hdacs especially decently potent ones like vorinostat are shit.

 

[Zagro]

hdac6i and hdac4i is best for bone pan hdacs especially decently potent ones like vorinostat are shit.

Thats what i also thought but you need pan-HDAC inhibition for pro-osteogenic effects

 

[Aryan Incel]

HGH mogs all the peptides and HGH secretagous

 

[Palang]

Introduction​

I see many people on this forum do not know the difference between chondrocytic igf1 and serum. They wonder how come most ISS studies on GH don’t show much or any increase in FAH? It’s because HGH (semi-continuous exposure) is not a viable option for Local IGF-1. My thread will go over the most viable option (GH pathway) for Local IGF-1. (I will have thread on local IGF-1 vs Serum soon)​

​

​

Summary​

A highly effective approach for enhancing local IGF-1 signaling involves combining GHRP-2, CJC-1295 (no DAC), and a somatostatin (SST) inhibitor such as melatonin.
For optimal results, injections should be performed after at least 3 hours of fasting, followed by a carbohydrate intake 30 minutes post-injection to support the GH → IGF-1 conversion.

Reasoning

The most reliable way to stimulate local IGF-1 is to amplify your body’s natural GH pulse rather than forcing a prolonged, artificial elevation. GHRP-2 and CJC-1295 (no DAC) do exactly that.
View attachment 4366110

They avoid issues such as STAT5b resistance, which can blunt GH → IGF-1 signaling.
(As referenced in “Regular Meals Matter: Bone Growth and Beyond,” disturbances in STAT5b severely impair IGF-1–dependent growth.)
View attachment 4366095

• GHRP-2 → GHS-R1a (ghrelin receptor)
• CJC-1295 (no DAC) → GHRH receptor

By activating both pathways, they enhance GH secretion far more than either alone.
This dual-pathway synergy is repeatedly supported in GH-stimulation research. ( Lol they grew from GHRP nasal spray as well ).

View attachment 4366092
SST Inhibition


Somatostatin is one of the body’s strongest GH-inhibiting hormones. It works directly against GHRH and suppresses pituitary GH release.

To get the highest possible GH peak, lowering somatostatin is essential. Melatonin has been shown in studies to increase GH lower SST. For example, one study shows dosages up to 5mg melatonin increased GH and decreased SST compared to placebo both prior and after exercise.



References : Nassar E, Mulligan C, Taylor L, Kerksick C, Galbreath M, Greenwood M, Kreider R, Willoughby DS. Effects of a single dose of N-Acetyl-5-methoxytryptamine (Melatonin) and resistance exercise on the growth hormone/IGF-1 axis in young males and females. J Int Soc Sports Nutr. 2007 Oct 23;4:14. doi: 10.1186/1550-2783-4-14. PMID: 17956623; PMCID: PMC2174513.

https://journals.physiology.org/doi/full/10.1152/ajpendo.00513.2001

Pihoker C, Badger TM, Reynolds GA, Bowers CY. Treatment effects of intranasal growth hormone releasing peptide-2 in children with short stature. J Endocrinol. 1997 Oct;155(1):79-86. doi: 10.1677/joe.0.1550079. PMID: 9390009.

Can I combine 10IU HGH with somostatin inhibitor?

 

[kise]

Thats what i also thought but you need pan-HDAC inhibition for pro-osteogenic effects

no, also did you ever debate saif about abalo or no

 

[kise]

Can I combine 10IU HGH with somostatin inhibitor?

i woul do 20 ius of gh

 

[Stacyslayerᛉ]

Would it make sense to combine 10IUs of hgh with ghrp 6 and cjc 1295?

 

[Palang]

i woul do 20 ius of gh

Hard to Finance But would maybe do. 10 still better Than Natural I think. But would you combine with somostatin inhibitor the gh?

 

[kise]

Would it make sense to combine 10IUs of hgh with ghrp 6 and cjc 1295?

no giga fast way toi desens. Do either or

 

[stufftodo]

huperzine a, arginine, and acupuncture also lower somastatin

 

[stufftodo]

there are also difference in gh -> igf1 conversion and circulation

exogenous gh is more well-studied though so i wouldn't say secretagogues are definitively better

 

[Zagro]

no, also did you ever debate saif about abalo or no

Nah i stopped debating him after the rhGH one because he never reads my responses fully neither does he read anything he provides himself, whenever he’s close to losing the debate the responses get even worse

 

[kise]

Nah i stopped debating him after the rhGH one because he never reads my responses fully neither does he read anything he provides himself, whenever he’s close to losing the debate the responses get even worse

add him on disc @ihatepthrp hes a bum who cherry pick study my rrecord against him is 7-0

 

[Zagro]

add him on disc @ihatepthrp hes a bum who cherry pick study my rrecord against him is 7-0

Yeah but even the cherry-picked studies are false lol, busy working on threads man maybe i can debate with him another time

 

[greedpsl]

Introduction​

I see many people on this forum do not know the difference between chondrocytic igf1 and serum. They wonder how come most ISS studies on GH don’t show much or any increase in FAH? It’s because HGH (semi-continuous exposure) is not a viable option for Local IGF-1. My thread will go over the most viable option (GH pathway) for Local IGF-1. (I will have thread on local IGF-1 vs Serum soon)​

​

​

Summary​

A highly effective approach for enhancing local IGF-1 signaling involves combining GHRP-2, CJC-1295 (no DAC), and a somatostatin (SST) inhibitor such as melatonin.
For optimal results, injections should be performed after at least 3 hours of fasting, followed by a carbohydrate intake 30 minutes post-injection to support the GH → IGF-1 conversion.

Reasoning

The most reliable way to stimulate local IGF-1 is to amplify your body’s natural GH pulse rather than forcing a prolonged, artificial elevation. GHRP-2 and CJC-1295 (no DAC) do exactly that.
View attachment 4366110

They avoid issues such as STAT5b resistance, which can blunt GH → IGF-1 signaling.
(As referenced in “Regular Meals Matter: Bone Growth and Beyond,” disturbances in STAT5b severely impair IGF-1–dependent growth.)
View attachment 4366095

• GHRP-2 → GHS-R1a (ghrelin receptor)
• CJC-1295 (no DAC) → GHRH receptor

By activating both pathways, they enhance GH secretion far more than either alone.
This dual-pathway synergy is repeatedly supported in GH-stimulation research. ( Lol they grew from GHRP nasal spray as well ).

View attachment 4366092
SST Inhibition


Somatostatin is one of the body’s strongest GH-inhibiting hormones. It works directly against GHRH and suppresses pituitary GH release.

To get the highest possible GH peak, lowering somatostatin is essential. Melatonin has been shown in studies to increase GH lower SST. For example, one study shows dosages up to 5mg melatonin increased GH and decreased SST compared to placebo both prior and after exercise.



References : Nassar E, Mulligan C, Taylor L, Kerksick C, Galbreath M, Greenwood M, Kreider R, Willoughby DS. Effects of a single dose of N-Acetyl-5-methoxytryptamine (Melatonin) and resistance exercise on the growth hormone/IGF-1 axis in young males and females. J Int Soc Sports Nutr. 2007 Oct 23;4:14. doi: 10.1186/1550-2783-4-14. PMID: 17956623; PMCID: PMC2174513.

https://journals.physiology.org/doi/full/10.1152/ajpendo.00513.2001

Pihoker C, Badger TM, Reynolds GA, Bowers CY. Treatment effects of intranasal growth hormone releasing peptide-2 in children with short stature. J Endocrinol. 1997 Oct;155(1):79-86. doi: 10.1677/joe.0.1550079. PMID: 9390009.

bump

 

[dancepilled]

For optimal results, injections should be performed after at least 3 hours of fasting, followed by a carbohydrate intake 30 minutes post-injection to support the GH → IGF-1 conversion.

Yo, is 30mins enough for the gh peptides to actually be done releasing gh so the insulin doesnt suppress them?