Growth-Hormone Peptides; full breakdown

[aids]

Get this dog shit out of sticky. Which mod thought this was worth that?

 

[latent]

The mods know heightmaxxing is cope and using hgh can result in other imperfections this is why this is not botb

 

[unSlayer0]

The mods know heightmaxxing is cope and using hgh can result in other imperfections this is why this is not botb

Im thinking about taking that shit but i dont know if there are really other side effects that could happend with it

 

[latent]

Im thinking about taking that shit but i dont know if there are really other side effects that could happend with it

do you have idiopathic short stature?

 

[unSlayer0]

do you have idiopathic short stature?

No

 

[latent]

No

Then it's not worth it

 

[unSlayer0]

Then it's not worth it

Aight thanks twin

 

[mogmypsl999]

Im thinking about taking that shit but i dont know if there are really other side effects that could happend with it

yooo whats up zeta, depends on you're growth plates if they're open. if you keep the doses low and cycled, your chance of acromegaly is low - pretty low i guess. acromegaly CAN happen at 6-8iu+ over years

 

[lolpizzahaha]

After 15.

its so fucking over for me

 

[pablodave]

Explanation of popular Growth-Hormone Peptides

in this thread, i will expain some popular GH Peptides, their use and function.

Spoiler: a List of Peptides and hormones that will be explained:

- MK677
- CJC 1295 with DAC / without DAC
- Ipamorelin
- Hexarelin
- GHRP 4/6
- MGF
- HGH
- IGF-1 LR3

Why are GH Peptides / Hormones a huge benefit for looksmax aswell as bone and muscle building?

IGF-1 spike → hyperplasia New muscle fibers + denser cortical bone
Collagen upregulation Thicker, tighter skin; faster scar/wrinkle repair.
Lipolysis boost Lower visceral fat → sharper waistline & facial definition.
Intracellular water + glycogen Fuller “3-D” muscles within days.
Synergy with different GH compounds Faster recovery, joint support, vascularity.

GH Peptides / Hormones that cause those benefits:

IGF-1 spike --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), IGF-1 LR3, MK-677, Hexarelin, GHRP-6/4, Ipamorelin
Denser cortical bone --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), IGF-1 LR3, MK-677
Collagen upregulation / skin repair --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), MK-677, IGF-1 LR3
Lipolysis / visceral fat loss --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), Hexarelin
Intracellular water + glycogen --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), IGF-1 LR3, MK-677 (mainly subcutaneous water)
Recovery / joint support --> MGF, PEG-MGF, IGF-1 LR3, MK-677, CJC-1295 (no DAC), CJC-1295 (DAC)
Vascularity / repartitioning (Huge looksmax) --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), IGF-1 LR3, MK-677 (indirect bc of subq water)


Breakdown of every Compound:

MK677 (Ibutamoren) The basic Gymbro nattycard taker:

Oral GH secretagogue, tablet or sublingual, 24h active. Boosts IGF-1 & GH levels long-term.

Benefits:
– Fuller face & muscles (water + glycogen)
– Smoother, thicker skin (collagen ↑)
– Fat loss over time (esp. visceral)
– Deeper sleep = better recovery & skin regeneration
– Hunger increase → easy lean bulk or mass gain

Can be stacked with other compounds as it mainly boosts IGF-1 24h; MK only isn't really a looksmax. sorry gymbros (Stacks and realistic expectations coming lather)


-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------


CJC-1295 with DAC
Long-acting GHRH analog, active ~5–8 days.


Looksmax Benefits:
– Constant IGF-1 elevation = steady collagen & fat loss
– Easy anti-aging protocol
– Way less water = bloat than MK677

Via subQ injection 2x weekly
Cycled 12 weeks on, 8 weeks off


CJC-1295 without DAC (aka Mod GRF 1-29)
Short-acting GHRH analog, pulse-based. Taken 1–3×/day, usually with Ipamorelin.


Looksmax Benefits:
– Natural GH pulse mimicry = safer for long-term use
– Boosts night-time collagen & fat metabolism
– Synergistic with GHRPs for skin, face leanness, recovery

Annoying. MUST be pinned 2x a day to notice benefits.

Difference between with and without DAC?

DAC is basically just the half-life which increases with DAC.
with DAC --> 6-8 days
without DAC --> about 30 minutes

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Ipamorelin
Cleanest GHRP, no cortisol or prolactin spikes. Short-acting GH pulse stimulator. CJC without DACs teamplayer.


Looksmax Benefits:
– Night-time GH boost = tighter skin, fat burning, deeper sleep
– Synergizes well with CJC-1295 (no DAC)
– No bloating, very low side effects → safe for long-term use

Gets mostly pinned in the same syringe as CJC without DAC, again, annyoing.


-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Hexarelin
Strongest GHRP; very potent GH + IGF-1 release. Short-acting, desensitizes quickly.

Looksmax Benefits:
– Rapid fullness & strength gains
– Joint lubrication + tendon healing
– Can cause water retention → use short bursts (4–6 weeks)

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

GHRP-6 / GHRP-4
Mid-strength GHRPs. GHRP-6 boosts appetite heavily, GHRP-4 less so. Both stimulate GH/IGF-1 pulses.


Looksmax Benefits:
– Muscle fullness + recovery (via GH spike)
– GHRP-6: great for bulking (massive hunger)
– Skin healing + fat loss when stacked with CJC-1295 (no DAC)
– Cheap alternative for short GH cycles

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

MGF (Mechano Growth Factor)
Splice variant of IGF-1, released post-training. Short-acting, local growth stimulator.
(this one's for the real gymcels)

Looksmax Benefits:
– Muscle regeneration & satellite cell activation
– Local hypertrophy when injected IM post-workout
– Boosts density & fullness in lagging areas
– Best combined with IGF-1 LR3 or PEG-MGF for full effect

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

HGH (Somatropin, GH 191AA)
Human Growth Hormone; master hormone for IGF-1, collagen, and fat metabolism.
The grail for pubertycels

Looksmax Benefits:
– Fat loss (especially visceral & facial)
– Collagen boost --> tighter, younger skin
– Fuller muscles (water + glycogen retention)
– Enhances all other peptide stacks
– Bone remodeling & density – strengthens jawline, zygos, ribcage, wrists
– If growth plates are open: can trigger actual bone lengthening (height, limb, mandible)

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Spoiler

My Personal Holy Grail

IGF-1 LR3
Long-acting IGF-1 analog (~20–30h). Promotes cell growth, nutrient partitioning, and recovery.
Gets cycled; 4-6 weeks on. 16 weeks off.

Looksmax Benefits:
– Hyperplasia → new muscle fibers, not just hypertrophy
– Facial bone density ↑ (mandible, zygos)
– Fuller, leaner muscles (nutrient shuttling + insulin-mimetic)
– Accelerates recovery, collagen & skin healing
– Best used post-workout IM or subQ, stacked with HGH or PEG-MGF

Does not help with bone growth, density or remodelling!!


We go even deeper, little FAQ with slight stacking help:

Spoiler: My growthplates are open, how to increase height?

6IU HGH
15-25mg MK677 (thats why it's in here)
(IF you hit the gym, add IGF-1 LR3 75mcg PWO)

This is a protocol outline, not a precise dosage recommendation. It simply shows how GH-axis compounds can be stacked for height growth when epiphyseal plates are still open.

Spoiler: My growthplates are closed, can I still thicken my face?

Yes and no. You can't lengthen bones anymore (jaw, zygos, brow ridge), but you can thicken them slightly.

3-5IU HGH
10-20mg MK677
100-200mcg MGF 2x weeky

Don't expect surgical changes, your plates are closed

Spoiler: I want to look fuller and more “3D” without fat gain, what’s the best route?

3IU HGH (AM)
50–80mcg IGF-1 LR3 (PWO IM in delts or arms) (subQ systemic possible too)
100mcg PEG-MGF 2×/week

IGF-1 LR3 + PEG-MGF = muscle fiber growth + intracellular fullness. Best for delts, arms, traps.

Spoiler: I’m skinny and struggle with appetite, best stack for mass and hunger?

15–25mg MK-677 (evening)
4IU HGH (morning)
100mcg GHRP-6 pre-meal (1–2× daily)

MK-677 and GHRP-6 cause intense hunger; stack builds lean mass while keeping GH high.

Spoiler: I want rapid strength, recovery and “thickness” boost in short time

100mcg Hexarelin (PWO or pre-bed)
100mcg CJC-1295 (no DAC)
2IU HGH (AM)
100mcg MGF (PWO IM)


This is an aggressive short-cycle stack (4–6 weeks). Hexa = potent GH release, MGF = local repair/growth.

Spoiler: I want natural GH pulses while sleeping, clean skin + fat loss

100mcg CJC-1295 (no DAC)
100mcg Ipamorelin (pre-bed)
2–3IU HGH (AM fasted)


This stack mimics your body’s natural night GH pulses. Great for skin, lean gains, and safe long-term use.

Spoiler: I want max GH benefits but only want to inject once/twice a week

1mg CJC-1295 with DAC (2×/week)
3IU HGH (AM)
Optional: 10–15 mg MK-677 (ED for steady IGF-1 support)


Lazy but effective. CJC with DAC binds to albumin = long half-life. Keeps IGF-1 elevated all week without daily pinning.

I hope this helps for the first as a guideline for newbies.
Customized questions can be commented

Now, I want to go into Side effects and prevention:

Spoiler: HGH

Sides:
– Water retention / bloating
– Acromegaly (long-term high dose)
– IGF-1-related cancer risk (very rare, overstated)
– Insulin resistance


Prevention:
– 6 IU max daily
– Add Metformin or Berberine (500–1000 mg ED)
– Optional: Eplerenone (25 mg ED) to reduce facial bloat

Spoiler: MK677

Sides:
– Hunger spikes
– Lethargy / brain fog
– Water retention
– ↑ Fasting blood glucose


Prevention:
– Use in PM to avoid lethargy
– 10 mg ED if sensitive
– Stack with Berberine or Metformin for glucose control

Spoiler: IGF-1 LR3

Sides:
– Hypoglycemia
– Gut growth (excessive use)
– Local swelling at injection site


Prevention:
– Always post-workout
– Keep dose 120 mcg max
– Eat carbs before/after injection
- DON'T cycle longer than 6 weeks and make sure to pause at least 3-4 months

Spoiler: CJC-1295 (with DAC)

Sides:
– Slight prolactin rise (rare)
– Water retention
– Injection site irritation


Prevention:
– Dose only 2 mg per week
– Monitor IGF-1 levels if staying long-term

Spoiler: CJC-1295 (no DAC) + Ipamorelin

Sides:
– Prolactin (in rare cases with high dose)
– Temporary lightheadedness


Prevention:
– Stick to 200mcg CJC / 250mcg IPA per compound
– Combine only at night for smoother effect

Spoiler: Hexarelin

Sides:
– Rapid desensitization (max 4–6 weeks)
– Cortisol & prolactin increase
– Bloating, hunger


Prevention:
– Keep cycles short (≤6 weeks)
– Optional: Add Cabergoline 0.25 mg 1×/week if prolactin ↑
– Monitor mood & water balance

Spoiler: GHRP-6 / GHRP-4

Sides:
– Extreme hunger (GHRP-6)
– Mild cortisol/prolactin rise
– Bloating


Prevention:
– Use only when bulking
– Combine with Mod-GRF (CJC no DAC) to balance pulses

Spoiler: MGF / PEG-MGF

Sides:
– Injection site swelling
– Mild fatigue
– Unknown systemic risks (PEG form)


Prevention:
– Keep PEG-MGF to 2×/week
– Avoid injecting in same site repeatedly
– Stay under 200 cmg/dose

Keep in mind: this is just general info and a rough guideline. Always adjust doses based on your own goals and context.

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

That’s all for now. Questions can be asked in the comments. Hopefully this thread gets marked as a solution, since I’ve seen countless threads with GH peptide questions.

If this Thread gets a good reputation, I will drop a v2 based on my personal expieriences with different GH Peptides.

Spoiler: Studies/Sources

HGH

Acromegalic Cardiomyopathy: An Entity on its own? The Effects of GH and IGF-I Excess and Treatment on Cardiovascular Risk Factors - PubMed

Acromegaly is a chronic disease resulting from constantly elevated concentrations of growth hormone (GH) and insulin-like growth factor I (IGF-I). If not adequately treated, GH and IGF-I excess is associated with various cardiovascular risk factors. These symptoms mainly include hypertension and...

pubmed.ncbi.nlm.nih.gov

Evaluation of fluid status in patients with acromegaly through bioelectrical impedance vector analysis: a cross-sectional study - PMC

The acromegalic state is associated with an increase in total body water and sodium. The aim of our study was to assess the hydration status of patients with acromegaly using bioimpedance vector analysis (BIVA), differentiating patients according to ...

pmc.ncbi.nlm.nih.gov

Mk677

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects - PubMed

Aging is associated with declining activity of the GH axis, possibly contributing to adverse body composition changes and increased incidence of cardiovascular disease. The stimulatory effects on the GH-insulin-like growth factor I (IGF-I) axis of orally administered MK-677, a GH-releasing...

pubmed.ncbi.nlm.nih.gov

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial - PubMed

Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated.

pubmed.ncbi.nlm.nih.gov

IGF-1 LR3

Effects of insulin-like growth factor-1/binding protein-3 complex on muscle atrophy in rats - PubMed

Muscle atrophy and wasting is a serious problem that occurs in patients with prolonged debilitating illness, burn injury, spinal injury, as well as with space flight. Current treatment for such atrophy, which often relies on nutritional supplementation and physical therapy, is of limited value...

pubmed.ncbi.nlm.nih.gov

Hypoglycemic effects of insulin-like growth factor-1 in experimental uremia: can concomitant growth hormone administration prevent this effect? - PubMed

The risk of hypoglycemia limits the clinical application of insulin-like growth factor-1 (IGF-1). Our studies aimed to evaluate the mode of occurrence as well as the prevention of this side effect. Acute administration (i.v. infusion) of IGF-1 in subtotal nephrectomized uremic (U), sham-operated...

pubmed.ncbi.nlm.nih.gov

CJC 1295 with DAC

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults - PubMed

Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 microg/kg. There was evidence of a cumulative effect after multiple doses. These data...

pubmed.ncbi.nlm.nih.gov

Hexarelin

Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response study - PubMed

Dose-response data for GH-releasing peptides are limited. We studied the effects of varying doses (0-1.0 microgram/kg) of hexarelin, a novel GH-releasing peptide, administered iv to healthy adult males on GH, PRL, and cortisol release. In addition, we studied the effect of administration of a...

pubmed.ncbi.nlm.nih.gov

GHRP-6

GHRP-6 mimics ghrelin-induced stimulation of food intake and suppression of locomotor activity in goldfish - PubMed

Ghrelin was first identified and characterized from rat stomach as an endogenous ligand for the growth hormone secretagogue (GHS) receptor (GHS-R). Ghrelin also acts as an orexigenic factor and regulates energy balance in rodents. In goldfish, native ghrelin consists of 11 molecular variants...

pubmed.ncbi.nlm.nih.gov

MGF

Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages - PubMed

Loss of muscle mass and strength is a major problem during aging and the expression of Mechano Growth Factor (MGF), a member of the IGF-1 (insulin-like Growth Factor 1) super family, has been shown to be both exercise and age dependent. MGF, also called IGF-1Ec, has a unique E domain with a 49bp...

pubmed.ncbi.nlm.nih.gov

Metformin (+HGH)

Effects of a combination of recombinant human growth hormone with metformin on glucose metabolism and body composition in patients with metabolic syndrome - PubMed

Abdominal obesity and insulin resistance are central findings in metabolic syndrome. Since treatment with recombinant human growth hormone (rhGH) can reduce body fat mass in patients with organic GH deficiency, rhGH therapy may also have favourable effects on patients with metabolic syndrome...

pubmed.ncbi.nlm.nih.gov

BERBERINE

Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion - PubMed

Administration of berberine leads to remission of metabolic syndrome and decreases in waist circumference, SBP, triglycerides, and total insulin secretion, with an increase in insulin sensitivity.

pubmed.ncbi.nlm.nih.gov

Eplerenone

The aldosterone antagonist and facultative diuretic eplerenone: a critical review - PubMed

Eplerenone is a new aldosterone-receptor blocker that differs from spironolactone by virtue of higher selectivity for the aldosterone receptor. Therefore, eplerenone treatment is associated with comparative and absolute low incidences of gynecomastia, mastodynia, and abnormal vaginal bleeding...

pubmed.ncbi.nlm.nih.gov

Spoiler: Mod Tag

@Gengar @Master @NumbThePain @Randomized Shame @Quncho @Clavicular

looks chat-gpt ish

 

[enchanted_elixir]

Explanation of popular Growth-Hormone Peptides

in this thread, i will expain some popular GH Peptides, their use and function.

Spoiler: a List of Peptides and hormones that will be explained:

- MK677
- CJC 1295 with DAC / without DAC
- Ipamorelin
- Hexarelin
- GHRP 4/6
- MGF
- HGH
- IGF-1 LR3

Why are GH Peptides / Hormones a huge benefit for looksmax aswell as bone and muscle building?

IGF-1 spike → hyperplasia New muscle fibers + denser cortical bone
Collagen upregulation Thicker, tighter skin; faster scar/wrinkle repair.
Lipolysis boost Lower visceral fat → sharper waistline & facial definition.
Intracellular water + glycogen Fuller “3-D” muscles within days.
Synergy with different GH compounds Faster recovery, joint support, vascularity.

GH Peptides / Hormones that cause those benefits:

IGF-1 spike --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), IGF-1 LR3, MK-677, Hexarelin, GHRP-6/4, Ipamorelin
Denser cortical bone --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), IGF-1 LR3, MK-677
Collagen upregulation / skin repair --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), MK-677, IGF-1 LR3
Lipolysis / visceral fat loss --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), Hexarelin
Intracellular water + glycogen --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), IGF-1 LR3, MK-677 (mainly subcutaneous water)
Recovery / joint support --> MGF, PEG-MGF, IGF-1 LR3, MK-677, CJC-1295 (no DAC), CJC-1295 (DAC)
Vascularity / repartitioning (Huge looksmax) --> HGH, CJC-1295 (no DAC), CJC-1295 (DAC), IGF-1 LR3, MK-677 (indirect bc of subq water)


Breakdown of every Compound:

MK677 (Ibutamoren) The basic Gymbro nattycard taker:

Oral GH secretagogue, tablet or sublingual, 24h active. Boosts IGF-1 & GH levels long-term.

Benefits:
– Fuller face & muscles (water + glycogen)
– Smoother, thicker skin (collagen ↑)
– Fat loss over time (esp. visceral)
– Deeper sleep = better recovery & skin regeneration
– Hunger increase → easy lean bulk or mass gain

Can be stacked with other compounds as it mainly boosts IGF-1 24h; MK only isn't really a looksmax. sorry gymbros (Stacks and realistic expectations coming lather)


-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------


CJC-1295 with DAC
Long-acting GHRH analog, active ~5–8 days.


Looksmax Benefits:
– Constant IGF-1 elevation = steady collagen & fat loss
– Easy anti-aging protocol
– Way less water = bloat than MK677

Via subQ injection 2x weekly
Cycled 12 weeks on, 8 weeks off


CJC-1295 without DAC (aka Mod GRF 1-29)
Short-acting GHRH analog, pulse-based. Taken 1–3×/day, usually with Ipamorelin.


Looksmax Benefits:
– Natural GH pulse mimicry = safer for long-term use
– Boosts night-time collagen & fat metabolism
– Synergistic with GHRPs for skin, face leanness, recovery

Annoying. MUST be pinned 2x a day to notice benefits.

Difference between with and without DAC?

DAC is basically just the half-life which increases with DAC.
with DAC --> 6-8 days
without DAC --> about 30 minutes

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Ipamorelin
Cleanest GHRP, no cortisol or prolactin spikes. Short-acting GH pulse stimulator. CJC without DACs teamplayer.


Looksmax Benefits:
– Night-time GH boost = tighter skin, fat burning, deeper sleep
– Synergizes well with CJC-1295 (no DAC)
– No bloating, very low side effects → safe for long-term use

Gets mostly pinned in the same syringe as CJC without DAC, again, annyoing.


-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Hexarelin
Strongest GHRP; very potent GH + IGF-1 release. Short-acting, desensitizes quickly.

Looksmax Benefits:
– Rapid fullness & strength gains
– Joint lubrication + tendon healing
– Can cause water retention → use short bursts (4–6 weeks)

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

GHRP-6 / GHRP-4
Mid-strength GHRPs. GHRP-6 boosts appetite heavily, GHRP-4 less so. Both stimulate GH/IGF-1 pulses.


Looksmax Benefits:
– Muscle fullness + recovery (via GH spike)
– GHRP-6: great for bulking (massive hunger)
– Skin healing + fat loss when stacked with CJC-1295 (no DAC)
– Cheap alternative for short GH cycles

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

MGF (Mechano Growth Factor)
Splice variant of IGF-1, released post-training. Short-acting, local growth stimulator.
(this one's for the real gymcels)

Looksmax Benefits:
– Muscle regeneration & satellite cell activation
– Local hypertrophy when injected IM post-workout
– Boosts density & fullness in lagging areas
– Best combined with IGF-1 LR3 or PEG-MGF for full effect

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

HGH (Somatropin, GH 191AA)
Human Growth Hormone; master hormone for IGF-1, collagen, and fat metabolism.
The grail for pubertycels

Looksmax Benefits:
– Fat loss (especially visceral & facial)
– Collagen boost --> tighter, younger skin
– Fuller muscles (water + glycogen retention)
– Enhances all other peptide stacks
– Bone remodeling & density – strengthens jawline, zygos, ribcage, wrists
– If growth plates are open: can trigger actual bone lengthening (height, limb, mandible)

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Spoiler

My Personal Holy Grail

IGF-1 LR3
Long-acting IGF-1 analog (~20–30h). Promotes cell growth, nutrient partitioning, and recovery.
Gets cycled; 4-6 weeks on. 16 weeks off.

Looksmax Benefits:
– Hyperplasia → new muscle fibers, not just hypertrophy
– Facial bone density ↑ (mandible, zygos)
– Fuller, leaner muscles (nutrient shuttling + insulin-mimetic)
– Accelerates recovery, collagen & skin healing
– Best used post-workout IM or subQ, stacked with HGH or PEG-MGF

Does not help with bone growth, density or remodelling!!


We go even deeper, little FAQ with slight stacking help:

Spoiler: My growthplates are open, how to increase height?

6IU HGH
15-25mg MK677 (thats why it's in here)
(IF you hit the gym, add IGF-1 LR3 75mcg PWO)

This is a protocol outline, not a precise dosage recommendation. It simply shows how GH-axis compounds can be stacked for height growth when epiphyseal plates are still open.

Spoiler: My growthplates are closed, can I still thicken my face?

Yes and no. You can't lengthen bones anymore (jaw, zygos, brow ridge), but you can thicken them slightly.

3-5IU HGH
10-20mg MK677
100-200mcg MGF 2x weeky

Don't expect surgical changes, your plates are closed

Spoiler: I want to look fuller and more “3D” without fat gain, what’s the best route?

3IU HGH (AM)
50–80mcg IGF-1 LR3 (PWO IM in delts or arms) (subQ systemic possible too)
100mcg PEG-MGF 2×/week

IGF-1 LR3 + PEG-MGF = muscle fiber growth + intracellular fullness. Best for delts, arms, traps.

Spoiler: I’m skinny and struggle with appetite, best stack for mass and hunger?

15–25mg MK-677 (evening)
4IU HGH (morning)
100mcg GHRP-6 pre-meal (1–2× daily)

MK-677 and GHRP-6 cause intense hunger; stack builds lean mass while keeping GH high.

Spoiler: I want rapid strength, recovery and “thickness” boost in short time

100mcg Hexarelin (PWO or pre-bed)
100mcg CJC-1295 (no DAC)
2IU HGH (AM)
100mcg MGF (PWO IM)


This is an aggressive short-cycle stack (4–6 weeks). Hexa = potent GH release, MGF = local repair/growth.

Spoiler: I want natural GH pulses while sleeping, clean skin + fat loss

100mcg CJC-1295 (no DAC)
100mcg Ipamorelin (pre-bed)
2–3IU HGH (AM fasted)


This stack mimics your body’s natural night GH pulses. Great for skin, lean gains, and safe long-term use.

Spoiler: I want max GH benefits but only want to inject once/twice a week

1mg CJC-1295 with DAC (2×/week)
3IU HGH (AM)
Optional: 10–15 mg MK-677 (ED for steady IGF-1 support)


Lazy but effective. CJC with DAC binds to albumin = long half-life. Keeps IGF-1 elevated all week without daily pinning.

I hope this helps for the first as a guideline for newbies.
Customized questions can be commented

Now, I want to go into Side effects and prevention:

Spoiler: HGH

Sides:
– Water retention / bloating
– Acromegaly (long-term high dose)
– IGF-1-related cancer risk (very rare, overstated)
– Insulin resistance


Prevention:
– 6 IU max daily
– Add Metformin or Berberine (500–1000 mg ED)
– Optional: Eplerenone (25 mg ED) to reduce facial bloat

Spoiler: MK677

Sides:
– Hunger spikes
– Lethargy / brain fog
– Water retention
– ↑ Fasting blood glucose


Prevention:
– Use in PM to avoid lethargy
– 10 mg ED if sensitive
– Stack with Berberine or Metformin for glucose control

Spoiler: IGF-1 LR3

Sides:
– Hypoglycemia
– Gut growth (excessive use)
– Local swelling at injection site


Prevention:
– Always post-workout
– Keep dose 120 mcg max
– Eat carbs before/after injection
- DON'T cycle longer than 6 weeks and make sure to pause at least 3-4 months

Spoiler: CJC-1295 (with DAC)

Sides:
– Slight prolactin rise (rare)
– Water retention
– Injection site irritation


Prevention:
– Dose only 2 mg per week
– Monitor IGF-1 levels if staying long-term

Spoiler: CJC-1295 (no DAC) + Ipamorelin

Sides:
– Prolactin (in rare cases with high dose)
– Temporary lightheadedness


Prevention:
– Stick to 200mcg CJC / 250mcg IPA per compound
– Combine only at night for smoother effect

Spoiler: Hexarelin

Sides:
– Rapid desensitization (max 4–6 weeks)
– Cortisol & prolactin increase
– Bloating, hunger


Prevention:
– Keep cycles short (≤6 weeks)
– Optional: Add Cabergoline 0.25 mg 1×/week if prolactin ↑
– Monitor mood & water balance

Spoiler: GHRP-6 / GHRP-4

Sides:
– Extreme hunger (GHRP-6)
– Mild cortisol/prolactin rise
– Bloating


Prevention:
– Use only when bulking
– Combine with Mod-GRF (CJC no DAC) to balance pulses

Spoiler: MGF / PEG-MGF

Sides:
– Injection site swelling
– Mild fatigue
– Unknown systemic risks (PEG form)


Prevention:
– Keep PEG-MGF to 2×/week
– Avoid injecting in same site repeatedly
– Stay under 200 cmg/dose

Keep in mind: this is just general info and a rough guideline. Always adjust doses based on your own goals and context.

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That’s all for now. Questions can be asked in the comments. Hopefully this thread gets marked as a solution, since I’ve seen countless threads with GH peptide questions.

If this Thread gets a good reputation, I will drop a v2 based on my personal expieriences with different GH Peptides.

Spoiler: Studies/Sources

HGH

Acromegalic Cardiomyopathy: An Entity on its own? The Effects of GH and IGF-I Excess and Treatment on Cardiovascular Risk Factors - PubMed

Acromegaly is a chronic disease resulting from constantly elevated concentrations of growth hormone (GH) and insulin-like growth factor I (IGF-I). If not adequately treated, GH and IGF-I excess is associated with various cardiovascular risk factors. These symptoms mainly include hypertension and...

pubmed.ncbi.nlm.nih.gov

Evaluation of fluid status in patients with acromegaly through bioelectrical impedance vector analysis: a cross-sectional study - PMC

The acromegalic state is associated with an increase in total body water and sodium. The aim of our study was to assess the hydration status of patients with acromegaly using bioimpedance vector analysis (BIVA), differentiating patients according to ...

pmc.ncbi.nlm.nih.gov

Mk677

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects - PubMed

Aging is associated with declining activity of the GH axis, possibly contributing to adverse body composition changes and increased incidence of cardiovascular disease. The stimulatory effects on the GH-insulin-like growth factor I (IGF-I) axis of orally administered MK-677, a GH-releasing...

pubmed.ncbi.nlm.nih.gov

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial - PubMed

Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated.

pubmed.ncbi.nlm.nih.gov

IGF-1 LR3

Effects of insulin-like growth factor-1/binding protein-3 complex on muscle atrophy in rats - PubMed

Muscle atrophy and wasting is a serious problem that occurs in patients with prolonged debilitating illness, burn injury, spinal injury, as well as with space flight. Current treatment for such atrophy, which often relies on nutritional supplementation and physical therapy, is of limited value...

pubmed.ncbi.nlm.nih.gov

Hypoglycemic effects of insulin-like growth factor-1 in experimental uremia: can concomitant growth hormone administration prevent this effect? - PubMed

The risk of hypoglycemia limits the clinical application of insulin-like growth factor-1 (IGF-1). Our studies aimed to evaluate the mode of occurrence as well as the prevention of this side effect. Acute administration (i.v. infusion) of IGF-1 in subtotal nephrectomized uremic (U), sham-operated...

pubmed.ncbi.nlm.nih.gov

CJC 1295 with DAC

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults - PubMed

Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 microg/kg. There was evidence of a cumulative effect after multiple doses. These data...

pubmed.ncbi.nlm.nih.gov

Hexarelin

Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response study - PubMed

Dose-response data for GH-releasing peptides are limited. We studied the effects of varying doses (0-1.0 microgram/kg) of hexarelin, a novel GH-releasing peptide, administered iv to healthy adult males on GH, PRL, and cortisol release. In addition, we studied the effect of administration of a...

pubmed.ncbi.nlm.nih.gov

GHRP-6

GHRP-6 mimics ghrelin-induced stimulation of food intake and suppression of locomotor activity in goldfish - PubMed

Ghrelin was first identified and characterized from rat stomach as an endogenous ligand for the growth hormone secretagogue (GHS) receptor (GHS-R). Ghrelin also acts as an orexigenic factor and regulates energy balance in rodents. In goldfish, native ghrelin consists of 11 molecular variants...

pubmed.ncbi.nlm.nih.gov

MGF

Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages - PubMed

Loss of muscle mass and strength is a major problem during aging and the expression of Mechano Growth Factor (MGF), a member of the IGF-1 (insulin-like Growth Factor 1) super family, has been shown to be both exercise and age dependent. MGF, also called IGF-1Ec, has a unique E domain with a 49bp...

pubmed.ncbi.nlm.nih.gov

Metformin (+HGH)

Effects of a combination of recombinant human growth hormone with metformin on glucose metabolism and body composition in patients with metabolic syndrome - PubMed

Abdominal obesity and insulin resistance are central findings in metabolic syndrome. Since treatment with recombinant human growth hormone (rhGH) can reduce body fat mass in patients with organic GH deficiency, rhGH therapy may also have favourable effects on patients with metabolic syndrome...

pubmed.ncbi.nlm.nih.gov

BERBERINE

Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion - PubMed

Administration of berberine leads to remission of metabolic syndrome and decreases in waist circumference, SBP, triglycerides, and total insulin secretion, with an increase in insulin sensitivity.

pubmed.ncbi.nlm.nih.gov

Eplerenone

The aldosterone antagonist and facultative diuretic eplerenone: a critical review - PubMed

Eplerenone is a new aldosterone-receptor blocker that differs from spironolactone by virtue of higher selectivity for the aldosterone receptor. Therefore, eplerenone treatment is associated with comparative and absolute low incidences of gynecomastia, mastodynia, and abnormal vaginal bleeding...

pubmed.ncbi.nlm.nih.gov

Spoiler: Mod Tag

@Gengar @Master @NumbThePain @Randomized Shame @Quncho @Clavicular

Good job.