realflicker
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Bro ong I need help formatting ts. Someone help me.
DHTs effects on hair are mainly negative due to chronic GA-transmitted scalp tension being present which is induced by peri-pubertal and post-pubertal craniofacial bone growth and/or hyperplasia and chronic contraction of muscles connected to the GA.
The tension causes a pro-inflammatory cascade such as increased ROS,IL-1 COX-2 signaling, TNF-α, and more) which causes increase of TGF-β1 alongside increased androgen activity ( aka dht, ar 5ar2, ). The presence of DHT and TGF-β1 mediates perifollicular fibrosis, calcification of capillary networks supporting AGA-prone hair follicles and dermal sheath thickening
DHT elevation in this context is itself a consequence of tension-induced inflammatory signaling. This explains why DHT inhibitors have demonstrated reductions in fibrosis progression in AGA: by suppressing androgen-mediated TGF-β1 activity, they interrupt the fibrotic arm of the cascade, even though the upstream tension driving it remains.
In conclusion, yes getting rid of the substrate through 5ari will work and is still a viable option. However, even with nuked substrate scalp tension can exacerbate the effects to a significant degree. You can counter this through maximising your gut microbiome and ATP. I also am in favor of keeping neurosteroids at baseline even though you could theoretically supplement pre-cursors or allopreg straightup.
You can maximise ATP with traditional and easily accessible supplements like CoQ10, Topical caffeine, creatine, PQQ, etc.
As for the gut you could use sodium butyrate or other butyrate supplements. I don’t know a lot about diet other than how beneficial carbs are so I didn’t include it.
A good hair loss stack thats not that expensive ( if you can get raws and formulate it ) is KX-826; the reason why I prefer this AA rather than Ru-58841 is because RU’S metabolite goes systemic ( Im pretty sure ) as well as KX being a stronger antagonizer. Another topical I would use it topical arginine and/or adenosine. Adenosine has similar benefits to ATP but arginine is another story in which I can make another thread. I would also maximise the gut and atp like prior said. Possibly also an EDA2R inhibitor.
DHTs effects on hair are mainly negative due to chronic GA-transmitted scalp tension being present which is induced by peri-pubertal and post-pubertal craniofacial bone growth and/or hyperplasia and chronic contraction of muscles connected to the GA.
The tension causes a pro-inflammatory cascade such as increased ROS,IL-1 COX-2 signaling, TNF-α, and more) which causes increase of TGF-β1 alongside increased androgen activity ( aka dht, ar 5ar2, ). The presence of DHT and TGF-β1 mediates perifollicular fibrosis, calcification of capillary networks supporting AGA-prone hair follicles and dermal sheath thickening
DHT elevation in this context is itself a consequence of tension-induced inflammatory signaling. This explains why DHT inhibitors have demonstrated reductions in fibrosis progression in AGA: by suppressing androgen-mediated TGF-β1 activity, they interrupt the fibrotic arm of the cascade, even though the upstream tension driving it remains.
In conclusion, yes getting rid of the substrate through 5ari will work and is still a viable option. However, even with nuked substrate scalp tension can exacerbate the effects to a significant degree. You can counter this through maximising your gut microbiome and ATP. I also am in favor of keeping neurosteroids at baseline even though you could theoretically supplement pre-cursors or allopreg straightup.
You can maximise ATP with traditional and easily accessible supplements like CoQ10, Topical caffeine, creatine, PQQ, etc.
As for the gut you could use sodium butyrate or other butyrate supplements. I don’t know a lot about diet other than how beneficial carbs are so I didn’t include it.
A good hair loss stack thats not that expensive ( if you can get raws and formulate it ) is KX-826; the reason why I prefer this AA rather than Ru-58841 is because RU’S metabolite goes systemic ( Im pretty sure ) as well as KX being a stronger antagonizer. Another topical I would use it topical arginine and/or adenosine. Adenosine has similar benefits to ATP but arginine is another story in which I can make another thread. I would also maximise the gut and atp like prior said. Possibly also an EDA2R inhibitor.
