HDAC Inhibition during puberty -epigenetic enhancement of growth and development

[ajshabs]

hdac inhibitors could be used to boost natural growth + development during puberty

not like gh or steroids — this is epigenetic, not hormonal
basically you’re not forcing growth, you’re just taking the brakes off your dna during the time your body’s already trying to grow


what’s an hdac inhibitor?
hdacs = enzymes that keep certain genes “switched off” by tightening the dna

when you inhibit them, the dna loosens and more genes can activate — especially ones involved in bone growth, muscle development, and facial structure

so instead of adding more hormones, you just make your existing growth system work better

why puberty matters:

puberty is the only time where:

your growth plates are open (so bones can still lengthen)
testosterone is increasing naturally
face bones are shaping (jawline, cheekbones etc)
muscles respond better to training and diet
tissue remodels faster

hdac inhibitors during this window could (in theory) amplify all that

possible benefits of hdac inhibition during puberty (if done right):

denser bones (better cheekbones, jaw, orbital rims)
slightly taller height (growth plates stay active longer)
more lean muscle growth from same test levels
faster tissue recovery/remodeling
long-term changes that might stick (epigenetic memory)

what compounds do this?
these are drugs already used in medicine (like for epilepsy or cancer):

valporic acid (VPA) – known hdac inhibitor
vorinostat / trichostatin A – very potent, mostly research use
givinostat – newer, more selective version

most of these are not safe for casual use — they affect brain chemistry and other systems, so any actual use would have to be super controlled and spaced out (like once every few weeks in microdoses)

example theoretical use (vpa):

250–500mg per day for 5–7 days
then take 2–3 weeks off
only during early–mid puberty (13–17)
idea is to hit short windows without causing damage

why it’s interesting:
hdac inhibition isn’t about adding more fuel (like gear) it’s about removing the limiters your dna puts on certain growth genes
it could make your natural growth hit harder, without pushing it past your genetic limit

 

[ajshabs]

bump

 

[Iwillbehtn]

bump

Loox has vorinostat in his course, it's almost impossible to source however in adequate dosing, as the dosage for cancer treatment regularly described is pretty dangerous (cytotoxic meaning it kills your cells) in normal healthy individuals. I would be extremely hesitant.

 

[slaters]

And what happens if you combine this with hormones and pth analogs

 

[ajshabs]

And what happens if you combine this with hormones and pth analogs

combining hdac inhibitors with pth analogs and hormones during puberty could amplify bone growth

hdac inhibitors unlock growth genes, pth analogs directly stimulate bone formation

and hormones like test/gh fuel the whole process; it’d be a high-risk, high-reward stack if timed perfectly, but could easily cause permanent dysregulation if misused.

 

[slaters]

combining hdac inhibitors with pth analogs and hormones during puberty could amplify bone growth

hdac inhibitors unlock growth genes, pth analogs directly stimulate bone formation

and hormones like test/gh fuel the whole process; it’d be a high-risk, high-reward stack if timed perfectly, but could easily cause permanent dysregulation if misused.

Always wanted to try this for more frame and height but I value my face so idk if it’s worth it
I might be able to get my hands on tetraparatide and I can get my hands on VPA but Idk
My times running out for this so ig I better decide

 

[ajshabs]

Always wanted to try this for more frame and height but I value my face so idk if it’s worth it
I might be able to get my hands on tetraparatide and I can get my hands on VPA but Idk
My times running out for this so ig I better decide

tetraparatide + vpa will enhance skeletal and craniofacial development, but vpa especially comes with neurotoxicity concerns, and once you mess with your brain or hormone system, there’s no reset button.

if your face is already decent, risking it for a bit more frame or height might do more harm than good.

low, intermittent dosing under medical supervision is the only semi-safe route

which is almost impossible to get as i doubt any medical official will allow you to do dose vpa + teri for pure asthetic reasons aha otherwise it’s just gambling with your genetics

but idk ig lol it’s a big desicion

 

[slaters]

tetraparatide + vpa will enhance skeletal and craniofacial development, but vpa especially comes with neurotoxicity concerns, and once you mess with your brain or hormone system, there’s no reset button.

if your face is already decent, risking it for a bit more frame or height might do more harm than good.

low, intermittent dosing under medical supervision is the only semi-safe route

which is almost impossible to get as i doubt any medical official will allow you to do dose vpa + teri for pure asthetic reasons aha otherwise it’s just gambling with your genetics

but idk ig lol it’s a big desicion

I wonder if ancillaries and maybe something like cerebrolysin could help
You’d def have to monitor calcium levels and megadose it on pth