Aryan Incel
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This is going to be a quick little thread about something that gets no where near enough recognition on this site, which is hormone receptors. Example of some of these receptors are androgen receptors, IGF-1 receptors, Glucocorticoid receptors, Estrogen receptors and many more.
First off what are they?
Hormone receptors bind to specific hormones, acting like a lock for the hormone's "key" (think of it like how enzymes bind to specific substrate(as shown in the image below)). Then this binding event triggers a response within the cell.
Now how does it actually work?
First the hormone circulating in the body finds a cell with the specific receptor and binds. The binding then activates the receptor, which then starts a chain reaction inside the cell. This chain reaction leads to a specific cellular response depending on the protein.
Now why is this important?
The main reason why this is important is everyone has varying levels of hormone receptor sensitivity.
This means there isnโt a one size fits all approach to the amount of pharmaceuticals used. This is what pisses me off the most about greycels is they always go for certain amount instead of a range (granted I sometimes do the same). What I mean is whenever someone asks how much test they should use on a cycle, the usual answer is 500 mg/ week. This is all well and good as a ball park range but some people only need 350 mg/ week to gain there desired physique whereas on the other side of the spectrum some people need 700 mg+/ week to gain the same physique. Another example is Dutasteride everyone usually just says youโll be fine with 0.5 mg, but for some people that dosing will do fuck all and they need 2.5 mg to see any results. What Iโm trying to say here is most people lack nuance when they tell people about dosing.
How to find out about your receptor sensitivity?
There are 2 ways to determine your receptor sensitivity.
The first way is through getting it tested professionally from a doctor. When you get your results you can adjust dosages accordingly.
The other way is through trial and error. This is a riskier and less scientific way of doing things. But it involves testing different dosages on yourself and seeing if you experience any differences and adjusting accordingly.
How to change it?
Right now you canโt change it due to it being a mostly controlled by genetic and epigenetics. However in the coming years I wouldnโt be surprised if they come up with pharmaceuticals/ technology which can actually physically alter your hormone receptor sensitivity.
First off what are they?
Hormone receptors bind to specific hormones, acting like a lock for the hormone's "key" (think of it like how enzymes bind to specific substrate(as shown in the image below)). Then this binding event triggers a response within the cell.
Now how does it actually work?
First the hormone circulating in the body finds a cell with the specific receptor and binds. The binding then activates the receptor, which then starts a chain reaction inside the cell. This chain reaction leads to a specific cellular response depending on the protein.
Now why is this important?
The main reason why this is important is everyone has varying levels of hormone receptor sensitivity.
This means there isnโt a one size fits all approach to the amount of pharmaceuticals used. This is what pisses me off the most about greycels is they always go for certain amount instead of a range (granted I sometimes do the same). What I mean is whenever someone asks how much test they should use on a cycle, the usual answer is 500 mg/ week. This is all well and good as a ball park range but some people only need 350 mg/ week to gain there desired physique whereas on the other side of the spectrum some people need 700 mg+/ week to gain the same physique. Another example is Dutasteride everyone usually just says youโll be fine with 0.5 mg, but for some people that dosing will do fuck all and they need 2.5 mg to see any results. What Iโm trying to say here is most people lack nuance when they tell people about dosing.
How to find out about your receptor sensitivity?
There are 2 ways to determine your receptor sensitivity.
The first way is through getting it tested professionally from a doctor. When you get your results you can adjust dosages accordingly.
The other way is through trial and error. This is a riskier and less scientific way of doing things. But it involves testing different dosages on yourself and seeing if you experience any differences and adjusting accordingly.
How to change it?
Right now you canโt change it due to it being a mostly controlled by genetic and epigenetics. However in the coming years I wouldnโt be surprised if they come up with pharmaceuticals/ technology which can actually physically alter your hormone receptor sensitivity.
@Orka @Volksstaffel @HighIQ ubermensch @ybuyhgui
