How can tret impact the eyes, even tho it supposedly does not go systemic?

[Mongrelcel]

Studies indicate that the amount of tretinoin that goes systemic is negligible - and yet, me & many others have felt negative sides (dry eyes, damaged meibomian glands) even when taking maximum precaution to not let any tret get even near the eyes

What mechanism could be causing this? If it did not get there topically, and it does not go systemic in any significant amount, then how can tret impact the function of meibomian glands?

The Influence of 13-cis Retinoic Acid on Human Meibomian Gland Epithelial Cells

Meibomian gland dysfunction (MGD) is a primary cause of dry eye disease. One of the risk factors for MGD is exposure to 13-cis retinoic acid (13-cis RA), a metabolite of vitamin A. However, the mechanism is not well understood. We hypothesize that 13-cis ...

www.ncbi.nlm.nih.gov

 

[khvirgin]

how do you know it doesnt go systemic?

If you have dry eyes and dont even put tret anywhere near your eyes then something it's happening

 

[Mongrelcel]

how do you know it doesnt go systemic?

there have been studies done on this

If you have dry eyes and dont even put tret anywhere near your eyes then something it's happening

I can confidently say it's tret, problems begun with tret and lessened when I stopped using tret
given that clinical research says that retinoids damage the meibomian glands, I'm sure it had to somehow be tret

 

[Deleted member 15827]

i ve had no effect and ive been using for it 6 months everyday max strength no side effects

 

[oldcelloser]

0 impact, but avoid the eye area....its too strong

 

[oldslapcel]

I had exact same issue and conclusion boyo. Get severe dry eyes no matter what.

I am needling+LLLT maxxing, it boosts collagen and fights wrinkling way more than tret anyway (proven in comparision studies). And without tret face is actually less irritated so you can actually needle harder or even sun exposure a bit, things you cant really do on tret. I think tret is cope if you are needling tbh.

 

[PURE ARYAN GENETICS]

I had exact same issue and conclusion boyo. Get severe dry eyes no matter what.

I am needling+LLLT maxxing, it boosts collagen and fights wrinkling way more than tret anyway (proven in comparision studies). And without tret face is actually less irritated so you can actually needle harder or even sun exposure a bit, things you cant really do on tret. I think tret is cope if you are needling tbh.

well you can't do tret and needle at the same time

 

[Raskens1]

I've had the same issues. I applied far away from the eyes, used vaseline as a border AND rinsed of tret after 1 minute. I still got issues with dry eyes. I've read something about cell communication with tret. In other words trer affects the skin at parts where it's not absorbed tjrough cell communication. I would assume tret communicates with the meibomian glands and dries them out.

 

[Mongrelcel]

I had exact same issue and conclusion boyo. Get severe dry eyes no matter what.

I am needling+LLLT maxxing, it boosts collagen and fights wrinkling way more than tret anyway (proven in comparision studies). And without tret face is actually less irritated so you can actually needle harder or even sun exposure a bit, things you cant really do on tret. I think tret is cope if you are needling tbh.

lifefuel if microneedling gave you similar results as tret

for me so far hasn't done much, but I havent been at it for long
mind sharing routine?

what's LLLT? elab pls

 

[oldslapcel]

lifefuel if microneedling gave you similar results as tret

for me so far hasn't done much, but I havent been at it for long
mind sharing routine?

what's LLLT? elab pls

Had been on tret for 1.5 years. I very very slowly improved skin but only in 2 microneedling sessions the change was massive without being dry/irritated and eye dryness all day.

LLLT is red light therapy

Pretty much every "Tret vs Microneedling" study for any cause (acne, scarring, wrinkling) Microneedling always has better results.

For example:

Comparison between the therapeutic effect of microneedling versus tretinoin in patients with comedonal acne: a randomized clinical trial

Background: Microneedling has been shown to be a clinically effective and safe treatment for comedonal acne vulgaris. The aim of the present study was to compare the clinical effectof microneedling and the most commonly used topical drug, tretinoin, in the treatment of comedonal acne.Methods...

www.iranjd.ir

Conclusion: Compared with tretinoin, microneedling seems to be a more effective, permanent and satisfactory treatment in the treatment of comedonal acne.

Typical treatment is one session every 2-4 weeks (depends on how fast you heal, I do once every 2 weeks thanks to not using tret so thats why I see tret counterproductive atm)

 

[Deleted member 2729]

LLLT is red light therapy

Pretty much every "Tret vs Microneedling" study for any cause (acne, scarring, wrinkling) Microneedling always has better results.

For example:

Comparison between the therapeutic effect of microneedling versus tretinoin in patients with comedonal acne: a randomized clinical trial

Background: Microneedling has been shown to be a clinically effective and safe treatment for comedonal acne vulgaris. The aim of the present study was to compare the clinical effectof microneedling and the most commonly used topical drug, tretinoin, in the treatment of comedonal acne.Methods...

www.iranjd.ir

Conclusion: Compared with tretinoin, microneedling seems to be a more effective, permanent and satisfactory treatment in the treatment of comedonal acne.

Typical treatment is one session every 2-4 weeks (depends on how fast you heal, I do once every 2 weeks thanks to not using tret so thats why I see tret counterproductive atm)

Microneedling doesn't treat acne, just scars. And lasers mogg anyways for scar removal

 

[oldslapcel]

You are literally quoting a post with a linked study that proves it treats better acne than tretinoin
This forum is retarded and can't inform themselves and is a tretinoinmaxxx echo chamber and people just repeat it but I have found more than 6 comparative studies already where microneedling is beating literally every method in the planet for collagen and repair induction, its way better than people portray it here and has 0 side effects unlike tretinoin

 

[oldslapcel]

Check this old 38yo foid who did microneedling monotherapy (nothing else) only 8 sessions (shes even being lazy) and judge results. How many 38 yos do you see with that skin

 

[PURE ARYAN GENETICS]

You are literally quoting a post with a linked study that proves it treats better acne than tretinoin
This forum is retarded and can't inform themselves and is a tretinoinmaxxx echo chamber and people just repeat it but I have found more than 6 comparative studies already where microneedling is beating literally every method in the planet for collagen and repair induction, its way better than people portray it here and has 0 side effects unlike tretinoin

yeah bro but most needles are trash quality. and the ones that are proven not trash are $1k+ and only available to salons. most normies use the worst dogshit chink roller with shit technique and that fucks their skin hard

 

[oldslapcel]

Dr Pen is not expensive, even some low end clinics use it. And yeah dermarollers are shit, they enter the skin in an angle and cause more trauma than necessary.

 

[Mongrelcel]

@oldslapcel depth?

 

[oldslapcel]

I use 1.5mm on deep forehead wrinkles/nasolabials, 1mm rest of the face, 0.5mm nose and 0.25mm undereyes (too thin skin). You must have visible erythema for best results (some pinpoint bleeding is ok too). Once I stop my session my temple forehead vein is literally about to explode from all circulation stimuli lol