I am a shit person

[wollet2]

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[Deleted member 4362]

0

 

[Incellectually_Shy]

Yes. Quite shiddy, indeed.

However...I am much shiddier than you. Observe:

The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability​

Genetic variants in and around the transcription factor 4 (TCF4) gene are associated with range of disorders that are frequently associated with cognitive dysfunction.1–3 The most recent schizophrenia GWAS reported three independent single nucleotide polymorphisms (SNPs) in TCF4 that surpassed the threshold for genome wide significance.4 Intriguingly, rare TCF4 single nucleotide variants (SNVs) have also been described in schizophrenia patients, although their impact on the function of the protein has not been established.5,6 In addition to the genetic studies in schizophrenia, TCF4 variants are associated with early information processing and cognitive markers, some of which are schizophrenia endophenotypes.7–10 Damaging TCF4 mutations have also been described in large-scale genotyping studies in patients with ID, neurodevelopmental disorders, and most recently ASD.11–15 Haploinsufficiency of TCF4 causes Pitt–Hopkins syndrome (PTHS); a rare form intellectual disability (ID) associated with characteristic facial features, autonomic dysfunction, and behavioral traits that resemble autism spectrum disorder (ASD).16–19 Collectively, these studies implicate TCF4 in a range of neurodevelopmental disorders.

The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability

AbstractBackground. Common genetic variants in and around the gene encoding transcription factor 4 (TCF4) are associated with an increased risk of schizoph

academic.oup.com

Observe again:

Gene: TCF4 -

gene.sfari.org

A very strange genotype.

And the rarity...?

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	97800	A=0.93291	C=0.06709, G=0.00000
European	Sub	80228	A=0.94664	C=0.05336, G=0.00000
African	Sub	6000	A=0.8507	C=0.1493, G=0.0000
African Others	Sub	202	A=0.827	C=0.173, G=0.000
African American	Sub	5798	A=0.8515	C=0.1485, G=0.0000
Asian	Sub	224	A=1.000	C=0.000, G=0.000
East Asian	Sub	184	A=1.000	C=0.000, G=0.000
Other Asian	Sub	40	A=1.00	C=0.00, G=0.00
Latin American 1	Sub	222	A=0.968	C=0.032, G=0.000
Latin American 2	Sub	1176	A=0.9558	C=0.0442, G=0.0000
South Asian	Sub	4918	A=0.8015	C=0.1985, G=0.0000

 

[Vermilioncore]

I know