I feel really bad, i need help

[Deleted member 12688]

I’m in another state rn and i don’t have any weed or anything so i feel like shit, i can’t sleep and i’m feeling really down tbh

What drugs can i buy at a store or pharmacy or anywhere where i don’t need an ID? Anything that gets me high plz


@kjsbdfiusdf @CupOfCoffee @Chad1212 @Latebloomer10 @portuguesecel @Jagged0 @gamma @Maesthetic @Adriana Lima

 

[Mr.cope]

You’re supposed to be a mulatto slayer, stfu and go fuck some girls

 

[mogstar]

Don’t do drugs

 

[Deleted member 12688]

You’re supposed to be a mulatto slayer, stfu and go fucks some girls

I did but girls can’t help me with this man

 

[Deleted member 10987]

Go dick some cuties

 

[Deleted member 6217]

I had the same yesterday tbh i just got drunk of my dads alcohol jfl

 

[Jagged0]

I’m in another state rn and i don’t have any weed or anything so i feel like shit, i can’t sleep and i’m feeling really down tbh

What drugs can i buy at a store or pharmacy or anywhere where i don’t need an ID? Anything that gets me high plz


@kjsbdfiusdf @CupOfCoffee @Chad1212 @Latebloomer10 @portuguesecel @Jagged0 @gamma @Maesthetic @Adriana Lima

I heard screaming just go er bro makes you feel better

 

[Deleted member 6403]

Your serotonin levels are high, bro

 

[CupOfCoffee]

Your serotonin levels are high, bro

Don't listen to this bullshit @moonblunt lol

 

[Deleted member 6403]

Don't listen to this bullshit @moonblunt lol

Bull shit how?

 

[Doober]

DRAMAMINE

 

[Deleted member 8461]

What country you in? Look for ethnobotanical stores that sell kratom

 

[CupOfCoffee]

Bull shit how?

Being an asshole internet memelord trying to convince people that serotonin is actually bad. Despite literally 50+ years of research on it proving it's importance in mental stability, cognitive flexibility, neurogenesis, and mood regulation. But keep pretending you know shit because you read a few articles and watched a few videos from random people online

 

[Deleted member 6403]

Despite literally 50+ years of research on it proving it's importance in mental stability, cognitive flexibility, neurogenesis, and mood regulation

You mean research built on top of faulty research? I personally been lowering my serotonin levels and I've noticed several positive effects such as less hyperactivity, better concentration, and less emotional volatility.

 

[studiocel]

Being an asshole internet memelord trying to convince people that serotonin is actually bad. Despite literally 50+ years of research on it proving it's importance in mental stability, cognitive flexibility, neurogenesis, and mood regulation. But keep pretending you know shit because you read a few articles and watched a few videos from random people online

You mean research built on top of faulty research? I personally been lowering my serotonin levels and I've noticed several positive effects such as less hyperactivity, better concentration, and less emotional volatility.

Both of you are right

 

[CupOfCoffee]

You mean research built on top of faulty research? I personally been lowering my serotonin levels and I've noticed several positive effects such as less hyperactivity, better concentration, and less emotional volatility.

I'm not even gonna try to respond.

 

[Deleted member 6403]

I'm not even gonna try to respond.

Have 70+ more studies but cba to post

Serotonin antagonists (could) prevent / treat osteoporosis
"Not sure if Peat has mentioned this before, but I decided to post it anyway. The take of the story is that serotonin antagonists, and especially 5-HT3 antagonists like ondansetron would be very good treatment for osteoporosis."

Lowering Serotonin In The Brain Abolishes Fatigue
"This study however, goes a step further and claims that exercise-derived (but probably any other as well) fatigue is fully abolished by inhibiting tryptophan hydroxylase, and thus reducing serotonin in the brain. In addition, the study claims that reduced brain serotonin improved the ability of mice to cool off when their bodies heated up due to the exercise."

One Reason Why Ray Peat Recommends Low(er) Fat Diet
"Although I have not read anywhere in his articles about this connection, I came upon this study and immediately saw why Ray may be leaning towards a low(er) fat diet. Long story short - high fat diets increase serotonin synthesis and levels in plasma and tissues, and serotonin apparently directly contributed to obesity. The entire study is good read so I recommend reading it for those that are not bored by biochemical topics."

Acetaminophen raises serotonin/adrenaline, aspirin lowers it
"The effects were observed in the brain, but they probably apply elsewhere given that aspirin is shown to reduce plasma serotonin. There are quite a few studies showing increased risk of heart attacks resulting from chronic intake of acetaminophen and ibuprofen. If these NSAIDs do in fact raise serotonin that would explain why they are bad for the heart, and why aspirin is protective (lowering serotonin) given that is blood thinning effects are not sufficient to explain the protection. For instance, ibuprofen also lowers platelets aggregation but is bad for the heart. Ray has said in the past that anti-serotonin drugs are likely to be heart protective."

Serotonin And Nitric Oxide Are The True Causes Of Migraine
"Ray has written about the connections between serotonin and migraine, but AFAIK he did not name a direct causative agent. This study claims that serotonin causes release of nitric oxide in the meningeal area of the brain and spinal cord and that is the cause of migraine.
The study also implicates a specific serotonin "receptor" where serotonin exerts its action and causes release of NO. The "receptor" is 5-HT2B. A very potent antagonist at that (and others) receptor is cyproheptadine, and not surprisingly there are a number of studies showing that cyproheptadine does indeed reduce migraine symptoms.
Finally, if NO is the direct cause of migraine then agents that reduce NO production should be helpful as well. Two of the better known ones are niacinamide and vitamin B12. I think aspirin has some anti-NO action as well."

Serotonin Inhibits The Senses
"The hallucinogenic effects of LSD are thought to be due to removing of the inhibition of the "thinking" part of the brain over sensory responsivity. This implies that serotonin inhibits that responsivity. This study seems to confirm that view and makes one wonder how something that inhibits the senses like SSRI can be good for depression."

Serotonin and histamine produce gastric lesions
"If there was any doubt that serotonin and histamine are not good for you hen chronically elevated, here is an older study showing both substances producing gastric lesions in rats. Look in the section "Production of gastric lesions" for details. If this was known for so long then it is beyond me how drugs like Zelnorm ever got approved for stomach conditions or why SSRI continue to be prescribed for such conditions as well..."

Serotonin Is Involved In The Formation Of Traumatic Memories
"The study makes several points. First, serotonin is involved in the formation of traumatic memories when under shock / stress. Second, memories do not appear to be stored in the synapses, which implies that in theory lost memories (like in patients with Alzheimers or concussions) can be restored in humans as long as the neurons are still alive. Last, traumatic memories may be a lot more difficult to erase once formed, which is not very good news for people with PTSD."

 

[Deleted member 6403]

Both of you are right
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I'm not even gonna try to respond.

Study confirms science behind serotonin and depression is backwards
"What can I say - Ray is right once again, which we knew from the start. In the words of the actual study - "serotonin is a downer". It appears SSRIs work by forcing the brain to achieve homeostasis, not by modulating serotonin levels. Again, Ray did say that as well - i.e. drug companies did not really know how their SSRI drugs work."

Lack of serotonin makes one immune to depression
"Not sure why this is not hitting the news everywhere, but I find it particularly telling as to whether serotonin is good of bad for depression."

Serotonin Antagonists Extend Lifespan, SSRI Dramatically Shorten It
"This study looked specifically at mianserin, but did compare it to other drugs (including cyproheptadine). The conclusion was that mianserin and cyproheptadine extend lifespan by up to 30% by mimicking the effects of caloric restriction. Interestingly, mianserin increases appetite just like cyproheptadine, which the authors state is what creates a psychological state that makes the organism believe they are in caloric restriction. Unsurprisingly, a number of SSRI drugs caused decrease in lifespan, sometimes up to 80%! I have attached the study and the supplemental info. The supplemental info has the full list of the drugs tested and their effects on lifespan. For a good example of Peat being right on serotonin take a look at cyproheptadine's effects on lifespan (+20%) and compare it to a drug like Sertraline (Zoloft, -80%) or Paroxetine (Paxil, -76%) "

The serotonin myth and the propaganda machine
"Yet another blistering criticism of the serotonin idea and the introduction of the SSRI. It also gives a bit of an explanation as to why the SSRIs became dominant drugs decades after being invented - propaganda!"

Low serotonin is key to "perceive, think, act"
"Ray has written about the uselessness of the authoritarian concept of "protocol" as a guide of behavior, thinking and living in general. Ray's motto instead is that the only valid protocol would be something along the lines of "perceive, think, act". This study seems to establish that low serotonin (high dopamine) is key to being able to act according to Ray's motto. High serotonin, on the other hand, was associated with a protocol-like thinking and behavior, which the study calls "flexible, goal-directed responding". The paper also cites studies showing that serotonin is implicated in punishment and behavioral inhibition, as well as guilt, shame and depression. Btw, I find it funny that they call the "goal-directed responding" "flexible" while the "stimulus-response habitual response" is viewed as rigid and inflexible."

Serotonin Causes Autism; Blocking It May Treat Autism
"Once again, a testament to Ray's brilliance in clearly explaining the links between elevated serotonin in the brain and conditions like autism. Other scientists have also worked on the serotonin-autism hypothesis and as a result there has been a small human study with autism that found significant reduction in symptoms from low dose cyproheptadine. Unfortunately, the dose used in that study was rather small, so the effects could have been even more dramatic with the proper dose. However, I think this is the first study that specifically points to serotonin as the direct culprit behind autism, and that blocking the 5-HT2C "receptor" fully reverses neurological damage caused by autism. Known 5-HT2C antagonists include our old friend cyproheptadine (particularly effective at 5-HT2C), as well as mianserin, ketanserin, ritanserin and maybe even lisuride (even though for lisuride only 5-HT2B antagonism has been shown). The co-discoverer of HIV Luc Montagnier has been proposing for years treating autism with antibiotics. Some of the antibiotics he has used have strongly anti-serotonin effects, so the positive results he reported no longer look like a scam when you consider this study."

 

[Deleted member 6403]

I'm not even gonna try to respond.

Both of you are right
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High, Not Low, Serotonin Linked To Social Anxiety
"After decades of prescribing SSRI to treat anxiety, and especially "social" anxiety, evidence is finally being published in bastions of dogma like JAMA that anxiety disorders are likely caused by high levels of serotonin rather than low. This makes the prescription of SSRI one of the worst "treatments" for social and other types of anxiety. It is also worth noting that both serotonin synthesis is also enhanced, which suggests overactive TPH1, also implicated in depression, suicide, and various neurological disorders like autism, ALS, AD, etc."

Cyproheptadine May Treat Ebola Infection
"In light of the recent studies I posted showing anti-serotonin compounds to be helpful for a host of infections such as malaria, flu, or even HIV this study is not that surprising. However, it is good to have some extra tools in the arsenal against viral attacks especially when the tool is our good old friend cyproheptadine. "

The JCV uses a serotonin receptor to infect cells
"The JCV is the potantial cause of the dreaded PML condition, which may effect people with "autoimmune" conditions (MS, lupus, rheumatoid arthritis) receiving immune-suppresive therapy. It looks like the JCV requires the 5-HT2 receptor for successful cell infection and 5-HT2 antagonists may block the virus' propagation. Yet another good use for cyproheptadine. More importantly, I wonder how many other viruses require a serotonin "receptor" for successful infection and if cyproheptadine can be a viable general-purpose antiviral drug."

Cyproheptadine May Prevent And Treat HIV Infection
"Now, this study adds to the evidence implicating serotonin in viral pathologies, and shows that cyproheptadine can both block infection and inhibit established infection with HIV. In higher doses, cyproheptadine completely eradicated the virus. The other compounds the study found effective all had cytotoxicity, while cyproheptadine did not, even in very high doses."

Anti-serotonin, Pro-dopamine Drug Approved For Psychosis And Bipolar Disease
"After more than 5 decades of claiming that psychosis conditions like schizophrenia are caused by excessive dopaminergic activity and depression is a deficiency of serotonin, big pharma is doing 180 degrees reversal. A new drug was just approved for treating bipolar disorder and schizophrenia in adults, and its effects are basically a combination of cyproheptadine and bromocriptine - a combination we have discussed on the forum before. Keep in mind that current medical dogma states that the psychosis of conditions like schizophrenia is caused specifically by agonism of the D2 "receptor" and typical first-line therapy drugs for the condition are potent D2 antagonists, sometimes in combination with an SSRI.
This newly approved drug is an agonist of the D2 and 5-HT1 "receptors" (like bromocriptine) and antagonist of the 5-HT2 and H1 "receptors" (like cyproheptadine). Sometimes I wonder how can FDA approve two drugs with clearly opposite mechanisms of action without questioning the theory behind one or the other..."

Schizophrenia / Psychosis Linked To Traumatic Experience And Stress
"I have suspected this for a long time, but the official version to this day is that schizophrenia is primarily a gene-driven disease linked to a "misbehaving" cluster of about 300 genes. The fact that most of these genes are related to serotonin metabolism is considered, of course, irrelevant to the pathology even in light of common medical knowledge that traumatic events elevate brain serotonin."

SSRI (Prozac) Drugs Cause Irreversible Bone Loss
"Ray has written about the detrimental effects of serotonin on bone health and how serotonin antagonist could be a potential treatment for osteoporosis. This study confirms Ray's points and shows that drug Prozac (and possible other SSRIs) causes irreversible bone loss."

"As you can see, the study also found that high doses folic acid acted like serotonin antagonist in the breast and inhibited the bone loss process. While folic acid in pregnant or nursing women is certainly not a bad idea, high dose folic acid for other adults may be dangerous. Something like glycine and/or aspirin would be much better."

Serotonin Antagonists As Therapy For Alzheimer Disease
"As I posted in another thread, over 90% of the drugs tested for Alzheimer during the last 10 years have veen utter and abject failure. This is a pretty solid indication that the theory of Alzheimer's pathology and proposed beneficial pathways on which these drugs were based is solidly wrong."

"Aside from the failure of all of these drugs, it is quite common to treat Alzheimer patients with SSRI drugs to "improve" their mood and claims have been made that SSRI would even improve cognition. Nothing short of abomination, considering something as simple as aspirin can probably cure the condition."

"As the saying goes, "no matter how beautiful the theory, you have to acknowledge reality sometimes", and so it seems that finally Big Pharma is embarking on the right path. Of course, none of this publicly acknowledged and officially new drugs that act in ways opposite to SSRI or the cholinergic poisons used for the last 20 years, are presented as "modulators" rather than as antagonists. Be that as it may, the latest trial used the drug idalopirdine that is a very specific and direct serotonin antagonist, and was found beneficial for people with Alzheimer's. While the PR articles dances carefully around the issue of serotonin "modulation" the study authors state directly that serotonin antagonism can be a viable therapy for Alzheimer's. No wonder cyproheptadine disappeared from the pharmacies of Europe and USA. It won't be long before we see it sold as off-label treatment for the low cost of $9,899/month."

SSRI Drugs Increase Stroke Mortality In People With Diabetes
"The study was done on people with diabetes and the presumption was that it was the diabetes that gave them the stroke, not the SSRI. I, personally, dispute that assumption and think that the SSRI was responsible for both the increased stroke incidence and increased mortality from that stroke, as serotonin is a well known blood-clotting agent."

Chronic Pain Disorder Is Mediated By Serotonin
"In yet another confirmation of how "beneficial" for us the "happiness hormone" serotonin is, this study showed that the development of chronic pain syndrome is dependent on serotonin. Blocking serotonin eliminated the chronic pain condition. So, for all those poor people overdosing on Oxycontin, it looks like a little cyproheptadine can go a long way without the risk of killing them."

Itching May Be Driven By Serotonin
"I have always wondered about this phenomenon and why it is that people with chronic conditions or depression seem to have a problem with excessive itching. It turns out that itching is closely related to pain and as such the release of serotonin. So, rather than scratching your itch you may be better off reaching for the Benadryl or cyproheptadine."

DHT Lowers Serotonin Synthesis, May Treat (testicular) Cancer
"This is a great study for a number of reasons. First, it suggests that DHT is not the evil substances for male reproductive organs. This includes prostate cancer, for which DHT to this day is cite as the main culprit. Second, the study establishes the key role serotonin plays in the pathogenesis of testicular (and other) cancer and the overexpression of the serotonin-producing enzyme TPH in testicular tumors. TPH is actually overexpressed in most cancers but this fact is not widely publicized. This study states that explicitly and I hope this trend will continue. Third, the study shows that inhibiting TPH and thus serotonin synthesis may be a viable treatment for at least this type of cancer. Fourth, if DHT also inhibits TPH in the brain (and I don't see why it would not) and has proven potent anti-depressant effects then the theory of serotonin as a cure for depression is becoming highly untenable. Finally, given the beneficial effects of TPH inhibition on a variety of conditions such as obesity, diabetes, hypertension, pulmonary edema, cystic fibrosis, etc using DHT (mostly by males) would be a great alternative to the number of patented and still experimental TPH inhibitors that come with a host of side effects as well. Given the high conversion of DHEA into DHT in peripheral tissues, this would also explain a good deal of DHEA anti obesity and anti-depressive effects. In fact, recent studies discovered just that - i.e. the beneficial effects of DHEA on insulin sensitivity and metabolism are at least partly due to its conversion into DHT in muscle."

Poverty Causes Depression By Increasing Serotonin Activity
"The conditions of learned helplessness and PTSD have many features in common and both of them have been linked to dysfunction of the monoaminergic system. There has been a lot of research over the last decade tying adverse life conditions in childhood to mood and memory problems as an adult. Unfortunately, most of the studies paint serotonin as the "good guy" and a main component of "treatment" for such conditions involves giving SSRI drugs. The SSRI drugs act mainly on the so-called serotonin transporter, which is responsbile for de-activating serotonin by removing from the synapse and storing it into the neurons. The SSRI drugs inhibit the activity of the serotonin transporter and thus increase serotonin activity in the brain. Btw, sodium is a co-factor for that transporter, so this is also why low-salt diet increases serotonin activity. This study found that living in poverty as a child results in overmethylation of the gene that codes for the serotonin transporter, thus inhibiting its activity. This result in the same effects as taking an SSRI drug and increases serotonin availability and activity in various brain regions, especially the amygdala. As a result, people with decreased activity of this serotonin transporter display symptoms of depression when presented with threats, but also in normal life situations. The only thing that annoys me about this study is that it does not directly call out serotonin as the bad guy here. But we all know that when career depends on certain status quo, nobody wants to rock the boat too much."

Serotonin May Be The Cause Of Fibrosis In Scleroderma (systemic Sclerosis)
"Ray has said numerous times that serotonin is intimately involved in fibrotic conditions of the lungs, and my own research shows that it is involved in many other fibrotic conditions including cirrhosis, cystic fibrosis, and of course carcinoid syndrome. This study now adds the condition known as systemic sclerosis or scleroderma to the list of conditions where serotonin plays a causative role. This suggests that lowering serotonin may be therapeutic in this condition for which officially there is no cure and it is eventually fatal."

Maternal Inflammation Causes Brain Damage (autism) By Raising Serotonin
"I posted several studies recently about maternal hypothyroidism and stress being linked to autism, as well as the use of serotonin antagonist to reverse autism pathology in an animal model. This study adds more weight to the serotonin-autism connection. It showed that triggering flu-like symptoms and the release of endotoxin in the pregnant mother raised serotonin several-fold and caused brain damage and behavioral abnormality in offspring reminiscent of autism."

An Anti-serotonin, Pro-dopamine Drugs May Treat Systemic Sclerosis
"Big Pharma is slowly prepping us for the inevitable admission that serotonin is really not that good for us. Of course, it will not happen publicly but through the approval of drugs that block serotonin and promote dopamine activity. This news piece shows that the drug terguride (a lisuride derivative) is currently in a large scale human trial after being PROVEN to reverse symptoms of systemic sclerosis (also known as scleroderma). I posted a study some time ago showing that drugs like lisuride are effective treatment for fibrosis of some organs. Even today, the official position on fibrotic diseases like systemic sclerosis is that they are uncurable, but apparently behind the scenes the truth is different. The German pharmaceutical company Medac, in August, will begin Phase 3 of a clinical trial to access the therapeutic potential of terguride, a disease-modifying drug for the treatment of diffuse cutaneous systemicsclerosis."

 

[Deleted member 6403]

I'm not even gonna try to respond.

Both of you are right
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Stress Activates A Serotonin Gene In Pregnant Women And That Causes Autism
"This study now ties maternal stress to the activation of the serotonin gene 5-HTTLPR, which downregulates the activity of the serotonin transporter and thus leads to elevations of brain and plasma serotonin. Given that the link between stress and elevated serotonin is apparently quite well known in pregnancy research, it is baffling that SSRI drugs are prescribed to women to help them "deal with stress" or to "treat" their depression."

Ritanserin Restores Energetic Function (metabolism) During The Night
"I wanted to post this study as a separate thread as it caught my eye with its obvious relevance to Peat's views on sleep and metabolism. The restorative slow wave sleep (SWS) is highly dependent on metabolism and disturbances in oxidative metabolism immediately manifest in SWS. As such, SWS disturbances in SWS have been observed in pretty much all chronic conditions (especially psychiatric ones) and the aging process in general. It seems that ritanserin is able to reverse the disturbances in SWS by improving metabolism during the night."

Serotonin As The Cause Of Acute Pancreatitis
"As some of you know, pancreatitis is a condition very common among alcoholics and people on SSRI drugs. When it is acute it can be quite deadly and its incidence has been skyrocketing lately, which concided with rising rates of alcohol abuse among middle-class citizens in the Western world. The drug companies continue to deny that serotonin is involved in the pathology of any GI disease, but quietly they are running trials with inhibitors of TPH as treatment for IBS, IBD, and even some GI cancers. This study shows that the activation of the 5-HT2 receptor is crucial for the development of the acute pancreatitis pathology and antagonists at that receptor (cyproheptadine, ritanserin, etc) can successfully treat the condition."

Children With Autism Have High Serotonin Levels
"I posted a few studies on using anti-serotonin drugs (specifically 5-HT2 antagonists) as a potential treatment for autism. This study adds more weight to the evidence for causative role of serotonin in autism by finding out that children with autism have abnormally high blood serotonin levels. There are a few recent clinical trials with TPH inhibitors for treating IBS and I think these would be prime candidates for treating autism as they target serotonin in the gut, which is where autism is thought to be centered as well."

The Darker Side Of Serotonin Finally Exposed - It Increases Anxiety And Suicide
"I guess the fact that such studies are finally starting to come out is a good sign. I don't think this will hurt Prozac sales in any way, but at least now doctors may start to discuss with patients the potential dangers of SSRI, which up until last year were considered to be pure myth. It still baffles me how can FDA approve drugs in the face of evidence that they cause the very problems they are designed to treat. I am beginning to suspect more than just pure idiotism here... Finally, I think the even bigger takeaway from the study is that the study found stress to increase levels of serotonin, which then acted as the primary cause of anxiety and depression. So, there you have it plain and simple - stress makes you depressed and taking an SSRI is a great way to mimic this process ad recreate it pharmacologically."

The Serotonin Receptor 5-HT2B Is Required For Cancer; Can Be Blocked
"I think this study should be sent to every pharma executive and brainwashed whitecoat who claims that serotonin is a good hormone promoting happiness and health. Actually, pharma companies have no illusions and know very well what's going on. Hence, the recent acquisition of Pfizer to the commercial rights of terguride - a potent antagonist of 5-HT2B, albeit a lot less effective than something like lisuride or non-selective antagonists like cyproheptadine or ritanserin. Pfizer knows quite well that 5-HT2B is required for the development of fibrosis and that antagonizing that receptor can cure fibrosis. Given that fibrosis is the preceding stage to cancer, it is not surprising at all that the studies below found the 5-HT2B receptor to be required for the development of cancer as well. And just as in the case of terguride, blocking said 5-HT2B receptor was therapeutic for the established cancer. The drug used in the study was ritanserin, but any other 5-HT2B antagonist such as cyproheptadine, lisuride, and even ketanserin should work just as well."

Delirium In ICU Patients May Be Just Serotonin Syndrome
"I have several friends who are ER physicians and one of them works in the ICU as well. The topic of post-surgical delirium has come up many times and all of them vehemently denied that serotonin has anything to do with it. The current view is that the mechanism and cause is unknown and heredity probably has a big role, as well as prior/current substance abuse. The fact that delirium shares most of the signs/symptoms of serotonin syndrome is simply brushed aside as coincidence. Well, once again, serotonin seems to be rearing its ugly head. This study found that a significant portion of ICU patients with delirium have serotonin syndrome. The sad part is that, just like my doctor friends, the attending doctors completely failed (or ignored) to properly recognize the condition and treat it appropriately with cyproheptadine. Another recent trial found that low dose cyproheptadine prevented most cases of delirium even though it did not do much for very severe cases already in progress. I suppose the even sadder part is that many ICU patients are treated with SSRI or other serotonergic drugs to "calm" them down. Given the direct effect of these drugs on inducing serotonin syndrome I wonder if the failure to recognize the connection is pure stupidity or is it being purposefully ignored to avoid implicating blockbuster drugs that make tons of money for the hospital..."

Inhibiting Serotonin During Protein Feeding Doubles Maximum Lifespan
"This study is actually on the effects of a high protein diet on brain neurotransmitters and lifespan. It was done in fruit flies but the serotonin in those fruit flies are essentially the same in humans. So, the results should hold. One of the big takeaways from the study is the explanation of why eating high protein diets has been linked to shorter lifespans. While eating protein itself tends to be dopaminergic due to lowering the ratio of tryptophan to the LNAA, the anticipation of the high protein meal due to enforced starvation apparently activates the serotonergic system in the brain and specifically the 5-HT2 "receptor". Activation of serotonergic receptors has been reliably shown to decrease lifespan while blocking them may extend lifespan in many species. So, the forced (read: stressful) restriction of viable nutrients while allowing the animal to perceive its availability is what leads to the activation of the serotonergic system and shortened lifespan. Yet another example that stress is a major factor in aging! Both of the studies above were done on a worm animal model. This study was done on fruit flies. I would like to see this replicated in higher species like mice, rats, and moneys but I think even this replication across less complex species is important as it suggests the mechanism of lifespan extension is valid. Anyways, the study found that increasing the perceived value of protein through forced starvation and then letting the animal eat at will activates both the enzyme tryptophan hydroxylase (TPH) and the 5-HT2 serotonin receptor. TPH is the enzyme that synthesizes serotonin from tryptophan. The study found that inhibiting TPH and/or blocking 5-HT2 increase lifespan by almost 100% - i.e. basically doubled it. This means drugs like cyproheptadine, mianserin, ketanserin, ritanserin and some other non-specific serotonin antagonists can all be used as a part of a life extension strategy."

SSRI Drugs Damage Bone By Increasing Adrenaline
"Over the last few years there have been a number of studies linking SSRI use with increased risk of fracture. Subsequent studies found this link to be definitively causal - i.e. SSRI drugs cause those fractures. However, the mechanism of action was officially ascribed to the medical establishment''s favorite category - "unknown". Now this study sheds more light on the mechanism and finds (unsurprisingly) that serotonin crease due to SSRI activates the sympathetic system and it is the increased adrenaline as a result that triggers bone loss. Administering an anti-adrenaline drug (a beta blocker) greatly diminished the bone loss. Aside from the fact that a much safer drug like clonidine could have been used, the study also failed to make the connection between serotonin and cortisol. Cortisol is a much bigger factor in bone and tissue loss then adrenaline and serotonin is perhaps the biggest promoter of cortisol synthesis through the upregulation of ACTH. Adrenaline also promotes cortisol synthesis as part of the sympathetic response. It just so happens that the drug clonidine lowers both adrenaline and cortisol, and as such should be a much better option than the dreaded beta blockers that can leave males impotent and women demented. Finally, let's not forget Ray's writings about anti-serotonin drugs being very anabolic to the bone. So, instead of taking an SSRI and then trying to reverse its stimulated bone loss, it's much better to take an anti-serotonin drug as that will not only treat the depression but will also give you bones of steel as well :"

Children Conceived In Winter Have Much Higher Risk Of Autism
"Not sure why the study considers January to May to be winter months, but this is yet another study that links maternal metabolism (and serotonin) to autism. The official explanation is increased flu infection and lower vitamin D levels in the winter. While these may be contributing factors, I posted a few studies that strong causative link between hypothyroidism and serotonin excess in the mother to autism in children, including successful treatments with serotonin antagonist (mostly animal models)."

 

[CupOfCoffee]

Have 70+ more studies but cba to post

Serotonin antagonists (could) prevent / treat osteoporosis
"Not sure if Peat has mentioned this before, but I decided to post it anyway. The take of the story is that serotonin antagonists, and especially 5-HT3 antagonists like ondansetron would be very good treatment for osteoporosis."

Lowering Serotonin In The Brain Abolishes Fatigue
"This study however, goes a step further and claims that exercise-derived (but probably any other as well) fatigue is fully abolished by inhibiting tryptophan hydroxylase, and thus reducing serotonin in the brain. In addition, the study claims that reduced brain serotonin improved the ability of mice to cool off when their bodies heated up due to the exercise."

One Reason Why Ray Peat Recommends Low(er) Fat Diet
"Although I have not read anywhere in his articles about this connection, I came upon this study and immediately saw why Ray may be leaning towards a low(er) fat diet. Long story short - high fat diets increase serotonin synthesis and levels in plasma and tissues, and serotonin apparently directly contributed to obesity. The entire study is good read so I recommend reading it for those that are not bored by biochemical topics."

Acetaminophen raises serotonin/adrenaline, aspirin lowers it
"The effects were observed in the brain, but they probably apply elsewhere given that aspirin is shown to reduce plasma serotonin. There are quite a few studies showing increased risk of heart attacks resulting from chronic intake of acetaminophen and ibuprofen. If these NSAIDs do in fact raise serotonin that would explain why they are bad for the heart, and why aspirin is protective (lowering serotonin) given that is blood thinning effects are not sufficient to explain the protection. For instance, ibuprofen also lowers platelets aggregation but is bad for the heart. Ray has said in the past that anti-serotonin drugs are likely to be heart protective."

Serotonin And Nitric Oxide Are The True Causes Of Migraine
"Ray has written about the connections between serotonin and migraine, but AFAIK he did not name a direct causative agent. This study claims that serotonin causes release of nitric oxide in the meningeal area of the brain and spinal cord and that is the cause of migraine.
The study also implicates a specific serotonin "receptor" where serotonin exerts its action and causes release of NO. The "receptor" is 5-HT2B. A very potent antagonist at that (and others) receptor is cyproheptadine, and not surprisingly there are a number of studies showing that cyproheptadine does indeed reduce migraine symptoms.
Finally, if NO is the direct cause of migraine then agents that reduce NO production should be helpful as well. Two of the better known ones are niacinamide and vitamin B12. I think aspirin has some anti-NO action as well."

Serotonin Inhibits The Senses
"The hallucinogenic effects of LSD are thought to be due to removing of the inhibition of the "thinking" part of the brain over sensory responsivity. This implies that serotonin inhibits that responsivity. This study seems to confirm that view and makes one wonder how something that inhibits the senses like SSRI can be good for depression."

Serotonin and histamine produce gastric lesions
"If there was any doubt that serotonin and histamine are not good for you hen chronically elevated, here is an older study showing both substances producing gastric lesions in rats. Look in the section "Production of gastric lesions" for details. If this was known for so long then it is beyond me how drugs like Zelnorm ever got approved for stomach conditions or why SSRI continue to be prescribed for such conditions as well..."

Serotonin Is Involved In The Formation Of Traumatic Memories
"The study makes several points. First, serotonin is involved in the formation of traumatic memories when under shock / stress. Second, memories do not appear to be stored in the synapses, which implies that in theory lost memories (like in patients with Alzheimers or concussions) can be restored in humans as long as the neurons are still alive. Last, traumatic memories may be a lot more difficult to erase once formed, which is not very good news for people with PTSD."

I find it very hard to believe that you read through all these studies without your ADHD pea brain giving up. Let alone actually understanding the context behind everything and what every single receptor mentioned does and the implications. I'll try to give these a read when I have time. But a word of advice bro, don't think it doesn't matter what advice you give out to people. My advice is for people who are depressed to TRY raising their serotonin and seeing how that affects them, but it is not the same for everyone. Don't discourage people from trying different things if their life depends on it. Be careful

 

[Deleted member 6403]

ADHD pea brain giving up.

I'm cured from that at this point. Perhaps more ad hominems?

 

[CupOfCoffee]

I'm cured from that at this point. Perhaps more ad hominems?

So you read that shit and didn't just copy-paste

 

[Deleted member 6403]

But a word of advice bro, don't think it doesn't matter what advice you give out to people. My advice is for people who are depressed to TRY raising their serotonin and seeing how that affects them, but it is not the same for everyone. Don't discourage people from trying different things if their life depends on it. Be careful

I never give advice that I myself don't practice. Dopamine should be prioritized over serotonin.

 

[Deleted member 6403]

So you read that shit and didn't just copy-paste

Ofc

 

[CupOfCoffee]

I never give advice that I myself don't practice. Dopamine should be prioritized over serotonin.

They're both equally important. Imbalances in both lead to mental illness

 

[Deleted member 6403]

Imbalances in both lead to mental illness

So you do agree that high serotonin:low dopamine levels are harmful then?

 

[CupOfCoffee]

So you do agree that high serotonin:low dopamine levels are harmful then?

Obviously lol I've had that when I came off Wellbutrin or when I had Adderall withdrawals. Nothing feels enjoyable and I felt like I wanted to lay in my bed all day, I would get bored of sex in the middle of the act and music did nothing for me. But when I came off of ecstasy I had a different but equally bad feeling of unease and lack of contentment, which to me was clearly my brain starved of serotonin 2-4 days after.

 

[ShowerMaxxing]

You mean research built on top of faulty research? I personally been lowering my serotonin levels and I've noticed several positive effects such as less hyperactivity, better concentration, and less emotional volatility.

So u started taking ur ADHD meds

 

[eyelidcel]

I never give advice that I myself don't practice. Dopamine should be prioritized over serotonin.

Dopamine is King NGL