Ideal thyroid hormones protocol for bone growth?

[Napoleon1800]

Would it be t3 alone, t4 alone or combination usage?

I feel that t3 with dose split multiple times across the day would perform the best while minimising catabolism and cardiac stress

Thoughts?

 

[jeoyw9192]

Would it be t3 alone, t4 alone or combination usage?

I feel that t3 with dose split multiple times across the day would perform the best while minimising catabolism and cardiac stress

Thoughts?

Bumping

 

[Edelweiss]

3:1 t4 to t3 ratio

 

[Napoleon1800]

3:1 t4 to t3 ratio

Why not t3 alone?

 

[insignia_]

Would it be t3 alone, t4 alone or combination usage?

I feel that t3 with dose split multiple times across the day would perform the best while minimising catabolism and cardiac stress

Thoughts?

Wait what? How do thyroid hormones relate to bone growth? I searched it up and it seems like it’s related to the speed of bone growth activity, but it may be wrong idk. Lmk

 

[childishkillah]

T3 and T4 would prolly lead to more bone resorption than new bone

 

[Napoleon1800]

T3 and T4 would prolly lead to more bone resorption than new bone

Well it depends on the dose

 

[Napoleon1800]

Wait what? How do thyroid hormones relate to bone growth? I searched it up and it seems like it’s related to the speed of bone growth activity, but it may be wrong idk. Lmk

It increase chondrocyte proliferation, but also increases growth velocity, could potentially result in more growth of the jaw bone but it depends on the dose and combination which I’m trying to figure out

 

[childishkillah]

Well it depends on the dose

Could you give me your sources? I read about this topic in July and I remember almost nuufiin

 

[Napoleon1800]

Could you give me your sources? I read about this topic in July and I remember almost nuufiin

Role of Thyroid Hormones in Skeletal Development and Bone Maintenance - PMC

The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates the critical role for thyroid hormones during development, linear growth, and adult bone turnover and maintenance. Thyrotoxicosis is an established cause of ...

pmc.ncbi.nlm.nih.gov

Role of thyroid hormones in craniofacial development - PubMed

The development of the craniofacial skeleton relies on complex temporospatial organization of diverse cell types by key signalling molecules. Even minor disruptions to these processes can result in deleterious consequences for the structure and function of the skull. Thyroid hormone deficiency...

pubmed.ncbi.nlm.nih.gov

What’s interesting is for this one they didn’t see any significant changes however I mean the people were already past the age of 20 when jaw stops growing and the t4 levels were to turn the hypothyroid individuals euthyroid so not sure if this is worthwhile as reference

DETERMINATION OF MANDIBULAR BONE CHANGES IN PATIENTS WITH PRIMARY HYPOTHYROIDISM TREATED WITH LEVOTHYROXINE SODIUM - PMC

This study aimed to assess fractal dimension (FD) and the radiomorphometric indexes on the digital panoramic radiography (DPR) of patient with primary hypothyroidism receiving levothyroxine sodium replacement therapy. A total of 115 subjects were ...

pmc.ncbi.nlm.nih.gov