Igf 1 signaling

[iblamemyself!]

Heard this from a few guys, and i cant seem to find what it is, closest i got was some guy on tiktok talking about milk
What is it and how do I do it

 

[sexgod]

igf-1 signalling

 

[jflwarrior05]

tiktok is surely best source of knowledge. especially made by people with looksmaxxingmogger courses in bio

 

[TheTD7]

Anterior pituitary secretes GH, which circulates and binds to GHRs on hepatocytes and other target tissues. GH receptor binding leads to dimerization of receptor.

GH binding activates JAK2. Activated JAK2 phosphorylates both the receptor and signal transducer and activator of transcription (STAT5). Phosphorylated STAT5 dimerizes and translocates to the nucleus where it promotes transcription of the IGF1 gene (and IGFBP genes iirc, but not sure about this).

The liver is the major source of circulating IGF1 (endocrine action) (ofc other tissues too, like muscle and bone also produce IGF1 locally (autocrine/paracrine action)). After it geta released IGF-1 circulates bound to IGF binding proteins (IGFBPs)which stabilize it and modulate its bioavailability.

The IGF1R is a tyrosine kinase receptor expressed on growth plate chondrocytes (for height gain), osteoblasts (increases bone matrix synthesis) and myocytes (promotes protein synthesis nd hypertrophy)

When IGF1 binds IGF1R, PI3K-Akt pathway promotes protein synthesis (by mTOR activation), and glucose uptake.
MAPK (Ras-Raf-MEK-ERK) pathway promotes cell differentiation /proliferation.


This is IGF1 signaling but i don't know what the fuck you mean by "how do i do it"? like nigga wtf? it's not a technique or something, it's a physiological pathway your body runs everyday under endocrine system's control.

 

[Prøphet]

A blue cell and his igf1 signalling

 

[jflwarrior05]

Anterior pituitary secretes GH, which circulates and binds to GHRs on hepatocytes and other target tissues. GH receptor binding leads to dimerization of receptor.

GH binding activates JAK2. Activated JAK2 phosphorylates both the receptor and signal transducer and activator of transcription (STAT5). Phosphorylated STAT5 dimerizes and translocates to the nucleus where it promotes transcription of the IGF1 gene (and IGFBP genes iirc, but not sure about this).

The liver is the major source of circulating IGF1 (endocrine action) (ofc other tissues too, like muscle and bone also produce IGF1 locally (autocrine/paracrine action)). After it geta released IGF-1 circulates bound to IGF binding proteins (IGFBPs)which stabilize it and modulate its bioavailability.

The IGF1R is a tyrosine kinase receptor expressed on growth plate chondrocytes (for height gain), osteoblasts (increases bone matrix synthesis) and myocytes (promotes protein synthesis nd hypertrophy)

When IGF1 binds IGF1R, PI3K-Akt pathway promotes protein synthesis (by mTOR activation), and glucose uptake.
MAPK (Ras-Raf-MEK-ERK) pathway promotes cell differentiation /proliferation.


This is IGF1 signaling but i don't know what the fuck you mean by "how do i do it"? like nigga wtf? it's not a technique or something, it's a physiological pathway your body runs everyday under endocrine system's control.

HAHAHA

 

[Deleted member 112562]

HAHAHA

You can just "JFL" react.

 

[jflwarrior05]

You can just "JFL" react.

no way bra

 

[Deleted member 112562]

no way bra

You seem to not understand, else you would rep my answers.

Are you deaf by any chance?

 

[miloeatscookies]

blue thinks normal hooman function is something special