I'll be trying aromatase inhibitors for height maxxing.

[chopped_guy]

Idc anymore if aromatase inhibitors are cope or not. To convince myself they're not I gathered a few studies on idiopathic short stature; they were closest to a normal healthy human being like myself.

Yackobovitch-Gavan et al. 2025 (Israel) - POSITIVE RESULTS​

"AI treatment extends the growth period, resulting in an AHt surpassing initial predictions. Our findings underscore the potential of AI treatment in midpubertal boys with a short PAHt due to advanced BA and in those treated with GH for ISS."
This was with anastrozole though.

Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, Damaso L, Merinbaum D, Singh RJ, Gaete X, Mericq V. Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature. J Clin Endocrinol Metab. 2016 Dec;101(12):4984-4993. doi: 10.1210/jc.2016-2891. Epub 2016 Oct 6. PMID: 27710241; PMCID: PMC5155684.
"Combination therapy with AI/GH increases height potential in pubertal boys with ISS more than GH and AI alone treated for 24–36 months with a strong safety profile." ​

"Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm)."

Did not have a control group but appears to work.

There are two studies that show negative result, I'll pretend they don't exist.

ppl here preach exemestane even though it's the drug least studied, I didn't find a single RCT on it.

So I'm going to use letrozole, it's the strongest on paper.

The following are my current stats:
15yo
170cm (around 5'7")
49.5kg rn (i know this is bad)
grew 5cm in 8 months
5'8" Dad and 5' mom​

Current PAH is 175cm (5'9")

I'm trying to gain 3-4 more inches in total height that would put me 5'10-5'11 Which is realistic.

My full stack what ill be doing:
2.5mg of letrozole ED, i know you ppl with say this will crash my E2 hard but this is the dose actually studied.
Mirtazapine 15mg ED; antidepressant most likely to cause significant weight gain, which is desired.
Melatonin 3mg ED; actually good sleep is kinda hard ngl.
60k IU of vitamin D every 15 days; why not? half the world is deficient anyway.
[Please don't ask where i get these from]
​

Anything i'm doing wrong?

 

[savage21]

Idc anymore if aromatase inhibitors are cope or not. To convince myself they're not I gathered a few studies on idiopathic short stature; they were closest to a normal healthy human being like myself.

Yackobovitch-Gavan et al. 2025 (Israel) - POSITIVE RESULTS​

"AI treatment extends the growth period, resulting in an AHt surpassing initial predictions. Our findings underscore the potential of AI treatment in midpubertal boys with a short PAHt due to advanced BA and in those treated with GH for ISS."
This was with anastrozole though.

Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, Damaso L, Merinbaum D, Singh RJ, Gaete X, Mericq V. Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature. J Clin Endocrinol Metab. 2016 Dec;101(12):4984-4993. doi: 10.1210/jc.2016-2891. Epub 2016 Oct 6. PMID: 27710241; PMCID: PMC5155684.​

"Combination therapy with AI/GH increases height potential in pubertal boys with ISS more than GH and AI alone treated for 24–36 months with a strong safety profile." ​

"Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm)."

Did not have a control group but appears to work.

There are two studies that show negative result, I'll pretend they don't exist.

ppl here preach exemestane even though it's the drug least studied, I didn't find a single RCT on it.

So I'm going to use letrozole, it's the strongest on paper.

The following are my current stats:​

15yo​

170cm (around 5'7")​

49.5kg rn (i know this is bad)​

grew 5cm in 8 months​

5'8" Dad and 5' mom​

Current PAH is 175cm (5'9")

​

I'm trying to gain 3-4 more inches in total height that would put me 5'10-5'11 Which is realistic.​

​

My full stack what ill be doing:​

2.5mg of letrozole ED, i know you ppl with say this will crash my E2 hard but this is the dose actually studied. ​

Mirtazapine 15mg ED; antidepressant most likely to cause significant weight gain, which is desired. ​

Melatonin 3mg ED; actually good sleep is kinda hard ngl. ​

60k IU of vitamin D every 15 days; why not? half the world is deficient anyway. ​

[Please don't ask where i get these from] ​

​

Anything i'm doing wrong?

Have you even gotten your E2 levels checked?
Why are you taking an AI for no reason.
You will crash your estrogen and nuke your bone development aswell as your brain function.

 

[GoErOnFoids]

Are your arms the size of my cock

 

[Deleted member 57377]

Might as well throw in some hgh. Good luck tho.

 

[chopped_guy]

Might as well throw in some hgh. Good luck tho.

Kinda expensive i don't have 50k to spend in a year.

 

[savage21]

Kinda expensive i don't have 50k to spend in a year.

HGH does not cost 50k btw. Even on mainstream vendors it’s like 90 cents per IU

 

[chopped_guy]

Have you even gotten your E2 levels checked?
Why are you taking an AI for no reason.
You will crash your estrogen and nuke your bone development aswell as your brain function.

Good idea. Height >>> brain function, atleast for me. But im probably mid puberty

 

[OmgBPbrootal]

Idc anymore if aromatase inhibitors are cope or not. To convince myself they're not I gathered a few studies on idiopathic short stature; they were closest to a normal healthy human being like myself.

Yackobovitch-Gavan et al. 2025 (Israel) - POSITIVE RESULTS​

"AI treatment extends the growth period, resulting in an AHt surpassing initial predictions. Our findings underscore the potential of AI treatment in midpubertal boys with a short PAHt due to advanced BA and in those treated with GH for ISS."
This was with anastrozole though.

Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, Damaso L, Merinbaum D, Singh RJ, Gaete X, Mericq V. Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature. J Clin Endocrinol Metab. 2016 Dec;101(12):4984-4993. doi: 10.1210/jc.2016-2891. Epub 2016 Oct 6. PMID: 27710241; PMCID: PMC5155684.​

"Combination therapy with AI/GH increases height potential in pubertal boys with ISS more than GH and AI alone treated for 24–36 months with a strong safety profile." ​

"Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm)."

Did not have a control group but appears to work.

There are two studies that show negative result, I'll pretend they don't exist.

ppl here preach exemestane even though it's the drug least studied, I didn't find a single RCT on it.

So I'm going to use letrozole, it's the strongest on paper.

The following are my current stats:​

15yo​

170cm (around 5'7")​

49.5kg rn (i know this is bad)​

grew 5cm in 8 months​

5'8" Dad and 5' mom​

Current PAH is 175cm (5'9")

​

I'm trying to gain 3-4 more inches in total height that would put me 5'10-5'11 Which is realistic.​

​

My full stack what ill be doing:​

2.5mg of letrozole ED, i know you ppl with say this will crash my E2 hard but this is the dose actually studied. ​

Mirtazapine 15mg ED; antidepressant most likely to cause significant weight gain, which is desired. ​

Melatonin 3mg ED; actually good sleep is kinda hard ngl. ​

60k IU of vitamin D every 15 days; why not? half the world is deficient anyway. ​

[Please don't ask where i get these from] ​

​

Anything i'm doing wrong?

lol we are the exact same person body wise except you weigh less and are prob in earlier puberty stages. You gonna monitor e2 or you dont really care and js gonna crash it?

 

[chopped_guy]

HGH does not cost 50k btw. Even on mainstream vendors it’s like 90 cents per IU

? Bro then that would be fire, do you know a source?

 

[Deleted member 57377]

Kinda expensive i don't have 50k to spend in a year.

It's only like 10k for pharma grade but ok.

 

[Deleted member 57377]

It's only like 10k for pharma grade but ok.

5k for ugl hgh.

 

[savage21]

? Bro then that would be fire, do you know a source?

I only know my niche sources (I’m gonna gatekeep). There are many mainstream sources though just search online. But honestly, be wary of what you inject and take. I wouldn’t recommend taking an AI for no reason

 

[CoolMan78]

It's only like 10k for pharma grade but ok.

Not even 10k thou it depend on your dose and stuff

 

[Deleted member 57377]

Not even 10k thou it depend on your dose and stuff

I just assumed the higher end of the dose they give to them kids in the studies.

 

[chopped_guy]

I looked up, rhGH doses used for idiopathic short stature.
0.05 mg/kg/day ≈ 0.15 IU/kg/day,
since 1 mg of rhGH = ~3 IU.
That's fucking 7.5 IU of GH every day

 

[chopped_guy]

It's only like 10k for pharma grade but ok.

ngl AI costs more than 300 times less

 

[Deleted member 57377]

ngl AI costs more than 300 times less

It's not one or the other, you need both for the most optimal outcome.

 

[OmgBPbrootal]

It's not one or the other, you need both for the most optimal outcome.

What if you only take AI

 

[chopped_guy]

What if you only take AI

Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm). AI/GH had higher fat free mass accrual. Measures of bone health, safety labs, and adverse events were similar in all groups. Letrozole caused higher T and lower estradiol than anastrozole.

One of the studies I read, ppl expected to gain 13 cm gained 18cm that's like just 5cm gain over normal, just don't expect something dramatic.

 

[chopped_guy]

Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm). AI/GH had higher fat free mass accrual. Measures of bone health, safety labs, and adverse events were similar in all groups. Letrozole caused higher T and lower estradiol than anastrozole.

One of the studies I read, ppl expected to gain 13 cm gained 18cm that's like just 5cm gain over normal, just don't expect something dramatic.

Over 3 years

 

[Deleted member 57377]

What if you only take AI

Growth plates stay open for longer, so in theory you could grow a bit taller but you won't go over your genetic limit.

 

[Deleted member 57377]

Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm). AI/GH had higher fat free mass accrual. Measures of bone health, safety labs, and adverse events were similar in all groups. Letrozole caused higher T and lower estradiol than anastrozole.

One of the studies I read, ppl expected to gain 13 cm gained 18cm that's like just 5cm gain over normal, just don't expect something dramatic.

Why would this be applicable to those without ISS?

 

[chopped_guy]

Growth plates stay open for longer, so in theory you could grow a bit taller but you won't go over your genetic limit.

Won't go over genetic limit??? what my genetic PAH is just 173-175cm

Why would this be applicable to those without ISS?

ISS means idiopathic short stature aka no GHD.

 

[chopped_guy]

The closest we have to healthy ppl. CDGP trials also exist but these were in ppl with delayed puberty and growth not mid puberty males

 

[poopjeet]

The closest we have to healthy ppl. CDGP trials also exist but these were in ppl with delayed puberty and growth not mid puberty males

Makes sense but you're gonna fuck up your BMD, lipids and god knows what.

 

[Deleted member 57377]

Won't go over genetic limit??? what my genetic PAH is just 173-175cm

ISS means idiopathic short stature aka no GHD a

The idea is, is that those with ISS are short for no apparent reason, as in their height is not correlated with their expected height, so the use of AI and GH just gets them closer to their true expected height based on genetics.

 

[chopped_guy]

The idea is, is that those with ISS are short for no apparent reason, as in their height is not correlated with their expected height, so the use of AI and GH just gets them closer to their true expected height based on genetics.

So both AI and GH are cope?

 

[Deleted member 57377]

So both AI and GH are cope?

For normal people, most likely, but if you got the money it doesn't hurt to try.

 

[chopped_guy]

Makes sense but you're gonna fuck up your BMD, lipids and god knows what.

Acceptable at this point

 

[chopped_guy]

For normal people, most likely, but if you got the money it doesn't hurt to try.

Atleast i can cope with the fact my parent are slightly short

 

[poopjeet]

Atleast i can cope with the fact my parent are slightly short

A 15yo nga citing studies? Don't do this you're gonna mess up your brain too

 

[poopjeet]

CDGP studies are actually closer to healthy controls, they just have delayed puberty and AIs still add around 2cm per year of treatment but you're not "early puberty"

 

[chopped_guy]

CDGP studies are actually closer to healthy controls, they just have delayed puberty and AIs still add around 2cm per year of treatment but you're not "early puberty"

Source bro?

 

[poopjeet]

Source bro?

Wickman et al. 2001; this study was with testosterone + letrozole but 6.7cm gains vs placebo that's huge (p=0.04 aka statistically significant) in just 12 months.

Rohani et al. 2019; this is perfect just Letrozole vs controls, +2.2cm (p=0.04) over one year.

This is my source nga

 

[chopped_guy]

Wickman et al. 2001; this study was with testosterone + letrozole but 6.7cm gains vs placebo that's huge (p=0.04 aka statistically significant) in just 12 months.

Rohani et al. 2019; this is perfect just Letrozole vs controls, +2.2cm (p=0.04) over one year.

This is my source nga

Finally someone with a working brain, What if i add exogenous T to my stack?

 

[chopped_guy]

Like in the first study you mentioned ?

 

[OmgBPbrootal]

For normal people, most likely, but if you got the money it doesn't hurt to try.

How long are AI's detectable in the body by lab tests.

 

[poopjeet]

Finally someone with a working brain, What if i add exogenous T to my stack?

You're choice but from what studies show it will be better

 

[chopped_guy]

How long are AI's detectable in the body by lab tests.

half life of E2 is 90 minutes for naturally circulating estradiol, my guess is within a day. wait lemme check anyway, google says 2-3 days for letrozole to acheive maximal suppression of estrogen.

 

[Iblamegirthquake]

Idc anymore if aromatase inhibitors are cope or not. To convince myself they're not I gathered a few studies on idiopathic short stature; they were closest to a normal healthy human being like myself.

Yackobovitch-Gavan et al. 2025 (Israel) - POSITIVE RESULTS​

"AI treatment extends the growth period, resulting in an AHt surpassing initial predictions. Our findings underscore the potential of AI treatment in midpubertal boys with a short PAHt due to advanced BA and in those treated with GH for ISS."
This was with anastrozole though.

Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, Damaso L, Merinbaum D, Singh RJ, Gaete X, Mericq V. Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature. J Clin Endocrinol Metab. 2016 Dec;101(12):4984-4993. doi: 10.1210/jc.2016-2891. Epub 2016 Oct 6. PMID: 27710241; PMCID: PMC5155684.​

"Combination therapy with AI/GH increases height potential in pubertal boys with ISS more than GH and AI alone treated for 24–36 months with a strong safety profile." ​

"Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm)."

Did not have a control group but appears to work.

There are two studies that show negative result, I'll pretend they don't exist.

ppl here preach exemestane even though it's the drug least studied, I didn't find a single RCT on it.

So I'm going to use letrozole, it's the strongest on paper.

The following are my current stats:​

15yo​

170cm (around 5'7")​

49.5kg rn (i know this is bad)​

grew 5cm in 8 months​

5'8" Dad and 5' mom​

Current PAH is 175cm (5'9")

​

I'm trying to gain 3-4 more inches in total height that would put me 5'10-5'11 Which is realistic.​

​

My full stack what ill be doing:​

2.5mg of letrozole ED, i know you ppl with say this will crash my E2 hard but this is the dose actually studied. ​

Mirtazapine 15mg ED; antidepressant most likely to cause significant weight gain, which is desired. ​

Melatonin 3mg ED; actually good sleep is kinda hard ngl. ​

60k IU of vitamin D every 15 days; why not? half the world is deficient anyway. ​

[Please don't ask where i get these from] ​

​

Anything i'm doing wrong?

I wanna give some input here. Ive also read through alot of these studies and most of the time the kids e2 arent crashed, the e2 levels will be lower, but stay in the safe range. This is because its much harder to crash your e2 when your not taking exogenous testosterone. To put it in the simplest words, the brain detects that e2 is low, so it makes more test, so that the aromatase that cant be blocked can have more test to aromatize. Usually in the studies it will be like a 30%-60% increase in test and like a 40%ish drop in e2.

Since this thread is kinda old idek if your gonna respond to this, but did you ever take the letrozole? Im in a very similar position to you, 5'7 been 15 for about a month and a bit. I'm gonna take 1mg ed once i get my source figured out (The payment methods are all shit for every lab.) Maybe u wanna tell me your letro source

 

[chopped_guy]

most of the time the kids e2 arent crashed, the e2 levels will be lower, but stay in the safe range. This is because its much harder to crash your e2 when your not taking exogenous testosterone. To put it in the simplest words, the brain detects that e2 is low, so it makes more test, so that the aromatase that cant be blocked can have more test to aromatize. Usually in the studies it will be like a 30%-60% increase in test and like a 40%ish drop in e2.

Since this thread is kinda old idek if your gonna respond to this, but did you ever take the letrozole? Im in a very similar position to you, 5'7 been 15 for about a month and a bit. I'm gonna take 1mg ed once i get my source figured out (The payment methods are all shit for every lab.) Maybe u wanna tell me your letro source

Yeah i took letrozole, i don't recommend it, it crashes E2 hard, from what studides ive read anastrozole is better, because does not drop IGF-1 unlike letrozole.

Cognition? I read two RCTs that reported memory issues (but this was subjective)

This study which used objective methods and double blind concluded "Our results suggest that blockade of oestrogen biosynthesis with an aromatase inhibitor does not influence cognitive performance in peripubertal males."
PMID: 20421333.

PPL are gonna give you trash advice here, do ur own research.
peer reviewed blinded placebo controlled study >>>>>>> Any self proclaimed "high" IQ incel

 

[chopped_guy]

I wanna give some input here. Ive also read through alot of these studies and most of the time the kids e2 arent crashed, the e2 levels will be lower, but stay in the safe range. This is because its much harder to crash your e2 when your not taking exogenous testosterone. To put it in the simplest words, the brain detects that e2 is low, so it makes more test, so that the aromatase that cant be blocked can have more test to aromatize. Usually in the studies it will be like a 30%-60% increase in test and like a 40%ish drop in e2.

Since this thread is kinda old idek if your gonna respond to this, but did you ever take the letrozole? Im in a very similar position to you, 5'7 been 15 for about a month and a bit. I'm gonna take 1mg ed once i get my source figured out (The payment methods are all shit for every lab.) Maybe u wanna tell me your letro source

I would recommend you get anastrozole either from research chem sites like me e.g. swisschems nextchems etc. Or get pharma grade from india or china. DO NOT USE UGLs, If you do pls monitor E2 regularly (may be underdosed or overdosed)

 

[chopped_guy]

I wanna give some input here. Ive also read through alot of these studies and most of the time the kids e2 arent crashed, the e2 levels will be lower, but stay in the safe range. This is because its much harder to crash your e2 when your not taking exogenous testosterone. To put it in the simplest words, the brain detects that e2 is low, so it makes more test, so that the aromatase that cant be blocked can have more test to aromatize. Usually in the studies it will be like a 30%-60% increase in test and like a 40%ish drop in e2.

Since this thread is kinda old idek if your gonna respond to this, but did you ever take the letrozole? Im in a very similar position to you, 5'7 been 15 for about a month and a bit. I'm gonna take 1mg ed once i get my source figured out (The payment methods are all shit for every lab.) Maybe u wanna tell me your letro source

"most of the time the kids e2 arent crashed" Bruh all studies contradict that, especially ones for letrozole

There are several RCTs on this, Most concluded AIs are well tolerated (considering height gain).

One more thing DO NOT take AIs if you are prepubertal, There is no Test to be convereted to estrogen, mechanism won't work


Yeah man payment methods were rough for me too, I used crypto to pay

But what i can objectively say is hGH + AI outperforms AI or hGH monotherapy, maybe try using both but hGH is hard to source (like rlly hard) I can't give a legit source of hGH that works globally, where I'm from hGH is not controlled.

I can feel you bro, being 5'7 at 15 whilst you peers are probably 5'9 on average is rough.

I never unwatch threads i posted just because of situtations like this.

 

[Iblamegirthquake]

"most of the time the kids e2 arent crashed" Bruh all studies contradict that, especially ones for letrozole

There are several RCTs on this, Most concluded AIs are well tolerated (considering height gain).

One more thing DO NOT take AIs if you are prepubertal, There is no Test to be convereted to estrogen, mechanism won't work


Yeah man payment methods were rough for me too, I used crypto to pay

But what i can objectively say is hGH + AI outperforms AI or hGH monotherapy, maybe try using both but hGH is hard to source (like rlly hard) I can't give a legit source of hGH that works globally, where I'm from hGH is not controlled.

I can feel you bro, being 5'7 at 15 whilst you peers are probably 5'9 on average is rough.

I never unwatch threads i posted just because of situtations like this.

I think the reason most studies such a decrease in e2 levels, is because they are almost all using 2.5mg ed. Since i already have letrozole on the way, i'm gonna try taking it at a pretty low dose, like 0.5mg ed and then work up from there. I also want to take it for the really significant increases in DHT and test that are in a lot of studies. I think ill go up to 1mg ed and stay at that for 8 weeks and then come off of it and asses any changes (Height, weight, bf%, muscle mass, body hair, voice.) If i feel like shit after like 2 weeks, i'm just gonna come off of it and order anastrozole, the worst that happens is i have low e2 for like 4 weeks, as i just taper off of it i'm chilling.)

I feel like taking Letrozole towards the end of puberty like mid 16 or 17, to keep growth plates open for longer since its decreases e2 so much at those doses, would be a better use for it.

 

[b4yk]

"most of the time the kids e2 arent crashed" Bruh all studies contradict that, especially ones for letrozole

There are several RCTs on this, Most concluded AIs are well tolerated (considering height gain).

One more thing DO NOT take AIs if you are prepubertal, There is no Test to be convereted to estrogen, mechanism won't work


Yeah man payment methods were rough for me too, I used crypto to pay

But what i can objectively say is hGH + AI outperforms AI or hGH monotherapy, maybe try using both but hGH is hard to source (like rlly hard) I can't give a legit source of hGH that works globally, where I'm from hGH is not controlled.

I can feel you bro, being 5'7 at 15 whilst you peers are probably 5'9 on average is rough.

I never unwatch threads i posted just because of situtations like this.

240 ius of gh is like 100 a month, 8 ed, get a part time job, also nuking your e2 for multiple years is retarded, and up the melatonin dose

 

[chopped_guy]

I think the reason most studies such a decrease in e2 levels, is because they are almost all using 2.5mg ed. Since i already have letrozole on the way, i'm gonna try taking it at a pretty low dose, like 0.5mg ed and then work up from there. I also want to take it for the really significant increases in DHT and test that are in a lot of studies. I think ill go up to 1mg ed and stay at that for 8 weeks and then come off of it and asses any changes (Height, weight, bf%, muscle mass, body hair, voice.) If i feel like shit after like 2 weeks, i'm just gonna come off of it and order anastrozole, the worst that happens is i have low e2 for like 4 weeks, as i just taper off of it i'm chilling.)

I feel like taking Letrozole towards the end of puberty like mid 16 or 17, to keep growth plates open for longer since its decreases e2 so much at those doses, would be a better use for it.

Correct, Do go over 0.5mg ED unless E2 creeps up over 10 pg/mL, Most studies found anastrozole was better because letrozole crushed E2 which caused IGF-1 to tank, This is not an issue with 1mg anastrozole ED, 0.5mg letrozole is also gonna be fine.

Bro I'm also planning to run my stack til I reach 16-17 Or i get my desired height.

 

[chopped_guy]

240 ius of gh is like 100 a month, 8 ed, get a part time job, also nuking your e2 for multiple years is retarded, and up the melatonin dose

8 IUs ED? Might as well use the entire 10 IU vial. melatonin's GH increase does not meaningfully translate to sustained IGF-1 elevation, Im taking it because I don't have enough will power to have a decent sleep schedule.

 

[b4yk]

8 IUs ED? Might as well use the entire 10 IU vial. melatonin's GH increase does not meaningfully translate to sustained IGF-1 elevation, Im taking it because I don't have enough will power to have a decent sleep schedule.

i meant melatonin for sleep, you can go higher then 3mg

 

[160cmcurry]

Idc anymore if aromatase inhibitors are cope or not. To convince myself they're not I gathered a few studies on idiopathic short stature; they were closest to a normal healthy human being like myself.

Yackobovitch-Gavan et al. 2025 (Israel) - POSITIVE RESULTS​

"AI treatment extends the growth period, resulting in an AHt surpassing initial predictions. Our findings underscore the potential of AI treatment in midpubertal boys with a short PAHt due to advanced BA and in those treated with GH for ISS."
This was with anastrozole though.

Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, Damaso L, Merinbaum D, Singh RJ, Gaete X, Mericq V. Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature. J Clin Endocrinol Metab. 2016 Dec;101(12):4984-4993. doi: 10.1210/jc.2016-2891. Epub 2016 Oct 6. PMID: 27710241; PMCID: PMC5155684.​

"Combination therapy with AI/GH increases height potential in pubertal boys with ISS more than GH and AI alone treated for 24–36 months with a strong safety profile." ​

"Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm)."

Did not have a control group but appears to work.

There are two studies that show negative result, I'll pretend they don't exist.

ppl here preach exemestane even though it's the drug least studied, I didn't find a single RCT on it.

So I'm going to use letrozole, it's the strongest on paper.

The following are my current stats:​

15yo​

170cm (around 5'7")​

49.5kg rn (i know this is bad)​

grew 5cm in 8 months​

5'8" Dad and 5' mom​

Current PAH is 175cm (5'9")

​

I'm trying to gain 3-4 more inches in total height that would put me 5'10-5'11 Which is realistic.​

​

My full stack what ill be doing:​

2.5mg of letrozole ED, i know you ppl with say this will crash my E2 hard but this is the dose actually studied. ​

Mirtazapine 15mg ED; antidepressant most likely to cause significant weight gain, which is desired. ​

Melatonin 3mg ED; actually good sleep is kinda hard ngl. ​

60k IU of vitamin D every 15 days; why not? half the world is deficient anyway. ​

[Please don't ask where i get these from] ​

​

Anything i'm doing wrong?

tales

 

[Iblamegirthquake]

Correct, Do go over 0.5mg ED unless E2 creeps up over 10 pg/mL, Most studies found anastrozole was better because letrozole crushed E2 which caused IGF-1 to tank, This is not an issue with 1mg anastrozole ED, 0.5mg letrozole is also gonna be fine.

Bro I'm also planning to run my stack til I reach 16-17 Or i get my desired height.

Do you think i should take it at morning or at night? Im thinking morning. The letrozole arrived today and Im going to begin taking it come monday.