I'll be trying aromatase inhibitors for height maxxing.

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chopped_guy

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Idc anymore if aromatase inhibitors are cope or not. To convince myself they're not I gathered a few studies on idiopathic short stature; they were closest to a normal healthy human being like myself.

Yackobovitch-Gavan et al. 2025 (Israel) - POSITIVE RESULTS​

"AI treatment extends the growth period, resulting in an AHt surpassing initial predictions. Our findings underscore the potential of AI treatment in midpubertal boys with a short PAHt due to advanced BA and in those treated with GH for ISS."
This was with anastrozole though.

Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, Damaso L, Merinbaum D, Singh RJ, Gaete X, Mericq V. Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature. J Clin Endocrinol Metab. 2016 Dec;101(12):4984-4993. doi: 10.1210/jc.2016-2891. Epub 2016 Oct 6. PMID: 27710241; PMCID: PMC5155684.
"Combination therapy with AI/GH increases height potential in pubertal boys with ISS more than GH and AI alone treated for 24–36 months with a strong safety profile." ​

"Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm)."

Did not have a control group but appears to work.

There are two studies that show negative result, I'll pretend they don't exist.

ppl here preach exemestane even though it's the drug least studied, I didn't find a single RCT on it.

So I'm going to use letrozole, it's the strongest on paper.

The following are my current stats:
15yo
170cm (around 5'7")
49.5kg rn (i know this is bad)
grew 5cm in 8 months
5'8" Dad and 5' mom​

Current PAH is 175cm (5'9")


I'm trying to gain 3-4 more inches in total height that would put me 5'10-5'11 Which is realistic.

My full stack what ill be doing:
2.5mg of letrozole ED, i know you ppl with say this will crash my E2 hard but this is the dose actually studied.
Mirtazapine 15mg ED; antidepressant most likely to cause significant weight gain, which is desired.
Melatonin 3mg ED; actually good sleep is kinda hard ngl.
60k IU of vitamin D every 15 days; why not? half the world is deficient anyway.
[Please don't ask where i get these from]
​

Anything i'm doing wrong?
 
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chopped_guy said:
Idc anymore if aromatase inhibitors are cope or not. To convince myself they're not I gathered a few studies on idiopathic short stature; they were closest to a normal healthy human being like myself.

Yackobovitch-Gavan et al. 2025 (Israel) - POSITIVE RESULTS​

"AI treatment extends the growth period, resulting in an AHt surpassing initial predictions. Our findings underscore the potential of AI treatment in midpubertal boys with a short PAHt due to advanced BA and in those treated with GH for ISS."
This was with anastrozole though.

Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, Damaso L, Merinbaum D, Singh RJ, Gaete X, Mericq V. Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature. J Clin Endocrinol Metab. 2016 Dec;101(12):4984-4993. doi: 10.1210/jc.2016-2891. Epub 2016 Oct 6. PMID: 27710241; PMCID: PMC5155684.​

"Combination therapy with AI/GH increases height potential in pubertal boys with ISS more than GH and AI alone treated for 24–36 months with a strong safety profile." ​

"Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm)."

Did not have a control group but appears to work.

There are two studies that show negative result, I'll pretend they don't exist.

ppl here preach exemestane even though it's the drug least studied, I didn't find a single RCT on it.

So I'm going to use letrozole, it's the strongest on paper.

The following are my current stats:​

15yo​

170cm (around 5'7")​

49.5kg rn (i know this is bad)​

grew 5cm in 8 months​

5'8" Dad and 5' mom​

Current PAH is 175cm (5'9")

​

I'm trying to gain 3-4 more inches in total height that would put me 5'10-5'11 Which is realistic.​

​

My full stack what ill be doing:​

2.5mg of letrozole ED, i know you ppl with say this will crash my E2 hard but this is the dose actually studied. ​

Mirtazapine 15mg ED; antidepressant most likely to cause significant weight gain, which is desired. ​

Melatonin 3mg ED; actually good sleep is kinda hard ngl. ​

60k IU of vitamin D every 15 days; why not? half the world is deficient anyway. ​

[Please don't ask where i get these from] ​

​

Anything i'm doing wrong?
Click to expand...
Have you even gotten your E2 levels checked?
Why are you taking an AI for no reason.
You will crash your estrogen and nuke your bone development aswell as your brain function.
 
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savage21 said:
Have you even gotten your E2 levels checked?
Why are you taking an AI for no reason.
You will crash your estrogen and nuke your bone development aswell as your brain function.
Click to expand...
Good idea. Height >>> brain function, atleast for me. But im probably mid puberty
 
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chopped_guy said:
Idc anymore if aromatase inhibitors are cope or not. To convince myself they're not I gathered a few studies on idiopathic short stature; they were closest to a normal healthy human being like myself.

Yackobovitch-Gavan et al. 2025 (Israel) - POSITIVE RESULTS​

"AI treatment extends the growth period, resulting in an AHt surpassing initial predictions. Our findings underscore the potential of AI treatment in midpubertal boys with a short PAHt due to advanced BA and in those treated with GH for ISS."
This was with anastrozole though.

Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, Damaso L, Merinbaum D, Singh RJ, Gaete X, Mericq V. Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature. J Clin Endocrinol Metab. 2016 Dec;101(12):4984-4993. doi: 10.1210/jc.2016-2891. Epub 2016 Oct 6. PMID: 27710241; PMCID: PMC5155684.​

"Combination therapy with AI/GH increases height potential in pubertal boys with ISS more than GH and AI alone treated for 24–36 months with a strong safety profile." ​

"Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm)."

Did not have a control group but appears to work.

There are two studies that show negative result, I'll pretend they don't exist.

ppl here preach exemestane even though it's the drug least studied, I didn't find a single RCT on it.

So I'm going to use letrozole, it's the strongest on paper.

The following are my current stats:​

15yo​

170cm (around 5'7")​

49.5kg rn (i know this is bad)​

grew 5cm in 8 months​

5'8" Dad and 5' mom​

Current PAH is 175cm (5'9")

​

I'm trying to gain 3-4 more inches in total height that would put me 5'10-5'11 Which is realistic.​

​

My full stack what ill be doing:​

2.5mg of letrozole ED, i know you ppl with say this will crash my E2 hard but this is the dose actually studied. ​

Mirtazapine 15mg ED; antidepressant most likely to cause significant weight gain, which is desired. ​

Melatonin 3mg ED; actually good sleep is kinda hard ngl. ​

60k IU of vitamin D every 15 days; why not? half the world is deficient anyway. ​

[Please don't ask where i get these from] ​

​

Anything i'm doing wrong?
Click to expand...
lol we are the exact same person body wise except you weigh less and are prob in earlier puberty stages. You gonna monitor e2 or you dont really care and js gonna crash it?
 
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chopped_guy said:
? Bro then that would be fire, do you know a source?
Click to expand...
I only know my niche sources :feelskek: (I’m gonna gatekeep). There are many mainstream sources though just search online. But honestly, be wary of what you inject and take. I wouldn’t recommend taking an AI for no reason
 
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I looked up, rhGH doses used for idiopathic short stature.
0.05 mg/kg/day ≈ 0.15 IU/kg/day,
since 1 mg of rhGH = ~3 IU.
That's fucking 7.5 IU of GH every day
 
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OmgBPbrootal said:
What if you only take AI
Click to expand...
Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm). AI/GH had higher fat free mass accrual. Measures of bone health, safety labs, and adverse events were similar in all groups. Letrozole caused higher T and lower estradiol than anastrozole.

One of the studies I read, ppl expected to gain 13 cm gained 18cm that's like just 5cm gain over normal, just don't expect something dramatic.
 
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chopped_guy said:
Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm). AI/GH had higher fat free mass accrual. Measures of bone health, safety labs, and adverse events were similar in all groups. Letrozole caused higher T and lower estradiol than anastrozole.

One of the studies I read, ppl expected to gain 13 cm gained 18cm that's like just 5cm gain over normal, just don't expect something dramatic.
Click to expand...
Over 3 years
 
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chopped_guy said:
Height gain [mean (SE)] at 24 months was: AI, +14.0 (0.8) cm; GH, +17.1 (0.9) cm; AI/GH, +18.9 (0.8) cm (P < .0006, analysis of covariance). Height SDS was: AI, −1.73 (0.12); GH, −1.43 (0.14); AI/GH, −1.25 (0.12) (P < .0012). Those treated through 36 months grew more. Regardless of treatment duration, height SDS at near-final height [n = 71; age, 17.4 (0.2) years; bone age, 15.3 (0.1) years; height achieved, ∼97.6%] was: AI, −1.4 (0.1); GH, −1.4 (0.2); AI/GH, −1.0 (0.1) (P = .06). Absolute height change was: AI, +18.2 (1.6) cm; GH, +20.6 (1.5) cm; AI/GH, +22.5 (1.4) cm (P = .01) (expected height gain at −2.0 height SDS, +13.0 cm). AI/GH had higher fat free mass accrual. Measures of bone health, safety labs, and adverse events were similar in all groups. Letrozole caused higher T and lower estradiol than anastrozole.

One of the studies I read, ppl expected to gain 13 cm gained 18cm that's like just 5cm gain over normal, just don't expect something dramatic.
Click to expand...
Why would this be applicable to those without ISS?
 
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The closest we have to healthy ppl. CDGP trials also exist but these were in ppl with delayed puberty and growth not mid puberty males
 
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chopped_guy said:
Won't go over genetic limit??? what my genetic PAH is just 173-175cm

ISS means idiopathic short stature aka no GHD a
Click to expand...
The idea is, is that those with ISS are short for no apparent reason, as in their height is not correlated with their expected height, so the use of AI and GH just gets them closer to their true expected height based on genetics.
 
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DravidianBvll said:
The idea is, is that those with ISS are short for no apparent reason, as in their height is not correlated with their expected height, so the use of AI and GH just gets them closer to their true expected height based on genetics.
Click to expand...
So both AI and GH are cope?
 
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CDGP studies are actually closer to healthy controls, they just have delayed puberty and AIs still add around 2cm per year of treatment but you're not "early puberty"
 
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chopped_guy said:
Source bro?
Click to expand...
Wickman et al. 2001; this study was with testosterone + letrozole but 6.7cm gains vs placebo that's huge (p=0.04 aka statistically significant) in just 12 months.

Rohani et al. 2019; this is perfect just Letrozole vs controls, +2.2cm (p=0.04) over one year.

This is my source nga
 
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poopjeet said:
Wickman et al. 2001; this study was with testosterone + letrozole but 6.7cm gains vs placebo that's huge (p=0.04 aka statistically significant) in just 12 months.

Rohani et al. 2019; this is perfect just Letrozole vs controls, +2.2cm (p=0.04) over one year.

This is my source nga
Click to expand...
Finally someone with a working brain, What if i add exogenous T to my stack?
 
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OmgBPbrootal said:
How long are AI's detectable in the body by lab tests.
Click to expand...

half life of E2 is 90 minutes for naturally circulating estradiol, my guess is within a day. wait lemme check anyway, google says 2-3 days for letrozole to acheive maximal suppression of estrogen.
 
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