Inducing Longitudinal Bone Growth via IGF-1 production - HGH + AI [FULL USAGE GUIDE]

[Aㅤㅤㅤ]

4IUs is just cagefuel

Mind you, this is what I quite literally stated:

"Before we go any further with the guide below, I do want to emphasize that this entire guide is written under the assumption that you are a complete beginner on HGH, AI, or you've just never even seen a vial of HGH or a syringe in real life."

This is for COMPLETE BEGINNERS on combination therapy for HEIGHT-PURPOSES who MATCH THE DESCRIPTION TO USE IT (ISS, GHD, etc..).

You retards, as well as @Zagro, are utterly void of actual reading comprehension that, instead of actually providing any valid, supported counterargument towards ANY claims I made in this guide, you assert vague claims about it being 'cagefuel'.

How would it be cagefuel for a COMPLETE BEGINNER (with ISS, GHD, etc...) to use 4IUS for height purposes? LMFAO. No where in the guide did I ever claim you COULDN'T progress higher than that.

 

[Stacyslayerᛉ]

Mind you, this is what I quite literally stated:



This is for COMPLETE BEGINNERS on combination therapy for HEIGHT-PURPOSES who MATCH THE DESCRIPTION TO USE IT (ISS, GHD, etc..).

You retards, as well as @Zagro, are utterly void of actual reading comprehension that, instead of actually providing any valid, supported counterargument towards ANY claims I made in this guide, you assert vague claims about it being 'cagefuel'.

How would it be cagefuel for a COMPLETE BEGINNER (with ISS, GHD, etc...) to use 4IUS for height purposes? LMFAO. No where in the guide did I ever claim you COULDN'T progress higher than that.

DNR + Cagefuel

 

[Dylen]

Not a doctor, this isn't medical advice. Don't self medicate, it carries serious risks.

Taking AIs to keep growth plates open doesn't work.
People focus way too much on blood serum levels, which doesn't mean anything. Even if an AI completely crashes the estrogen circulating in your blood, it doesn't stop local tissue aromatization. The chondrocytes in the plates synthesize their own estradiol locally which fuses them.
Same problem with the testes, AIs can't really shut down local estrogen production in them either.
All you're doing is tanking your systemic estrogen which feels quite bad while your plates still close because of the local estradiol.

 

[superltn2007]

I personally think letrozole is too powerful and crashing ur estrogen levels near zero/zero is just.. not worth it.
It's used primarily for breast cancer patients BTW.

Don't take it daily

 

[gabzpsl]

Yes you will get more height and longer bones, but i read that you will have less and miss out on more facial bone MASS because estrogen strengthens and maintains bone density? Idk much about this ai/test/estrogen topic so someone please correct me or explain to me if im wrong

 

[noah777255]

Yes you will get more height and longer bones, but i read that you will have less and miss out on more facial bone MASS because estrogen strengthens and maintains bone density? Idk much about this ai/test/estrogen topic so someone please correct me or explain to me if im wrong

Did you ever figure it out? I’m wondering if I need to take a AI to begin with

 

[Hadi_the_destroyer]

How do I run 15 ius a day without get diabetes and killing myself
My plan is armed 1mg erda 4 mg and d3 k2 plus calcium carbonate, ofc also the 15 ius of growth a day. goal is height

 

[vinegar2]

incredible, what do you think about bone weakening with letrozole?

He answered that?

 

[eliy]

metformin and ESPECIALLY berberine is not even saving you from hgh IR

reta will though

 

[gunneybunny]

Is it worth it half way through the fourth stage of puberty?

 

[Cachenvy]

Will Read Later

 

[ccustard]

deadass worried more abt layout than the info, thought it was good until i saw him reccomend 2-4 iu shit will stunt your growth. studies found that the more hgh the better, and they used .07mg/kg/day as a base for the most successful studies. so if ur 160lbs u shouldn’t be under 16iu a day. ppl are going to trust this info just bc of the layout. also crashing ur estrogen w letrozole has 0 benefit over anastrozole, as found in trials. so you’re wrong there aswell. and ur acting like u will get any sides from 2-4iu. ur body naturally releases more than that in a day, doubling the hgh won’t do shit for you. mods need to take down this misinformation lmao, u def used chat gpt for ts.

 

[ccustard]

Not a doctor, this isn't medical advice. Don't self medicate, it carries serious risks.

Taking AIs to keep growth plates open doesn't work.
People focus way too much on blood serum levels, which doesn't mean anything. Even if an AI completely crashes the estrogen circulating in your blood, it doesn't stop local tissue aromatization. The chondrocytes in the plates synthesize their own estradiol locally which fuses them.
Same problem with the testes, AIs can't really shut down local estrogen production in them either.
All you're doing is tanking your systemic estrogen which feels quite bad while your plates still close because of the local estradiol.

ig you’re dnr studies that showed that hgh + ai grew more than just hgh alone

 

[ccustard]

How do I run 15 ius a day without get diabetes and killing myself
My plan is armed 1mg erda 4 mg and d3 k2 plus calcium carbonate, ofc also the 15 ius of growth a day. goal is height

i’m on 16 n not diabetic, run reta 1mg a week and you will be fine. also don’t run erda you will be out of the gym run vosoritide (or tyra300). if you don’t have the money then ur low iq n dont deserve height

 

[obeseltbslayer]

View attachment 5332942

Spoiler: Disclaimer

This guide is provided solely for educational and informational purposes. It is not medical advice and does not recommend or encourage the use of HGH, aromatase inhibitors, or any other medication. Discuss this with a qualified healthcare professional.

[IGF-1 induced production]
Human Growth Hormone (HGH) + Aromatase Inhibitors (AIs)
[FULL USAGE GUIDE]
The induction of longitudinal bone growth
View attachment 5332434
​

Introduction The science and requirements behind the stack​

Pre-requisites The exact tools, syringes, water, and sterilizing gear you need​

Reconstitution The step-by-step math and process of mixing HGH without destroying the protein​

HGH Injection How to draw, prep, and subcutaneously inject HGH​

AI (Dosing, Timing, Etc...) Oral dosing, timing, and choosing between Arimidex, Aromasin, and Letrozole​

Mitigation Strategies Controlling insulin resistance, thyroid, blood pressure, and lipids​

Bone Mineral Density Support The specific compounds to prevent your bones from turning brittle while estrogen is suppressed​

Spoiler: Note

Before we go any further with the guide below, I do want to emphasize that this entire guide is written under the assumption that you are a complete beginner on HGH, AI, or you've just never even seen a vial of HGH or a syringe in real life.

Introduction

This guide solely focuses on maximizing your linear height. Hence why I'll be focusing on how to use two specific compounds combined:

- Human Growth Hormone (HGH)
- Aromatase Inhibitors (AIs)

During puberty, your balls produce massive amounts of testosterone. Some of this testosterone aromatizes (converts) into estrogen. Estrogen is the exact hormone responsible for fusing your growth plates (the epiphyseal plates at the ends of your long bones). Once estrogen fuses those plates, your bones cannot grow any longer.

By combining HGH with an Aromatase Inhibitor (AI):

HGH:
Stimulates your liver to produce IGF-1, which then directly forces your bones to grow longer.

AI:
Prevents puberty-induced fusion. This would just mean that your testosterone is blocked from converting into estrogen, which keeps your growth plates open for years longer than normal.

Spoiler: Studies

Spoiler: Mauras et al., J Clin Endocrinol Metab (2016), RCT, 76 pubertal boys, ISS

GH + AI vs. GH alone vs. AI alone, 24 months. Groups: AI alone (n=25, anastrozole or letrozole), GH alone (n=25), combination (n=26).

At 24 months: adult height was increased more in the combination group (+18.8 cm) compared with the GH alone group (+17 cm) and aromatase inhibitor alone group (14.2 cm; P = .0002).
View attachment 5332531

Spoiler: ANSWER Program study (Norditropin real-world data), PMC7537098, males with GHD or ISS

n=142 GH-naïve patients, GHD (n=115) or ISS (n=27), mean baseline age 12.10 ± 3.00 (GHD) and 10.76 ± 3.07 (ISS).

Mean HSDS improved from −1.94 ± 0.77 at baseline to −0.92 ± 0.89 at AIT initiation, then further improved to −0.62 ± 0.95 after 1 year of concomitant GH plus AIT.
View attachment 5332561

Spoiler: Hou et al., J Clin Endocrinol Metab (2025), boys with ISS, bone age ≥13

View attachment 5332577

Now, there are only about three criteria you have to meet in order to touch these drugs, and if you don't meet them, just don't bother.

Spoiler: 1. Open growth plates (non-negotiable)

You must get a prescription for a left-wrist and hand X-ray to determine your bone age. If the radiologist's report says your epiphyseal plates are fused or closing, then I'm sad to say that this protocol will be utterly useless and will only cause side effects.

Spoiler: 2. Idiopathic Short Stature (ISS) or GH Deficiency (GHD)

HGH + AI is typically used for males diagnosed with ISS (which just means that you're abnormally short for your age with no known medical cause) or true Growth Hormone Deficiency (GHD).

Spoiler: 3. Active puberty

It is quite literally a MUST that you're in active puberty (typically Tanner Stage 2 to 4). If you haven't even started puberty yet, blocking estrogen would just be utterly useless and could fuck up your development. If you are past puberty, it just means your plates are already closed.

Pre-requisites

If you do not have every single item that I will be listing below sitting somewhere on your table before you pop the plastic caps off your vials, don't even consider starting. You'll just end up with a disgusting bacterial abscess or ruined peptides.
​

HGH & AI​

1. HGH (Lyophilized Powder)
View attachment 5327063


2. AI (Oral Tablets)
View attachment 5326769

​

Liquids​

1. Bacteriostatic Water (BAC Water)
View attachment 5327104

​

Needles and syringes​

1. The Mixing Syringe (Reconstitution)
View attachment 5327151


2. The Injection Syringe (Insulin Syringe)
View attachment 5327172

​

Sanitization and disposal​

1. 70% Isopropyl Alcohol Prep Pads
View attachment 5327312


2. Sharps Disposal Container
View attachment 5327315

​

Storage​

1. Refrigerator
View attachment 5327200


Reconstitution

Because this guide assumes you're a complete beginner, I'm basically going to use the easiest mixing math possible. If you, somehow, after reading the instructions, fuck up the math, you will either inject too little and waste your time, or inject too much and cause severe joint swelling.

With that said, follow these exact steps to mix your HGH.
​

Step 1: Prep your workspace​

​

Step 2: Sterilize the vials​

​

Step 3: Draw the BAC water​

​

Step 4: Mix the HGH (Gently)​

​

Step 5: Dissolve the powder​

Beginner Reconstitution Math (10 IU Vial)
Almost all standard HGH vials contain 10 IU of powder.

By adding exactly 1 mL (100 units on an insulin syringe) of BAC water:

10 units on your insulin syringe = 1 IU of HGH
20 units on your insulin syringe = 2 IU of HGH
30 units on your insulin syringe = 3 IU of HGH
40 units on your insulin syringe = 40 units on the syringe = 4 IU of HGH
​

Step 6: Store in the fridge​

HGH Injection

HGH is injected into the fat layer right under your skin (a subcutaneous injection). Do not go deep into the muscle. The stomach fat is the easiest and least painful spot for a beginner.
​

Step 1: Prep your syringe and vial​

​

Step 2: Draw your dose​

​

Step 3: Choose and prep the injection site​

​

Step 4: Inject the HGH​

Step 5: Clean up​

AI (Dosing, Timing, Etc...)

As I've already stated before, the purpose of the Aromatase Inhibitor (AI) is to systematically suppress estrogen to zero or near-zero levels. This delays the calcification and fusion of your epiphyseal plates.

AIs are oral tablets. You swallow them with water. You do not inject them.
​

Choosing your AI​

​

Letrozole (Femara) View attachment 5331910 This is the strongest AI on the market. It blocks up to 98% of your body's estrogen conversion. Because it is so potent, it is the standard choice in clinical trials for short boys.​

Anastrozole (Arimidex) View attachment 5331926 This is slightly milder, blocking about 80% to 85% of estrogen. It is used if Letrozole is too hard to acquire, or if Letrozole's side effects are too brutal for you to tolerate.​

​

Dosing​

​

Letrozole​	Anastrozole​
2.5 mg (usually one full tablet)​	1 mg (usually one full tablet)​

These are both taken once daily.​

​

Timing & administration​

Because AIs have incredibly long half-lives (Letrozole has a half-life of 2 to 4 days; Anastrozole has a half-life of 48 hours), the exact time of day you take the pill really doesn't matter.

1. Take the pill at the exact same time every day to keep your hormone levels completely flat.
2. You can take it with or without food.
3. If you miss a dose, do not take a double dose the next day. Just take your regular single pill and keep going.
​

Side-effects​

You need to understand that crushing your estrogen to zero to keep your growth plates open has side effects. Estrogen is still important for joint lubrication and brain function. If you're on this protocol, you will likely experience:

1. Dry, creaky, or aching joints (especially in your knees and elbows)
2. Mild fatigue or brain fog
3. Lower HDL (good cholesterol) levels

Mitigation Strategies

When you run this stack, you have to understand that you are fundamentally altering your biochemistry. You are forcing your body to grow while simultaneously taking it of a vital protective hormone (estrogen).

If you do not run a mitigation stack alongside this stack, you will end up with things like insulin resistance, a fucked thyroid, high blood pressure, and shitty cholesterol levels.
​

Glucose​

HGH makes your cells highly resistant to insulin. It prevents them from absorbing glucose, leaving your blood sugar constantly elevated. If you ignore this, you can give yourself type-2 diabetes.
​

1. Metformin (500 mg/daily) View attachment 5332065 Take it with my largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

2. Berberine (500 mg/daily) View attachment 5332077 Take it with your largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

​

Thyroid​

HGH speeds up the conversion of T4 into T3. Yes, this may sound great for burning fat, but it quickly drains your body's T4 storage. Once your T4 is depleted, your thyroid output stalls. You will feel absolutely exhausted, freezing cold, and you will start holding fat.
​

1. T4, Levothyroxine (50 mcg/daily) View attachment 5332205 Take this every single morning. You must take this on an empty stomach, at least 30 minutes before eating or drinking anything else, or your body won't absorb it. DO NOT BY T3. You only need T4 because the HGH is already handling the conversion.​

​

Cardiovascular​

Because you are taking Letrozole or Anastrozole to crush your estrogen, your liver will stop producing healthy amounts of HDL (good cholesterol), and your LDL (bad cholesterol) will skyrocket like fucking crazy. At the same time, HGH causes you to hold onto sodium and water, which volume-loads your heart and spikes your blood pressure.

​

1. Get a blood pressure monitor and use it every morning.​

1. Telmisartan (40mg/daily) View attachment 5332274 Use this if your pressure climbs above 130/80. It lowers blood pressure, protects your kidneys, and actually helps with insulin sensitivity.​

2. Citrus Bergamot ((1000 mg/daily) + Omega-3 Fish Oil (4g/daily) View attachment 5332291 These keep your lipids from turning into absolute sludge while your estrogen is suppressed.​

Bone Mineral Density Support

Estrogen is the primary hormone that basically tells your bones to absorb calcium and maintain their density. Without it, you develop osteopenia (the medical term for weak bones) which leads directly to fractures. If your bones are weak, they cannot support the rapid linear growth that the HGH is trying to force.

You must run this specific support protocol to keep your skeleton strong while your growth plates remain open.

1. 5000 IU Vitamin D3 and 100 mcg Vitamin K2
View attachment 5332382


2. 1000 mg of Calcium Citrate
View attachment 5332384


3. Heavy Axial Loading (Weightlifting)
View attachment 5332416

​

---

Thanks for reading ​

mirin guide jit, would adding test + erda be worth of plates closed and monitoring on point?

 

[obeseltbslayer]

i’m on 16 n not diabetic, run reta 1mg a week and you will be fine. also don’t run erda you will be out of the gym run vosoritide (or tyra300). if you don’t have the money then ur low iq n dont deserve height

is erda that bad for joints n shi like you cant workout?

 

[ccustard]

is erda that bad for joints n shi like you cant workout?

yes it is extremely common for people to not be able to workout while running it especially over 4mg, but this is alll anecdotal so you may be fine, i’ve never ran it. but vosoritide won’t give u this affect and it will give results not as good as erda, but still crazy.

 

[oblivionorb]

View attachment 5332942

Spoiler: Disclaimer

This guide is provided solely for educational and informational purposes. It is not medical advice and does not recommend or encourage the use of HGH, aromatase inhibitors, or any other medication. Discuss this with a qualified healthcare professional.

[IGF-1 induced production]
Human Growth Hormone (HGH) + Aromatase Inhibitors (AIs)
[FULL USAGE GUIDE]
The induction of longitudinal bone growth
View attachment 5332434
​

Introduction The science and requirements behind the stack​

Pre-requisites The exact tools, syringes, water, and sterilizing gear you need​

Reconstitution The step-by-step math and process of mixing HGH without destroying the protein​

HGH Injection How to draw, prep, and subcutaneously inject HGH​

AI (Dosing, Timing, Etc...) Oral dosing, timing, and choosing between Arimidex, Aromasin, and Letrozole​

Mitigation Strategies Controlling insulin resistance, thyroid, blood pressure, and lipids​

Bone Mineral Density Support The specific compounds to prevent your bones from turning brittle while estrogen is suppressed​

Spoiler: Note

Before we go any further with the guide below, I do want to emphasize that this entire guide is written under the assumption that you are a complete beginner on HGH, AI, or you've just never even seen a vial of HGH or a syringe in real life.

Introduction

This guide solely focuses on maximizing your linear height. Hence why I'll be focusing on how to use two specific compounds combined:

- Human Growth Hormone (HGH)
- Aromatase Inhibitors (AIs)

During puberty, your balls produce massive amounts of testosterone. Some of this testosterone aromatizes (converts) into estrogen. Estrogen is the exact hormone responsible for fusing your growth plates (the epiphyseal plates at the ends of your long bones). Once estrogen fuses those plates, your bones cannot grow any longer.

By combining HGH with an Aromatase Inhibitor (AI):

HGH:
Stimulates your liver to produce IGF-1, which then directly forces your bones to grow longer.

AI:
Prevents puberty-induced fusion. This would just mean that your testosterone is blocked from converting into estrogen, which keeps your growth plates open for years longer than normal.

Spoiler: Studies

Spoiler: Mauras et al., J Clin Endocrinol Metab (2016), RCT, 76 pubertal boys, ISS

GH + AI vs. GH alone vs. AI alone, 24 months. Groups: AI alone (n=25, anastrozole or letrozole), GH alone (n=25), combination (n=26).

At 24 months: adult height was increased more in the combination group (+18.8 cm) compared with the GH alone group (+17 cm) and aromatase inhibitor alone group (14.2 cm; P = .0002).
View attachment 5332531

Spoiler: ANSWER Program study (Norditropin real-world data), PMC7537098, males with GHD or ISS

n=142 GH-naïve patients, GHD (n=115) or ISS (n=27), mean baseline age 12.10 ± 3.00 (GHD) and 10.76 ± 3.07 (ISS).

Mean HSDS improved from −1.94 ± 0.77 at baseline to −0.92 ± 0.89 at AIT initiation, then further improved to −0.62 ± 0.95 after 1 year of concomitant GH plus AIT.
View attachment 5332561

Spoiler: Hou et al., J Clin Endocrinol Metab (2025), boys with ISS, bone age ≥13

View attachment 5332577

Now, there are only about three criteria you have to meet in order to touch these drugs, and if you don't meet them, just don't bother.

Spoiler: 1. Open growth plates (non-negotiable)

You must get a prescription for a left-wrist and hand X-ray to determine your bone age. If the radiologist's report says your epiphyseal plates are fused or closing, then I'm sad to say that this protocol will be utterly useless and will only cause side effects.

Spoiler: 2. Idiopathic Short Stature (ISS) or GH Deficiency (GHD)

HGH + AI is typically used for males diagnosed with ISS (which just means that you're abnormally short for your age with no known medical cause) or true Growth Hormone Deficiency (GHD).

Spoiler: 3. Active puberty

It is quite literally a MUST that you're in active puberty (typically Tanner Stage 2 to 4). If you haven't even started puberty yet, blocking estrogen would just be utterly useless and could fuck up your development. If you are past puberty, it just means your plates are already closed.

Pre-requisites

If you do not have every single item that I will be listing below sitting somewhere on your table before you pop the plastic caps off your vials, don't even consider starting. You'll just end up with a disgusting bacterial abscess or ruined peptides.
​

HGH & AI​

1. HGH (Lyophilized Powder)
View attachment 5327063


2. AI (Oral Tablets)
View attachment 5326769

​

Liquids​

1. Bacteriostatic Water (BAC Water)
View attachment 5327104

​

Needles and syringes​

1. The Mixing Syringe (Reconstitution)
View attachment 5327151


2. The Injection Syringe (Insulin Syringe)
View attachment 5327172

​

Sanitization and disposal​

1. 70% Isopropyl Alcohol Prep Pads
View attachment 5327312


2. Sharps Disposal Container
View attachment 5327315

​

Storage​

1. Refrigerator
View attachment 5327200


Reconstitution

Because this guide assumes you're a complete beginner, I'm basically going to use the easiest mixing math possible. If you, somehow, after reading the instructions, fuck up the math, you will either inject too little and waste your time, or inject too much and cause severe joint swelling.

With that said, follow these exact steps to mix your HGH.
​

Step 1: Prep your workspace​

​

Step 2: Sterilize the vials​

​

Step 3: Draw the BAC water​

​

Step 4: Mix the HGH (Gently)​

​

Step 5: Dissolve the powder​

Beginner Reconstitution Math (10 IU Vial)
Almost all standard HGH vials contain 10 IU of powder.

By adding exactly 1 mL (100 units on an insulin syringe) of BAC water:

10 units on your insulin syringe = 1 IU of HGH
20 units on your insulin syringe = 2 IU of HGH
30 units on your insulin syringe = 3 IU of HGH
40 units on your insulin syringe = 40 units on the syringe = 4 IU of HGH
​

Step 6: Store in the fridge​

HGH Injection

HGH is injected into the fat layer right under your skin (a subcutaneous injection). Do not go deep into the muscle. The stomach fat is the easiest and least painful spot for a beginner.
​

Step 1: Prep your syringe and vial​

​

Step 2: Draw your dose​

​

Step 3: Choose and prep the injection site​

​

Step 4: Inject the HGH​

Step 5: Clean up​

AI (Dosing, Timing, Etc...)

As I've already stated before, the purpose of the Aromatase Inhibitor (AI) is to systematically suppress estrogen to zero or near-zero levels. This delays the calcification and fusion of your epiphyseal plates.

AIs are oral tablets. You swallow them with water. You do not inject them.
​

Choosing your AI​

​

Letrozole (Femara) View attachment 5331910 This is the strongest AI on the market. It blocks up to 98% of your body's estrogen conversion. Because it is so potent, it is the standard choice in clinical trials for short boys.​

Anastrozole (Arimidex) View attachment 5331926 This is slightly milder, blocking about 80% to 85% of estrogen. It is used if Letrozole is too hard to acquire, or if Letrozole's side effects are too brutal for you to tolerate.​

​

Dosing​

​

Letrozole​	Anastrozole​
2.5 mg (usually one full tablet)​	1 mg (usually one full tablet)​

These are both taken once daily.​

​

Timing & administration​

Because AIs have incredibly long half-lives (Letrozole has a half-life of 2 to 4 days; Anastrozole has a half-life of 48 hours), the exact time of day you take the pill really doesn't matter.

1. Take the pill at the exact same time every day to keep your hormone levels completely flat.
2. You can take it with or without food.
3. If you miss a dose, do not take a double dose the next day. Just take your regular single pill and keep going.
​

Side-effects​

You need to understand that crushing your estrogen to zero to keep your growth plates open has side effects. Estrogen is still important for joint lubrication and brain function. If you're on this protocol, you will likely experience:

1. Dry, creaky, or aching joints (especially in your knees and elbows)
2. Mild fatigue or brain fog
3. Lower HDL (good cholesterol) levels

Mitigation Strategies

When you run this stack, you have to understand that you are fundamentally altering your biochemistry. You are forcing your body to grow while simultaneously taking it of a vital protective hormone (estrogen).

If you do not run a mitigation stack alongside this stack, you will end up with things like insulin resistance, a fucked thyroid, high blood pressure, and shitty cholesterol levels.
​

Glucose​

HGH makes your cells highly resistant to insulin. It prevents them from absorbing glucose, leaving your blood sugar constantly elevated. If you ignore this, you can give yourself type-2 diabetes.
​

1. Metformin (500 mg/daily) View attachment 5332065 Take it with my largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

2. Berberine (500 mg/daily) View attachment 5332077 Take it with your largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

​

Thyroid​

HGH speeds up the conversion of T4 into T3. Yes, this may sound great for burning fat, but it quickly drains your body's T4 storage. Once your T4 is depleted, your thyroid output stalls. You will feel absolutely exhausted, freezing cold, and you will start holding fat.
​

1. T4, Levothyroxine (50 mcg/daily) View attachment 5332205 Take this every single morning. You must take this on an empty stomach, at least 30 minutes before eating or drinking anything else, or your body won't absorb it. DO NOT BY T3. You only need T4 because the HGH is already handling the conversion.​

​

Cardiovascular​

Because you are taking Letrozole or Anastrozole to crush your estrogen, your liver will stop producing healthy amounts of HDL (good cholesterol), and your LDL (bad cholesterol) will skyrocket like fucking crazy. At the same time, HGH causes you to hold onto sodium and water, which volume-loads your heart and spikes your blood pressure.

​

1. Get a blood pressure monitor and use it every morning.​

1. Telmisartan (40mg/daily) View attachment 5332274 Use this if your pressure climbs above 130/80. It lowers blood pressure, protects your kidneys, and actually helps with insulin sensitivity.​

2. Citrus Bergamot ((1000 mg/daily) + Omega-3 Fish Oil (4g/daily) View attachment 5332291 These keep your lipids from turning into absolute sludge while your estrogen is suppressed.​

Bone Mineral Density Support

Estrogen is the primary hormone that basically tells your bones to absorb calcium and maintain their density. Without it, you develop osteopenia (the medical term for weak bones) which leads directly to fractures. If your bones are weak, they cannot support the rapid linear growth that the HGH is trying to force.

You must run this specific support protocol to keep your skeleton strong while your growth plates remain open.

1. 5000 IU Vitamin D3 and 100 mcg Vitamin K2
View attachment 5332382


2. 1000 mg of Calcium Citrate
View attachment 5332384


3. Heavy Axial Loading (Weightlifting)
View attachment 5332416

​

---

Thanks for reading ​

thanks for the song jt made reading this much more enjoyable. nice thread high effort

 

[yimz_]

View attachment 5332942

Spoiler: Disclaimer

This guide is provided solely for educational and informational purposes. It is not medical advice and does not recommend or encourage the use of HGH, aromatase inhibitors, or any other medication. Discuss this with a qualified healthcare professional.

[IGF-1 induced production]
Human Growth Hormone (HGH) + Aromatase Inhibitors (AIs)
[FULL USAGE GUIDE]
The induction of longitudinal bone growth
View attachment 5332434
​

Introduction The science and requirements behind the stack​

Pre-requisites The exact tools, syringes, water, and sterilizing gear you need​

Reconstitution The step-by-step math and process of mixing HGH without destroying the protein​

HGH Injection How to draw, prep, and subcutaneously inject HGH​

AI (Dosing, Timing, Etc...) Oral dosing, timing, and choosing between Arimidex, Aromasin, and Letrozole​

Mitigation Strategies Controlling insulin resistance, thyroid, blood pressure, and lipids​

Bone Mineral Density Support The specific compounds to prevent your bones from turning brittle while estrogen is suppressed​

Spoiler: Note

Before we go any further with the guide below, I do want to emphasize that this entire guide is written under the assumption that you are a complete beginner on HGH, AI, or you've just never even seen a vial of HGH or a syringe in real life.

Introduction

This guide solely focuses on maximizing your linear height. Hence why I'll be focusing on how to use two specific compounds combined:

- Human Growth Hormone (HGH)
- Aromatase Inhibitors (AIs)

During puberty, your balls produce massive amounts of testosterone. Some of this testosterone aromatizes (converts) into estrogen. Estrogen is the exact hormone responsible for fusing your growth plates (the epiphyseal plates at the ends of your long bones). Once estrogen fuses those plates, your bones cannot grow any longer.

By combining HGH with an Aromatase Inhibitor (AI):

HGH:
Stimulates your liver to produce IGF-1, which then directly forces your bones to grow longer.

AI:
Prevents puberty-induced fusion. This would just mean that your testosterone is blocked from converting into estrogen, which keeps your growth plates open for years longer than normal.

Spoiler: Studies

Spoiler: Mauras et al., J Clin Endocrinol Metab (2016), RCT, 76 pubertal boys, ISS

GH + AI vs. GH alone vs. AI alone, 24 months. Groups: AI alone (n=25, anastrozole or letrozole), GH alone (n=25), combination (n=26).

At 24 months: adult height was increased more in the combination group (+18.8 cm) compared with the GH alone group (+17 cm) and aromatase inhibitor alone group (14.2 cm; P = .0002).
View attachment 5332531

Spoiler: ANSWER Program study (Norditropin real-world data), PMC7537098, males with GHD or ISS

n=142 GH-naïve patients, GHD (n=115) or ISS (n=27), mean baseline age 12.10 ± 3.00 (GHD) and 10.76 ± 3.07 (ISS).

Mean HSDS improved from −1.94 ± 0.77 at baseline to −0.92 ± 0.89 at AIT initiation, then further improved to −0.62 ± 0.95 after 1 year of concomitant GH plus AIT.
View attachment 5332561

Spoiler: Hou et al., J Clin Endocrinol Metab (2025), boys with ISS, bone age ≥13

View attachment 5332577

Now, there are only about three criteria you have to meet in order to touch these drugs, and if you don't meet them, just don't bother.

Spoiler: 1. Open growth plates (non-negotiable)

You must get a prescription for a left-wrist and hand X-ray to determine your bone age. If the radiologist's report says your epiphyseal plates are fused or closing, then I'm sad to say that this protocol will be utterly useless and will only cause side effects.

Spoiler: 2. Idiopathic Short Stature (ISS) or GH Deficiency (GHD)

HGH + AI is typically used for males diagnosed with ISS (which just means that you're abnormally short for your age with no known medical cause) or true Growth Hormone Deficiency (GHD).

Spoiler: 3. Active puberty

It is quite literally a MUST that you're in active puberty (typically Tanner Stage 2 to 4). If you haven't even started puberty yet, blocking estrogen would just be utterly useless and could fuck up your development. If you are past puberty, it just means your plates are already closed.

Pre-requisites

If you do not have every single item that I will be listing below sitting somewhere on your table before you pop the plastic caps off your vials, don't even consider starting. You'll just end up with a disgusting bacterial abscess or ruined peptides.
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HGH & AI​

1. HGH (Lyophilized Powder)
View attachment 5327063


2. AI (Oral Tablets)
View attachment 5326769

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Liquids​

1. Bacteriostatic Water (BAC Water)
View attachment 5327104

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Needles and syringes​

1. The Mixing Syringe (Reconstitution)
View attachment 5327151


2. The Injection Syringe (Insulin Syringe)
View attachment 5327172

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Sanitization and disposal​

1. 70% Isopropyl Alcohol Prep Pads
View attachment 5327312


2. Sharps Disposal Container
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Storage​

1. Refrigerator
View attachment 5327200


Reconstitution

Because this guide assumes you're a complete beginner, I'm basically going to use the easiest mixing math possible. If you, somehow, after reading the instructions, fuck up the math, you will either inject too little and waste your time, or inject too much and cause severe joint swelling.

With that said, follow these exact steps to mix your HGH.
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Step 1: Prep your workspace​

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Step 2: Sterilize the vials​

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Step 3: Draw the BAC water​

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Step 4: Mix the HGH (Gently)​

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Step 5: Dissolve the powder​

Beginner Reconstitution Math (10 IU Vial)
Almost all standard HGH vials contain 10 IU of powder.

By adding exactly 1 mL (100 units on an insulin syringe) of BAC water:

10 units on your insulin syringe = 1 IU of HGH
20 units on your insulin syringe = 2 IU of HGH
30 units on your insulin syringe = 3 IU of HGH
40 units on your insulin syringe = 40 units on the syringe = 4 IU of HGH
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Step 6: Store in the fridge​

HGH Injection

HGH is injected into the fat layer right under your skin (a subcutaneous injection). Do not go deep into the muscle. The stomach fat is the easiest and least painful spot for a beginner.
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Step 1: Prep your syringe and vial​

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Step 2: Draw your dose​

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Step 3: Choose and prep the injection site​

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Step 4: Inject the HGH​

Step 5: Clean up​

AI (Dosing, Timing, Etc...)

As I've already stated before, the purpose of the Aromatase Inhibitor (AI) is to systematically suppress estrogen to zero or near-zero levels. This delays the calcification and fusion of your epiphyseal plates.

AIs are oral tablets. You swallow them with water. You do not inject them.
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Choosing your AI​

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Letrozole (Femara) View attachment 5331910 This is the strongest AI on the market. It blocks up to 98% of your body's estrogen conversion. Because it is so potent, it is the standard choice in clinical trials for short boys.​

Anastrozole (Arimidex) View attachment 5331926 This is slightly milder, blocking about 80% to 85% of estrogen. It is used if Letrozole is too hard to acquire, or if Letrozole's side effects are too brutal for you to tolerate.​

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Dosing​

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Letrozole​	Anastrozole​
2.5 mg (usually one full tablet)​	1 mg (usually one full tablet)​

These are both taken once daily.​

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Timing & administration​

Because AIs have incredibly long half-lives (Letrozole has a half-life of 2 to 4 days; Anastrozole has a half-life of 48 hours), the exact time of day you take the pill really doesn't matter.

1. Take the pill at the exact same time every day to keep your hormone levels completely flat.
2. You can take it with or without food.
3. If you miss a dose, do not take a double dose the next day. Just take your regular single pill and keep going.
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Side-effects​

You need to understand that crushing your estrogen to zero to keep your growth plates open has side effects. Estrogen is still important for joint lubrication and brain function. If you're on this protocol, you will likely experience:

1. Dry, creaky, or aching joints (especially in your knees and elbows)
2. Mild fatigue or brain fog
3. Lower HDL (good cholesterol) levels

Mitigation Strategies

When you run this stack, you have to understand that you are fundamentally altering your biochemistry. You are forcing your body to grow while simultaneously taking it of a vital protective hormone (estrogen).

If you do not run a mitigation stack alongside this stack, you will end up with things like insulin resistance, a fucked thyroid, high blood pressure, and shitty cholesterol levels.
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Glucose​

HGH makes your cells highly resistant to insulin. It prevents them from absorbing glucose, leaving your blood sugar constantly elevated. If you ignore this, you can give yourself type-2 diabetes.
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1. Metformin (500 mg/daily) View attachment 5332065 Take it with my largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

2. Berberine (500 mg/daily) View attachment 5332077 Take it with your largest carb-heavy meal. It forces your muscles to absorb glucose and stops your liver from dumping sugar into your blood.​

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Thyroid​

HGH speeds up the conversion of T4 into T3. Yes, this may sound great for burning fat, but it quickly drains your body's T4 storage. Once your T4 is depleted, your thyroid output stalls. You will feel absolutely exhausted, freezing cold, and you will start holding fat.
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1. T4, Levothyroxine (50 mcg/daily) View attachment 5332205 Take this every single morning. You must take this on an empty stomach, at least 30 minutes before eating or drinking anything else, or your body won't absorb it. DO NOT BY T3. You only need T4 because the HGH is already handling the conversion.​

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Cardiovascular​

Because you are taking Letrozole or Anastrozole to crush your estrogen, your liver will stop producing healthy amounts of HDL (good cholesterol), and your LDL (bad cholesterol) will skyrocket like fucking crazy. At the same time, HGH causes you to hold onto sodium and water, which volume-loads your heart and spikes your blood pressure.

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1. Get a blood pressure monitor and use it every morning.​

1. Telmisartan (40mg/daily) View attachment 5332274 Use this if your pressure climbs above 130/80. It lowers blood pressure, protects your kidneys, and actually helps with insulin sensitivity.​

2. Citrus Bergamot ((1000 mg/daily) + Omega-3 Fish Oil (4g/daily) View attachment 5332291 These keep your lipids from turning into absolute sludge while your estrogen is suppressed.​

Bone Mineral Density Support

Estrogen is the primary hormone that basically tells your bones to absorb calcium and maintain their density. Without it, you develop osteopenia (the medical term for weak bones) which leads directly to fractures. If your bones are weak, they cannot support the rapid linear growth that the HGH is trying to force.

You must run this specific support protocol to keep your skeleton strong while your growth plates remain open.

1. 5000 IU Vitamin D3 and 100 mcg Vitamin K2
View attachment 5332382


2. 1000 mg of Calcium Citrate
View attachment 5332384


3. Heavy Axial Loading (Weightlifting)
View attachment 5332416

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Thanks for reading ​

Bump

 

[Adonis.]

dnr, I can't get my hands on hgh it's over

Legit supper easy to get btw

 

[harste09]

Have some real fun and add in anadrol and some tren that will really increase IGF-1 expression

 

[2s2f]

Legit supper easy to get btw

I posted that reply when the Chinese government put restrictions on it and a bunch of sources stopped shipping it