Interesting write up about peptides

[Seth Walsh]

Don't know who this guy is. Don't know if he's injecting everything there but it seems really excessive. Don't know why anyone would ever inject Oxytocin and PT-141.

@Alarico8 @6ft8InTheNetherlands @her @Dr Shekelberg


All the Selank and "Brain Peptide" stuff also seems a bit dodgy. Can't find much info on DSIP and FTPP Adipotide. Never heard of FOX-04 DRI until now. Thought you'd find this interesting.

 

[Deleted member 656]

Nice to see metion of BPC-157 and TB 500. You should look into those two if you haven't already. A lot of reported benefits especially with the latter but I don't have your scientific clout to make sense of it all. From r/peptides;

• TB 500 has been shown to help regrow hair in addition to PRP
• TB 500 stimulates myoblasts and myocytes.. Addresses inflammation. Its VEGF properties rectify eye, immune, kidney, liver, muscle, skin, ulcer, and brain health
• TB 500 Animal subjects have proven a significant increase in muscle growth which clearly improves strength and endurance as well as a huge enhancement in muscle tone itself.
• TB 500 might improve spinal cord wounds. It promotes angiogenesis, neurogenesis, synaptogenesis, and oligodendrogenesis.

Seems to be a very strong endorsement of topical GHK-Cu as well which is in line with what you've been telling us all along.

 

[Yummyinmytummy]

Nice to see metion of BPC-157 and TB 500. You should look into those two if you haven't already. A lot of reported benefits especially with the latter but I don't have your scientific clout to make sense of it all. From r/peptides;

• TB 500 has been shown to help regrow hair in addition to PRP
• TB 500 stimulates myoblasts and myocytes.. Addresses inflammation. Its VEGF properties rectify eye, immune, kidney, liver, muscle, skin, ulcer, and brain health
• TB 500 Animal subjects have proven a significant increase in muscle growth which clearly improves strength and endurance as well as a huge enhancement in muscle tone itself.
• TB 500 might improve spinal cord wounds. It promotes angiogenesis, neurogenesis, synaptogenesis, and oligodendrogenesis.

Seems to be a very strong endorsement of topical GHK-Cu as well which is in line with what you've been telling us all along.

will that shit make me taller?

 

[Seth Walsh]

Nice to see metion of BPC-157 and TB 500. You should look into those two if you haven't already. A lot of reported benefits especially with the latter but I don't have your scientific clout to make sense of it all. From r/peptides;

• TB 500 has been shown to help regrow hair in addition to PRP
• TB 500 stimulates myoblasts and myocytes.. Addresses inflammation. Its VEGF properties rectify eye, immune, kidney, liver, muscle, skin, ulcer, and brain health
• TB 500 Animal subjects have proven a significant increase in muscle growth which clearly improves strength and endurance as well as a huge enhancement in muscle tone itself.
• TB 500 might improve spinal cord wounds. It promotes angiogenesis, neurogenesis, synaptogenesis, and oligodendrogenesis.

Seems to be a very strong endorsement of topical GHK-Cu as well which is in line with what you've been telling us all along.

I heard mention of BPC-157 improving the gut brain axis too. I just find things online and can interpret them well, down to the mechanisms etc. Yeah I'll need to look into BPC and TB a bit more. Interesting info you shared on TB500, I didn't know that. And yeah, another advocate of ...... http://www.fromtexttospeech.com/output/0387154001579378797/53000635.mp3

It's hyped so much but not really overhyped in the way you'd think. Because it is really special and helps with everything (at least that's what it feels like), with no downsides, which is what's most important to me.

 

[Deleted member 656]

will that shit make me taller?

@Seth Walsh aren't you so glad to be able to help such intelligent and respectable people.

I heard mention of BPC-157 improving the gut brain axis too. I just find things online and can interpret them well, down to the mechanisms etc. Yeah I'll need to look into BPC and TB a bit more. Interesting info you shared on TB500, I didn't know that. And yeah, another advocate of ...... http://www.fromtexttospeech.com/output/0387154001579378797/53000635.mp3

It's hyped so much but not really overhyped in the way you'd think. Because it is really special and helps with everything (at least that's what it feels like), with no downsides, which is what's most important to me.

The supposed downside is that it helps cancer spread if you already have it, which it's hard to be sure you don't.

 

[Seth Walsh]

@Seth Walsh aren't you so glad to be able to help such intelligent and respectable people.

I just like discussing stuff. People who post stuff like that are either really dedicated trolls or are too low IQ to use google, or completely deluded, or all of those things.

Including me in a heightmaxing debate is like putting me infront of a fired ballistic missile. I'm not going to convince them, help them, change their perspective or provide good reason which they can digest. It's just not possible. Me vs heightmaxers is like mixing vinegar with baking soda or some shit...

 

[Yummyinmytummy]

@Seth Walsh aren't you so glad to be able to help such intelligent and respectable people.

I KNEW WHAT YOU WERE GONNA SAY BEFORE YOU EVEN SAID IT, YOURE SO PREDICTABLE. LITERALLY NPC CHARACTER TIER.
YOU THINK YOURE SMART BECAUSE YOU READ A FEW LINES AND MEMORISED IT LIKE A FUCKING ROBOT.

JUST LOL AT YOU.

 

[Deleted member 656]

I KNEW WHAT YOU WERE GONNA SAY BEFORE YOU EVEN SAID IT

 

[Seth Walsh]

@Seth Walsh aren't you so glad to be able to help such intelligent and respectable people.

The supposed downside is that it helps cancer spread if you already have it, which it's hard to be sure you don't.

Didn't see your second quote. Yeah I know BPC-157 makes cells divide more rapidly, which can be good and/or bad. Probably the same effect with TB 500 then. Senolytics are very interesting. Quercetin is the main one, but that guy seems to talk about FOX-04 DRI as being a powerful senolytic.

 

[Deleted member 3990]

Just inject Oxytocin and Progesterone into your gf daily to make her loyal theory

 

[Seth Walsh]

Just inject Oxytocin and Progesterone into your gf daily to make her loyal theory

You need Scopolamine too

 

[Deleted member 656]

I heard mention of BPC-157 improving the gut brain axis too.

How would that even work? I thought that was a bacterial issue.

Didn't see your second quote. Yeah I know BPC-157 makes cells divide more rapidly, which can be good and/or bad. Probably the same effect with TB 500 then.

To you reckon either could help with recovery post-exercise?

Quercetin

Isn't that the thing that kills scenesent cells without the need for autophagy / fasting? I remember it from the ResveraCel supplement.

 

[Deleted member 3990]

I am interested in peptides but am still a strong believer in hormones

You might look up Oxyandrogens (a big study is coming out about it this summer)

 

[Seth Walsh]

How would that even work? I thought that was a bacterial issue.

To you reckon either could help with recovery post-exercise?


Isn't that the thing that kills scenesent cells without the need for autophagy / fasting? I remember it from the ResveraCel supplement.

Don't know how BPC works on the gut-brain tbh.

Yeah it'll definitely improve with recovery post exercise.

Yep it is. Senesence is one of the hallmarks of aging so getting rid of all senescent cells is very important if you want to maximize your anti-aging potential, and just to stay as healthy as possible too.

I am interested in peptides but am still a strong believer in hormones

You might look up Oxyandrogens (a big study is coming out about it this summer)

Anything that has any effect on the HPTA is something I'll always stay away from. I'll check out Oxyandrogens. Hope they're not SARMS 2.0.

SARMS are selective to Androgen Receptors but still cause HTPA shutdown? I've always been asking this. How can they be what they claim if the cause a shutdown in your endocrine system?

Maybe these Oxyandrogens will be what SARMS claim to really be. But I'm sure they will still increase risk of hairloss and acne.

 

[Deleted member 3990]

Don't know how BPC works on the gut-brain tbh.

Yeah it'll definitely improve with recovery post exercise.

Yep it is. Senesence is one of the hallmarks of aging so getting rid of all senescent cells is very important if you want to maximize your anti-aging potential, and just to stay as healthy as possible too.

Anything that has any effect on the HPTA is something I'll always stay away from. I'll check out Oxyandrogens. Hope their not SARMS 2.0.

SARMS are selective to Androgen Receptors but still cause HTPA shutdown? I've always been asking this. How can they be what they claim if the cause a shutdown in your endocrine system?

Maybe these Oxyandrogens will be what SARMS claim to really be. But I'm sure they will still increase risk of hairloss and acne.

I think Oxyandrogens should open ways to inject T without shutting natural production down (idk exactely but I think your body doesnt recognize them as real Androgens and thus normal production in, for example gonads, will continue)

Afaik most of them are from the Adrenals

They might be Androgens which virilize your brain much more than the usuals

but we will see when the study is released

You might check my 11KDHT thread, there was a guy on the last few sites, who took an Oxyandrogen and shredded most of his bf%

 

[Seth Walsh]

I think Oxyandrogens should open ways to inject T without shutting natural production down

Afaik most of them are from the Adrenals

They might be Androgens which virilize your brain much more than the usuals

but we will see when the study is released

You might check my 11KDHT thread, there was a guy on the last few sites, who took an Oxyandrogen and shredded most of his bf%

Cool. I'll check it out. We produce a small amount of T in our adrenals. I wonder if OAs boost the amount created there.

 

[Deleted member 3990]

Cool. I'll check it out. We produce a small amount of T in our adrenals. I wonder if OAs boost the amount created there.

cool thing is the combination of DHEA and KDHT

KDHT cant be aromatized, lowers cortisol, estrogens and prolactin (like DHT)

and KDHT increases the number of Androgens which are converted from DHEA

so taking DHEA and KDHT may increase your Androgen levels substantially without fucking with it (because it is (nearly) a natural process)

Cool. I'll check it out

Thanks

Good that you will look over it, because you can substract and analyize such things better than me probably

 

[Seth Walsh]

cool thing is the combination of DHEA and KDHT

KDHT cant be aromatized, lowers cortisol, estrogens and prolactin (like DHT)

and KDHT increases the number of Androgens which are converted from DHEA

so taking DHEA and KDHT may increase your Androgen levels substantially without fucking with it (because it is (nearly) a natural process)

Complicated stuff. I don't fully understand it tbh. I always though KDHT10 was some type of DHT cream. DHEA is pretty early on in the chain so it'd be interesting to see if KDHT modulates some of the unwanted hormone elevations as a result of increasing DHEA. I'm not 100% sure but from what I recall cAMP helps the Luteinizing Hormone convert to Cholesterol after it's released by the Leydig Cells, then the Cholesterol is involved in the production of DHEA and some forms of Pregnenolone.

A DHEA supplement (DHEA booster or whatever) is something that'd almost certainly cause acne in most people, especially teens. I think the "Test Booster" that I took in the past actually increased by DHEA. As a result, Test, Estrogen, Progesterone, DHT all go up. Acne, pseudo-gyno, mood-swings, transforming to a coomer day by day. DHEA definitely isn't something I think should be messed around with. But I've no clue what the effects of DHEA+KDHT are, but they look intriguing!

 

[Deleted member 656]

@Seth Walsh are senescent cells still metabolically active and do they still perform their function?

 

[Seth Walsh]

@Seth Walsh are senescent cells still metabolically active and do they still perform their function?

No they're complete junk. They're in a state of irreversible cellular arrest and they're genotoxic. They contribute to oxidative stress, mechanisms of aging and DNA damage through things like p53, p16.

 

[Deleted member 656]

No they're complete junk. They're in a state of irreversible cellular arrest and they're genotoxic. They contribute to oxidative stress, mechanisms of aging and DNA damage through things like p53, p16.

I thought fasting to remove senescent cells also increases growth hormone levels exponentially though so that once you break the fast you can very rapidly replace them and get back to working at full capacity.

If you're just taking senolytics to purge the senescent cells without the elevated growth hormone levels to replace them would that not mean simply having a deficiency of healthy cells and overworking the ones you do have? Or am I inventing a concern that isn't real?

 

[Seth Walsh]

I thought fasting to remove senescent cells also increases growth hormone levels exponentially though so that once you break the fast you can very rapidly replace them and get back to working at full capacity.

If you're just taking senolytics to purge the senescent cells without the elevated growth hormone levels to replace them would that not mean simply having a deficiency of healthy cells and overworking the ones you do have? Or am I inventing a concern that isn't real?

Senolytics would only be needed if you have lots of senescent cells if they've already accumulated and are causing stress and damage. Your GH will rise when you fast for a good period of time and that's due to the lowered insulin levels more than anything.

So senolytics aren't needed if you can already use autophagy from time to time to clear out bad cells. Intermittent fasting should always be apart of someone's regime. I think you're looking too deep into it. If you have a healthy lifestyle you probably have very few senescent cells, and they're managed anyways without the need for senolytics or too much fasting.

One of the reasons people should fast from time-to-time is to clear out senescent cells properly, if there is an accumulation.

Sidenote: I made a program that spits out all of my old posts. Problem is you need to be logged in to looksmax.me for it to work. And I cba to programatically log my account into here and fetch all the posts. I read some posts from Nov/Dec saying that some of my posts are lost forever, but they're not. It looks like some new people are on here now and interested in things like hallmarks of aging etc. I'll try compile a list of my most informative posts from the past on anti-aging stuff seeing that more people are asking questions that you and I already know the answers too. There's just a lot to explain and it's tiring to reiterate on things I talked about in the past like PQQ etc...

And for everyone wondering, I don't hate Lifeisgood. I was just really pissed off that morning and when I checked the PMs I had enough. I'm back here so I can discuss/talk and learn new things. The reason I left for two months is because I literally got threatened with blackmail because I didn't answer some question that I didn't care about and didn't have to answer. It's cool to see you and some others get more interested in the field and finding new info online, because that's all I did tbh.

But yeah, I think your looking too much into it. Senescent cells aren't a worry for anyone healthy, especially if your 19-24 like most of us.

This is looksmaxing after all, so it's important to find out what are the best things to do in all departments, without making routines too stressful or over-complicated.

That guy on medium is definitely over-complicating things. BPC-157 looks interesting but causing rapid cell division isn't ideal at all. Ideally we don't want more cells, where there can potentially be more problems (per cell). We just want each cell to be as healthy as possible so it doesn't go into apoptosis or senesence. Increasing mitochondria count in healthy cells is very beneficial and that's where understanding PGC1α is really important.

 

[Deleted member 656]

Senolytics would only be needed if you have lots of senescent cells if they've already accumulated and are causing stress and damage. Your GH will rise when you fast for a good period of time and that's due to the lowered insulin levels more than anything.

So senolytics aren't needed if you can already use autophagy from time to time to clear out bad cells. Intermittent fasting should always be apart of someone's regime. I think you're looking too deep into it. If you have a healthy lifestyle you probably have very few senescent cells, and they're managed anyways without the need for senolytics or too much fasting.

One of the reasons people should fast from time-to-time is to clear out senescent cells properly, if there is an accumulation.

Sidenote: I made a program that spits out all of my old posts. Problem is you need to be logged in to looksmax.me for it to work. And I cba to programatically log my account into here and fetch all the posts. I read some posts from Nov/Dec saying that some of my posts are lost forever, but they're not. It looks like some new people are on here now and interested in things like hallmarks of aging etc. I'll try compile a list of my most informative posts from the past on anti-aging stuff seeing that more people are asking questions that you and I already know the answers too. There's just a lot to explain and it's tiring to reiterate on things I talked about in the past like PQQ etc...

And for everyone wondering, I don't hate Lifeisgood. I was just really pissed off that morning and when I checked the PMs I had enough. I'm back here so I can discuss/talk and learn new things. The reason I left for two months is because I literally got threatened with blackmail because I didn't answer some question that I didn't care about and didn't have to answer. It's cool to see you and some others get more interested in the field and finding new info online, because that's all I did tbh.

But yeah, I think your looking too much into it. Senescent cells aren't a worry for anyone healthy, especially if your 19-24 like most of us.

This is looksmaxing after all, so it's important to find out what are the best things to do in all departments, without making routines too stressful or over-complicated.

That guy on medium is definitely over-complicating things. BPC-157 looks interesting but causing rapid cell division isn't ideal at all. Ideally we don't want more cells, where there can potentially be more problems (per cell). We just want each cell to be as healthy as possible so it doesn't go into apoptosis or senesence. Increasing mitochondria count in healthy cells is very beneficial and that's where understanding PGC1α is really important.

You used to allude to a megathread on anti-aging you were working on but never got around to releasing. I suppose compiling the old comments would achieve the same thing. The search function means they're all there but finding them is time-consuming, and you changed your mind on things throughout posting, like no longer encouraging use of berberine before you left. It makes it all more confusing than it has to be. But it's necessarily confusing anyway because of the body's inherent complexity. Not an accessible topic for most of us which means you never get the dialogue you're after and which would lead to us getting somewhere, as we have done with looks theory.

 

[Seth Walsh]

You used to allude to a megathread on anti-aging you were working on but never got around to releasing. I suppose compiling the old comments would achieve the same thing. The search function means they're all there but finding them is time-consuming, and you changed your mind on things throughout posting, like no longer encouraging use of berberine before you left. It makes it all more confusing than it has to be. But it's necessarily confusing anyway because of the body's inherent complexity. Not an accessible topic for most of us which means you never get the dialogue you're after and which would lead to us getting somewhere, as we have done with looks theory.

My outlook on Berberine changed because I started using it and experienced the benefits/downsides to it first hand. Berberine still has it's place but it's not too important and isn't something to be taken frequently and continuously, just like Metformin. Best way to learn is just through personal research and trial/error. I scrapped the anti-aging book thingy. I still have so much to learn so that's what I'm gonna keep doing.

 

[Deleted member 2205]

This longevity shit is really interesting tbh

 

[Deleted member 3635]

cool thing is the combination of DHEA and KDHT

KDHT cant be aromatized, lowers cortisol, estrogens and prolactin (like DHT)

and KDHT increases the number of Androgens which are converted from DHEA

so taking DHEA and KDHT may increase your Androgen levels substantially without fucking with it (because it is (nearly) a natural process)

Thanks

Good that you will look over it, because you can substract and analyize such things better than me probably

How much mg of dhea doctor shekel berg

 

[Deleted member 3990]

How much mg of dhea doctor shekel berg

none

 

[Deleted member 3635]

none

So dhea and kdht is a no go ?