Leuprolide acetate to delay growth plate closure. A better ai alternative ??

mathis said:
pubmed.ncbi.nlm.nih.gov

Efficacy and Safety of Leuprolide Acetate 6-Month Depot for the Treatment of Central Precocious Puberty: A Phase 3 Study - PubMed

Six-month intramuscular LA depot demonstrated 48-week efficacy with a safety profile consistent with other GnRH agonist formulations.
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Need more information on this but seem like an intresting one
Click to expand...
Yeh inhibiting gonadotropin would most likely be better
I wont read these but u can

Leuprolide - StatPearls - NCBI Bookshelf

www.ncbi.nlm.nih.gov
academic.oup.com

36-Month Treatment Experience of Two Doses of Leuprolide Acetate 3-Month Depot for Children With Central Precocious Puberty

Context:. We have recently demonstrated short-term (6-month) efficacy and safety of leuprolide acetate 3-month depot 11.25 and 30 mg in children with centr
academic.oup.com academic.oup.com
Idk if those links say anything useful but 🤷‍♂️
 
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Rigged said:
Yeh inhibiting gonadotropin would most likely be better
I wont read these but u can

Leuprolide - StatPearls - NCBI Bookshelf

www.ncbi.nlm.nih.gov
academic.oup.com

36-Month Treatment Experience of Two Doses of Leuprolide Acetate 3-Month Depot for Children With Central Precocious Puberty

Context:. We have recently demonstrated short-term (6-month) efficacy and safety of leuprolide acetate 3-month depot 11.25 and 30 mg in children with centr
academic.oup.com academic.oup.com
Idk if those links say anything useful but 🤷‍♂️
Click to expand...
Im gonna do some more rechearch today thx
 
thread set to watch!
 
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im gonna do a final thread covering everything abt this product today/tomorow if you want to be tagged just answer this thread
 
mathis said:
im gonna do a final thread covering everything abt this product today/tomorow if you want to be tagged just answer this thread
Click to expand...
tag me
 
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Enough is enough can we actually get this guy banned
You are genuinely a waste of space
 
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Please how do we get this guy banned im serious, everytime I see him post or reply I’ve wanted to say this but didn’t want to be rude.

Did you read a single word of the study
 
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research on spironolactone. been thinking about it as an alternative to ai
 
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  • WTF
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Tallest person here said:
Please how do we get this guy banned im serious, everytime I see him post or reply I’ve wanted to say this but didn’t want to be rude.

Did you read a single word of the study
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You are the type of guy who beleive to be intelligent when you are actually at most average. You talk but never gave any argument. Yapper final boss
 
mathis said:
You are the type of guy who beleive to be intelligent when you are actually at most average. You talk but never gave any argument. Yapper final boss
Click to expand...
Lower Lutenizing hormone which led to less estrogen yes, but basically an equal loss in testosterone and reduced growth velocity

Learn to read
 
Tallest person here said:
Please how do we get this guy banned im serious, everytime I see him post or reply I’ve wanted to say this but didn’t want to be rude.

Did you read a single word of the study
Click to expand...
I have read every molecule of this studie and i looked to this one for a precise goal which isnt the one you may think abt. I can anderstand that you arent intellectually gifted but then dont waist everyone time please
 
mathis said:
I have read every molecule of this studie and i looked to this one for a precise goal which isnt the one you may think abt. I can anderstand that you arent intellectually gifted but then dont waist everyone time please
Click to expand...
waste* , understand*
I understand if English isn’t your first lnaguage

What precise goal buddy, you put it in the title: a better ai alternative. This is clearly a terrible idea if you have any cells in that cranium of yours
 
Tallest person here said:
waste* , understand*
I understand if English isn’t your first lnaguage

What precise goal buddy, you put it in the title: a better ai alternative. This is clearly a terrible idea if you have any cells in that cranium of yours
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I have started to learn englist a week ago. Here is the title i putted "Leuprolide acetate to delay growth plate closure. A better ai alternative ??" Seem like you forgot to read the end
 
Tallest person here said:
Lower Lutenizing hormone which led to less estrogen yes, but basically an equal loss in testosterone and reduced growth velocity

Learn to read
Click to expand...
Low iq. Its just abt ajusting the dosage but you cant know this since you talk abt somthing you have no knowledge on
 
mathis said:
I have started to learn englist a week ago. Here is the title i putted "Leuprolide acetate to delay growth plate closure. A better ai alternative ??" Seem like you forgot to read the end
Click to expand...
?? I mentioned the end in my comment
Now that I know English isn’t your first language it’s actually rude of me to say you should be banned, sorry about that. I still think I’m right though
 
Tallest person here said:
?? I mentioned the end in my comment
Now that I know English isn’t your first language it’s actually rude of me to say you should be banned, sorry about that. I still think I’m right though
Click to expand...
You havent putted "??" In your answer no. My title was an interrogation. Not a affirmation. Seem crazy to me that i have to explain this. But ofc bro ban me because i dont speak english !
 
mathis said:
You havent putted "??" In your answer no. My title was an interrogation. Not an affirmation. Seem crazy to me that i have to explain this. But ofc bro ban me because i dont speak english !
Click to expand...
You aren’t reading my comments correctly .
I know what the point of the thread is which is to show a “better” ai alternative.

But you are wrong about it since it affects other things too much (testosterone was suppressed 100%)

I said that I SHOULDNT have said to ban you
Because it is not your fault that English is not your first language
 
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Tallest person here said:
You aren’t reading my comments correctly .
I know what the point of the thread is which is to show a “better” ai alternative.

But you are wrong about it since it affects other things too much (testosterone was suppressed 100%)

I said that I SHOULDNT have said to ban you
Because it is not your fault that English is not your first language
Click to expand...
Ok i anderstand. Im gonna explain to you why you are wrong on Leuprolide acetate :


Operation at adequate dose:

GH Stimulation: Leuprolide acetate stimulates the production of GH by the pituitary gland.
Action of GH: GH stimulates the growth of bones and cartilage, particularly at the growth plates.
Slowing Closure: Stimulation of GH by leuprolide acetate helps slow the closure of growth plates, thereby prolonging the period of bone growth.

High dose effects:

Desensitization of cells: Too high a dose of leuprolide acetate can cause desensitization of cells to growth hormone.
Decreased response to GH: This desensitization decreases the response of cells to GH, which can slow the child's bone growth and overall growth.

Its why, dosage its extremly important. Leuprolide acetate is one of the most used product for short predicted height in child. Do you think they would give somthing that dont work?
 
Tallest person here said:
You aren’t reading my comments correctly .
I know what the point of the thread is which is to show a “better” ai alternative.

But you are wrong about it since it affects other things too much (testosterone was suppressed 100%)

I said that I SHOULDNT have said to ban you
Because it is not your fault that English is not your first language
Click to expand...
I dont have the knowledge( yet ) to explain you more abt this. I dont seek to be right but only the truth because at the end its the only thing that will truly benefit us. If you want i’ll tag you when i will have enought knowledge on this ( i will do a final thread trying to cover everything )
 
mathis said:
I dont have the knowledge( yet ) to explain you more abt this. I dont seek to be right but only the truth because at the end its the only thing that will truly benefit us. If you want i’ll tag you when i will have enought knowledge on this ( i will do a final thread trying to cover everything )
Click to expand...
Yo why u always online damn but um heres sum stuff about Leuprolide Acetate

Alr so as yk it's a synthetic peptide analogue of gonadal hormone that interacts with the HPG axis, targeting the gnrh receptors on pituitary gonadotropes. Because of its shape, binding is easy and intracellular signaling cascades involving PLC, g-proteins, and downstream effectors such as DAG and IP3 are initiated. These decrease the release of LH and FSH via modifying gene expression and cellular function within the pituitary gland. It gradually causes receptor desensitization and downregulation, which lowers gnrh receptor reactivity. This lowers T levels in niggas, which causes hypogonadism and poor spermatogenesis. This is something im sure you already know but long term use of it affects GH secretion through GHRH. Long term use also metabolically changes how fat is metabolized, which raises triglyceride and cholesterol levels and reduces insulin sensitivity

Hope this helps also @ me in post thx
 
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Rigged said:
Yo why u always online damn but um heres sum stuff about Leuprolide Acetate

Alr so as yk it's a synthetic peptide analogue of gonadal hormone that interacts with the HPG axis, targeting the gnrh receptors on pituitary gonadotropes. Because of its shape, binding is easy and intracellular signaling cascades involving PLC, g-proteins, and downstream effectors such as DAG and IP3 are initiated. These decrease the release of LH and FSH via modifying gene expression and cellular function within the pituitary gland. It gradually causes receptor desensitization and downregulation, which lowers gnrh receptor reactivity. This lowers T levels in niggas, which causes hypogonadism and poor spermatogenesis. This is something im sure you already know but long term use of it affects GH secretion through GHRH. Long term use also metabolically changes how fat is metabolized, which raises triglyceride and cholesterol levels and reduces insulin sensitivity

Hope this helps also @ me in post thx
Click to expand...
All you said is true ty bro. No problem i’ll tag you
 
"Mean height velocity ranged 5.0 to 5.3 cm/year post-baseline in previously treated patients and declined from 10.1 to 6.5 cm/year at week 20 in treatment-naïve patients. Mean bone age advanced slower than chronological age. Patient/parent-reported outcomes remained stable. No new safety signals were identified. No adverse event led to treatment discontinuation."

Interesting. I'd like to see the effects of this post-puberty. The real question we should be asking: will it ultimately lead to a taller final stature?
The abstract seems comparable to what you'd see in aromatase deficient teenage males...
 
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Intrigued to see a long term study on this
 
SkullDynamics said:
"Mean height velocity ranged 5.0 to 5.3 cm/year post-baseline in previously treated patients and declined from 10.1 to 6.5 cm/year at week 20 in treatment-naïve patients. Mean bone age advanced slower than chronological age. Patient/parent-reported outcomes remained stable. No new safety signals were identified. No adverse event led to treatment discontinuation."

Interesting. I'd like to see the effects of this post-puberty. The real question we should be asking: will it ultimately lead to a taller final stature?
The abstract seems comparable to what you'd see in aromatase deficient teenage males...
Click to expand...
Yep definitly an intresting product i’ll tag you when i will have done my thread on this
 
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mogpending said:
@Osie
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Using this to grow in height is essentially castrating yourself for greater height gains. It will reduce both your estradiol and testosterone levels, so it does work well and even leads to similar height gains like an AI, but you'll probably feel worse on it than traditional AI. It's mainly good for people who are experiencing puberty too early or have a disease where their height growth will be compromised so sacrificing a healthy puberty (healthy = constantly rising T levels). Rather than idiopathic short stature cases, as it can make male hormone markers look hypogondal.
 
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Osie said:
Using this to grow in height is essentially castrating yourself for greater height gains. It will reduce both your estradiol and testosterone levels, so it does work well and even leads to similar height gains like an AI, but you'll probably feel worse on it than traditional AI. It's mainly good for people who are experiencing puberty too early or have a disease where their height growth will be compromised so sacrificing a healthy puberty (healthy = constantly rising T levels). Rather than idiopathic short stature cases, as it can make male hormone markers look hypogondal.
Click to expand...
Offtopic man should I take glu + cho to heightmax while still having open plates? And also while using lite heightmaxing stack with mk
 
Roge said:
Offtopic man should I take glu + cho to heightmax while still having open plates? And also while using lite heightmaxing stack with mk
Click to expand...
I'll answer in PM's, I just seen it.
 
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Roge said:
Offtopic man should I take glu + cho to heightmax while still having open plates? And also while using lite heightmaxing stack with mk
Click to expand...
idk what he told u but it does stunt your spine so i dont recommend
 
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