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Ancient origins of low lean mass among South Asians and implications for modern type 2 diabetes susceptibility - Scientific Reports
Living South Asians have low lean tissue mass relative to height, which contributes to their elevated type 2 diabetes susceptibility, particularly when accompanied by obesity. While ongoing lifestyle transitions account for rising obesity, the origins of low lean mass remain unclear. We analysed...
www.nature.com
Tdlr :
We analysed proxies for lean mass and stature among South Asian skeletons spanning the last 11,000 years (n = 197) to investigate the origins of South Asian low lean mass. Compared with a worldwide sample (n = 2,003), South Asian skeletons indicate low lean mass.
In conclusion, our analyses suggest that the low lean mass phenotype characteristic of contemporary people of South Asian ancestry has existed for at least 11,000 years. The available data have insufficient resolution to show whether or not there were further small changes in proportional lean mass since the adoption of food production, or as a consequence of more recent famines. Given the antiquity of this phenotype, the most likely explanations for low lean mass in South Asia appears to be either climatic adaptation or neutral evolutionary processes, but the available data do not allow us to distinguish between these hypotheses at present. Consistent with previous work, our data indicate that stature, which is also associated with elevated T2D susceptibility, fell sharply with the transition to food production, and continued to decline more slowly until the 20th century. The implication of our results is that South Asian low lean mass, and associated NCD susceptibility, may have a genetic basis and is unlikely to change in the short term, so that other strategies (such as behavioural and/or dietary intervention) are required to address the epidemic of NCDs that is particularly acute in South Asia.
@Jason Voorhees @SidharthTheSlayer @Gengar @coispet @SecularIslamist
