Meta-analysis: SSRI are a jew scam who to turn people into cucks

I was on mirtazapin for 2 months and then suddenly stopped. It's the worst thing I have ever done to my brain, I feel even more depressed than before. Shit lowers your libido, now it came back to normal since I've stopped taking them. If I have 1 advice: NEVER TAKE ANTIDEPRESSANTS.
Therapy is much more effective, it's really helping me atm.
It's a very good drug hormonally speaking. It increased my libido and pleasure, I tried to stop it just to know how it feels... It's really insanely bad, felt like a conscient nightmare, with restlessness and everything I want to never think or remember started floating in my head and in an extremely vivid and realist way
 
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It's a very good drug hormonally speaking. It increased my libido and pleasure, I tried to stop it just to know how it feels... It's really insanely bad, felt like a conscient nightmare, with restlessness and everything I want to never think or remember started floating in my head and in an extremely vivid and realist way
Apparently you should never stop taking it suddenly it fucks your brain chemistry
 
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It's a very good drug hormonally speaking. It increased my libido and pleasure, I tried to stop it just to know how it feels... It's really insanely bad, felt like a conscient nightmare, with restlessness and everything I want to never think or remember started floating in my head and in an extremely vivid and realist way
of course, it spiked your libido.
serotonin is bad, the overexpression of the 5-HT receptors leads to a lowered libido and anorgasmia. I've never understood the concept of SSRI's, all they do is make you feel numb.

it's funny how the anti-depressants that do the complete and utter opposite to SSRI's are the ones that produce better outcomes in clinically depressed individuals.
 
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it's funny how the anti-depressants that do the complete and utter opposite to SSRI's are the ones that produce better outcomes in clinically depressed individuals.
which ones are you referring to?
 
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which ones are you referring to?
agomelatine.
the drug displays a significant agonistic affinity for the melatonin receptor family whilst also possessing antagonistic properties on the 5-HT receptor family.

it works better in combination with other drugs, but a friend of mine had chronic depression and it was also causing bad insomnia, so he gave it a go and within a couple of weeks his mood was lifted and he got out of a bad depression. He'd been on Prozac for a long time and he described the feeling as 'numb'.

I read a paper about serotonin receptor antagonists producing a smoother less symptomatic decline in depression, I'll try and dig it up.
 
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agomelatine.
the drug displays a significant agonistic affinity for the melatonin receptor family whilst also possessing antagonistic properties on the 5-HT receptor family.

it works better in combination with other drugs, but a friend of mine had chronic depression and it was also causing bad insomnia, so he gave it a go and within a couple of weeks his mood was lifted and he got out of a bad depression. He'd been on Prozac for a long time and he described the feeling as 'numb'.

I read a paper about serotonin receptor antagonists producing a smoother less symptomatic decline in depression, I'll try and dig it up.
Yeah, theses drugs do much more than increasing one or 2 neurotransmitters, my psychiatrist commented on 5htp worsening anxiety and depression, and that nobody really knows how exactly ssris works. Several studies show serotonin being a biomarker and inducer of depression in animals and humans. Meanwhile antagonism of certains serotonin receptors are known to ease depression, in this case in a simple and solid mechanism.


To add more: https://www.researchgate.net/public...umans_Implications_for_its_dual_action_status

It appears to exhibit no serotonergic symptoms or toxicity in over-dose by itself, nor is there evidence that it precipitates ST in combination with monoamine oxidase inhibitors, as would be expected if it raises intra-synaptic serotonin levels. Mirtazapine has no demonstrable serotonergic effects in humans and there is insufficient evidence to designate it as a dual-action drug.
Scary stuff:
Up to 80% of young men experience sexual distinction on SSRIs

Clark et al24 reported that the SSRIs citalopram, fluoxetine, paroxetine, and sertraline and the SNRI venlafaxine were associated with significantly greater rates (70%–80%) of reported total sexual dysfunction, including negative impacts on desire, arousal, and orgasm, than was the placebo

It appears that the negative effects of excess serotonin induced by SSRIs are long-lasting as only 5.8% of patients experienced complete recovery within 6 months, whereas 81.4% showed no improvement at all by the end of that period


This should convince anyone that theses shits are toxic. And there's much more, like doubled risk of diabetes type 2 and irreversible bone loss.
 
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Yeah, theses drugs do much more than increasing one or 2 neurotransmitters, my psychiatrist commented on 5htp worsening anxiety and depression, and that nobody really knows how exactly ssris works. Several studies show serotonin being a biomarker and inducer of depression in animals and humans. Meanwhile antagonism of certains serotonin receptors are known to ease depression, in this case in a simple and solid mechanism.


To add more: https://www.researchgate.net/public...umans_Implications_for_its_dual_action_status

It appears to exhibit no serotonergic symptoms or toxicity in over-dose by itself, nor is there evidence that it precipitates ST in combination with monoamine oxidase inhibitors, as would be expected if it raises intra-synaptic serotonin levels. Mirtazapine has no demonstrable serotonergic effects in humans and there is insufficient evidence to designate it as a dual-action drug.
to also add onto the whole serotonin thing, whilst on dihydrotestosterone I've noticed my mood has gone through the roof, which completely contradicts the modern hypothesis in which suggests serotonin is involved in regulating mood, and that more equals better..

dihydrotestosterone affects serotonin in more than one way, firstly, estradiol upregulates the 5-HT receptor family density, whilst also influencing the expression of the receptors. Dihydrotestosterone potently opposes estradiol, therefore, serotonin receptor density decreases whilst the expression of the receptor is also decreased. DHT also inhibits tryptophan within the brain, therefore impacting the synthesis of 5-tryprophan-hydroxy. Another thing I want to add, 3a-androstanediol (one of dht's major metabolites) is a potent positive allosteric GABA-A receptor modulator, equating to lowered anxiety and depression.
 
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to also add onto the whole serotonin thing, whilst on dihydrotestosterone I've noticed my mood has gone through the roof, which completely contradicts the modern hypothesis in which suggests serotonin is involved in regulating mood, and that more equals better..

dihydrotestosterone affects serotonin in more than one way, firstly, estradiol upregulates the 5-HT receptor family density, whilst also influencing the expression of the receptors. Dihydrotestosterone potently opposes estradiol, therefore, serotonin receptor density decreases whilst the expression of the receptor is also decreased. DHT also inhibits tryptophan within the brain, therefore impacting the synthesis of 5-tryprophan-hydroxy. Another thing I want to add, 3a-androstanediol (one of dht's major metabolites) is a potent positive allosteric GABA-A receptor modulator, equating to lowered anxiety and depression.
Gaba agonism, benzodiazepines for example, are anti serotonin. Mesterolone also makes my mood amazing.

But damm man, how can a male take a drug that causes sexual disfunction on 80% of it's users?
 
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Gaba agonism, benzodiazepines for example, are anti serotonin. Mesterolone also makes my mood amazing.

But damm man, how can a male take a drug that causes sexual disfunction on 80% of it's users?
it's fucked, probably one of the worst pharmaceutical interventions ever.
causes impotence, erectile dysfunction, and loss of libido, an excess of serotonin also depletes dopamine in most areas of the brain.

serotonin is the devil, dopamine is what we should be focussing on.
It appears that the negative effects of excess serotonin induced by SSRIs are long-lasting as only 5.8% of patients experienced complete recovery within 6 months, whereas 81.4% showed no improvement at all by the end of that period
that's just plain evil tbh.
and for what gain? these drugs barely work.
 
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of course, it spiked your libido.
serotonin is bad, the overexpression of the 5-HT receptors leads to a lowered libido and anorgasmia. I've never understood the concept of SSRI's, all they do is make you feel numb.

it's funny how the anti-depressants that do the complete and utter opposite to SSRI's are the ones that produce better outcomes in clinically depressed individuals.
Ssris are antidepressants. And they dont make you feel numb, they make you feel content with your life. Although not saying they are worth it
 
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Ssris are antidepressants. And they dont make you feel numb, they make you feel content with your life. Although not saying they are worth it
they're shit.
there are so many other ways you can reduce depressive symptoms, only uneducated NPC's take the Jewish overlord's castration pill.
 
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they're shit.
there are so many other ways you can reduce depressive symptoms, only uneducated NPC's take the Jewish overlord's castration pill.
not saying they are worth it
For most people they arent worth it. 10% of the depressive population has genetic biological depression, they are justified in taking them.

People like me and OP aren't.
 
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For most people they arent worth it. 10% of the depressive population has genetic biological depression, they are justified in taking them.

People like me and OP aren't.
alright, I'd advise you to check out the link that OP posted.
how's your libido? :feelskek:
 
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alright, I'd advise you to check out the link that OP posted.
how's your libido? :feelskek:
Im not even on it.

Pretty high I think about sex 24/7 and have been jacking off 4 times a day for 2 years
 
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and have been jacking off 4 times a day for 2 years
brilliant, no wonder you're a fat, depressed loser. (no offense)
SSRI's are objectively bad, look into it, there isn't a justified reason to be using them when there are plenty of alternative methods to decrease the depressive load.
 
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okay, you were though correct?
so my point stands.
 
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agomelatine.
the drug displays a significant agonistic affinity for the melatonin receptor family whilst also possessing antagonistic properties on the 5-HT receptor family.

it works better in combination with other drugs, but a friend of mine had chronic depression and it was also causing bad insomnia, so he gave it a go and within a couple of weeks his mood was lifted and he got out of a bad depression. He'd been on Prozac for a long time and he described the feeling as 'numb'.

I read a paper about serotonin receptor antagonists producing a smoother less symptomatic decline in depression, I'll try and dig it up.
Never heard of agomelatine, will definitely look into it. Downregulating serotonin is something I've thought about doing for awhile, especially since my recent neurotic symptoms are most likely due to an over-excitation of the 5-HT system. I am prescribed Prozac lol.

Gaba agonism, benzodiazepines for example, are anti serotonin. Mesterolone also makes my mood amazing.
Damn, very good point. Would be very interesting to see how my brain reacts to the use of GABA agonists without a substance upregulating serotonin.
 
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Never heard of agomelatine, will definitely look into it. Downregulating serotonin is something I've thought about doing for awhile, especially since my recent neurotic symptoms are most likely due to an over-excitation of the 5-HT system. I am prescribed Prozac lol.
your libido will literally sky-rocket if you were to use serotonin receptor antagonists. Everyone is different though, some people respond greatly to serotonin, others don't.

personally, for me, my mood is up when dopamine, norepinephrine are through the roof and serotonin is on the lower side.
also calibrating your reward path systems correctly makes things 100x better.
 
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your libido will literally sky-rocket if you were to use serotonin receptor antagonists. Everyone is different though, some people respond greatly to serotonin, others don't.

personally, for me, my mood is up when dopamine, norepinephrine are through the roof and serotonin is on the lower side.
also calibrating your reward path systems correctly makes things 100x better.
Indeed, I jumpstart myself with PQQ Energy + Caffeine for that dopamine-norepinephrine boost right before work and I’m zoned in the whole time.
 
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Indeed, I jumpstart myself with PQQ Energy + Caffeine for that dopamine-norepinephrine boost right before work and I’m zoned in the whole time.
that's a great option.
dopamine and norepinephrine mog the shit out of serotonin.
are you taking the Prozac atm? or is it only prescribed fro you?
 
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Ssris are antidepressants. And they dont make you feel numb, they make you feel content with your life. Although not saying they are worth it
Feeling numb is one of their main and more frequent side effects...
 
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that's a great option.
dopamine and norepinephrine mog the shit out of serotonin.
are you taking the Prozac atm? or is it only prescribed fro you?
I do take it currently, gonna get off of it for good though this time. Was thinking I might taper with 5-HTP.
 
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I do take it currently, gonna get off of it for good though this time. Was thinking I might taper with 5-HTP.
Supposedly majority of it it is decarboxylated into serotonin outside of the blood-brain barrier. 5-hydroxytryptophan can cross the blood-brain barrier, of course, but serotonin cannot. The efficacy with the supplementation of 5-HTP is iffy because of this reason, sure some will cross the BBB and eventually be converted into serotonin via the L-amino acid decarboxylase enzyme, but a large chunk of it will fail to make it to the brain unaltered. The same thing goes for people taking Levo-dopa, majority of it is going to peripherally converted into dopamine before it reaches the brain, this is why a combination of both Levo-dopa and a dopa-decarboxylase inhibitor is used in Parkinson's treatment, carbidopa (decarboxylase inhibitor) cannot cross the BBB, meaning it will inhibit the conversion of L-dopa to dopamine and allow the L-dopa to cross the BBB in which dopa-decarboxylase isn't inhibited.
 
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Supposedly majority of it it is decarboxylated into serotonin outside of the blood-brain barrier. 5-hydroxytryptophan can cross the blood-brain barrier, of course, but serotonin cannot. The efficacy with the supplementation of 5-HTP is iffy because of this reason, sure some will cross the BBB and eventually be converted into serotonin via the L-amino acid decarboxylase enzyme, but a large chunk of it will fail to make it to the brain unaltered. The same thing goes for people taking Levo-dopa, majority of it is going to peripherally converted into dopamine before it reaches the brain, this is why a combination of both Levo-dopa and a dopa-decarboxylase inhibitor is used in Parkinson's treatment, carbidopa (decarboxylase inhibitor) cannot cross the BBB, meaning it will inhibit the conversion of L-dopa to dopamine and allow the L-dopa to cross the BBB in which dopa-decarboxylase isn't inhibited.
Mirin knowledge, have you tried this out yourself?
 
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Mirin knowledge, have you tried this out yourself?
no, I haven't, but I'd like to in the future. The combination of levodopa and carbidopa interests me.
I've used dopamine receptor agonists, they made me hypersexual, addicted to porn, highly autistic and borderline psychopathic. There obviously seems to be a perfect median.
 
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no, I haven't, but I'd like to in the future. The combination of levodopa and carbidopa interests me.
I've used dopamine receptor agonists, they made me hypersexual, addicted to porn, highly autistic and borderline psychopathic. There obviously seems to be a perfect median.
Anyway back from PSSR?
im 80% recovered a year later. I get morning erection. Can have sex and enjoy masturbation. I longer get night fluid if I don’t masturbate unless I’m bored and I don’t feel the need or the same level of libido.
 
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Yh
 
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SEROTONIN IS A BYPRODUCT/MARKER OF STRESS.
HARMFUL MONOAMINE.

I TAKE 1MG CYPROHEPTADINE ALMOST EVERY NIGHT TO REDUCE IT.

SSRIs WERE CREATED WHEN THE PATENTS FOR MAOIs EXPIRED.
THEY'RE NOT USEFUL AT ALL, THEY WERE MADE JUST TO ENRICH PHARMACEUTICAL COMPANIES.

THE ONLY SEROTONINERGIC EXCEPTION: [ISPOILER]psilocybe cubensis Mexican B+[/ISPOILER]


</end of thread>
 
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This site explains everything in good detail and understandable way about why seratonin is bad and dopamine is the real happiness hormone. It has tons of sources in the texts

@Dyorotic2
 
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SEROTONIN IS A BYPRODUCT/MARKER OF STRESS.
HARMFUL MONOAMINE.

I TAKE 1MG CYPROHEPTADINE ALMOST EVERY NIGHT TO REDUCE IT.

SSRIs WERE CREATED WHEN THE PATENTS FOR MAOIs EXPIRED.
THEY'RE NOT USEFUL AT ALL, THEY WERE MADE JUST TO ENRICH PHARMACEUTICAL COMPANIES.

THE ONLY SEROTONINERGIC EXCEPTION: [ISPOILER]psilocybe cubensis Mexican B+[/ISPOILER]


</end of thread>
based based based.
serotonin is horrible, it makes men incompetent and submissive, it makes you emotional and weak-willed, easily bent.
also, cyproheptadine is a weak anti-androgen, just keep that in mind.
 
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based based based.
serotonin is horrible, it makes men incompetent and submissive, it makes you emotional and weak-willed, easily bent.
also, cyproheptadine is a weak anti-androgen, just keep that in mind.
Doesn't seratonin make you emotionally and pleasure numb? Thats why people using ssri are numb af
 
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Doesn't seratonin make you emotionally and pleasure numb? Thats why people using ssri are numb af
the typical SSRI user is a morbidly obese diabetic single mother that thinks being gloomy because she regrets not shoving a coat hanger up her meat roast pussy when she was 30 means she's depressed.

but all jokes aside, SSRIs are dogshit, if they don't placebo you out of your depression, they'll end up downregulating your 5-HT receptor family and when you discontinue the drug you'll be back at square one, not only that but during the time that you're voluntarily flooding your brain with serotonin, you'll lose your libido, ability to form an erection and you won't be able to cum, serotonin also depletes your brain of dopamine. Put two and two together.
 
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the typical SSRI user is a morbidly obese diabetic single mother that thinks being gloomy because she regrets not shoving a coat hanger up her meat roast pussy when she was 30 means she's depressed.

but all jokes aside, SSRIs are dogshit, if they don't placebo you out of your depression, they'll end up downregulating your 5-HT receptor family and when you discontinue the drug you'll be back at square one, not only that but during the time that you're voluntarily flooding your brain with serotonin, you'll lose your libido, ability to form an erection and you won't be able to cum, serotonin also depletes your brain of dopamine. Put two and two together.
So whats best to do if you feel lethargic every day, can't feel that much pleasure from mundane things, and just bored of life?
 
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So whats best to do if you feel lethargic every day, can't feel that much pleasure from mundane things, and just bored of life?
I'm not an expert, at all, but the first thing I'd suggest that you do is completely cut off pornography (if you already haven't), don't masturbate at all, go at least 90 days without fapping or watching any porn, that's enough to rejuvenate your dopamine receptors, you then need to calibrate your reward pathways to be susceptible to activities that wouldn't have given you a rush of dopamine, reading? studying? focusing on a career path? etc.

just by quitting porn and masturbation, you'll notice a difference, i've dabbled here and there with drugs, specifically dopamine receptor agonists like cabergoline and bromocriptine, both made me hyper-sexual and addicted to porn (because of my un-calibrated reward pathways) whilst barely improving my mood and motivation.
 
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I'm not an expert, at all, but the first thing I'd suggest that you do is completely cut off pornography (if you already haven't), don't masturbate at all, go at least 90 days without fapping or watching any porn, that's enough to rejuvenate your dopamine receptors, you then need to calibrate your reward pathways to be susceptible to activities that wouldn't have given you a rush of dopamine, reading? studying? focusing on a career path? etc.

just by quitting porn and masturbation, you'll notice a difference, i've dabbled here and there with drugs, specifically dopamine receptor agonists like cabergoline and bromocriptine, both made me hyper-sexual and addicted to porn (because of my un-calibrated reward pathways) whilst barely improving my mood and motivation.
I fap 3 times everyday on cuck porn, is this indeed bad??
 
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you're joking, right? please say yes.
Larp, but i do fap 3 times to beastiality, scat, pregnant gangbang, hijab porn etc. My dopamine receptors are extremely fried from porn use for years that i can't get a good hit on vanilla porn, i need some bizarre shit to get some dopamine.
Will try to quit from today completely
 
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but i do fap 3 times to beastiality, scat, pregnant gangbang, hijab porn etc.
jesus fucking christ.
it's over if you're onto scat porn and pregnant women. And you wonder why you have anhedonia?
 
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jesus fucking christ.
it's over if you're onto scat porn and pregnant women. And you wonder why you have anhedonia?
I know, but the dopamine hit is soo good, from today i will cut every porn forever, its very hard tho, don't know what to do
 
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I know, but the dopamine hit is soo good, from today i will cut every porn forever, its very hard tho, don't know what to do
just don't watch it, that simple.
after a week you'll feel so much better, it's just once you relapse the hit of dopamine is 10000x stronger because you've given your receptors the opportunity to resensitize
 
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just don't watch it, that simple.
after a week you'll feel so much better, it's just once you relapse the hit of dopamine is 10000x stronger because you've given your receptors the opportunity to resensitize
Yeah remember when i did nofap and no porn once when i was 15 (back then i was full of life and energy) and after two weeks it hit a peak and holy shit it felt very bad i felt extremely horny that i started to download Skyrim sexy mods and make a female character with a big as and boobs and prostitute her so she gets fucked, got a huge boner the whole time it felt like i was on a drug after i relapsed, i felt incredible, porn is literally like meth
 
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I remember reading a few studies on the effect of cyproheptadine on hormones. If my memory doesn't cuck me it's weak anti androgenic mechanism are only by suppressing adrenal glands, the studies were made mostly in women with adrenal diseases such hirsutism, by this mechanism it blocks cortisol, Wich is good, adrenal glands androgens have some drawbacks and may be more effective at giving you a high noorwood number. They are kinda irrelevant, the amount barely make a difference, your androgens should come from the testicles, which cypro probably increase. Paradoxically it can increase prolactin in some but it's kinda rare to happen. (Idk if you already know all the shit on adrenals but it's better explain anyway)


I sincerely think that this porn dopamine connection is a bunch of broscience and likely irrelevant. Just take zinc and b6 and you will get at least several fold more dopamine than nofap.

I fapped 10 times before lab tests on the results my prolactin very low (5, Wich is the lower end of reference) I wasn't even taking anything so one more proff that nofap is bullshit. Masturbation reduce cortisol, anxiety, depression and increases overall well being.

@TsarTsar444
 
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I've only took them for a year and they ruined my libido. I used to not be able to go through a day without fapping, now I can do nofap for weeks like it's nothing.
 
1. Antidepressants are no more effective than placebo for mild-to-moderate depression;
2. In fact, studies have demonstrated that as many as 85% of people recover spontaneously from depression.
Interesting . What about combining SSRIs with a lift weighting program and a diet that promotes fat loss and muscle growth?
I've only took them for a year and they ruined my libido. I used to not be able to go through a day without fapping, now I can do nofap for weeks like it's nothing.
Did they help with your depression and anxiety ?
Doesn't seratonin make you emotionally and pleasure numb? Thats why people using ssri are numb af
They increase serotonin levels.
 
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Ssri is legit u broscientist foilhat

but not good if they lower ur libido.
 

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