Metformin as an anti-aging supplement.

[Deleted member 275]

It's prescribed in a high dosage for diabetes-patients. But in a low dosage, supposedly, it is great for anti-aging:

Metformin: A Hopeful Promise in Aging Research

Even though the inevitable process of aging by itself cannot be considered a disease, it is directly linked to life span and is the driving force behind all age-related diseases. It is an undisputable fact that age-associated diseases are among the leading ...

www.ncbi.nlm.nih.gov

'Food intake and body weight are decreased as a result of a direct action of metformin on the hypothalamic centers regulating satiety and feeding; it may also influence metabolic and cellular processes associated with the development of chronic conditions of aging, including inflammation, fatty liver, oxidative damage, protein glycation, cellular senescence, diminished autophagy, apoptosis, and development of several types of cancer.
A number of recent studies support the role of metformin in improving health span and life span in different animal models.The possibility exists, therefore, for similar beneficial actions of metformin in human health and longevity.'

Thoughts?

@eduardkoopman do you use this?

 

[BearBoy]

side effects?

 

[damnit]

yes, it's an alternative to fasting/caloric restriction as an ampk activator (but not as good). It could also lower test levels though anecdotally and lower b12 after taking it it over the years .The TAME trial is studying its anti aging properties.

 

[eduardkoopman]

It's prescribed in a high dosage for diabetes-patients. But in a low dosage, supposedly, it is great for anti-aging:

Metformin: A Hopeful Promise in Aging Research

Even though the inevitable process of aging by itself cannot be considered a disease, it is directly linked to life span and is the driving force behind all age-related diseases. It is an undisputable fact that age-associated diseases are among the leading ...

www.ncbi.nlm.nih.gov

'Food intake and body weight are decreased as a result of a direct action of metformin on the hypothalamic centers regulating satiety and feeding; it may also influence metabolic and cellular processes associated with the development of chronic conditions of aging, including inflammation, fatty liver, oxidative damage, protein glycation, cellular senescence, diminished autophagy, apoptosis, and development of several types of cancer.
A number of recent studies support the role of metformin in improving health span and life span in different animal models.The possibility exists, therefore, for similar beneficial actions of metformin in human health and longevity.'

Thoughts?

@eduardkoopman do you use this?

at 1st glance looks interesting.
I never used it. Nor recall reading up on it, investigating it.
So I have nothing to say about this, since I don't know anything about it yet.

 

[Deleted member 275]

side effects?

Dunno tbh. Quick googling:

Based on a 60-year history of use as an anti-diabetic drug for the treatment of T2DM, metformin is accepted as a comparatively safe drug.

a dependence on the use of metformin as a prophylactic to delay aging could serve to decrease the incentive to pursue the proven benefits of lifestyle changes such as improved diet and exercise.

long-term chronic use of metformin would require attention to the potential occurrence of vitamin B12 deficiency

couldnt find any real negatives tbh. Most arguments against metformin were saying that lazy people could use this instead of healthy diet+exercise, and therefore lose the positive side-effects of those things as a result. Since with metformin it becomes easy to stay a healthy bodyweight so people stop exercising and watching their diet.

 

[PURE ARYAN GENETICS]

side effects?

not many sides supposedly

 

[BearBoy]

Dunno tbh. Quick googling:



couldnt find any real negatives tbh. Most arguments against metformin were saying that lazy people could use this instead of healthy diet+exercise, and therefore lose the positive side-effects of those things as a result. Since with metformin it becomes easy to stay a healthy bodyweight so people stop exercising and watching their diet.

cant this shit lower IGF?

 

[Deleted member 275]

cant this shit lower IGF?

no idea tbh. I know MorePlatesMoreDates takes it aswell as a health supplement.

 

[damnit]

bump

"
By way of example, however, let us examine more closely the mechanisms of
mitochondrial damage associated with one of the most popularly prescribed
medications worldwide, metformin.165 Metformin, prescribed for type 2 diabetes,
effectively blocks dietary thiamine uptake by acting as a thiamine transporter
inhibitor.166 This means that while metformin is present, the SLC transporters
will preferentially pull metformin into the mitochondria instead of thiamine and
all of those processes dependent upon thiamine will be starved. Metformin’s
actions on the thiamine transporters are in addition to its depletion of vitamin
B12,167 which impairs homocysteine metabolism,168 the derailment of
mitochondrial complex I activity, presumably by depleting the CoQ10 crucial to
electron transport, and the depletion of folate.169 The net effects of metformin are
damaged and inefficient mitochondria that produce up to 48% less ATP,170
leaving those who take the drug with a reduced oxidative capacity171; a reduction
of exercise-induced insulin sensitivity (by up to 54%172); an increase in
mitochondrial uncoupling; and at the cell level an increased propensity for
Warburg-like reallocation of resources. In other words, the energetic stress
caused by metformin leads to compensatory reactions consistent with those in
tumorogenesis.173 Consider the implications of a drug that effectively derails
mitochondrial functioning prescribed to at least 49 million Americans
annually174; individuals that because of diet and sometimes latent genetic
factors175 already bear a degree of mitochondrial damage176 and thiamine
deficiency.177,178 From that perspective, metformin seems contraindicated, despite
its ability to lower circulating glucose. The comorbid conditions that plague
many metformin users, physical and mental fatigue, myalgia, neuropathy,
cognitive decline, and heart rate irregularities, represent not separate disease
processes but manifestations of mitochondrial decline with beriberi and
dysautonomic function as the underlying cause."

as @Seth Walsh puts it, metformin seems to be a cop-out substance ,essentially a lazy way out.. this excerpt is taken from

Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition​

Derrick Lonsdale, Chandler Marrs

 

[Whatashame]

metformin is exactly the opposite as an anti aging supplement. It makes you age faster.