obbs
Iron
- Joined
- Oct 24, 2025
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What's your experience with methylphenidate (Medikinet/Ritalin/Concerta) while on GLP-1 peptides like tirzepatide (Mounjaro/Zepbound), semaglutide (Ozempic/Wegovy) or retatrutide? I started 10 mg methylphenidate retard (extended release) about 5 days ago, and I barely feel any effect. it seems super delayed or weak. I suspect it's because of the delayed gastric emptying from the GLP-1 (I'm on tirzepatide right now). Does anyone else have this? Did switching to immediate release (IR) help, or do you just need a higher dose? Or is the combo just not great overall?