Minoxidil non-responders gtfih

[FootLongDong]

(Excuse my bad English niggas)

The main takeaway of the video below is:

Minoxidil is not the compound which promotes hairgrowth, but minoxidilsulfat

Minoxidil nonresponder have low enzymeactivity therefore no minoxidil gets converted

The solution:
tretinoin elevates enzymeactivity therefore the conversion of minoxidil. It even made minoxidil non responders to responders in less than a week of usage (proven in different studies)

My Opinion:
Tretinoin (aka Retin-A) may be hard to get( in Pharma-great quality )
That’s why you should work with Retinaldehyd(the pre form of tretinoin and available without prescription and equally as effektiv as tretinoin)
Or the pre-pre form of tretinoin Retinol which is far less effective but will still have a great effect.



Im open for discussions and leave your opinion below.

 

[hairyballscel]

great info tbh, bookmarked

 

[goat2x]

good thread
my problem with minox is the extreme skin side effects

 

[Deleted member 6217]

good thread
my problem with minox is the extreme skin side effects

i fucking hate it its the only reason preventing me from using it

 

[goat2x]

i fucking hate it its the only reason preventing me from using it

Yeah we are on the same boat brother
I look like a zombie when i use it

 

[Deleted member 6217]

Yeah we are on the same boat brother
I look like a zombie when i use it

just get fringe haircut and get a ht

 

[goat2x]

just get fringe haircut and get a ht

I need it for eyebrows bro

 

[Deleted member 6217]

I need it for eyebrows bro

eyebrow transplant is like 1k

 

[goat2x]

eyebrow transplant is like 1k

Nah nigga it aint that bad
I just want to do every soft max possible

 

[Zeta ascended]

Looks like it's worth a try. I used mminoxidil for beard for like 9 months with some pretty shitty results.

 

[DrTony]

(Excuse my bad English niggas)

The main takeaway of the video below is:

Minoxidil is not the compound which promotes hairgrowth, but minoxidilsulfat

Minoxidil nonresponder have low enzymeactivity therefore no minoxidil gets converted

The solution:
tretinoin elevates enzymeactivity therefore the conversion of minoxidil. It even made minoxidil non responders to responders in less than a week of usage (proven in different studies)

My Opinion:
Tretinoin (aka Retin-A) may be hard to get( in Pharma-great quality )
That’s why you should work with Retinaldehyd(the pre form of tretinoin and available without prescription and equally as effektiv as tretinoin)
Or the pre-pre form of tretinoin Retinol which is far less effective but will still have a great effect.



Im open for discussions and leave your opinion below.

Have you looked at the actual raw data? Not the abstract. The data.

I am shocked at the stupidity of people not taking initiative and instead relying on some dude who said something on youtube.

 

[FootLongDong]

Have you looked at the actual raw data? Not the abstract. The data.

I am shocked at the stupidity of people not taking initiative and instead relying on some dude who said something on youtube.

You seem to thinking high of yourself but it seems you dont know what you’re talkin about I saw the whole video and analyzed it myself also more plates more dates is always high quality

Dumb people like you always think they re the smartest cuz you re never confronted with things you can’t possibly solve

Don’t bother answering you’re now on my ignore list

 

[DrTony]

Well if you look at the table with the raw data on that tretinoin paper, you would be WAAAAAAAAY less excited.
And if you were a MX responder in the first place, tret may actually decrease it.

 

[Gonion]

And if you were a MX responder in the first place, tret may actually decrease it.

Why?

 

[DrTony]

Why?

Who knows. No explanation given. Just the table with the data from the participants. Lots of the participants who had good minox sensitivity score before taking tret saw their score tank (halved) after applying tret. This is downplayed or outright omitted in the abstract! It may be that tretinoin merely modulates (not increases per se) sulfotransferase enzymes.

 

[FootLongDong]

Why?

Because of high level ignorance and arrogance from an low iq incel in who’s information/posts I’m no longer interested whatsoever

 

[Gonion]

Who knows. No explanation given. Just the table with the data from the participants. Lots of the participants who had good minox sensitivity score before taking tret saw their score tank (halved) after applying tret. This is downplayed or outright omitted in the abstract! It may be that tretinoin merely modulates (not increases per se) sulfotransferase enzymes.

Can you post the study link?

 

[DrTony]

Can you post the study link?

Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes - PubMed

Minoxidil sulfate is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil. For hair growth, sulfotransferase enzymes expressed in outer root sheath of the hair follicle sulfonate minoxidil. The large intra-subject variability in follicular...

pubmed.ncbi.nlm.nih.gov

Go to Table 1


TABLE 1 The value of the Minoxidil Response Test (MRT) and
the predicted minoxidil response of each subject (R, responder; NR,
nonresponder) before and after 5-day application of 0.1% tretinoin
Baseline 5 day tretinoin
Subject ID MRT Response MRT Response
1 0.082 NR 0.079 NR
2 0.221 NR 0.282 NR
3 0.250 NR 0.425 R
4 0.290 NR 0.575 R
5 0.310 NR 0.277 NR
6 0.324 NR 0.412 R
7 0.343 NR 0.383 NR
8 0.419 R 1.042 R
9 0.433 R 0.405 R
10 0.439 R 0.487 R
11 0.495 R 0.615 R
12 0.558 R 0.538 R
13 0.605 R 1.077 R
14 0.678 R 0.459 R
15 0.766 R 0.365 NR
16 0.806 R 0.743 R
17 0.968 R 0.493 R
18 1.033 R 1.008 R
19 1.158 R 0.861 R
20 1.203 R 1.082 R

 

[Gonion]

Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes - PubMed

Minoxidil sulfate is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil. For hair growth, sulfotransferase enzymes expressed in outer root sheath of the hair follicle sulfonate minoxidil. The large intra-subject variability in follicular...

pubmed.ncbi.nlm.nih.gov

Go to Table 1


TABLE 1 The value of the Minoxidil Response Test (MRT) and
the predicted minoxidil response of each subject (R, responder; NR,
nonresponder) before and after 5-day application of 0.1% tretinoin
Baseline 5 day tretinoin
Subject ID MRT Response MRT Response
1 0.082 NR 0.079 NR
2 0.221 NR 0.282 NR
3 0.250 NR 0.425 R
4 0.290 NR 0.575 R
5 0.310 NR 0.277 NR
6 0.324 NR 0.412 R
7 0.343 NR 0.383 NR
8 0.419 R 1.042 R
9 0.433 R 0.405 R
10 0.439 R 0.487 R
11 0.495 R 0.615 R
12 0.558 R 0.538 R
13 0.605 R 1.077 R
14 0.678 R 0.459 R
15 0.766 R 0.365 NR
16 0.806 R 0.743 R
17 0.968 R 0.493 R
18 1.033 R 1.008 R
19 1.158 R 0.861 R
20 1.203 R 1.082 R

Thank you. It seems that for values over 0.5 tretinoin worsens the enzimatic activity. Incredible that even in the whole study they don't properly highlight this

 

[DrTony]

Thank you. It seems that for values over 0.5 tretinoin worsens the enzimatic activity. Incredible that even in the whole study they don't properly highlight this

0.4 was the cutoff differentiating R and NR

 

[Gonion]

0.4 was the cutoff differentiating R and NR

Yes I know. The 0.4-0.5 range is where you have a very small response to minoxidil that will be enhanced by tretinoin

 

[Zeta ascended]

Tretinoin (aka Retin-A) may be hard to get( in Pharma-great quality )
That’s why you should work with Retinaldehyd(the pre form of tretinoin and available without prescription and equally as effektiv as tretinoin)
Or the pre-pre form of tretinoin Retinol which is far less effective but will still have a great effect.

You can get powdered tretinoin from this site. I'm tryna figure out if I could just dump like 7 grams of the powder to a 60 ml minoxidil bottle to get around a .01 solution that works.
https://nootropicsunlimited.com/product/tretinoin-powder-500mg