MK-677; LUM-201; L-163,191; MEGA-THREAD (Revealing the truth)

[rsj]

The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

 

[brotato78]

dnr

 

[bluebandz]

dnr heavily mirin effort tho so i will leave u a rep. Here’s the thing though. MK does not increase insulin senseitivyt, i think you meant resistance. It also bloats u hella.
and as for gaining muscle it barely does anything ive had friends who took it. It doesn’t do much.

 

[rsj]

dnr heavily mirin effort tho so i will leave u a rep. Here’s the thing though. MK does not increase insulin senseitivyt, i think you meant resistance. It also bloats u hella.
and as for gaining muscle it barely does anything ive had friends who took it. It doesn’t do much.

corrected, and anecdotal evidence can be shaky but, yeah some people just wont respond perfectly to a compound, it happens even with simple things like creatine. some people say its pretty helpful, some say it does nothing.

 

[bluebandz]

corrected, and anecdotal evidence can be shaky but, yeah some people just wont respond perfectly to a compound, it happens even with simple things like creatine. some people say its pretty helpful, some say it does nothing.

Agreed. Overall I wouldn’t use it or reccomend anyone to use it but it does SOMETHING. Very high iq thread.

 

[N4rco]

BUMP

 

[cpedy]

View attachment 5264199The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

What’s your thoughts on 15mg a day as I’m really seeking the appetite effect I’m already tall. Also the bottle I got is 60 15mg pills

 

[rsj]

What’s your thoughts on 15mg a day as I’m really seeking the appetite effect I’m already tall. Also the bottle I got is 60 15mg pills

mk-677 is cool but not extremely powerful, it would just likely do less on you but you still can get benefits from it.

 

[Shirobon]

View attachment 5264199The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

havent heard about ts in awhile
definitely interesting seeing it be brought back up again

 

[Hollywood]

Does MK affect hunger ?

 

[AG_pilled]

agonist of the ghrelin receptor

Does MK affect hunger ?

Yes, literally in the first line brotocycle .

 

[Hollywood]

Yes, literally in the first line brotocycle .

dnr

 

[jstmarlin]

View attachment 5264199The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

its quite expensive where I live, would 12.5mg maybe 3x a week be any good?

 

[rsj]

its quite expensive where I live, would 12.5mg maybe 3x a week be any good?

no sorry bro that dose is too low

 

[r3taboy]

im on mk 667 right now 25 mg/day ive seen a little improvement in muscle mass so far (around 20 days in one cpasule per day)

 

[Dolorous]

Bump. Hoping you're right, OP. Lots of disagreement over this thing and I hate the feeling of confliction when it comes to shit like this.

Might be slightly better if you include a number of sources, just a suggestion though

 

[N4rco]

View attachment 5264199The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

View attachment 5264199The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

I’m planning on hopping on MK-0677 for 120 days (25 MG every evening) +Vitamin E and p5p vitamin b6 so I don’t nuke my hormones from the prolactin spikes should I document it?

 

[rsj]

I’m planning on hopping on MK-0677 for 120 days (25 MG every evening) +Vitamin E and p5p vitamin b6 so I don’t nuke my hormones from the prolactin spikes should I document it?

it's not that deep but sure

 

[jstmarlin]

no sorry bro that dose is too low

im just worried about insulin getting fucked. would running it eod be alr

 

[AtrophicPyra]

View attachment 5264199The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

mk677 is shit you didnt do enough research

 

[rsj]

mk677 is shit you didnt do enough research

you didn't do enough research. the research is very promising. now although personal use has left me a bit disappointing but its not going to change your life over night yk.

 

[AtrophicPyra]

you didn't do enough research. the research is very promising. now although personal use has left me a bit disappointing but its not going to change your life over night yk.

yk what ur right abt it indirectly supporting muscle growth, some direct like the increase of serum igf1 levels as u said,

but it was proven in a study to not aid in final adult height, i dont remember the study name but if u look hard enough youll find it

 

[Trenscension]

It makes you gain more mass and muscle

Running it solo won't, increased igf-1 won't do shit unless paired with an aas base. Even hgh monotherapy, which is FAR more potent than mk, has been revealed to cause negligible growth. The difference in serum igf-1 levels mk actually offers is comparable to someone with slightly better genetics, you're very unlikely to even be pushed outside of the natural range on mk.

It makes you taller

Any amount of igf-1 won't make you grow past your genetic baseline, it will just let you reach that final height quicker. This has been well documented for years lol

Overall shit thread, you know nothing op

 

[rsj]

Running it solo won't, increased igf-1 won't do shit unless paired with an aas base. Even hgh monotherapy, which is FAR more potent than mk, has been revealed to cause negligible growth. The difference in serum igf-1 levels mk actually offers is comparable to someone with slightly better genetics, you're very unlikely to even be pushed outside of the natural range on mk.

Any amount of igf-1 won't make you grow past your genetic baseline, it will just let you reach that final height quicker. This has been well documented for years lol

Overall shit thread, you know nothing op

a shit thread doesn’t get this many reps. a shit thread does not remain relevant for this long. i didn’t even claim it would make you taller past your genetic baseline using it alone.

 

[lowltn14]

ill read this later promising thread though, I think mk definetly has its use cases

 

[Ishaked829]

good thread, very high effort

 

[poopmakser49]

View attachment 5264199The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

I’m 15 and around like 5,7.1 rn, mom is 5,10 and dad’s 5,11. I see a lot of people say mk is cope and you’d be better off taking HGH. Tho im worried about storage etc, Id have to go through a very large extra length to get HGH and use it. Also, the sides of mk seem way better compared to those of HGH, and since it’s oral. Do you think it would be worth it for me?
edit: should also probably mention my puberty has been late as fuck and really weird, wasn’t able to do certain things until like mid 13, haven’t even started growing full armpit hair yet, though it’s coming more in. And mustache hair etc is really thin. Was like 5,5 in december and grew to 5,6 by feb.

 

[noober]

Bump

 

[Jaotheltn]

im just worried about insulin getting fucked. would running it eod be alr

i used 15 mg a day for like a month, my bloodsugar shot up to 103ng/dl LMAOO, but i started doing like 30 minutes of walking and 30 minutes of running cardio and also upped dose to 30mg a day, and my levels went back down to 80 range, as long as you do a lot of cardio your blood sugar wont be too fucked, plus just dont eat a lot of sugar which isnt hard to not do

 

[jstmarlin]

i used 15 mg a day for like a month, my bloodsugar shot up to 103ng/dl LMAOO, but i started doing like 30 minutes of walking and 30 minutes of running cardio and also upped dose to 30mg a day, and my levels went back down to 80 range, as long as you do a lot of cardio your blood sugar wont be too fucked, plus just dont eat a lot of sugar which isnt hard to not do

Awesome then thanks bro mirin the 103ng/dl

 

[rsj]

View attachment 5264199The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

bump

 

[apkhaza]

View attachment 5264199The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

I have 461 ug/l of igf-1 should i start mk? Or will it close it too early

 

[rsj]

I have 461 ug/l of igf-1 should i start mk? Or will it close it too early

probably not bro you should be fine

 

[rsj]

View attachment 5264199The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

bump

 

[l4one]

View attachment 5264199The most misunderstood compound on Looksmax.org...

Ibutamoren also known as MK-677, MK-0677, LUM-201, L-163,191 or Oratrope is a orally-available micromolecule agonist of the ghrelin receptor and is also a growth hormone secretagogue, which mimics growth hormone in the brain and signals IGF-1.

Known benefits of the compound:

• It makes you gain more mass and muscle
• It makes you taller
• It gives you better sleep

Reasoning for the mass and muscle claim:

The initial bullet point is primarily supported by the article "Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure". The researchers gave the twenty-four obese males, aged 18–50 years old and eventually concluded "We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate." The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" the article concluded "Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated." The group contained 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age. The mass and muscle increase is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.​

Reasoning for the height claim:

The second bullet point is primarily supported by the article "Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children". The researchers gave the eighteen prepubertal children, aged around 10 years old and eventually concluded "We conclude that short-term administration of ibutamoren mesylate can increase GH, IGF-I, and IGFBP-3 levels in some children with GH deficiency. Thus this compound is applicable for testing its effect on growth velocity". The researchers were able to quickly see a massive impact on the group. The second proof for this claim is titled "Lumos Pharma Announces Encouraging Interim Results from Two Phase 2 Trials Evaluating Oral LUM-201 for Moderate Pediatric Growth Hormone Deficiency".
In the Phase 2 OraGrowtH210 trial, children with moderate growth hormone deficiency taking oral LUM-201 achieved a remarkable annualized height velocity of 8.2 to 8.6 cm/year over a 6-month period. This high 6-month growth rate successfully matched the height increases typically seen with standard daily growth hormone injections, proving the oral drug's strong effectiveness for height growth.
The height increase claim is also heavily supported by the simple premise of heightened IGF-1 leading to increased height with open growth plates and is supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

Reasoning for the sleep claim:

The third bullet point is primarily supported by the article "Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man". The researchers gave young adults and older adults high-dose MK-677 and eventually concluded "The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence". The researchers were able to quickly see a massive impact on the groups, with young subjects experiencing an approximately 50% increase in stage IV sleep and more than a 20% increase in REM sleep, while older adults saw a nearly 50% increase in REM sleep and decreased REM latency. The better sleep claim is also heavily supported by anecdotal claims across this forum, bodybuilding and "biohacking" communities.
​

FAQ: Can this compound close my growth plates early?
MK-677 doesn't interact with testosterone or estrogen (which signals growth plate closure). Theoretically if the IGF-1 signalling was too high it could close it too early but the MK-677 is just not strong enough at the signalling to do that and has never been reported or seen via MK-677.

What are the side effects?
The only real side effect is heightened insulin resistance. MK-677 consistently reduces insulin resistance and increases fasting blood glucose levels. This can be mitigated with supplements like berberine (although it can potentially decrease some of the IGF-1 signalling), Chromium picolinate or ALA (alpha-lipoic acid). You can also mitigate it by simply not taking the supplement for extended periods or breaks. Monitoring your blood pressure is recommenced (although not necessary IN MY OPINION for most people taking it, especially in small doses short term, this isn't medical advice please don't sue me). MK-677 is pretty unlikely to damage your general health especially if you take breaks and mitigate the side effects via supplements. Minor side effects and potential/theoretical ones are: Water retention and swelling (minor), moderate muscle and joint pain, numbness, and tingling (minor), increased cancer tumor growth (theoretical, has never been seen before and is caused by the general growth hormone being released throughout the whole body and would only effect you if you already have a cancer tumor in your body), and if your susceptible to congestive heart failure there's a likelihood your rate of heart failure would increase when taking this because of a study with elderly individuals showing this happening.

Can this increase my height?
If your growth plates are open it probably can. Kids and teens with short stature were given this with only moderate to mild GH deficiency and grew 8.2cm-8.5cm (~3.3 inches) in only 6 months. Even if you have normal GH levels the overall increase of GH would still be beneficial for height, especially if taken long term. Like I said earlier, this claim is also supported by the sheer amount of anecdotal evidence.

Does MK-677 actually build muscle and strength?
It increases fat-free mass (lean body mass) by boosting GH and IGF-1 levels. In a 12-month study, users gained about 1.1 kg of fat-free mass while the placebo group lost mass. It is also highly anti-catabolic, meaning it reverses nitrogen wasting and helps prevent muscle breakdown. However, while it makes you hold more intracellular water and lean mass, studies haven't proven that it significantly increases raw physical strength or functional gym performance. It will make you look bigger and fuller, but it doesn't build contractile muscle tissue the way anabolic steroids or SARMs do.

Will it help with my sleep?
Yes, sleep improvement is one of the most consistently proven benefits in clinical trials. A study showed that prolonged oral treatment with MK-677 increased Stage IV (deep) sleep by about 50% and REM sleep by more than 20% in young adults. Older adults also saw a nearly 50% increase in REM sleep. Because growth hormone is naturally secreted during deep sleep, the compound significantly enhances overall sleep architecture, leading to much better physical and neurological recovery.

What's the best dosing?
The most common amount in studies is one 25 mg capsule a day. Although due to heightened insulin resistance I personally think taking one before you go to the gym, and if your not going to the gym that day, just skip the dose.

What happens when I stop taking it?
Your IGF-1 levels will return to baseline, and you'll probably lose a couple pounds of water-weight. Nothing crazy, really.

Is it cope?
Nope definitely not, and it can lead to growth, muscle gain and better sleep across your whole body.

Conclusion:
Ultimately, MK-677 is one of the most interesting, underrated, overhated and well-researched compounds out there for biohacking your GH/IGF-1 axis. Whether your goal is to squeeze out extra height and trying to avoid being a manlet, pack on some extra lean mass and water fullness, or just get the best deep sleep of your life, both the clinical trials and years of anecdotal evidence show that it works. It's not a SARM or the most powerful thing for growth but interesting to say the least. Stay safe, and I hope you enjoyed reading.

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