Modern medicine cannot solve my disease...

[gargomel]

They don't know what causes my disease and they have no idea. I only receive symptom suppression treatments. Opinions?

 

[asdvek]

Modern medicine is jew poison

 

[gargomel]

Modern medicine is jew poison

I'm alive thanks to antibiotics I disagree

 

[theotheg]

I'm alive thanks to antibiotics I disagree

they are only prolonging your death just to spit in your face, repent and believe in the gospel

 

[ChimpBall]

What is your disease

 

[gargomel]

What is your disease

Ulcerative colitis

 

[asdvek]

I'm alive thanks to antibiotics I disagree

nuking gut microbiome

 

[gargomel]

nuking gut microbiome

Would you rather die from infection than your gut microbiome?

 

[asdvek]

Would you rather die from infection than your gut microbiome?

you need to find out what causes the disease in the first place

 

[ChimpBall]

Ulcerative colitis

 

[averagenormie]

They don't know what causes my disease and they have no idea. I only receive symptom suppression treatments. Opinions?

What is your disease?

 

[gargomel]

What is your disease?

Ulcerative colitis

 

[gargomel]

View attachment 3394317

Imagine removing an organ from your body and still not getting any closer to your healthy life.

 

[averagenormie]

Ulcerative colitis

Unfortunately the only cure is surgery, otherwise eat low fiber and low dairy

 

[gargomel]

Unfortunately the only cure is surgery, otherwise eat low fiber and low dairy

Actually, it has nothing to do with eating or drinking because it is an immune system disorder, but when the intestine heals, I can eat anything and I am very curious about why I got this disease. I hope one day we will find the reason.

 

[averagenormie]

Actually, it has nothing to do with eating or drinking because it is an immune system disorder, but when the intestine heals, I can eat anything and I am very curious about why I got this disease. I hope one day we will find the reason.

some foods may still trigger symptoms, diet impacts gut health, which is tied to disease progression

 

[gargomel]

some foods may still trigger symptoms, diet impacts gut health, which is tied to disease progression

What do you think is the cause of this disease?

 

[mfk]

Actually, it has nothing to do with eating or drinking because it is an immune system disorder, but when the intestine heals, I can eat anything and I am very curious about why I got this disease. I hope one day we will find the reason.

just get the surgery you high inhib skank

ppl will get ccw rotations and limb lengthening (both of which are not typically medically necessary) to looksmax but you won’t get a medically incentivized surgery to treat your autoimmune disease, which is likely caused by a mix of environmental + hereditary reasons from your shitty genetics

then you’ll blame modern medicine for it jfl

 

[gargomel]

just get the surgery you high inhib skank

ppl will get ccw rotations and limb lengthening (both of which are not typically medically necessary) to looksmax but you won’t get a medically incentivized surgery to treat your autoimmune disease, which is likely caused by a mix of environmental + hereditary reasons from your shitty genetics

then you’ll blame modern medicine for it jfl

If surgery was a good thing, everyone would have surgery in the first place and be saved, but we use dozens of medications before surgery.

 

[mfk]

If surgery was a good thing, everyone would have surgery in the first place and be saved, but we use dozens of medications before surgery.

Why would anyone want surgery as a first option? It’s incredibly invasive and presents risks. If you could treat the condition and improve quality of life of medication beforehand, then that is logically the better choice.

But anyways, have fun suffering eating food and not knowing whether or not you’ll be on the toilet in pain for the days after, all because you’re too pussy to get the surgery you need

 

[mfk]

What do you think is the cause of this disease?

shitty lifestyle + environment + bad genetics

 

[JohnDoe]

Give @Rigged a pm, maybe he knows something that might help.

 

[(In)CelibatePsycho2]

I’m glad I don’t have this disease
Or really any desease

 

[gargomel]

shitty lifestyle + environment + bad genetics

Considering that athletes also get it, I don't think it is due to lifestyle, but I definitely agree with the genetics part because there are other autoimmune diseases in my family.

 

[Whatever]

Imagine removing an organ from your body and still not getting any closer to your healthy life.

Not all colectomies remove the entire colon, I myself have had a partial colectomy and am completely normal now, actually better because it was too long before. If you can get only the ulcerated part of yours removed, that would be ideal.

 

[gargomel]

I’m glad I don’t have this disease
Or really any desease

lol I was also seeing news about this disease, then I caught this disease and I had no health problems before.

 

[gargomel]

Not all colectomies remove the entire colon, I myself have had a partial colectomy and am completely normal now, actually better because it was too long before. If you can get only the ulcerated part of yours removed, that would be ideal.

The colon needs to be completely removed because the disease will recur.

 

[mfk]

Considering that athletes also get it, I don't think it is due to lifestyle, but I definitely agree with the genetics part because there are other autoimmune diseases in my family.

lol buddy athletes get cancer too

Anyone can get anything and each person has a unique lifestyle. Just because someone is an athlete doesn’t mean they’re not doing drugs, smoking, or anything of that sort.

Being an athlete doesn’t automatically mean a good lifestyle. They have a far better than average lifestyle in the vast majority of cases but you’re cherry-picking athletes to try and prove a false narrative that your disease has nothing to do with YOUR lifestyle, when it very well could.

 

[averagenormie]

What do you think is the cause of this disease?

Immune dysfunction and gut microbiome imbalance

 

[gargomel]

lol buddy athletes get cancer too

Anyone can get anything and each person has a unique lifestyle. Just because someone is an athlete doesn’t mean they’re not doing drugs, smoking, or anything of that sort.

Being an athlete doesn’t automatically mean a good lifestyle. They have a far better than average lifestyle in the vast majority of cases but you’re cherry-picking athletes to try and prove a false narrative that your disease has nothing to do with YOUR lifestyle, when it very well could.

You are telling me to have the intestines removed, but autoimmune diseases come in packages and are caused by similar genetic factors, and even if I have the intestines removed, it is very likely that I will get another autoimmune disease. What is your advice at this point?

 

[mfk]

You are telling me to have the intestines removed, but autoimmune diseases come in packages and are caused by similar genetic factors, and even if I have the intestines removed, it is very likely that I will get another autoimmune disease. What is your advice at this point?

Just because your faulty genetics may have played a role in developing ulcerative colitis does not mean you’ll definitively end up developing any other autoimmune disease??

You think removing your intestines will suddenly tell your body to activate another autoimmune disease? If that actually happens then it’s is actually so over for you, sorry.

 

[gargomel]

Just because your faulty genetics may have played a role in developing ulcerative colitis does not mean you’ll definitively end up developing any other autoimmune disease??

You think removing your intestines will suddenly tell your body to activate another autoimmune disease? If that actually happens then it’s is actually so over for you, sorry.

No, having my intestines removed is not a guarantee that another autoimmune disease will become active. But my immune system is stupid and tends to produce autoantibodies, and it's very common for people who have one autoimmune disease to also have other autoimmune diseases. Maybe you, too, may have an autoimmune disease one day. But I still think you're smart because everything you said made sense.

 

[mfk]

No, having my intestines removed is not a guarantee that another autoimmune disease will become active. But my immune system is stupid and tends to produce autoantibodies, and it's very common for people who have one autoimmune disease to also have other autoimmune diseases. Maybe you, too, may have an autoimmune disease one day. But I still think you're smart because everything you said made sense.

Yes it isn’t a guarantee. But that second condition may end up developing regardless of whether or not you get the surgery. And in the instance you don’t get the surgery, you’d live life suffering with full symptoms from both conditions.

In your shoes, if I were to end up developing a second autoimmune condition down the line, I’d take the chance to suppress and treat the first one in any case, just so that my quality of life isn’t as shit as it would be if I had to deal with both conditions in full force.

And yeah, I’ve had an autoimmune condition called Vernal Keratoconjunctivitis when I was a child up until my mid teens (6-15). It was 9 years of extensive suffering that almost made me go blind at multiple points throughout my childhood. I’m fortunate enough that the condition is known to go away as you grow older, and is now almost completely dormant for me. Luckily, my vision has healed and is basically perfect too. The reasons behind the disease developing in the first place is also fairly unknown.

And thank you for the compliment, I’m also enjoying this insightful discussion with you

 

[Rigged]

Give @Rigged a pm, maybe he knows something that might help.

@(In)CelibatePsycho2 whats so funny

Anything that could be a reasonable solution to UC doesnt exist yet, i could go for days reverse engineering UC the only solutions are the ones currently in testing, gargomel was just born a decade too early, also u missunderstand what UC is, its from an overactive immune response within the gut lamina propria caused by mutations in NOD2 or IL23R, but it can be weakned with anything that targets some specific immune pathways, with like IL-23 inhibitors or JAK-STAT signal mods, which as i said sadly are still in trial

The only thing i think anyone could add is that just cuz u think lifestyle isnt the issue, doesnt mean ur right UC could be from build up of environmental stressors like xenobiotics, antibiotics, microplastics, they all compromise the intestinal barrier. Even athletes can get dysbiosis from high protein or NSAIDs

 

[gargomel]

@(In)CelibatePsycho2 whats so funny

Anything that could be a reasonable solution to UC doesnt exist yet, i could go for days reverse engineering UC the only solutions are the ones currently in testing, gargomel was just born a decade too early, also u missunderstand what UC is, its from an overactive immune response within the gut lamina propria caused by mutations in NOD2 or IL23R, but it can be weakned with anything that targets some specific immune pathways, with like IL-23 inhibitors or JAK-STAT signal mods, which as i said sadly are still in trial

The only thing i think anyone could add is that just cuz u think lifestyle isnt the issue, doesnt mean ur right UC could be from build up of environmental stressors like xenobiotics, antibiotics, microplastics, they all compromise the intestinal barrier. Even athletes can get dysbiosis from high protein or NSAIDs

Did the genetic mutation happen later because I was healthy for decades?

 

[JohnDoe]

@(In)CelibatePsycho2 whats so funny

Anything that could be a reasonable solution to UC doesnt exist yet, i could go for days reverse engineering UC the only solutions are the ones currently in testing, gargomel was just born a decade too early, also u missunderstand what UC is, its from an overactive immune response within the gut lamina propria caused by mutations in NOD2 or IL23R, but it can be weakned with anything that targets some specific immune pathways, with like IL-23 inhibitors or JAK-STAT signal mods, which as i said sadly are still in trial

The only thing i think anyone could add is that just cuz u think lifestyle isnt the issue, doesnt mean ur right UC could be from build up of environmental stressors like xenobiotics, antibiotics, microplastics, they all compromise the intestinal barrier. Even athletes can get dysbiosis from high protein or NSAIDs

Well that fucking sucks. @gargomel unlucky buddy but that's the same for most diseases these days, they treat symptoms instead of the root cause. Most doctors are clowns who have more ego than knowledge.

 

[gargomel]

Well that fucking sucks. @gargomel unlucky buddy but that's the same for most diseases these days, they treat symptoms instead of the root cause. Most doctors are clowns who have more ego than knowledge.

Thanks bro. Yes, I am very unlucky. I am 18 years old and in the prime of my youth. I hope a cure can be found as soon as possible. I have faith in technology.

 

[Rigged]

Did the genetic mutation happen later because I was healthy for decades?

No they are there from the start, what changed is how those genes were triggered or expressed due to envirnment

Think of it like a switch ur gene predisposition is the switch, but then something in ur environment flipped it on, u couldve been healthy for years because ur body kept things balanced on ita own, then over time small stressors like gut infections, antibiotics disrupting your microbiome, or chronic inflammation from something as basic and “cope” as stress or diet built up and ended up overwhelming the balance which triggered ur immune system to overreact, which turned into UC

So the mutation didnt randomly appear it was always there all that was needed was a “right” combo of factors to start the disease. Thats y some people with the same genes never get UC

 

[gargomel]

No they are there from the start, what changed is how those genes were triggered or expressed due to envirnment

Think of it like a switch ur gene predisposition is the switch, but then something in ur environment flipped it on, u couldve been healthy for years because ur body kept things balanced on ita own, then over time small stressors like gut infections, antibiotics disrupting your microbiome, or chronic inflammation from something as basic and “cope” as stress or diet built up and ended up overwhelming the balance which triggered ur immune system to overreact, which turned into UC

So the mutation didnt randomly appear it was always there all that was needed was a “right” combo of factors to start the disease. Thats y some people with the same genes never get UC

How many years would you give for definitive treatment? Before I die I want to know why I got caught in this shit

 

[Rigged]

How many years would you give for definitive treatment? Before I die I want to know why I got caught in this shit

5-10 years to be able to identify what exactly kickstarted UC for the individual person, 10-20 years for CRISPR to be a definitive solution and treatment, even longer for it to be commonly available

 

[gargomel]

5-10 years to be able to identify what exactly kickstarted UC for the individual person, 10-20 years for CRISPR to be a definitive solution and treatment, even longer for it to be commonly available

Why do different medications work for everyone? For example, while anti-TNF works for me, it has no effect on anyone else. Could it be that diseases similar to ulcerative colitis are brought together under a single heading?

 

[IAMNOTANINCEL]

just eat raw meat, don't eat plants and supplement a lot of rotten meat
you take gut nuking antibiotics and wonder why you still have this shit?

 

[gargomel]

just eat raw meat, don't eat plants and supplement a lot of rotten meat
you take gut nuking antibiotics and wonder why you still have this shit?

Ironically I've only taken antibiotics twice in my life and it was years ago.

 

[IAMNOTANINCEL]

Ironically I've only taken antibiotics twice in my life and it was years ago.

but you still probably just kept eating like shit later so you couldnt replenish the gut bacteria after which is why youre still affected
the lack of bacteria is 100% making it worse or even causing it, my theory is that toxins and stressors reach your gut and there's nothing to fight them off

 

[Rigged]

Why do different medications work for everyone? For example, while anti-TNF works for me, it has no effect on anyone else. Could it be that diseases similar to ulcerative colitis are brought together under a single heading?

yeh its an issue on how we classify diseases, UC isnt one single disease, its a collection of conditions with similar symptoms, for some UC is driven by an overproduction of specific inflammatory cytokines like TNF-a, so anti-TNF drugs like infliximab work, then for another person the issue could be in IL-23 singlas or issues with T-cell reg, so a drug that targets those paths like IL-23 inhibitors work better, its like treating a fever the cause could be a bacterial infection, a virus, or an autoimm reaction, then theres gene mutations like in IL23R, NOD2, or ATG16L1 all of them affect how ur immune system responds to inflam, some could have a TNF-driven disease because of their genetics, while another person could have a fully different inflam path, to add to that environmental exposure (epigenetics) also change how those genes end up being expressed, which makes the disease even more individual

Then theres microbiome differences and immune system variability, but i wont get into those

 

[gargomel]

but you still probably just kept eating like shit later so you couldnt replenish the gut bacteria after which is why youre still affected
the lack of bacteria is 100% making it worse or even causing it, my theory is that toxins and stressors reach your gut and there's nothing to fight them off

Yes, I developed it while on the worst diet of my life and drinking kefir was good, but some people say it developed suddenly.

 

[IAMNOTANINCEL]

Yes, I developed it while on the worst diet of my life and drinking kefir was good, but some people say it developed suddenly.

there it is
please try this

-only eating raw animal products from healthy animals
-no plants
-frequent supplementation of rotten animal products

you don't really have anything to lose

 

[gargomel]

yeh its an issue on how we classify diseases, UC isnt one single disease, its a collection of conditions with similar symptoms, for some UC is driven by an overproduction of specific inflammatory cytokines like TNF-a, so anti-TNF drugs like infliximab work, then for another person the issue could be in IL-23 singlas or issues with T-cell reg, so a drug that targets those paths like IL-23 inhibitors work better, its like treating a fever the cause could be a bacterial infection, a virus, or an autoimm reaction, then theres gene mutations like in IL23R, NOD2, or ATG16L1 all of them affect how ur immune system responds to inflam, some could have a TNF-driven disease because of their genetics, while another person could have a fully different inflam path, to add to that environmental exposure (epigenetics) also change how those genes end up being expressed, which makes the disease even more individual

Then theres microbiome differences and immune system variability, but i wont get into those

If the genes are precisely identified, wouldn't Crispr be applied quickly? In other words, if we detect the genes, we should not waste time finding the cause and quickly apply genetic editing.

 

[gargomel]

there it is
please try this

-only eating raw animal products from healthy animals
-no plants
-frequent supplementation of rotten animal products

you don't really have anything to lose

Interestingly, vegetables feel better, but my doctor said it has nothing to do with eating or drinking.

 

[Rigged]

If the genes are precisely identified, wouldn't Crispr be applied quickly? In other words, if we detect the genes, we should not waste time finding the cause and quickly apply genetic editing.

Downstream affects of those genes is what causes UC, we dont fully understand the pathways so its too risky, knowing what the problem is isnt enough, also editing one gene wont fix the entire network

Edit: crisprs designed to edit signle genes