copingcoper
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HGH with no risks?
Hgh is perscribed to kids and teens with idiopathic short stature (iss)
A teenager with ISS is generally considered healthy in every other aspect of their life. They typically have normal hormone levels (including growth hormone), normal body proportions, and no underlying chronic illness or systemic disease. They are simply at the lower end of the height distribution for their age and gender.
So theoretically, A healthy, non-short child, could use gh and be fine
FDA Approval: In the United States, the FDA has approved the use of synthetic human growth hormone for the treatment of ISS in children and adolescents whose height is significantly below the typical range (typically more than $2.25$ standard deviations below the mean) and whose predicted adult height is in the short range
So basically they are normal just short
Safety of GH treatment in ISS
An evaluation by Quigley et al35 of safety data from the controlled trial of GH therapy of children with ISS31 and the subsequent dose-response study,32 as well as an evaluation of more than 8,000 ISS patients followed in a large post-marketing database for children treated with GH,26 have shown that there are no safety issues in GH therapy different from those seen with treatment of GH deficiency.
This conversation has focused on an observational study (published in 2025) of 291 children born small for gestational age (SGA) who received growth hormone (GH) treatment in France.
ONLY 1.37% of the HGH USERS HAD SERIOUS EFFECTS
Dosing protocol:
body weight in Kg x .37mg = mg per week
1 mg = 3 ius
Get a glucose monitor and berberine
A common hgh side effect is fluid retention. To combat this you can get water retention supplements, often called natural diuretics or "water pills," help reduce excess fluid and bloating by promoting increased urination
idk if this is water or what just thought id share.
Hgh is perscribed to kids and teens with idiopathic short stature (iss)
A teenager with ISS is generally considered healthy in every other aspect of their life. They typically have normal hormone levels (including growth hormone), normal body proportions, and no underlying chronic illness or systemic disease. They are simply at the lower end of the height distribution for their age and gender.
So theoretically, A healthy, non-short child, could use gh and be fine
FDA Approval: In the United States, the FDA has approved the use of synthetic human growth hormone for the treatment of ISS in children and adolescents whose height is significantly below the typical range (typically more than $2.25$ standard deviations below the mean) and whose predicted adult height is in the short range
So basically they are normal just short
Safety of GH treatment in ISS
An evaluation by Quigley et al35 of safety data from the controlled trial of GH therapy of children with ISS31 and the subsequent dose-response study,32 as well as an evaluation of more than 8,000 ISS patients followed in a large post-marketing database for children treated with GH,26 have shown that there are no safety issues in GH therapy different from those seen with treatment of GH deficiency.
This conversation has focused on an observational study (published in 2025) of 291 children born small for gestational age (SGA) who received growth hormone (GH) treatment in France.
1. Patient Demographics & Baseline Health
- Study Group: The 291 children had persistent short stature and a mean age of 8.08 years at the start of the study.
- Existing Conditions: Over half of the participants (55.3%) had at least one chronic disease (such as asthma or GH deficiency), and 23.4% had a congenital or genetic disorder (like Silver-Russell or Noonan syndrome).
2. Adverse Events (AEs) and Probability
- General Frequency: 51.2% of patients experienced at least one adverse event during the study.
- Most Common Nonserious Effects: The most frequent were increased IGF-I levels (17.2%), headaches (9.3%), and joint pain (4.5%).
- Serious Adverse Events (SAEs):
- A total of 86 SAEs occurred in 46 individual patients (approximately 15.8% of the group).
- Causality: The vast majority (84.9%) of these serious events were considered unlikely to be related to the GH treatment and were common medical issues like appendicitis or gastroenteritis.
- Direct Relation: Only 6 SAEs (approx. 7% of the 86 events) were classified as "possibly" or "probably" related to the GH treatment. These events occurred in just 4 individual patients (~1.37% of the total study population) and included type 2 diabetes, testicular infarction, asthma, and hip issues.
3. Determinants of Risk
- Increased Risk: Factors that increased the likelihood of adverse events included the presence of chronic diseases, taking concomitant medications, and longer participation in the study registry.
- Decreased Risk: Interestingly, a higher GH dose at the final visit was associated with a reduced risk of experiencing an adverse event
ONLY 1.37% of the HGH USERS HAD SERIOUS EFFECTS
Dosing protocol:
body weight in Kg x .37mg = mg per week
1 mg = 3 ius
Get a glucose monitor and berberine
A common hgh side effect is fluid retention. To combat this you can get water retention supplements, often called natural diuretics or "water pills," help reduce excess fluid and bloating by promoting increased urination
idk if this is water or what just thought id share.
