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Naked mole-rat hyaluronic acid differs from human and mouse hyaluronic acid in that its molecular chain of disaccharides is longer.
It exerts superior cytoprotective effects in a polymer length-dependent manner:
“Here, we show that vHMM-HA [very high molecular mass hyaluronic acid, the longer polysaccharides that is the naked mole rat’s hyaluronic acid] (>6.1 MDa) has superior cytoprotective properties compared to the shorter HMM-HA. It protects not only NMR cells, but also mouse and human cells from stress-induced cell-cycle arrest and cell death in a polymer length-dependent manner.” (Takasugi et al, 1)
Interestingly, high molecular mass hyaluronic acid (like that in humans) versus naked mole rat hyaluronic acid have differing effects CD44, which results in the naked mole rat hyaluronic acid protect cells from p53 (which can cause cells to senesce or apoptosize):
“The cytoprotective effect is dependent on the major HA-receptor, CD44. We find that vHMM-HA suppresses CD44 protein-protein interactions, whereas HMM-HA promotes them. As a result, vHMM-HA and HMM-HA induce opposing effects on the expression of CD44-dependent genes, which are associated with the p53 pathway. Concomitantly, vHMM-HA partially attenuates p53 and protects cells from stress in a p53-dependent manner.” (Takasugi et al, 1)
Mice with an overexpressed nmrHas2 gene lived healthier, longer lives:
“To study whether the benefits of HMM-HA could be transferred to other animal species, we generated a transgenic mouse overexpressing naked mole-rat hyaluronic acid synthase 2 gene (nmrHas2). nmrHas2 mice showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, extended lifespan and improved healthspan.” (Zhang et al, 2)
Here’s the survival curves of female mice (a) and make mice (b):
The naked mole rat nmrHas2 gene2 increased median lifespan in female mice by 9% and maximum lifespan in males by 16%.
These transgenic mice had a younger epigenetic age compared to controls:
Referring to chart c, not only is the epigenetic age younger, but appears to age more slowly as well.
I am hoping that naked mole-rat hyaluronic acid will be available on the market in the near future.
Citations:
1. https://www.nature.com/articles/s41467-020-16050-w
2.
www.biorxiv.org
It exerts superior cytoprotective effects in a polymer length-dependent manner:
“Here, we show that vHMM-HA [very high molecular mass hyaluronic acid, the longer polysaccharides that is the naked mole rat’s hyaluronic acid] (>6.1 MDa) has superior cytoprotective properties compared to the shorter HMM-HA. It protects not only NMR cells, but also mouse and human cells from stress-induced cell-cycle arrest and cell death in a polymer length-dependent manner.” (Takasugi et al, 1)
Interestingly, high molecular mass hyaluronic acid (like that in humans) versus naked mole rat hyaluronic acid have differing effects CD44, which results in the naked mole rat hyaluronic acid protect cells from p53 (which can cause cells to senesce or apoptosize):
“The cytoprotective effect is dependent on the major HA-receptor, CD44. We find that vHMM-HA suppresses CD44 protein-protein interactions, whereas HMM-HA promotes them. As a result, vHMM-HA and HMM-HA induce opposing effects on the expression of CD44-dependent genes, which are associated with the p53 pathway. Concomitantly, vHMM-HA partially attenuates p53 and protects cells from stress in a p53-dependent manner.” (Takasugi et al, 1)
Mice with an overexpressed nmrHas2 gene lived healthier, longer lives:
“To study whether the benefits of HMM-HA could be transferred to other animal species, we generated a transgenic mouse overexpressing naked mole-rat hyaluronic acid synthase 2 gene (nmrHas2). nmrHas2 mice showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, extended lifespan and improved healthspan.” (Zhang et al, 2)
Here’s the survival curves of female mice (a) and make mice (b):
The naked mole rat nmrHas2 gene2 increased median lifespan in female mice by 9% and maximum lifespan in males by 16%.
These transgenic mice had a younger epigenetic age compared to controls:
Referring to chart c, not only is the epigenetic age younger, but appears to age more slowly as well.
I am hoping that naked mole-rat hyaluronic acid will be available on the market in the near future.
Citations:
1. https://www.nature.com/articles/s41467-020-16050-w
2.
Increased hyaluronan by naked mole-rat HAS2 extends lifespan in mice
Abundant high molecular weight hyaluronic acid (HMW-HA) contributes to cancer resistance and possibly longevity of the longest-lived rodent, the naked mole-rat [1][1], [2][2] . To study whether the benefits of HMW-HA could be transferred to other animal species, we generated a transgenic mouse...
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