Nanofat injection as a treatment of infraorbital dark circles

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introduction​

A number of factors can cause dark circles around the eyes including excessive pigmentation, thin and translucent lower eyelid skin overlying the orbicularis oculi muscle, and shadowing due to skin laxity and tear trough. Although a number of treatment options are available, autologous fat transplantation is an effective method for the treatment of lower lid dark circles, but irregularities caused by leaving visible lumps of the fat can occur. Mechanical emulsification of harvested fat achieves much more finer fat particles than micro-fat called nano-fat

what is Nanofat​

it is a minimally invasive procedure that involves the extraction of autologous fat from a patient, which is then transformed into “nanofat”, consisting of small fat particles with a diameter of less than 0.1 mm and containing high concentrations of stem cells and growth factors which in contrast to the traditional fat grafting method that acts primarily by producing a physical volume effect and this can lead to irregularities caused by visible lumps, nanofat grafting may act primarily by the activity of transplanted Nanofat derived Stem Cells in an emulsified fat suspension to promote skin rejuvenation

The Procedure​

The process of obtaining nanofat can be divided into three phases. The first phase is the fat harvesting procedure, which involves collecting fat from the abdomen (the most reliable collection site in males). . The fat is collected using a liposuction cannula with 1 mm side ports, taking approximately 40–50 mL of aspirate. The second phase involves the emulsification of the fat, Once the emulsification and filtering phase is complete, the resulting product is a translucent liquid that is rich in high-quality mesenchymal stem cells but devoid of any viable adipocytes . The final phase involves the injection of the nanofat product into the desired areas of the patient.

How Does It Work​

Adipocytes represent only 25% of the total number of cells in fat tissue, despite accounting for 80% to 90% of its volume [6]. The remaining 75% of the sample, known as the stromal vascular fraction (SVF), is rich in adipose-derived stem cells (ADSCs), endothelial cells, granulocytes, monocytes, macrophages, and lymphocytes. Recent studies suggest that the many cell types in the SVF may work together to create a microenvironment that promotes the regenerative capacity of both stem cells and tissues also increased collagen deposition, improved skin suppleness, development of new blood vessels, tissue remodeling, dermal thickening, and downregulation of melanogenic activity. Nanofat also appears to reduce inflammation and stimulate angiogenesis

Recovery and Results​

Nanofat grafting is a same-day procedure. It can take several days to see the final results. Depending on the initial volume that is absorbed further treatments may be necessary. and for side effects and complications studies have established the safety of the procedure. In fact, no significant complications have been reported except for temporary erythema, which appeared at the injection site with varying degrees and lasted for 2–3 weeks in the majority of patients. Unlike macrofat and microfat, nanofat has not been associated with infections, granulomas, or fat cysts

THESE ARE SOME RESULTS THAT I FOUND ONLINE

Refrences:

Nanofat in Plastic Reconstructive, Regenerative, and Aesthetic Surgery: A Review of Advancements in Face-Focused Applications

 

[ErbCel]

That's insane, both results reduced their lower eyelid exposure!