Norwoodcels

[Deleted member 3990]

Within 10 years you can take a custom wraparound hairfollicle transplant by Replicel

It will cost a bit tho

Follica, SM04554, JAK3I and better topical antiandrogens may come within 5 years

Promising future

 

[Deleted member 2933]

This means someone could change his hair type

 

[Artemide]

Hope this is real.
They have been making the same promises for years

 

[Deleted member 3990]

Hope this is real.
They have been making the same promises for years

replicel ?

They said they will release or publicate something in 2020 or early 2021

it looks good tbh, they also said the price

 

[Deleted member 4209]

big if true

 

[Deleted member 3990]

big if true

same method may fix your skin too

only cons are money and possibility of cancer

RCH-01 | RepliCel

RCH-01 is a proprietary autologous cell therapy being developed to treat pattern baldness.

replicel.com

 

[Almu]

same method may fix your skin too

only cons are money and possibility of cancer

RCH-01 | RepliCel

RCH-01 is a proprietary autologous cell therapy being developed to treat pattern baldness.

replicel.com

Just fix the cancer then

 

[Deleted member 3990]

The cool thing is, this is the second legit method against androgenetic alopecia besides antiandrogens


for example JAK inhibs. may not work on Norwooders
Also, you could desgin your hairline too

born with high hairline? just lower it

 

[Gazzamogga]

Hope this is real.
They have been making the same promises for years

strong posts to join date ratio

 

[Seth Walsh]

Within 10 years you can take a custom wraparound hairfollicle transplant by Replicel

It will cost a bit tho

Follica, SM04554, JAK3I and better topical antiandrogens may come within 5 years

Promising future

No need for JAK-STAT pathway inhibitors. SM04554 takes care of the root cause.

 

[JamesHowlett]

Doesn’t apply to me but I’m happy for all of you out there, this would be HUGE

 

[Introvertednarc]

Doesn’t apply to me but I’m happy for all of you out there, this would be HUGE

 

[Deleted member 3990]

No need for JAK-STAT pathway inhibitors. SM04554 takes care of the root cause.

yes

but:

 

[Seth Walsh]

yes

but:
View attachment 228392

Nice graph. Thing is, we don't need to inhibit anything and the PI3K/AKT pathways have nothing to do with MPB. Inhibiting JAK-STAT prolongs the Anagen phase, but more time in the growth phases doesn't necessarily mean there'll be substantially more growth, if any more than usual. I haven't heard any anecdotes from someone using Xeljanz so we can assume JAK inhibitors are ineffective.

SM04554 is a molecule extremely similar to Wnt and extremely selective to the Frizzled receptor. It's the only solution for those who naturally don't have any agonism at Frizzled via Wnt. You could in theory, cause a mutation on the APC gene and that'd allow the Beta Catenin to dislodge Groucho from the TCF and activate the Wnt target genes needed to sustain very active Anagen phases throughout life so that you don't recede like those who have no activity via Wnt at Frizzled.

There's nothing that can be "inhibited" to allow for the Beta Catenin not to be degraded in the proteosome. We need that initial agonism at Frizzled by either the Wnt or SM04554 molecules for the downstream effects to work.

Mutating APC would be a different and interesting approach, and that would work too, because in reality what's needed is the Beta Catenin to reach the Transcription Factor so it can target the Wnt target genes.

 

[diggbicc]

Within 10 years you can take a custom wraparound hairfollicle transplant by Replicel

elab what it is . TL DR?

 

[Deleted member 3990]

Nice graph. Thing is, we don't need to inhibit anything and the PI3K/AKT pathways have nothing to do with MPB. Inhibiting JAK-STAT prolongs the Anagen phase, but more time in the growth phases doesn't necessarily mean there'll be substantially more growth, if any more than usual. I haven't heard any anecdotes from someone using Xeljanz so we can assume JAK inhibitors are ineffective.

SM04554 is a molecule extremely similar to Wnt and extremely selective to the Frizzled receptor. It's the only solution for those who naturally don't have any agonism at Frizzled via Wnt. You could in theory, cause a mutation on the APC gene and that'd allow the Beta Catenin to dislodge Groucho from the TCF and activate the Wnt target genes needed to sustain very active Anagen phases throughout life so that you don't recede like those who have no activity via Wnt at Frizzled.

There's nothing that can be "inhibited" to allow for the Beta Catenin not to be degraded in the proteosome. We need that initial agonism at Frizzled by either the Wnt or SM04554 molecules for the downstream effects to work.

Mutating APC would be a different and interesting approach, and that would work too, because in reality what's needed is the Beta Catenin to reach the Transcription Factor so it can target the Wnt target genes.

JAK Inhibs are proven to help AAreata

but for the androgenic Alopecia it may be useless indeed

I myself vouch for SM04554 too, but I heard they delayed their last trial

 

[Seth Walsh]

JAK Inhibs are proven to help AAreata

but for the androgenic Alopecia it may be useless indeed

I myself vouch for SM04554 too, but I heard they delayed their last trial

With a mutated APC gene, Dvl doesn't need to translocate the rest of the destruction complex to the LRP receptor, because for the destruction complex to become inactive, it needs to separate itself from the Beta TrCP /E3 Ubiquitin Ligase. Without APC working, Dvl/GSK3/CKI/Axin and the Beta Catenin can separate from the Beta TrCP without Dvl having to translocate the destruction complex to the LRP receptor.

A JAK inhibitor + a 5AR inhibitor could work really well together for treating AA and I'd be interested to see some people who aren't MPB prone but experiencing AA to use that combo. Maybe someone running a DHT-heavy steroid cycle. I still think Dutasteride is the gold standard for treating AA though. But it makes a lot of sense to use JAK and 5AR inhibitors together because surely it'd be much more effective than just using Dutasteride alone.

 

[Deleted member 3990]

With a mutated APC gene, Dvl doesn't need to translocate the rest of the destruction complex to the LRP receptor, because for the destruction complex to become inactive, it needs to separate itself from the Beta TrCP /E3 Ubiquitin Ligase. Without APC working, Dvl/GSK3/CKI/Axin and the Beta Catenin can separate from the Beta TrCP without Dvl having to translocate the destruction complex to the LRP receptor.

A JAK inhibitor + a 5AR inhibitor could work really well together for treating AA and I'd be interested to see some people who aren't MPB prone but experiencing AA to use that combo. Maybe someone running a DHT-heavy steroid cycle. I still think Dutasteride is the gold standard for treating AA though. But it makes a lot of sense to use JAK and 5AR inhibitors together because surely it'd be much more effective than just using Dutasteride alone.

tfw greycel IQmogging most of active userbase here

 

[Deleted member 656]

tfw greycel IQmogging most of active userbase here

That's no greycel

Resurrection of Jesus - Wikipedia

en.m.wikipedia.org

 

[Deleted member 3990]

That's no greycel

Resurrection of Jesus - Wikipedia

en.m.wikipedia.org

... Arceus?

 

[Deleted member 656]

A JAK inhibitor + a 5AR inhibitor could work really well together for treating AA

Are the supposed sides of 5AR inhibitors that many users here preach about something one ought to be concerned about?

... Arceus?

C'est la vie

 

[Peachy]

same method may fix your skin too

only cons are money and possibility of cancer

RCH-01 | RepliCel

RCH-01 is a proprietary autologous cell therapy being developed to treat pattern baldness.

replicel.com

Jfl it actually has "cel" in the name

 

[Deleted member 3990]

Jfl it actually has "cel" in the name

by cels for cels

 

[Seth Walsh]

Are the supposed sides of 5AR inhibitors that many users here preach about something one ought to be concerned about?

C'est la vie

Yeah. Taking Fin/Dut without really needing to, is not worth it. You'll experience a lot of the side effects mentioned. As you said, so many things are milder 5AR inhibitors. Stinging Nettle Root is really good.

Again it's like a risk vs reward type thing. If you really need to take Fin/Dut then you need to take the risk. The side effects would be less noticeable because of the noticeably larger reward. Taking Fin/Dut when you can just take SNR or not even take any 5AR inhibitor, is just like calling the fire brigade to extinguish a small campfire.

There's nothing much to worry about concerning SNR side effects, maybe just a small decrease in libido. Saw Palmetto seems completely ineffective also from what I've seen. I'd caution people not to go ordering Fin/Dut unless they're *really* losing their hair.

 

[Deleted member 656]

Yeah. Taking Fin/Dut without really needing to, is not worth it. You'll experience a lot of the side effects mentioned. As you said, so many things are milder 5AR inhibitors. Stinging Nettle Root is really good.

Again it's like a risk vs reward type thing. If you really need to take Fin/Dut then you need to take the risk. The side effects would be less noticeable because of the noticeably larger reward. Taking Fin/Dut when you can just take SNR or not even take any 5AR inhibitor, is just like calling the fire brigade to extinguish a small campfire.

There's nothing much to worry about concerning SNR side effects, maybe just a small decrease in libido. Saw Palmetto seems completely ineffective also from what I've seen. I'd caution people not to go ordering Fin/Dut unless they're *really* losing their hair.

And what of GHK-Cu, and the copper peptides in general?

I know biotinyl-GHK is mixed with apigenin and oleanolic acid as part of the Procapil trident, with the sole purpose of oleanolic acid being to work as a 5AR inhibitor. That'd lead me to believe the copper peptides have a weak effect at most but I can't find any actual studies on it.

 

[Seth Walsh]

And what of GHK-Cu, and the copper peptides in general?

I know biotinyl-GHK is mixed with apigenin and oleanolic acid as part of the Procapil trident, with the sole purpose of oleanolic acid being to work as a 5AR inhibitor. That'd lead me to believe the copper peptides have a weak effect at most but I can't find any actual studies on it.

biotinyl-GHK is something I'll never bother with. Biotin is scary. It will literally give you acne. Search up "Poly-Cystic Ovarian Syndrome", men can't get the actual syndrome, but we can get the symptoms of it, and Biotin is very pro-PCOS. The reason why Pantothenic Acid megadosing works so well for some acne sufferers is because it lowers Biotin levels.

GHK-cu is just a beauty. There's something about IT specifically. Not copper peptides in general, or any other form of GHK. I've only used GHK-cu and have injected it too.

It's hard to find studies or even anecdotes about it because all you can find are articles from Dr Loren Pickart. But if I had to describe it's effects, it's as if it's HGH + some healing peptide like BPC-157, but the aesthetic version of both of those combined. I never applied it to my hair, but I did notice better hair and skin after injecting it. My hair is pretty dense anyways, but it just made everything a bit better.

I don't doubt the claims that it can repair damaged DNA, nerves and fibroblasts. But there's not really any scientific evidence to back all that up. I use SPF100 now, and don't use GHK-cu at the moment because it's really just a huge cherry on-top type thing.

A good moment to inject it would be before a sun holiday if you're injecting MT2 too and still using Retin-A/Adapalene, because I did notice it made my skin really healthy, moisturized and resilient looking.

And what of GHK-Cu, and the copper peptides in general?

I know biotinyl-GHK is mixed with apigenin and oleanolic acid as part of the Procapil trident, with the sole purpose of oleanolic acid being to work as a 5AR inhibitor. That'd lead me to believe the copper peptides have a weak effect at most but I can't find any actual studies on it.

Yeah, I've put "Copper Peptides" in my hair and jack shit changed. The GHK-cu definitely wasn't placebo though. And it's not like it's a miracle in 1 department. It just made my hair and skin better. As if it was a microdose of HGH, BPC-157 and like Argan Oil / Castor oil etc. It definitely made my hair softer and smoother.

 

[Deleted member 3990]

biotinyl-GHK is something I'll never bother with. Biotin is scary. It will literally give you acne. Search up "Poly-Cystic Ovarian Syndrome", men can't get the actual syndrome, but we can get the symptoms of it, and Biotin is very pro-PCOS. The reason why Pantothenic Acid megadosing works so well for some acne sufferers is because it lowers Biotin levels.

GHK-cu is just a beauty. There's something about IT specifically. Not copper peptides in general, or any other form of GHK. I've only used GHK-cu and have injected it too.

It's hard to find studies or even anecdotes about it because all you can find are articles from Dr Loren Pickart. But if I had to describe it's effects, it's as if it's HGH + some healing peptide like BPC-157, but the aesthetic version of both of those combined. I never applied it to my hair, but I did notice better hair and skin after injecting it. My hair is pretty dense anyways, but it just made everything a bit better.

I don't doubt the claims that it can repair damaged DNA, nerves and fibroblasts. But there's not really any scientific evidence to back all that up. I use SPF100 now, and don't use GHK-cu at the moment because it's really just a huge cherry on-top type thing.

A good moment to inject it would be before a sun holiday if you're injecting MT2 too and still using Retin-A/Adapalene, because I did notice it made my skin really healthy, moisturized and resilient looking.

Yeah, I've put "Copper Peptides" in my hair and jack shit changed. The GHK-cu definitely wasn't placebo though. And it's not like it's a miracle in 1 department. It just made my hair and skin better. As if it was a microdose of HGH, BPC-157 and like Argan Oil / Castor oil etc. It definitely made my hair softer and smoother.

Are you my Irish friend?

 

[Deleted member 656]

biotinyl-GHK is something I'll never bother with. Biotin is scary. It will literally give you acne. Search up "Poly-Cystic Ovarian Syndrome", men can't get the actual syndrome, but we can get the symptoms of it, and Biotin is very pro-PCOS. The reason why Pantothenic Acid megadosing works so well for some acne sufferers is because it lowers Biotin levels.

GHK-cu is just a beauty. There's something about IT specifically. Not copper peptides in general, or any other form of GHK. I've only used GHK-cu and have injected it too.

It's hard to find studies or even anecdotes about it because all you can find are articles from Dr Loren Pickart. But if I had to describe it's effects, it's as if it's HGH + some healing peptide like BPC-157, but the aesthetic version of both of those combined. I never applied it to my hair, but I did notice better hair and skin after injecting it. My hair is pretty dense anyways, but it just made everything a bit better.

I don't doubt the claims that it can repair damaged DNA, nerves and fibroblasts. But there's not really any scientific evidence to back all that up. I use SPF100 now, and don't use GHK-cu at the moment because it's really just a huge cherry on-top type thing.

A good moment to inject it would be before a sun holiday if you're injecting MT2 too and still using Retin-A/Adapalene, because I did notice it made my skin really healthy, moisturized and resilient looking.

Interesting you mention BPC-157. That's something I've heard very little about around here. What are your thoughts on it, and especially how is it relative to TB-500? Are TB-500's supposed cancer risks overblown?

Thanks a lot for all the input by the way. It feels as though everybody using or in the circle surrounding peptides has at best very limited biological understanding.

 

[Seth Walsh]

Are you my Irish friend?

No I live in the Shekel Shack in Luxembourg.

Interesting you mention BPC-157. That's something I've heard very little about around here. What are your thoughts on it, and especially how is it relative to TB-500? Are TB-500's supposed cancer risks overblown?

Thanks a lot for all the input by the way. It feels as though everybody using or in the circle surrounding peptides has at best very limited biological understanding.

I'm still trying to get my head around things too. The more simple we can make an approach, the better it should work for us. biotinyl-GHK and all the variations sound interesting but if I had to guess, they'd be a huge letdown and not as expected. I've never used BPC and never heard of the cancer risks surrounding TB-500. All I know is they help workout & injury recovery. I really don't know much about them at all though.

 

[Deleted member 3990]

No I live in the Shekel Shack in Luxembourg.

thougths about T3 and thyroidH

 

[Seth Walsh]

thougths about T3 and thyroidH

No need to take T3 ever really. I've taken it before. Take iodine to support your thyroid, that's a lot better.

 

[Deleted member 3990]

No need to take T3 ever really. I've taken it before. Take iodine to support your thyroid, that's a lot better.

you have proven now that you are indeed my high IQ irish friend

 

[Deleted member 3990]

No need to take T3 ever really. I've taken it before. Take iodine to support your thyroid, that's a lot better.

BIO | ≥99%(HPLC) | Selleck | GSK-3 inhibitor

BIO is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibit... Quality confirmed by NMR & HPLC. See customer reviews, validations & product citations.

www.selleckchem.com

could this work?

 

[Seth Walsh]

BIO | ≥99%(HPLC) | Selleck | GSK-3 inhibitor

BIO is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibit... Quality confirmed by NMR & HPLC. See customer reviews, validations & product citations.

www.selleckchem.com

could this work?

Work for hairloss? I doubt it. But I don't know anything about this compound.

 

[Deleted member 3990]

Work for hairloss? I doubt it. But I don't know anything about this compound.

it is a no-name indeed

should be close to sm04554

 

[Seth Walsh]

it is a no-name indeed

should be close to sm04554

Yeah could be. The mechanisms of GSK-3 are way over my head.

If inhibiting GSK-3 in the Wnt pathway allows for Beta Catenin to enter the nucleus and bind to transcription factors then it should get the same result as SM04554 just in a different way.

 

[forwardgrowth]

the best solutions for hair loss have always been five years away
is Seth Walsh MorePlatesMoreDates?

 

[Deleted member 3990]

the best solutions for hair loss have always been five years away
is Seth Walsh MorePlatesMoreDates?

true

daro and JAKI for example are not promising tbh
legit
Follica and SM04554 might be the best chemicals soon for us looksmaxing Norwooders

Yeah could be. The mechanisms of GSK-3 are way over my head. View attachment 229480

If inhibiting GSK-3 in the Wnt pathway allows for Beta Catenin to enter the nucleus and bind to transcription factors then it should get the same result as SM04554 just in a different way.

couldnt you also block Dickkopf ?

 

[forwardgrowth]

Thoughts on seti or feti?

 

[Seth Walsh]

the best solutions for hair loss have always been five years away
is Seth Walsh MorePlatesMoreDates?

Hi yes it's me ...uh Darik from uh MorePlatesMoreDates. I just took superphysiological amounts of oral castor oil and am feeling sick so no video tomorrow.

 

[Deleted member 3990]

Thoughts on seti or feti?

will help your asthma for sure

castor oils on steroid

 

[Seth Walsh]

true

daro and JAKI for example are not promising tbh
legit
Follica and SM04554 might be the best chemicals soon for us looksmaxing Norwooders

couldnt you also block Dickkopf ?

Too complicated for me

 

[Deleted member 3990]

Too complicated for me

you know more than me, so it is too complicated for me too automatically


I like you. Smart paired with humour

 

[Seth Walsh]

you know more than me, so it is too complicated for me too automatically


I like you. Smart paired with humour

Thanks Dr Shekels. Looking deeper into interactions with every gene in the Wnt pathway is too complicated for me and probably most people here, and it's not worth looking into alternative MOAs to achieve what SM04554 does, because SM04554 already achieves the result.

 

[her]

Thanks Dr Shekels. Looking deeper into interactions with every gene in the Wnt pathway is too complicated for me and probably most people here, and it's not worth looking into alternative MOAs to achieve what SM04554 does, because SM04554 already achieves the result.

Hi, @x30001. I missed you.

 

[Deleted member 3990]

Thanks Dr Shekels. Looking deeper into interactions with every gene in the Wnt pathway is too complicated for me and probably most people here, and it's not worth looking into alternative MOAs to achieve what SM04554 does, because SM04554 already achieves the result.

indeed

do you know how to create liposomal Finasteride (at home)?

 

[Seth Walsh]

indeed

do you know how to create liposomal Finasteride (at home)?

No clue. I'm not losing my hair so my knowledge in hair loss isn't the best. I would assume there'd be no difference no matter how you administer Finasteride other than maybe bioavailability. Applying it topically or even up your ass wouldn't mean the effects are localized, and it might not be absorbed at all through certain routes.

Never heard of liposomal Finasteride. Surely, if it works better than normal Finasteride, then it'd be selling all over the world.

 

[Deleted member 3990]

No clue. I'm not losing my hair so my knowledge in hair loss isn't the best. I would assume there'd be no difference no matter how you administer Finasteride other than maybe bioavailability. Applying it topically or even up your ass wouldn't mean the effects are localized, and it might not be absorbed at all through certain routes.

Never heard of liposomal Finasteride. Surely, if it works better than normal Finasteride, then it'd be selling all over the world.

it is trendy now

but I also never informed my self about topical 5ARI

At first it doesnt really make sense, because it doesmt fight DHT but the Conversion to it

but maybe there are 5AR enzymas in the head?

People found topical as efficient as oral

 

[Seth Walsh]

it is trendy now

but I also never informed my self about topical 5ARI

At first it doesnt really make sense, because it doesmt fight DHT but the Conversion to it

but maybe there are 5AR enzymas in the head?

People found topical as efficient as oral

Yeah I'd say it's just as efficient because it'd probably do the same thing as oral Finasteride.

 

[LordNorwood]

This thread seems high IQ as hell will read through when I have time