Norwoodcels

[Alexanderr]

Lifefuel.

 

[Deleted member 2933]

In

 

[leloucheREBORN]

i am 19 and started to norwood in the past month
I want avoid fin. Should i take minox and Copper-Peptide? Or what are you ideas..

 

[Soalian]

Magnesium Threonate seems to be able to block Dikkopf, does anyone have experience with this?

 

[Mayorga]

Magnesium Threonate seems to be able to block Dikkopf, does anyone have experience with this?

source?

 

[Soalian]

source?

PubMed

PubMed® comprises more than 38 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.

www.ncbi.nlm.nih.gov

 

[Deleted member 3990]

PubMed

PubMed® comprises more than 38 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.

www.ncbi.nlm.nih.gov

 

[Mayorga]

PubMed

PubMed® comprises more than 38 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.

www.ncbi.nlm.nih.gov

L-threonate is a metabolite of vit C though, nothing to do with Mag-Threonate

 

[LordNorwood]

@Seth Walsh mind shooting me a PM?

 

[Deleted member 3990]

Too complicated for me

the top 30 upregulated genes in balding dermal papilla cells in response to 100 nM DHT determined by microarray hybridization.


Gene Genebank ID Fold increase

tyrosyl-tRNA synthetase (YARS) NM_003680 5.07

dickkopf homolog 1 (DKK1) NM_012242 4.64

serum/glucocorticoid regulated kinase (SGK) NM_005627 4.53

a disintegrin-like and metalloprotease (ADAMTS5) NM_007038 3.75

solute carrier family 19 (SLC19A2) NM_006996 3.31

solute carrier family 2 (SLC2A3) NM_006931 2.99

H2A histone family, member Z (H2AFZ) NM_002106 2.86

RING1 and YY1 binding protein (RYBP) NM_012234 2.75

nuclear receptor coactivator 3 (NCOA3) NM_181659 2.63

adenosylmethionine decarboxylase 1 (AMD1) NM_001634 2.46

LPS-induced TNF-alpha factor (LITAF) NM_004862 2.36

ornithine decarboxylase 1 (ODC1) NM_002539 2.34

myeloid cell leukemia sequence 1 (MCL1) NM_182763 2.32

ATPase family homolog up-regulated in senescence cells (AFURS1) NM_024524 2.31

ADP-ribosylation factor-like 4C (ARL4C) NM_005737 2.3

cyclin-dependent kinase inhibitor 1A (p21) (CDKN1A) NM_000389 2.3

aldo-keto reductase family 1, member C1 (AKR1C1) NM_001353 2.29

DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (DDX5) NM_004396 2.27

fibroblast growth factor 7 (FGF7) NM_002009 2.26

solute carrier family 3 (SLC3A2) NM_002394 2.22

VAMP-associated membrane protein B (VA0AP) NM_003574 2.1

HSPC048 protein (HSPC048) NM_014148 2.09

syndecan binding protein (syntenin) (SDCBP) NM_005625 2.08

matrix metalloproteinase 3 (MMP3) NM_002422 2.08

cyclin-dependent kinase inhibitor 1A (p21) (CDKN1A) NM_078467 2.07

Kruppel-like factor 10 (KLF10) NM_005655 2.02

heme oxygenase (decycling) 1 (HMOX1) NM_002133 2.02

UDP-glucose ceramide glucosyltransferase (UGCG) NM_003358 2.01

solute carrier family 7 (SLC7A5) NM_003486 1.99

transforming growth factor, beta 2 (TGFB2) NM_003238 1.98

 

[Seth Walsh]

I can't PM anyone. I've no problem with people asking me questions on threads and I'll reply if I have anything good to add. I'm not motivated with hair stuff since I'm not losing hair at the moment.

@Dr Shekelberg what's going on with all those proteins?

 

[Deleted member 3990]

@Dr Shekelberg what's going on with all those proteins?

the top 30 upregulated genes in balding dermal papilla cells in response to 100 nM DHT determined by microarray hybridization.

since I'm not losing hair at the moment.

inject DHT

I'm not motivated with hair stuff since I'm not losing hair at the moment.

GSK3 Inhibitors could fill holes in your teeth, among other things

 

[mikeock]

The death of the Norwood Reaper will come with the invention of artificial, unlimited hair grafts for transplants

 

[Seth Walsh]

Upregulated genes after increased DHT? I don't think that necessarily means that killing those genes will lower your DHT. So I'm a bit confused what the importance of all those genes are. Dutasteride will lower your DHT, and then downregulate expression of those genes, but I don't see why those genes are of any importance to a practical end result.

Once Beta Catenin binds to its Transcription Factor (Lymphoid enhancer binding-factor), the LEF1 carries the Beta Catenin to the Wnt target genes in the DNA. LEF1 is a TCF that's apart of a High-mobility group, meaning it can regulate DNA-dependent processes like transcription, and that's what it does.

The Transcription Factor binds to a specific "promoter region" of the DNA. The TCF copies the genes DNA sequence to make an RNA molecule. The enzyme "RNA Polymerase" forms an RNA strand using the genetic data it copied from the DNA, and essentially overwrites the new genetic data onto those template DNA strands, changing the genetic data through transcription.

The 2 direct Wnt target genes of Beta Catenin concerning hairloss are movo1 and KRT81.

I won't really be adding more to these conversations in the future because I'm not motivated to and I don't see what the incentive is of researching enzymatic reactions at various proteins because maybe I'm not seeing what the objective of that is or it's out of my field of knowledge.

 

[Deleted member 3990]

Upregulated genes after increased DHT? I don't think that necessarily means that killing those genes will lower your DHT. So I'm a bit confused what the importance of all those genes are. Dutasteride will lower your DHT, and then downregulate expression of those genes, but I don't see why those genes are of any importance to a practical end result.

Once Beta Catenin binds to its Transcription Factor (Lymphoid enhancer binding-factor), the LEF1 carries the Beta Catenin to the Wnt target genes in the DNA. LEF1 is a TCF that's apart of a High-mobility group, meaning it can regulate DNA-dependent processes like transcription, and that's what it does.

The Transcription Factor binds to a specific "promoter region" of the DNA. The TCF copies the genes DNA sequence to make an RNA molecule. The enzyme "RNA Polymerase" forms an RNA strand using the genetic data it copied from the DNA, and essentially overwrites the new genetic data onto those template DNA strands, changing the genetic data through transcription.

The 2 direct Wnt target genes of Beta Catenin concerning hairloss are movo1 and KRT81.

I won't really be adding more to these conversations in the future because I'm not motivated to and I don't see what the incentive is of researching enzymatic reactions at various proteins because maybe I'm not seeing what the objective of that is or it's out of my field of knowledge.

understandable

 

[Mayorga]

forms an RNA strand using the genetic data it copied from the DNA, and essentially overwrites the new genetic data onto those template DNA strands, changing the genetic data through transcription.

ehm, you got something wrong there. after DNA is transcribed to RNA the RNA is then translated to a protein. this is what we know as gene expression. "overwriting" of DNA doesn't happen, bar some repair mechanisms like endo/exonucleases, but they work on a veery small scale. WNT/beta-catenin is important in AGA insofar that it controls the maturation of HF stem cells to progenitor cells, but its unlikely that thats the whole story imo.

 

[Seth Walsh]

understandable

Thanks

I realize I probably came off like a dick there. But if I didn't reply I'd also be a "dick". This isn't directed at you or anyone specific btw, but I'm just a normal guy and I like contributing but I hate being "summoned".

That's why I disabled PMs as soon as I made this account. Some guy today was saying I was ignoring him because I didn't PM him (not LordNorwood. Some other guy) when he "told" me to. Glad you understand what I mean and this stuff is interesting and I've no problem that you tagged me and I'm happy to chime in, but I can't contribute too well because I really don't know a lot about hairloss.

 

[Deleted member 3990]

Thanks

I realize I probably came off like a dick there. But if I didn't reply I'd also be a "dick". This isn't directed at you or anyone specific btw, but I'm just a normal guy and I like contributing but I hate being "summoned".

That's why I disabled PMs as soon as I made this account. Some guy today was saying I was ignoring him because I didn't PM him (not LordNorwood. Some other guy) when he "told" me to. Glad you understand what I mean and this stuff is interesting and I've no problem that you tagged me and I'm happy to chime in, but I can't contribute too well because I really don't know a lot about hairloss.

just want to give input

maybe I will correct your essays in few months, maybe not

 

[RODEBLUR]

Within 10 years you can take a custom wraparound hairfollicle transplant by Replicel

It will cost a bit tho

Follica, SM04554, JAK3I and better topical antiandrogens may come within 5 years

Promising future

Hope it doesn't so i can flex my life-long NW1

 

[DrunkenSailor]

Cope
No legit treatment in sight