hej1377
Chad-affirming care is a right, not a privilege
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Oxytocin is greatly involved in social bonding and feelings of love and attachment. Its very involved in social awareness, an oxytocin deifiency shows up in autism very commonly and seems to be one of the main reasons for the social aspects of ASD, therefore i think this thread is more widely applicable than most of you think. Oxytocin is also a big contributor to hightened feelings of well being and reduced anxiety, so if you're a high inhibcell but don't wanna deal with the withdrawl symptoms of gaba drugs then definitely take a look at the drugs listed below.
The reason for it being so impactfull yet so ignored in pharmacology mainly boils down to big challenges for the drug developers. Just the fact that is so impactfull makes it difficult to work with, it also affects shit like cardiovascular function and the entire system a lot of the female reproduction system which makes these drugs often marketed for pregnancy and labour.
Vassopressin receptors
Vasopressin is a hormone that basically bloats you and at the same time gives that "toxic boyfriend" effect so its involved in setting of signals in your brain that someone is about to steal your bitch so you become angry, jealous and territorial. Oxytocin and vasopressin are very similar on a molecular level which causes cross activation of eachothers receptors. The v1a receptor is mostly what gives aggression and a disturbed cardiovascular system, v1b is really what causes the kind of "panic" symptoms or an increase in anxiety or paranoia and the v2 receptor just makes you a bloatcell and is the reason largely for the physical issues like cardiovascular ones.
Vassopressin receptors
Vasopressin is a hormone that basically bloats you and at the same time gives that "toxic boyfriend" effect so its involved in setting of signals in your brain that someone is about to steal your bitch so you become angry, jealous and territorial. Oxytocin and vasopressin are very similar on a molecular level which causes cross activation of eachothers receptors. The v1a receptor is mostly what gives aggression and a disturbed cardiovascular system, v1b is really what causes the kind of "panic" symptoms or an increase in anxiety or paranoia and the v2 receptor just makes you a bloatcell and is the reason largely for the physical issues like cardiovascular ones.
Oxytocin agonists
This has been getting talked about more and more on here which worries me a bit. Theres of course studies showing very positive cognetive benefits from exogenous oxytocin. But they almost unanimously uses intraneural administration. This is since oxytocin only has a half life of about 3-5 minutes in plasma, it also has trouble crossing he blood-brain-barrier. This in combination just makes the oxytocin useless if its used intranasaly which seems most common here. So basically its just a gimick and straight copium, overall 2/10
Way-267464
This is an oxytocin agonist that is not a peptide. This is good since peptides generally have short half lives. I havent found any statistics about it's half life but simply it not being a peptide indicates that it probably is a lot more stable than other similar drugs.
this study(link) tried this drug on rats
Which seemed to cause a decrease in anxiety. This indicates that it succesfully is able to selectively stimulate oxytocin receptors selectively and not simultaneously affect the vassopressin receptors. It also confirms my speculation on stability since it worked systemically and didn't just get degraded.
More stats on it and a direct relevant quote is "WAY-267464 acts as a high-affinity and potent agonist at both human and mouse OTR. In a whole-cell binding assay, we determined the affinity (Ki, nM) of WAY-267464 at human and mouse OTR to be 58.4 ± 11.3 and 51.6 ± 5.9 respectively (Fig. 1A,B). In a cell-based functional assay measuring changes in [Ca2+]i in response to compound challenge, we determined the potency (EC50, nM) of WAY-267464 at human and mouse OTR to be 61.3 ± 4.5 and 29.0 ± 14.3 respectively (Fig. 1C,D). The maximal intrinsic"
This is an oxytocin agonist that is not a peptide. This is good since peptides generally have short half lives. I havent found any statistics about it's half life but simply it not being a peptide indicates that it probably is a lot more stable than other similar drugs.
this study(link) tried this drug on rats
Which seemed to cause a decrease in anxiety. This indicates that it succesfully is able to selectively stimulate oxytocin receptors selectively and not simultaneously affect the vassopressin receptors. It also confirms my speculation on stability since it worked systemically and didn't just get degraded.
More stats on it and a direct relevant quote is "WAY-267464 acts as a high-affinity and potent agonist at both human and mouse OTR. In a whole-cell binding assay, we determined the affinity (Ki, nM) of WAY-267464 at human and mouse OTR to be 58.4 ± 11.3 and 51.6 ± 5.9 respectively (Fig. 1A,B). In a cell-based functional assay measuring changes in [Ca2+]i in response to compound challenge, we determined the potency (EC50, nM) of WAY-267464 at human and mouse OTR to be 61.3 ± 4.5 and 29.0 ± 14.3 respectively (Fig. 1C,D). The maximal intrinsic"
LIT-001: the possible improvement of WAY
This is also a non-peptude oxytoxin agonist in preclinicals but on this drug we actually have quantified stats on how good it actually is and it seems better than the stats of wall WAY which is quoted above. A study you can read on nature.com (link) said "have shown that LIT-001 is a specific oxytocin receptor agonist with high affinity (EC50 = 25 nM and EC50 = 18 nM) and efficacy (Emax = 96% and 95%) for human and mouse receptors, respectively. Furthermore, the compound poorly antagonized vasopressin induced calcium release on V1aR (IC50 = 5900 nM) and was devoid of agonist or antagonist effect on V1bR." So it basically seems to fullfill all the requirements for a good oxytocin receptor agonist. Since its so effective and super selective.
This is also a non-peptude oxytoxin agonist in preclinicals but on this drug we actually have quantified stats on how good it actually is and it seems better than the stats of wall WAY which is quoted above. A study you can read on nature.com (link) said "have shown that LIT-001 is a specific oxytocin receptor agonist with high affinity (EC50 = 25 nM and EC50 = 18 nM) and efficacy (Emax = 96% and 95%) for human and mouse receptors, respectively. Furthermore, the compound poorly antagonized vasopressin induced calcium release on V1aR (IC50 = 5900 nM) and was devoid of agonist or antagonist effect on V1bR." So it basically seems to fullfill all the requirements for a good oxytocin receptor agonist. Since its so effective and super selective.
Now if youre planning on using trenbolone or youre a bit autistic i think this is especially applicable to you but everyone can benefit from these it seems
Maybe oxytocinace inhibitors deserved atleast a mention but they dont seem that great imo and i doubt this thread will get significant engagement so i cant be asked to include likely obsolete compounds
If anyone even dares too mention bonemass your entire family will be murdered in cold blood
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