H
hairyballscel
✡︎
- Joined
- Feb 21, 2020
- Posts
- 5,121
- Reputation
- 9,295
Latanoprost is a medicine that treats high pressure inside the eye, it is a synthetic prostaglandin analogue, which as well as naturally occurring prostaglandins such as PGF2a and PGE2, have been shown to induce increased pigmentation in the iris. Here is some examples:
The way this works is still not completely clear, but for your eyes to get darker, increased synthesis of melanin must occur....
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1771317/
- https://www.sciencedirect.com/science/article/abs/pii/S0039625797800197
Melanin is derived from the amino acid—tyrosine—through a synthesis regulated by the enzyme tyrosinase.
Tyrosinase is the most important enzyme in the synthesis of melanin, many skin lighteners work by inhibiting this enzyme. Tyrosinase inhibitors include hydroquinone arbutin, kojic acid, azelaic acid, L-ascorbic acid/Vitamin C. It no suprise that the aformentioned products are some of the best substances for lightening/treating hyperpigmentation.
Now this study claims that they have a drug which blocks the synthesis of tyrosinase, it works by using alpha-methyl-p-tyrosine
This study conducted an experiment to prove the effiacy of this drug in lightening BROWN EYES:
Now the arrow points to the amount of melanin content in the cells, we can see that use of alpha.-methyl-p-tyrosine decreases mealnin content in brown eyes, even without using latanoprost(the control), so this drug could possibly be used on its own to lighten dark eyes
It also decreased tyrinoase activity which is how skin lighteners often work
Except for one row, it consistently decreased melanin production, content and tyrosinase activity
"These results show that melanin production by iris melanocytes is inhibited by alpha.-methyl-p-tyrosine."
---------------------------------------------------------------------------
Results for brown-blue eyes
This is the second part of the study and it was conducted on blue-brown eyes, it still worked to inhibit melanin production, content and tyrosinase activity, but not as well as it did for brown eyes, as you can see, there a few rows melanin production increased, but this was probaly just random fluctuation, so this is probably more effective if you have very dark eyes.
"Although the present description concerns particularly the inhibition of melanin production induced by latanoprost, alpha.-methyl-p-tyrosine can be used successfully to inhibit the same Side effect of pigmentation induced by other pharmacological treatments or metabolic imbalance of different origin."
- This means that this drug doesn't have to be used in response to eye colour change from latanoprost, so it can be used without it
The name of the drug is metyrosine and for lightening the eyes it should be dosed at 100-500mg.
TLDR - metyrosine is a drug which significantly decreases melanin production, content and tyrosinase activity, those with high concentrations of melanin in the eyes have brown eyes, very little melanin makes eyes blue.
I could be wrong about all of this, seeing as there were no pics in the study, we don't know how this would translate visually, i want a discussion and wanna see ppls opinion on this
The way this works is still not completely clear, but for your eyes to get darker, increased synthesis of melanin must occur....
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1771317/
- https://www.sciencedirect.com/science/article/abs/pii/S0039625797800197
Melanin is derived from the amino acid—tyrosine—through a synthesis regulated by the enzyme tyrosinase.
Tyrosinase is the most important enzyme in the synthesis of melanin, many skin lighteners work by inhibiting this enzyme. Tyrosinase inhibitors include hydroquinone arbutin, kojic acid, azelaic acid, L-ascorbic acid/Vitamin C. It no suprise that the aformentioned products are some of the best substances for lightening/treating hyperpigmentation.
CA2287887A1 - The use of .alpha.-methyl-p-tyrosine to inhibit melanin production in iris melanocytes - Google Patents
The use of agents for blocking the synthesis of tyrosinase to prevent permanent pigmentation of the iris caused by melanin deposit induced by pharmacological treatments or by metabolic imbalance is described.
patents.google.com
Now this study claims that they have a drug which blocks the synthesis of tyrosinase, it works by using alpha-methyl-p-tyrosine
This study conducted an experiment to prove the effiacy of this drug in lightening BROWN EYES:
Now the arrow points to the amount of melanin content in the cells, we can see that use of alpha.-methyl-p-tyrosine decreases mealnin content in brown eyes, even without using latanoprost(the control), so this drug could possibly be used on its own to lighten dark eyes
It also decreased tyrinoase activity which is how skin lighteners often work
Except for one row, it consistently decreased melanin production, content and tyrosinase activity
"These results show that melanin production by iris melanocytes is inhibited by alpha.-methyl-p-tyrosine."
Results for brown-blue eyes
This is the second part of the study and it was conducted on blue-brown eyes, it still worked to inhibit melanin production, content and tyrosinase activity, but not as well as it did for brown eyes, as you can see, there a few rows melanin production increased, but this was probaly just random fluctuation, so this is probably more effective if you have very dark eyes.
"Although the present description concerns particularly the inhibition of melanin production induced by latanoprost, alpha.-methyl-p-tyrosine can be used successfully to inhibit the same Side effect of pigmentation induced by other pharmacological treatments or metabolic imbalance of different origin."
- This means that this drug doesn't have to be used in response to eye colour change from latanoprost, so it can be used without it
The name of the drug is metyrosine and for lightening the eyes it should be dosed at 100-500mg.
TLDR - metyrosine is a drug which significantly decreases melanin production, content and tyrosinase activity, those with high concentrations of melanin in the eyes have brown eyes, very little melanin makes eyes blue.
I could be wrong about all of this, seeing as there were no pics in the study, we don't know how this would translate visually, i want a discussion and wanna see ppls opinion on this
Cumskins when ethnics and blacks have blue and green eyes:
