whitebitchslayer
currently chasing 24” bidelt
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Introduction
Mechanism of Action
If we are to understand the potential uses for this drug fully, we must understand how it works in its clinical use for osteoporosis patients. Firstly, teriparatide promotes anabolism in the bone, this means it directly causes the formation of new bone matter within the body. In contrast to HGH (human growth hormone) and IGF-1 (insulin-like growth factor 1) it is bone-specific rather than full-body system-specific, a major difference we will discuss more later. It causes bone growth through modulating osteoblast activity (process where special cells known as osteoblasts build new bone tissue). There are 2 major steps in this process:
If we are to understand the potential uses for this drug fully, we must understand how it works in its clinical use for osteoporosis patients. Firstly, teriparatide promotes anabolism in the bone, this means it directly causes the formation of new bone matter within the body. In contrast to HGH (human growth hormone) and IGF-1 (insulin-like growth factor 1) it is bone-specific rather than full-body system-specific, a major difference we will discuss more later. It causes bone growth through modulating osteoblast activity (process where special cells known as osteoblasts build new bone tissue). There are 2 major steps in this process:
Proliferation
Proliferation is the increase in preosteoblast cells. These are defined as cells destined to become osteoblast cells and are derived from mesenchymal stem cells (MSCs). MSCs are stemcels with the ablity to become multiple different types of cells, teriparatide acts on the Wnt/β-catenin pathway and causes more of these cells to become preosteoblast cells which in turn mature into osteoblast cells which build bone tissue.
Differentiation
Differentiation is the process in which these preosteoblast cells turn into osteoblast cells. Teriparatide increases the rate at which preosteoblast cells mature by upregulating runt-related transcription factor 2 (runx2) and Osterix (SP7). This also has minor side advantages through increasing alkaline phosphatase and collagen type 1 which give further bone growth.
Cell death prevention
The next big point within the mechanism of action is the anti-apoptotic effects, osteoblast cells die very very fast but teriparatide prevents this premature death via PI3K/Akt signaling. This inhibits caspase-3 (enzyme which causes the cell death) and promotes bcl-2 signalling (protein which prevents cell death). The result of these processes is an exponentially longer cell life for osteoblasts and therefore gives them the ability to build even more bone tissue.
Advanced bone synthesis
The human bone matrix consists of organic matrix (30% of total bone matter) and inorganic matrix (70% of total bone matter). Next, we will look at how teriparatide affects the 2 parts of the bone. The organic matrix is 90% type 1 collagen, the primary function is to give the bones tensile strength. Type 1 collagen production is increased via osteoblasts and osteoblast progenitor cells. As discussed earlier, these are made through a very complex process, which is supercharged by teriparatides. The inorganic matrix consists of hydroxyapatite, which is the most important mineral in bone matter. Teriparatide enhances the secretion of osteocalcin and bone sialoprotein, both of which are involved in the mineral binding leading to hydroxyapatite. Osteoids, combined with calcium and phosphate, harden and become bone structure, then they are turned into osteocytes by the osteoblast cell. As you can see, teriparatides are perfectly designed to boost the production of both parts of the bone more than any other compound on the planet.
Other Effects
Along with the main effect of increasing bone mass, teriparatides also strengthen the bones, which reduces risk of fracture or breakage (especially advantageous for those with fragile bones). On the negative side, however, teriparatides can cause episodes of dizziness and high calcium levels in the blood. Since it is taken via injection it also has commonly associated sides suck as injection site pain and soreness.
Uses
Now that we understand the effects of teriparatide and how they work in the body, we will examine the possible uses for the purposes of looksmaxing. Firstly is the rapid regeneration of bone damage allows faster recovery from both minor and major surgery. I originally learned about this drug from a known figure in the cosmetic limb lengthening community who used it to recover from this surgery, as it causes significant bone damage. It can be used to recover with superhuman speed from cosmetic procedures. It can also be used to grow bone mass in your face and jaw. The human users whom I have spoken to note their jaw specifically being more prominent and better. The increase and advancement of bone in the skull will make a large impact on attractiveness for most people with low bone mass.
Teriparatide vs hGH and IGF1
Human growth hormone and insulin-like growth factor 1 are the most commonly used compounds for bone growth. The main advantage of teriparatide over these two compounds is that teriparatide only targets bones, unlike hGH, which targets organs and muscle too, and IGF1, which targets cartilage. The other advantage is that teriparatide has a much greater degree of effect, while a lot of people take both hGH injections (or IGF1/hGH inducing peptides) alongside teriparatide, the overall effectiveness of teriparatide is much greater.
The Main Drawback
The biggest drawback to teriparatide usage is the amount of money it costs. Some users in the looksmaxing community, who I have consulted, who do not wish to be named, claim they spend thousands every single month, however, the results speak for themselves and make it well worth it. If you can afford it or find ways to get high-quality teriparatide for relatively cheap, it can be powerful.
Sources, Studies, and More Info to Read
Below are links to studies done on the use of teriparatide. I'd suggest reading them if you are interested and somehow aren't tired of reading the word teriparatide.
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
If you read this, thank you it was alot of mind-numbing hours reading and typing. If you didn't, all you need to know is that teriparatide builds bone like no other drug but is expensive and a pain to get. Good luck
Along with the main effect of increasing bone mass, teriparatides also strengthen the bones, which reduces risk of fracture or breakage (especially advantageous for those with fragile bones). On the negative side, however, teriparatides can cause episodes of dizziness and high calcium levels in the blood. Since it is taken via injection it also has commonly associated sides suck as injection site pain and soreness.
Uses
Now that we understand the effects of teriparatide and how they work in the body, we will examine the possible uses for the purposes of looksmaxing. Firstly is the rapid regeneration of bone damage allows faster recovery from both minor and major surgery. I originally learned about this drug from a known figure in the cosmetic limb lengthening community who used it to recover from this surgery, as it causes significant bone damage. It can be used to recover with superhuman speed from cosmetic procedures. It can also be used to grow bone mass in your face and jaw. The human users whom I have spoken to note their jaw specifically being more prominent and better. The increase and advancement of bone in the skull will make a large impact on attractiveness for most people with low bone mass.
Teriparatide vs hGH and IGF1
Human growth hormone and insulin-like growth factor 1 are the most commonly used compounds for bone growth. The main advantage of teriparatide over these two compounds is that teriparatide only targets bones, unlike hGH, which targets organs and muscle too, and IGF1, which targets cartilage. The other advantage is that teriparatide has a much greater degree of effect, while a lot of people take both hGH injections (or IGF1/hGH inducing peptides) alongside teriparatide, the overall effectiveness of teriparatide is much greater.
The Main Drawback
The biggest drawback to teriparatide usage is the amount of money it costs. Some users in the looksmaxing community, who I have consulted, who do not wish to be named, claim they spend thousands every single month, however, the results speak for themselves and make it well worth it. If you can afford it or find ways to get high-quality teriparatide for relatively cheap, it can be powerful.
Sources, Studies, and More Info to Read
Below are links to studies done on the use of teriparatide. I'd suggest reading them if you are interested and somehow aren't tired of reading the word teriparatide.
Effect of teriparatide on bone mineral density and fracture in postmenopausal osteoporosis: meta-analysis of randomised controlled trials - PubMed
To determine the efficacy of teriparatide supplementation for improving bone mineral density (BMD) and fracture risk in postmenopausal osteoporosis and if effects vary with factors. We identified eight randomised controlled trials (n = 2388) using electronic databases, supplemented by a...
pubmed.ncbi.nlm.nih.gov
Fracture risk reduction during treatment with teriparatide is independent of pretreatment bone turnover - PubMed
Teriparatide-mediated relative fracture risk reduction was independent of pretreatment bone turnover, demonstrating that this therapy offers clinical benefit to patients across a range of disease severity.
pubmed.ncbi.nlm.nih.gov
Effect of Teriparatide on Bone Formation in the Human Femoral Neck - PubMed
TPTD stimulates bone formation rapidly in cancellous and endocortical envelopes of the FN. Our findings provide a mechanistic basis for TPTD-mediated improvement in FN bone mass and ultimately hip strength. This study is the first demonstration of the effect of any osteoporosis medication on...
pubmed.ncbi.nlm.nih.gov
Effect of Teriparatide on Bone Remodeling and Density in Premenopausal Idiopathic Osteoporosis: A Phase II Trial - PubMed
Teriparatide increased BFR and formation markers and was associated with marked aBMD improvements in most premenopausal women (82%) with IOP.
pubmed.ncbi.nlm.nih.gov
If you read this, thank you it was alot of mind-numbing hours reading and typing. If you didn't, all you need to know is that teriparatide builds bone like no other drug but is expensive and a pain to get. Good luck
