Randle cycle by @foidletslayer

[Sub5kang]

In short, go vegan.

What happened in a year bro you were the OG carnivore guy here

 

[boxillo]

book of context
1.1 Introduction to Randle cycle
1.2 how it’s activated
1.3 why it’s bad to activate it
I got lazy so fuck this

What is the randle cycle?

The Randle cycle describes the metabolic process of by which the body regulates the relative utilization of carbohydrates (glucose) and fats for energy production in response to nutrient availability and hormonal signals.

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How is the randle cycle activated?
The Randle cycle is activated when both carbs (glucose) and fatty acids are available for energy. Because cells preferentially oxidize one fuel at a time, the presence of high levels of one substrate inhibits the utilization of the other. Specifically, increased fatty acid oxidation suppresses glucose oxidation by inhibiting key enzymes in glycolysis and the pyruvate dehydrogenase complex, while high glucose availability and insulin signaling inhibit fatty acid oxidation. This mechanism allows the body to efficiently switch between fuels depending on nutrient availability.

---

Why it's bad to constantly activate it
If you consistently continue to consume meals high in both fats & carbs then it will place a metabolic strain on the body, as it cannot efficiently oxidize both fuels simultaneously. This dual-substrate overload can impair cellular energy utilization and contribute to metabolic inflexibility, increasing the risk of insulin resistance and other metabolic dysfunctions

---

In what scenario is the it’s effects negligible?
The effect is negligible only when the pathway is appropriately regulated. But what does proper activation entail? In humans, this occurs naturally through the physiological patterns of nutrient availability and hormonal signaling that have evolved to optimize energy metabolism.

The way humans in nature used to activate the Randle cycle is.
- Seasonally
- Separate from fat

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When were carbs consumed by primals
They’d only consume carbs when they were naturally available & they’d would never mix it with fat except if they have protein digestive enzymes (but that's a different topic)

---

Why is the randle cycle’s negatives negligible when consuming carbs alone

when you consume carbs that are sourced from fruits alone 3 things happen to you which are

---

But but glucose stays in your system for more than 3 days….

When you eat fruit (or any carbohydrate), glucose enters the bloodstream quickly and your body immediately responds by releasing insulin within minutes. In a health human’s blood glucose returns to baseline within less than 5 hours after glucose euphoria / carb consumption. Furthermore carb consumption is not even relevant to the Randle cycle…..

How it’s irrelevant to the randle cycle

The Randle cycle governs the competition between energy substrates in real time, rather than responding to lingering traces of glucose or fat accumulated over days.
Continuation

When you consume fruit in isolation, you supply your body with a singular, dominant fuel, glucose. In the absence of substantial LCFA, there is no meaningful substrate rivalry, and therefore the randle cycle remains largely dormant, if engaged at ALL.

Even if glycogen reserves remain saturated for hrs, or glucose is sequestered within tissues, the randle cycle is governed by the fuels actively present and competing in circulation at that moment, rather than by what has been previously stored.

You’re welcome, use this information as you will

@EvilSatanArseRapist @Tyler1 @asdvek @unknownfatcel @Saint @Ghoulish

Dnr

 

[foidletslayer]

Dnr

Shut the fuck up nigger

 

[boxillo]

Shut the fuck up nigger

It’s ok man we’ve all seen face low iq before this isn’t new man calm down

 

[foidletslayer]

It’s ok man we’ve all seen face low iq before this isn’t new man calm down

 

[subarunatsuki]

book of context
1.1 Introduction to Randle cycle
1.2 how it’s activated
1.3 why it’s bad to activate it
I got lazy so fuck this

What is the randle cycle?

The Randle cycle describes the metabolic process of by which the body regulates the relative utilization of carbohydrates (glucose) and fats for energy production in response to nutrient availability and hormonal signals.

---

How is the randle cycle activated?
The Randle cycle is activated when both carbs (glucose) and fatty acids are available for energy. Because cells preferentially oxidize one fuel at a time, the presence of high levels of one substrate inhibits the utilization of the other. Specifically, increased fatty acid oxidation suppresses glucose oxidation by inhibiting key enzymes in glycolysis and the pyruvate dehydrogenase complex, while high glucose availability and insulin signaling inhibit fatty acid oxidation. This mechanism allows the body to efficiently switch between fuels depending on nutrient availability.

---

Why it's bad to constantly activate it
If you consistently continue to consume meals high in both fats & carbs then it will place a metabolic strain on the body, as it cannot efficiently oxidize both fuels simultaneously. This dual-substrate overload can impair cellular energy utilization and contribute to metabolic inflexibility, increasing the risk of insulin resistance and other metabolic dysfunctions

---

In what scenario is the it’s effects negligible?
The effect is negligible only when the pathway is appropriately regulated. But what does proper activation entail? In humans, this occurs naturally through the physiological patterns of nutrient availability and hormonal signaling that have evolved to optimize energy metabolism.

The way humans in nature used to activate the Randle cycle is.
- Seasonally
- Separate from fat

---

When were carbs consumed by primals
They’d only consume carbs when they were naturally available & they’d would never mix it with fat except if they have protein digestive enzymes (but that's a different topic)

---

Why is the randle cycle’s negatives negligible when consuming carbs alone

when you consume carbs that are sourced from fruits alone 3 things happen to you which are

---

But but glucose stays in your system for more than 3 days….

When you eat fruit (or any carbohydrate), glucose enters the bloodstream quickly and your body immediately responds by releasing insulin within minutes. In a health human’s blood glucose returns to baseline within less than 5 hours after glucose euphoria / carb consumption. Furthermore carb consumption is not even relevant to the Randle cycle…..

How it’s irrelevant to the randle cycle

The Randle cycle governs the competition between energy substrates in real time, rather than responding to lingering traces of glucose or fat accumulated over days.
Continuation

When you consume fruit in isolation, you supply your body with a singular, dominant fuel, glucose. In the absence of substantial LCFA, there is no meaningful substrate rivalry, and therefore the randle cycle remains largely dormant, if engaged at ALL.

Even if glycogen reserves remain saturated for hrs, or glucose is sequestered within tissues, the randle cycle is governed by the fuels actively present and competing in circulation at that moment, rather than by what has been previously stored.

You’re welcome, use this information as you will

@EvilSatanArseRapist @Tyler1 @asdvek @unknownfatcel @Saint @Ghoulish

holy cortisol spike DNR

 

[foidletslayer]

holy cortisol spike DNR

subarunatsuki​

Iron​

JoinedSep 8, 2025Posts1Reputation0

Thanks for lending me the honor of being the first post you reply to though

 

[Never Get Up]

What happened in a year bro you were the OG carnivore guy here

I’m still a carnivore.

 

[foidletslayer]

I’m still a carnivore.

Oh really?

 

[Never Get Up]

Oh really?

Yes. I’ve been a raw carnivore for 18 months now. I have made threads on the Randle Cycle and carbohydrates a year ago.

Ultimate guide regarding carbohydrates, Randle Cycle, calories, weight, and nutritional science | Why humans are obligate hyper carnivores | High IQ

You obviously didn’t watch my video of me eating raw meat I didn’t, I just made an instant reply based off our interactions like a month ago. What made you change to raw meat?

looksmax.org

 

[foidletslayer]

Yes. I’ve been a raw carnivore for 18 months now. I have made threads on the Randle Cycle and carbohydrates a year ago.

Ultimate guide regarding carbohydrates, Randle Cycle, calories, weight, and nutritional science | Why humans are obligate hyper carnivores | High IQ

You obviously didn’t watch my video of me eating raw meat I didn’t, I just made an instant reply based off our interactions like a month ago. What made you change to raw meat?

looksmax.org

Cool shi I’ve understood the Randle cycle since 9th grade basic shi they taught us in school, it’s a luxury compared to what other school teach

 

[Never Get Up]

Cool shi I’ve understood the Randle cycle since 9th grade basic shi they taught us in school, it’s a luxury compared to what other school teach

The Randle Cycle specifically proves that we are in fact carnivores, not omnivores. Especially not vegans.

Anyone who seriously claims that humans are not carnivores have low IQ’s.

 

[subarunatsuki]

subarunatsuki​

Iron​

JoinedSep 8, 2025Posts1Reputation0

Thanks for lending me the honor of being the first post you reply to though

of course man

 

[Sub5kang]

I’m still a carnivore.

You da real og you got me off of grainsludge

 

[foidletslayer]

You da real og you got me off of grainsludge

What do you consider as grainsludge?

 

[Sub5kang]

What do you consider as grainsludge?

Any form of C*rb (sorry it's my trigger word) even if it isn't wheat based and not a grain necessarily it's still grainsludge to me

 

[Sub5kang]

Oh really?

I used to think calories weren't a unit of heat @Never Get Up

 

[Sub5kang]

Oh really?

Yeah that's why I tagged bro in the thread he schooled me last year
I used to be very against the idea of carni

Ultimate guide regarding carbohydrates, Randle Cycle, calories, weight, and nutritional science | Why humans are obligate hyper carnivores | High IQ

Nutrition science: 1. There are 0 100% controlled, long term studies with humans locked in labs for multiple decades to provide proof on ANY aspect of health and nutrition science. 2. ALL exogenous carbohydrates break down into glucose leading to raised glucose levels which is UNDOUBTEDLY the...

looksmax.org