they dont know fuckshit about biology, literally spouting absolute bullshit. do your own research and dont believe rando threads
@rotation
have u deadaas tried 100 mg or u larping
thing is, they claim that "30-200mg is for the full cardiovascular, anti-inflammatory, anti-oxidant properties" which is not really accurate to the pinpoint and melatonin’s antioxidant effects are present at much lower doses. If ehh melatonin at 30–200 mg improved hypertension, diabetes, and heart diseases and whatnot in a good way it'd be a common medical cardiology practice by now which isnt, the evidence is heavily limited and i believe that thread is taking niche very limited sources of evds and applying it into real world which isnt practical by all means
I genuinely take this every night. I've done 150 a couple times before
bro exogenous melatonin does not effect endogenous production
Sweet dreams tee is useless
huh no, as far as i know, exogenous melatonin signals feedback to the hypothalamus and pituitary. Chronic high dose use will ofc suppress endogenous production
it has chamomile and naturally occurring l-theanine
Sbg w magnesium glycinate thats it
whether my dose shuts down my natural production it doesn't matter. I'm gonna keep taking it for the rest of my life anyway. I notice on the days I forget I still sleep fine it just takes longer to fall asleep (5-10 mins w/melatonin; 10-30 mins without)
sbg?
to be clear, im not saying the evidence proves high dose melatonin suppresses production long term, just that it can influence signaling while it’s being used
Can u provide a source?
wym influencing signaling?
Should be good
no he cant bcs its wrong
Yeah cuz it’s very weird it’s my first time ever hearing this, that would mean it cause dependence which simply isn’t true
i misframed it earlier, my bad, more accurate would be that during such high dosage your body can interfere with the signalling and can potentially modulate receptor responsiveness while you’re taking it although there isnt like strong human evid showing long term suppression of endogenous melatonin production after stopping
I take 2mg malatonin max and Tap out after 10min max post goon
Yeah cuz i never heard it cause suppression in natural production that would mean dependence, either way even then we don’t even know if it interfere with signaling always, not that important of a substance anyway
it can affect how the circadian rhythm signal is expressed while you’re taking it
i've said that in the sense of this study as far as i remember, https://pubmed.ncbi.nlm.nih.gov/15135299/
yes it does effect circadian rhythm but in a positive way
source? it builds up a tolerance to it
All the studies on melatonin supplementation and melatonin production brochacho
I don't mind but I'm about to head to sleep, we can continue this after I wake up
Provided source as to what I was talking about, can be taken as controversial but there's some plausible truth to the words which I oversimplified
I don’t take the melatonin just for sleep I just have to take it before bed due to it’s effects on sleep
100mg won’t increase sleep quality if that’s the point of your stack if anything it will damage it sleep stacks are mostly cope if your going naturally.
Nigga critique the evidence provided dont just say shit, since you probs didnt read it heres 2 he provided plus 2 meta-analysises as a bonus on the matter
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
Theres many things that can do so, how many things do you want them to do?
The evidence is not limited we have many many studies and analysises on the matter, youre also framing it as if hes extrapolating anything which he is not
How is that bad reasoning, I’m saying that if 30-200 mg consistently produced medically meaningful improvement in diseases like hypertension, diabetes and so on, wouldnt we have large discussion in cardiology guidelines and trials
Gng the papers you linked don't really back up the claims, the papers you linked are small observational studies. The biomolecular one is an interesting theory but again, it doesn’t really show real human benefits and mdpi study also isn’t randomized and doesn’t have strong controls or hard endpoints like heart disease events, stroke and so onNigga critique the evidence provided dont just say shit, since you probs didnt read it heres 2 he provided plus 2 meta-analysises as a bonus on the matter
Effects of melatonin supplementation on oxidative stress: a systematic review and meta-analysis of randomized controlled trials - PubMed
The present study showed a promising effect of melatonin administration for reducing MDA, PCO, and increasing TAC levels. However, further studies especially with more attention to PCO level assessment are needed to confirm the findings of the present study in larger samples on different...
Melatonin effectiveness in amelioration of oxidative stress and strengthening of antioxidant defense system: Findings from a systematic review and dose-response meta-analysis of controlled clinical trials - PubMed
Results of the current meta-analysis showed that melatonin supplementation had a significant impact on attenuating of oxidative stress and enhancing antioxidant performance. Melatonin supplementation could be suggested as a safe complementary approach in amelioration of the chronic diseases.
I think ur thread relies a LOT on theoretical, small studies. but I don’t see large human trials showing that high dose melatonin actually improves long term health outcomes
Melatonin is never used to improve sleep quality just latency. It has zero effect on REM sleep patterns
pubmed.ncbi.nlm.nih.gov
No because we 100+ things that can do that, do you expect doctors to put patients on 100+ meds?
Idk i havent counted them, but yoi clearly missed the point megadoses are not for better sleep but to get the antioxidants benefits of melatonin
He made many claims, not just prcatical claims, this one backs up his claims about the theory behind it all
If you need randomized control trials scroll fown to the third link and you can read that the meta analysis was made of 15 randomized control trials
