Retatrutide: The Ultimate Fat Loss Drug (GTFIH, Summer Is Coming)

[PsychoDsk]

@PsychoDsk

Was gonna run reta few weeks ago but winstrol did the job

I think it’s just praised too much cuz of that dtren dude
There’s plenty other compounds that work just as well while being around for much longer

Good thread nonetheless

 

[Neucher]

Gonna try Retatrutide maybe once my Tirzepatide runs out in few months

 

[Stranger to myself]

Tbh I shouldve just started off with reta wasted my money on 5 amino

 

[MUSTYCOPER]

you better do that because I remember running dnp for the first time, I was downing a bunch of calories the craving is bad but atleast I did not put any weight while on it, still a waste and retarded though.

im on sema + dnp rn and its awful dont recommend. Just run glps and cut normally. Sure im burning fat, but i feel paralyzed waking up and feel like im dying of dehydration every waking second of the day. the fatigue is awful

 

[bigpapi123]

Source for Reta, in Aus btw

 

[shredranger]

im on sema + dnp rn and its awful dont recommend. Just run glps and cut normally. Sure im burning fat, but i feel paralyzed waking up and feel like im dying of dehydration every waking second of the day. the fatigue is awful

felt that way after the 10 day mark on DNP, sema just makes it worse. sema had me fatigued. so dnp and sema = bad. tirzepatide and retatrutide or retatrutide as a standalone is the shit. reason I stack? I switched over to reta while I was using tirzepatide and I slowly was titrating them up. suppresion is fine. might drop tirzepatide once it completely stops giving me the benefit of the suppresion as it is more pronounced than retatrutide on the food suppresion side and introduce cagri instead, which is technically not a glp1 but a great additive for the suppresion.

second time I used dnp, was for the sole reason of not adding weight while eating a lot over surplus for a week, basically being a loser. did it help? sure. did I feel like shit and sweaty while on it? yea, was it worth it? no sides to mention other than the typical ones while on it so.. for now.. we're alive and the bloodwork is fine. is this drug a bit too much demonized? I think it's a great tool. of course, you don't want to be destroying your ATP levels - mitochondria constantly as we don't know the result of that, no one runs it as easy as they'd run clen. wasn't wise to do what I did on the second run, but it seemed to work, lol. don't take this as a gateway to abuse eating like shit this will definitely get you something bad sooner or later, either if that's long term fucked up atp mitochrondia or w/e the science behind that is, or neuropathy forever, cataracts possibly.

 

[shredranger]

Tbh I shouldve just started off with reta wasted my money on 5 amino

5 scammino.

slup does not work for fat loss
5amino does not work
aod does not work (anti obesity drug.. lmao.....dont get me going on the studies behind that shit peptide)

reta works - boosts bmr, forgiving while I do cheat days surprisingly?
tirzepatide - great
sema - shitty but supressses appetite
cagri just to add on any of the above after you start getting hunger cues, fuck hunger.

working.. kind of
clen - demonized by retards it literally builds up in your system and after 3-4 days all sides go away if you titrate up slowly. it just does not work as effectively as the first time ever. it's true. it's meh.
yohimbine fasted - meh.
injectable l carnitine - meh
dnp - yes - dangerous if used by fags
caffeine - appetite
ephe - appetite (meh)

some cardio - yes
some deficit - def yes
how to do weight lifting when planning to get on very low %'s
most retards that say train exactly the same are not planning to get any lower than 10 percent nor have the mental capacity to do so
no u wont train the same it just wont happen
u will train until failure, possibly less excersises or some changes to your routine for instance ur not gonna be fcking doing deadlift sessions or heavy squat sessions, ur goal is to keep the muscle, u might as well switch to leg presses till failure. u want to retain ur muscles, minimal efforts to retain muscles just make sure to train TILL failure. at these stages the amount of excersises or sets are NOT the main goal
even sulek stopped doing squats and heavier compounds when cutting on the lows, unless if ur on shiton of anabolics and u can keep it up (even then its a bit hard) then u want to train as I stated. why did I go on all about this stuff? there are people doing a bunch of things wrong here so a retard like lucasegolifts might benefit by my advices, he's snooping over on these forums I can guarantee u, he has also done dnp btw and now he started reta lmfao. he didnt state to anyone that he has done dnp publically I just know.

large deficits and large cardio sessions - ur a retard like the insecure fat potatohead on tiktok named lucas that binges every other day because he doesnt know how to diet properly when getting on low %'s and ends up binging while what u want to do in very low stages is to control the amounts of cardio and deficit otherwise ur cns will get fried u will get inflammation like him and go ravenous with food also

 

[shredranger]

Was gonna run reta few weeks ago but winstrol did the job

I think it’s just praised too much cuz of that dtren dude
There’s plenty other compounds that work just as well while being around for much longer

Good thread nonetheless

reta is a godsent with the inflammation benefits, it also does boost your bmr and it is forgiving when I have cheat days, theres a lot more science behind it rather than it being a glp1, it is also being studied on far more than just a glp1.

dtren is just an idiot that promotes a dude named apex peds or some dumb shit that buys his raws from china and makes his stuff and resell for 4x the price, not impressive. dtren is just making money

 

[shredranger]

Was gonna run reta few weeks ago but winstrol did the job

I think it’s just praised too much cuz of that dtren dude
There’s plenty other compounds that work just as well while being around for much longer

Good thread nonetheless

winstrol is not really a fat burner or an appetite suppresant though so how can u compare even

 

[MUSTYCOPER]

winstrol is not really a fat burner or an appetite suppresant though so how can u compare even

Wow , love the info on this thread, its all one needs to get shredded. Im coming off dnp today. And starting reta tmrw paired with sema that im alr on. I binged 2 days in a row on dnp, queing the end of the cycle. I hope i wake up fresh and ready to get back on track with the reta pin.

 

[Dyorotic]

Also Tirz mogs Reta from all the anecdotes I heard. Triple G agonism didn't seem to do much more in terms of fat loss vs sides.

That's just patently false. The glucagon agonism changes everything. Blood glucose is way more aberrant and unpredictable on Tirz & Sema, whereas on Reta it's always perfect even in a very aggressive deficit.

It increases BMR more than Tirz/Sema

Also Reta has the strongest affinity @ GIP than any of them, it's primarily a GIP agonist.

If anything Reta's (relatively) weak affinity at GLP is a benefit, you can run it whilst bulking and reap all the anti-inflammatory, lipid-modulating, insulin sensitizing and cardioprotective benefits.

 

[Norwegian LTN]

Reta has other benefits like thrashing lipids aswell, and cope reta is much better than tirz in every study.

Its hard on the liver?

 

[Seth Walsh]

That's just patently false. The glucagon agonism changes everything. Blood glucose is way more aberrant and unpredictable on Tirz & Sema, whereas on Reta it's always perfect even in a very aggressive deficit.

It increases BMR more than Tirz/Sema

Also Reta has the strongest affinity @ GIP than any of them, it's primarily a GIP agonist.

If anything Reta's (relatively) weak affinity at GLP is a benefit, you can run it whilst bulking and reap all the anti-inflammatory, lipid-modulating, insulin sensitizing and cardioprotective benefits.

You definitely could be right.

Have you tried Reta? I was talking purely from an anecdotal stance, but never tried Retatrutide. So I admit I was likely just plain wrong in my post.

Have you any studies on the cost/benefit in terms of results and sides from Reta? I'm thinking of using it.

 

[Dyorotic]

You definitely could be right.

Have you tried Reta? I was talking purely from an anecdotal stance, but never tried Retatrutide. So I admit I was likely just plain wrong in my post.

Have you any studies on the cost/benefit in terms of results and sides from Reta? I'm thinking of using it.

Yeah I've tried all of them. I sustained Reta the longest and it was by far the most efficacious for fat loss with little to no sides.

I think the main thing here is it's potent affinity for GIP which, in my experience, is the true heavy hitter when it comes to incretin-based drugs. GIP regulates the entire process of adipogenesis and essentially makes it so even if you do put fat on, it never ends up as visceral fat. Subcutaneous fat is highly beneficial. Almost all subcutaneous fat comes into existence via the process of adipocyte hyperplasia/proliferation from undifferentiated pre-adipocytes, whereas visceral fat almost always accumulates via the process of adipocyte hypertrophy which is incredibly anti-metabolic and inherently diabetogenic.

With incretin-based drugs adipocytes start producing very large amounts of anti-inflammatory/pro-metabolic adipokines (adiponectin stands out here) instead of pro-inflammatory ones. They (sema/tirz/reta) fundamentally change the way your body gains and loses fat. From the studies I've read adiponectin raises to about 20% above baseline after chronic usage of Reta/Tirz (semaglutide doesn't touch GIP so I can't talk about whether or not GLP1Rs induce the same effect.

This is especially important for men because androgens very heavily induce the preferential accumulation of visceral fat (which is funny too because androgens also potently enhance catacholamine-induced lipolysis within VAT. It's almost as if in some men (genetic component here) visceral fat is the most prone to lipolysis (so you lose weight here first) but they also rapidly regain within visceral depots before they start building up subcutaneous depots. Hence why you see a lot of guys with pot bellies despite being within a healthy BMI.

Retatrutide obviously hits glucagon receptors too which produces an entirely new MOA when it comes to energy balance and weight loss. Glucagon agonism will absolutely shred VAT preferentially and keep blood glucose levels incredibly stable (no fatigue or hypoglycemia with Reta). I was always blown away when I tested my blood glucose after a day of eating next to nothing. Oh and glucagon agonism seems to abate the ratio of muscle-fat loss (less muscle loss with reta despite a higher total % of weight loss).

Anyway, incretin-based drugs resolve this problem entirely and there is absolutely no reason to not use them when they're so accessible and cheap nowadays. My main point here is there is clearly some major flexibility/use-case with these drugs outside of solely losing weight. Bodybuilders are currently popularizing the idea of running some form of incretin (relatively low dose) alongside their bulking phases because of how drastic the insulin-sensitizing effects are.

Sorry for the schizo ramble I just find Reta interesting

 

[Seth Walsh]

Yeah I've tried all of them. I sustained Reta the longest and it was by far the most efficacious for fat loss with little to no sides.

I think the main thing here is it's potent affinity for GIP which, in my experience, is the true heavy hitter when it comes to incretin-based drugs. GIP regulates the entire process of adipogenesis and essentially makes it so even if you do put fat on, it never ends up as visceral fat. Subcutaneous fat is highly beneficial. Almost all subcutaneous fat comes into existence via the process of adipocyte hyperplasia/proliferation from undifferentiated pre-adipocytes, whereas visceral fat almost always accumulates via the process of adipocyte hypertrophy which is incredibly anti-metabolic and inherently diabetogenic.

With incretin-based drugs adipocytes start producing very large amounts of anti-inflammatory/pro-metabolic adipokines (adiponectin stands out here) instead of pro-inflammatory ones. They (sema/tirz/reta) fundamentally change the way your body gains and loses fat. From the studies I've read adiponectin raises to about 20% above baseline after chronic usage of Reta/Tirz (semaglutide doesn't touch GIP so I can't talk about whether or not GLP1Rs induce the same effect.

This is especially important for men because androgens very heavily induce the preferential accumulation of visceral fat (which is funny too because androgens also potently enhance catacholamine-induced lipolysis within VAT. It's almost as if in some men (genetic component here) visceral fat is the most prone to lipolysis (so you lose weight here first) but they also rapidly regain within visceral depots before they start building up subcutaneous depots. Hence why you see a lot of guys with pot bellies despite being within a healthy BMI.

Retatrutide obviously hits glucagon receptors too which produces an entirely new MOA when it comes to energy balance and weight loss. Glucagon agonism will absolutely shred VAT preferentially and keep blood glucose levels incredibly stable (no fatigue or hypoglycemia with Reta). I was always blown away when I tested my blood glucose after a day of eating next to nothing. Oh and glucagon agonism seems to abate the ratio of muscle-fat loss (less muscle loss with reta despite a higher total % of weight loss).

Anyway, incretin-based drugs resolve this problem entirely and there is absolutely no reason to not use them when they're so accessible and cheap nowadays. My main point here is there is clearly some major flexibility/use-case with these drugs outside of solely losing weight. Bodybuilders are currently popularizing the idea of running some form of incretin (relatively low dose) alongside their bulking phases because of how drastic the insulin-sensitizing effects are.

Sorry for the schizo ramble I just find Reta interesting

Thank you Dyorotic mate. Much credence to you and very interesting, much needed post!

 

[cheekbonesforlife]

Yeah I've tried all of them. I sustained Reta the longest and it was by far the most efficacious for fat loss with little to no sides.

I think the main thing here is it's potent affinity for GIP which, in my experience, is the true heavy hitter when it comes to incretin-based drugs. GIP regulates the entire process of adipogenesis and essentially makes it so even if you do put fat on, it never ends up as visceral fat. Subcutaneous fat is highly beneficial. Almost all subcutaneous fat comes into existence via the process of adipocyte hyperplasia/proliferation from undifferentiated pre-adipocytes, whereas visceral fat almost always accumulates via the process of adipocyte hypertrophy which is incredibly anti-metabolic and inherently diabetogenic.

With incretin-based drugs adipocytes start producing very large amounts of anti-inflammatory/pro-metabolic adipokines (adiponectin stands out here) instead of pro-inflammatory ones. They (sema/tirz/reta) fundamentally change the way your body gains and loses fat. From the studies I've read adiponectin raises to about 20% above baseline after chronic usage of Reta/Tirz (semaglutide doesn't touch GIP so I can't talk about whether or not GLP1Rs induce the same effect.

This is especially important for men because androgens very heavily induce the preferential accumulation of visceral fat (which is funny too because androgens also potently enhance catacholamine-induced lipolysis within VAT. It's almost as if in some men (genetic component here) visceral fat is the most prone to lipolysis (so you lose weight here first) but they also rapidly regain within visceral depots before they start building up subcutaneous depots. Hence why you see a lot of guys with pot bellies despite being within a healthy BMI.

Retatrutide obviously hits glucagon receptors too which produces an entirely new MOA when it comes to energy balance and weight loss. Glucagon agonism will absolutely shred VAT preferentially and keep blood glucose levels incredibly stable (no fatigue or hypoglycemia with Reta). I was always blown away when I tested my blood glucose after a day of eating next to nothing. Oh and glucagon agonism seems to abate the ratio of muscle-fat loss (less muscle loss with reta despite a higher total % of weight loss).

Anyway, incretin-based drugs resolve this problem entirely and there is absolutely no reason to not use them when they're so accessible and cheap nowadays. My main point here is there is clearly some major flexibility/use-case with these drugs outside of solely losing weight. Bodybuilders are currently popularizing the idea of running some form of incretin (relatively low dose) alongside their bulking phases because of how drastic the insulin-sensitizing effects are.

Sorry for the schizo ramble I just find Reta interesting

looks like you know your stuff about Reta. How would you suggest I cycle Reta to shed 40-50 lbs of fat

 

[Seth Walsh]

Yeah I've tried all of them. I sustained Reta the longest and it was by far the most efficacious for fat loss with little to no sides.

I think the main thing here is it's potent affinity for GIP which, in my experience, is the true heavy hitter when it comes to incretin-based drugs. GIP regulates the entire process of adipogenesis and essentially makes it so even if you do put fat on, it never ends up as visceral fat. Subcutaneous fat is highly beneficial. Almost all subcutaneous fat comes into existence via the process of adipocyte hyperplasia/proliferation from undifferentiated pre-adipocytes, whereas visceral fat almost always accumulates via the process of adipocyte hypertrophy which is incredibly anti-metabolic and inherently diabetogenic.

With incretin-based drugs adipocytes start producing very large amounts of anti-inflammatory/pro-metabolic adipokines (adiponectin stands out here) instead of pro-inflammatory ones. They (sema/tirz/reta) fundamentally change the way your body gains and loses fat. From the studies I've read adiponectin raises to about 20% above baseline after chronic usage of Reta/Tirz (semaglutide doesn't touch GIP so I can't talk about whether or not GLP1Rs induce the same effect.

This is especially important for men because androgens very heavily induce the preferential accumulation of visceral fat (which is funny too because androgens also potently enhance catacholamine-induced lipolysis within VAT. It's almost as if in some men (genetic component here) visceral fat is the most prone to lipolysis (so you lose weight here first) but they also rapidly regain within visceral depots before they start building up subcutaneous depots. Hence why you see a lot of guys with pot bellies despite being within a healthy BMI.

Retatrutide obviously hits glucagon receptors too which produces an entirely new MOA when it comes to energy balance and weight loss. Glucagon agonism will absolutely shred VAT preferentially and keep blood glucose levels incredibly stable (no fatigue or hypoglycemia with Reta). I was always blown away when I tested my blood glucose after a day of eating next to nothing. Oh and glucagon agonism seems to abate the ratio of muscle-fat loss (less muscle loss with reta despite a higher total % of weight loss).

Anyway, incretin-based drugs resolve this problem entirely and there is absolutely no reason to not use them when they're so accessible and cheap nowadays. My main point here is there is clearly some major flexibility/use-case with these drugs outside of solely losing weight. Bodybuilders are currently popularizing the idea of running some form of incretin (relatively low dose) alongside their bulking phases because of how drastic the insulin-sensitizing effects are.

Sorry for the schizo ramble I just find Reta interesting

@Dyorotic

We've gotta talk at length about Retatrutide in private and trade notes on other things too. I really appreciate your response, and remember you from years back - always good stuff coming from you.