Roidmaxxing 101™ - How to get a physique halo

[Disturbed]

a comprehensive guide on all hair related compounds/pharma would be fine but some of the advice given in that thread is genuinely comical. A comprehensive guide on every pharmaceutical also isn’t really necessary since we know already what the most effective treatments are, and there are threads in botb about that already.

Well mine mogs all other botb ieo
But sure have any other ideas for a new thread? Would appreciate it

 

[undo]

Well mine mogs all other botb ieo
But sure have any other ideas for a new thread? Would appreciate it

agreed

 

[Disturbed]

agreed

Holy copying my banner

 

[undo]

Holy copying my banner

WDYM GANG NO THE FUCK I DID NOT??

 

[Disturbed]

WDYM GANGGG

I had that profile banner b4
I ditched it for my new one tho
It mogs

 

[undo]

I had that profile banner b4
I ditched it for my new one tho
It mogs

on god i js found it on pinterest

i need a good fucking avi tho this one is cheeks

 

[Disturbed]

on god i js found it on pinterest

i need a good fucking avi tho this one is cheeks

Griffith

 

[undo]

on god i js found it on pinterest

i need a good fucking avi tho this one is cheeks

imma change it rn lmk what u think

 

[undo]

Griffith

maybe yea but i would js be copying u

also the blood thing looks ass

 

[Disturbed]

maybe yea but i would js be copying u

also the blood thing looks ass

What blood thing
And nah you have already copied me

 

[Rm200010]

what medications and supports would you recommend for a beginner cycle of 500 test and gh

Anastrozole - Estrogen
Telmisartan - BP
Ezetimibe - Cholesterol
Isotretinoin - Skin/Acne
Liothyronine - Thyroid Function
HCG - Fertility/Natural Testosterone Production

 

[Azie555]

• To decrease bloating on-cycle use amiloride or eplerenone.

What about hctz and amiloride together arent they a good counter combine to eachother? Would that be better or worse?

 

[Rizzinator]

200-300g protein is ideal daily.

Holy kek

 

[trueRetard]

what medications and supports would you recommend for a beginner cycle of 500 test and gh

Beginner cycle and 500 test in one sentence (my first cycle will be 500 too)

 

[pio]

Beginner cycle and 500 test in one sentence (my first cycle will be 500 too)

if your taking the risk of steroids you might aswell get something out of it, 250 is like the same risk and less pros

 

[Shammed]

Natty lifting is cope. JFL at spending a decade training optimally to end up as looking like someone that has just ended his first cycle. If you're serious about Looksmaxing, you're going to take every shortcut to achieve your goal.

Why should I give a shit about roiding? A body halo is required for both female attention and male respect. If you have the body of a prepubescent boy, no one will take you seriously. You'll be the "friend", but never the guy she's looking for.

However, that doesn't mean a roided physique is able to compensate for a bad face. It is merely a multiplicator of your current looks level and adds few SMV points.

View attachment 4859439View attachment 4859449

After years of experience and research, the only three steroids you'll ever need are testosterone, boldenone, and trenbolone. Every other steroid, SARM, and prohormone is utter garbage and not worth it. Another compound that belongs into every stack is GH. Insulin isn't required for most people, but if you have a good source you might as well match the GH dose for optimal muscle accrual.

---

Spoiler: Scienceslop about other androgens

Every steroid is structurally derived from either testosterone, 19-nortestosterone, or dihydrotestosterone. These structural differences determine the interaction with the enzymes 5α-reductase and aromatase, the oestrogen and progesterone receptor, and other mechanisms of action.

View attachment 4866695

I will go over a few androgens.

Nandrolone: harsh on hair as it isn't able to be converted into a more tolerable metabolite (5α-dihydronandrolone) in androgenic tissues like skin when using using a 5α-reductase inhibitor. Redundant once you decide to use a topical anti-androgen like RU58841, as you could use stronger and better androgens instead. Nandrolone is also a ligand of the progesterone receptor.

17α-alkylated oral steroids: hepatotoxic in nature due to needing to be metabolised by the liver, which occurs independent of oral or injectable administration. Orals like Halotestin and Superdrol are known for acute strength gains and are used by powerlifters, whilst orals like Anavar are completely redundant.

DHT derivates: rape your hair follicles with the promise of looking drier temporarily. You can counteract this with RU58841, but as with nandrolone, you might as well just use trenbolone instead. They don't interact with aromatase and antagonise the oestrogen receptor, meaning they can be used to control E2 levels.

Exotic androgens: compounds like "The Clear", methyltrienolone, and norboletone are mostly rubbish. There aren't many studies and anecdotal evidence on them, which reduces our harm-reduction capabilities quite a bit. They are very rare and hard to synthesise, leading to these compounds being bunk in most cases.

#1: Testosterone is the main pillar of every steroid cycle and should be your main compound. It is a bioidentical hormone responsible for muscle accrual, bone remodelling, fat distribution, voice deepening, erythropoiesis, sexual wellness including libido, and mental drive. It undergoes 5α-reduction into dihydrotestosterone (DHT) and aromatises into oestradiol (E2). E2 is anabolic especially in conjunction with trenbolone, whereas DHT's existence is redundant.

Testosterone is typically administered with an ester that determines the pharmacokinetics of the compound. They most notably determine the half-life of the androgen. The ideal administration route is an intramuscular injection, but on TRT you may do subcutaneous injections for the sake of simplicity.

This is what you need for an injection:

• 22G needles for drawing the oil
• 25-27G (higher gauge -> smaller needle) needles to inject the oil
• Alcohol wipes
• 2-3mL syringes
• Optional: 29-31G needles for TRT

You can buy everything on Amazon or even in your local pharmacy for a total of 30usd. It is legal to buy injecting equipment. You prepare the injection by disinfecting the injection site and the top of the vial with an alcohol wipe. Ideal injection spots are the ventrogluteal, deltoid, and the vastus lateralis site.

View attachment 4866575

After preparing the injection site, you assemble the syringe by attaching the 22G needle to it and draw the oil. Then you add the 25-27G needle on top of the syringe and inject the oil into your preferred injection site (e.g. the ventrogluteal site). Aspirating (trying to draw blood with a needle) a needle is cope. However, it can get dangerous if you hit a major blood vessel and inject straight into it. This is extremely uncommon and chances are the needle will go through the blood vessel, which does eliminate any risks. Once you have pushed all of the oil in, throw the needle into a sharps container or into your regular rubbish bin and you're done. Here is also a video.

Contrary to popular belief, the added ester group doesn't have an impact on the pharmacodynamics of the steroid. It is argued that a longer ester is more anabolic, whereas a shorter one causes less aromatisation and concurrent bloat. A proposed mechanism for that is the increasing lipophilicity of longer esters. However, the ester is cleaved off before the testosterone is able to be aromatised, making this a baseless claim. The only thing that matters is the relative injection frequency.

The average male produces around 7mg of testosterone per day (=49mg per week). You would have to inject 66mg of testosterone propionate (relatively short ester weight) per week to match that dose. However, that range is still far from being supraphysiological. You would have to inject 200mg+ to notice supraphysiological effects.

According to this study, injecting 600mg of testosterone whilst training 3 times per week can result in a ~6kg fat-free mass gain within 10 weeks whilst the placebo group gains merely ~2kg of fat-free mass.

#2: Boldenone is a steroid that you can add to your cycle to control your E2 levels. It doesn't cause hair loss, thus making it a better option compared to exemestane, which has the androgenic metabolite 17ß-Hydroxyexemestane, that will rape your hair. Non-steroidal aromatase inhibitors like anastrozole and letrozole are harsh on your lipids, making them unideal to use.

Oestradiol is crucial for most neurotransmitters like serotonin and GABA. To acutely treat an E2 crash, you can use the oral dianabol, which has the metabolite methyloestradiol, that is much stronger than regular oestradiol. Alternatively, you can use exogenous E2 or HCG, which would take a few days to work.

The optimal testosterone-to-boldenone ratio is completely individual and depends on your own aromatisation rate. For most people a ratio of 3:1 to 2:1 is ideal, but measuring your E2 levels on each dose will give you clarity. Boldenone also increases appetite in most individuals due to the increased red blood cell count.

#3: Trenbolone is highly androgenic (and obviously anabolic) meaning it will completely eviscerate your skin and hair if you aren't using the appropiate ancillaries. The synergy of tren is very high with E2 and GH; it is the best steroid for gaining muscle mass, whilst simultaneously dropping bodyfat.

The effects of trenbolone like nutrition partitioning and glucocorticoid receptor antagonism are dose-dependent like with any other pathway in the body, which means "microdosing tren" in the double digits is nonsense. Take a higher dose or go home.

#4: Growth hormone (GH), besides being anabolic if coupled with other compounds, is more of a quality of life drug. It improves REM sleep, synergises with tren and E2, improves joint, bone, and soft tissue health, with some recognised cognitive benefits, making it a favourable compound.

The first cycle:

Your first steroid cycle should consist of 500mg testosterone and 6-8IU of GH. It will be the first time you are experiencing supraphysiological effects of androgens and is more than enough in the beginning. The cycle should last 20-25+ weeks and should be followed by a cruising phase of a few months, ideally matching the cycle length. After the cruise you may start blasting again and titrating the dosage up according to your personal needs.

Intermediate steroid cycles:

Once you're at the point where you're blasting 700-800mg+ of testosterone, you should throw in boldenone following your personal test-to-bold ratio. Thereafter, following the test-to-bold ratio, increase doses accordingly. Alternatively, you may decrease the test to 500mg and throw in tren whilst titrating up to the maximum amount you want to run. This cycle is going to be way harsher on your blood markers and hair, but if you're using the correct ancillaries you are going to make the most gains you have ever made while recomp'ing.

---

To reduce and/or completely eliminate most side effects and cover all pathways steroids negatively impact, we're going to discuss a handful of ancillaries.

#1: Skin and hair

Dutasteride: nukes an enzyme (5α-reductase) that converts testosterone into the metabolite dihydrotestosterone. 5α-reductase interacts with other androgens like nandrolone, converting them into their 5α-reduced forms. It is also responsible for the synthesis of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of the GABAA receptor.

A lack of that neurosteroid is the proposed mechanism of the Post-Finasteride syndrome, which only affects 0.1% of individuals. If you want to stay on the safe side, test your brain's genotype (your GABAergic architecture) with a single dose of finasteride, which has a half-life of 6-8 hours, meaning all side effects would be resolved within 1-2 days.

DHT is primarely an intracrine hormone, meaning it exerts its effects in the tissue it is produced in. The tissues in question are mostly the skin, hair follicles, and the penis. DHT is responsible for upregulating sebaceous gland activity, miniaturising hair follicles, and growing the penis during puberty, respectively. I would only recommend using a 5α-reductase inhibitor during puberty, if you are blasting gear. Take atleast 2.5mg daily.

View attachment 4859548

RU-58841: a topical nonsteroidal anti-androgen that didn't pass clinical trials. Its purpose is to reduce the effects of androgens on your skin and scalp by antagonising the androgen receptor (AR). RU-58841 (1-2nM) has a lower binding affinity than testosterone (0.5-1nM) and DHT (0.2-0.3nM), but overpowers them by occupying the receptor site. Apply it daily.

I make my own DIY RU solution:

• 50mL glass dropper bottle
• 2-4g of RU58841 powder
• 5-8mL of DMSO
• Rest is pure ethanol

Isotretinoin: a retinoid that atrophies sebaceous glands i.e. reduces acne and is decent for anti-aging purposes. It is commonly prescribed by dermatologists for treating persistent cystic acne and is well-studied, with the most notable downsides being mild hepatotoxicity, dry lips and skin, and worsening of your lipid profile.

If you have done a few courses of isotretinoin, downregulation of the sebaceous glands tends to be permanent, meaning you won't get acne after coming off. Taking 10-20mg long-term is well tolerated, but I prefer the approach of reaching a specific cumulative dose over months and never having to worry about acne again.

#2: Blood pressure and left ventricular hypertrophy

Nebivolol: a highly selective ß1-adrenergic receptor blocker that is commonly used to treat high blood pressure (BP). It has vasodilatory proporties and reduces the heart rate. Side effects include hypotension and fatigue, which normally don't occur when used and dosed correctly. Take it outside of your workout window, because a high heart rate is ideal for training. Take up to 5mg daily, any higher than that and it loses its selectivity.

Telmisartan: an Angiotensin II receptor blocker that lowers your BP and is nephroprotective (=protects your kidneys) whilst countering aldosterone-induced bloat. Research suggests partial PPARγ agonistic effects including reducing inflammation, enhanced insulin sensitivity etc. Take 40-80mg daily.

Only combine both beta-blockers and ARBs if your blood pressure and heart rate is too high (Stage 1+ on one of the ancillaries).

View attachment 4859674

#3: Cholesterol

Statins: work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway. They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream. They cause a reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins. Statins also slightly activate PPARα via an overexpression of COX-2.

Statins have a ±10% risk of causing diabetes in men. They also seem to have a negative impact on mitochondrial health, which includes reduced coQ10 levels. You can counteract this by supplementing it additionally, which I personally do at high doses.

There are two major groups of statins: hydrophilic and lipophilic statins. Hydrophilic statins (e.g. rosuvasatin and pravastatin) don't cross the BBB and cause more inflammation, whereas lipohilic statins (e.g. pitavastatin, atorvastatin, and simvastatin) cross the BBB and cause less inflammation.

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile. A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks. Dosage: Take 1-4mg daily.

Rosuvastatin is just as good as seen below. You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.

View attachment 4867229

Ezetimibe: inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol. It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein. It doesn't affect the absorption of fat-soluble vitamins. Take 5-10mg daily.

Bemdedoic acid: an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins. Take 180mg daily.

Bempedoic acid significantly reduces LDL cholesterol levels according to this study.



SR9009: an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. SR9009 has multiple benefits like boosting mitochondrial activity, fat metabolism, improving your circadian rhythm, endurance, and inflammation, along with other benefits of you can see below. It also improves the lipid profile.


View attachment 4867256

#4: Oxidative stress and organ health

NAC: a precursor to L-glutathione, that reduces oxidative stress, protects the liver, and organs in general. Is frequently used in clinical settings. Take 2-3g daily, ~1g if you are using a liposomal formulation.

Injectable L-glutathione: as mentioned, a very strong antioxidant that reduces inflammatory markers like TNF-α and IL-6 directly. It is mainly mito-, hepato-, and neuroprotective, making it a nice all-rounder to keep your organs healthy on-cycle. It is also used for skin lightening. Inject 500mg every day.

TUDCA: mainly used as liver support, although NAC/L-glutathione would be more than enough. Liver support is only required on compounds like tren and 17α-alkylated (=orally bioavailable) steroids.

Retatrutide: an agonist of the GLP-1, GIP, and glucagon receptor. You can expect an inprovement in insulin sensitivity, increased energy expenditure, reduced inflammation, and appetite suppression, whilst experiencing only limited side effects like GI irritation and skin sensitivity. It is also a godsent drug to improve your lipid profile significantly, as seen in this study.



View attachment 4872339

#5: Neuroprotection (including modulation of serotonin and oxytocin)

Neurotoxicity mostly occurs on compounds like tren and if you have raped your E2 levels too hard, which you shouldn't since oestrogen is anabolic, keeps your joints healthy, and is neuroprotective. Contrary to popular belief, oxytocin doesn't appear to be impaired on trenbolone. Rather the opposite occurs.

Besides that, oxytocin doesn't appear to be the muh social hormone after all according to this study:



N-Acetyl Semax: modulates BDNF and neurotransmitters like dopamine and serotonin. The acetylation makes BBB penetration easier (it is normally advised to take semax intranasally to bypass the BBB) and causes a higher receptor saturation whilst prolonging the half-life. Dihexa and cerebrolysin may be used alternatively. However, NA-Semax alone will do the job. Taking higher dosages up to 1-2mg is fully tolerated.

Escitalopram: an SSRI. A pure SERT blocker with only minimal secondary receptor interactions and comes with many benefits like being anxiolytic, improving depression and OCD, all whilst being neuroprotective.

Vortioxetine: an even better SSRI that isn't only a SERT blocker, but also a serotonin receptor modulator. It increases BDNF, dopamine, and norepinephrine in the frontal cortex leading to improved neuroplasticity and overall cognition. It doesn't cause any emotional bluntness, but rather lifts you up, and has low sexual side effects.

Rasagiline: a MAO-B inhibitor, which means it nukes the enzyme that normally metabolises dopamine, phenethylamine, and some trace amines, causing an excess of availability. MAO-A stays intact, resulting in normal serotonin and norepinephrine levels. Rasagiline is also slightly mitoprotective due to reducing oxidative stress in dopaminergic neurons.

LIT-001: an agonist of the oxytocin receptor that is able to pass the BBB and doesn't interact with the vasopressin receptor (=agonism would cause bloat). At higher doses it can even be an antagonist of the vasopressin receptor.

#6: Suppression of HPG-axis

HMG and HCG: these two compounds, even moreso the latter, are all you need to keep your HPG-axis intact. HCG imitates LH, whereas HMG imitates FSH, both stimulating your testes. Inject 100-250IU of HCG every other day (EOD) and take a break every 4-5 months (in case you are permablasting) to reset desensitisation of the Leydig cells. Even for people that plan to blast the next few years, it is recommended to do a HCG cycle 1-2x per year.

View attachment 4860270

Taurine: has antioxidant properties. It protects Leydig cells by reducing ROS and improves mitochondrial function. It is naturally abundant in seminal fluid, which means supplementing taurine results in improved sperm quality. take 1-3g daily.

#7: Prolactin management

Liposomal Pyridoxal-5-Phosphat (P-5-P): a good option to control your prolactin levels and to prevent lactation on low to moderate doses of tren. This should be your go-to compound for prolactin management. It also assists the production of neurotransmitters like dopamine, serotonin, and GABA. It is also a cofactor in many enzymes, supporting various processes in the body. Neuropathy is from high dose pyridoxine, not P-5-P. I'd recommend taking 100-200mg daily.

Cabergoline: binds selectively to dopamine D2 receptors and has a long half-life of roughly 2-3 days. It is primarely used to reduce hyperprolactinemia. Cabergoline reduces GH and IGF-1 levels. Take 0.125-0.25mg every 3 days, but only if you are actively experiencing side effects on high dose tren.

#8: Other safety measures, habits, and general advice

• Donate blood to keep your haematocrit (and red blood cell count) low, especially on boldenone and tren.
• Get full blood work before, during, and after a blasting phase. This way you can verify whether your gear is dosed correctly, how certain blood markers are affected etc.
• Locked in with diet and training. If you aren't doing this, NGMI.
• Do cardio. It improves lipids, heart health, insulin sensitivity, and so much more. It is one of the core pillar "ancillaries" that keeps you healthy.
• Good sleep with melatonin, DSIP, dual orexin receptor antagonists, magnesium l-threonate, maintaining the same sleeping/waking up time. Only take benzos and other sedatives if completely required.
• Keep fat intake low, carbs and protein high. 200-300g protein is ideal daily.
• Stay below 15-20% all throughout the cycle. Start the cycle at a very low bodyfat %.
• In the very rare case that you end up getting puffy and sensitive nipples, use topical raloxifene.
• To decrease bloating on-cycle use amiloride or eplerenone.

How do you source test without getting dog shit in a bottle?

 

[coldsigma]

How do you source test without getting dog shit in a bottle?

go on meso rx

 

[Irishdeltmaxer2187]

Dnr yet but seems wow


Botb??

no

 

[highcel]

solid post אח

 

[pjflee]

Not worth it

 

[Joe7566]

Might have to try at one point

 

[Sxnguinius]

Natty lifting is cope. JFL at spending a decade training optimally to end up as looking like someone that has just ended his first cycle. If you're serious about Looksmaxing, you're going to take every shortcut to achieve your goal.

Why should I give a shit about roiding? A body halo is required for both female attention and male respect. If you have the body of a prepubescent boy, no one will take you seriously. You'll be the "friend", but never the guy she's looking for.

However, that doesn't mean a roided physique is able to compensate for a bad face. It is merely a multiplicator of your current looks level and adds few SMV points.

View attachment 4859439View attachment 4859449

After years of experience and research, the only three steroids you'll ever need are testosterone, boldenone, and trenbolone. Every other steroid, SARM, and prohormone is utter garbage and not worth it. Another compound that belongs into every stack is GH. Insulin isn't required for most people, but if you have a good source you might as well match the GH dose for optimal muscle accrual.

---

Spoiler: Scienceslop about other androgens

Every steroid is structurally derived from either testosterone, 19-nortestosterone, or dihydrotestosterone. These structural differences determine the interaction with the enzymes 5α-reductase and aromatase, the oestrogen and progesterone receptor, and other mechanisms of action.

View attachment 4866695

I will go over a few androgens.

Nandrolone: harsh on hair as it isn't able to be converted into a more tolerable metabolite (5α-dihydronandrolone) in androgenic tissues like skin when using using a 5α-reductase inhibitor. Redundant once you decide to use a topical anti-androgen like RU58841, as you could use stronger and better androgens instead. Nandrolone is also a ligand of the progesterone receptor.

17α-alkylated oral steroids: hepatotoxic in nature due to needing to be metabolised by the liver, which occurs independent of oral or injectable administration. Orals like Halotestin and Superdrol are known for acute strength gains and are used by powerlifters, whilst orals like Anavar are completely redundant.

DHT derivates: rape your hair follicles with the promise of looking drier temporarily. You can counteract this with RU58841, but as with nandrolone, you might as well just use trenbolone instead. They don't interact with aromatase and antagonise the oestrogen receptor, meaning they can be used to control E2 levels.

Exotic androgens: compounds like "The Clear", methyltrienolone, and norboletone are mostly rubbish. There aren't many studies and anecdotal evidence on them, which reduces our harm-reduction capabilities quite a bit. They are very rare and hard to synthesise, leading to these compounds being bunk in most cases.

#1: Testosterone is the main pillar of every steroid cycle and should be your main compound. It is a bioidentical hormone responsible for muscle accrual, bone remodelling, fat distribution, voice deepening, erythropoiesis, sexual wellness including libido, and mental drive. It undergoes 5α-reduction into dihydrotestosterone (DHT) and aromatises into oestradiol (E2). E2 is anabolic especially in conjunction with trenbolone, whereas DHT's existence is redundant.

Testosterone is typically administered with an ester that determines the pharmacokinetics of the compound. They most notably determine the half-life of the androgen. The ideal administration route is an intramuscular injection, but on TRT you may do subcutaneous injections for the sake of simplicity.

This is what you need for an injection:

• 22G needles for drawing the oil
• 25-27G (higher gauge -> smaller needle) needles to inject the oil
• Alcohol wipes
• 2-3mL syringes
• Optional: 29-31G needles for TRT

You can buy everything on Amazon or even in your local pharmacy for a total of 30usd. It is legal to buy injecting equipment. You prepare the injection by disinfecting the injection site and the top of the vial with an alcohol wipe. Ideal injection spots are the ventrogluteal, deltoid, and the vastus lateralis site.

View attachment 4866575

After preparing the injection site, you assemble the syringe by attaching the 22G needle to it and draw the oil. Then you add the 25-27G needle on top of the syringe and inject the oil into your preferred injection site (e.g. the ventrogluteal site). Aspirating (trying to draw blood with a needle) a needle is cope. However, it can get dangerous if you hit a major blood vessel and inject straight into it. This is extremely uncommon and chances are the needle will go through the blood vessel, which does eliminate any risks. Once you have pushed all of the oil in, throw the needle into a sharps container or into your regular rubbish bin and you're done. Here is also a video.

Contrary to popular belief, the added ester group doesn't have an impact on the pharmacodynamics of the steroid. It is argued that a longer ester is more anabolic, whereas a shorter one causes less aromatisation and concurrent bloat. A proposed mechanism for that is the increasing lipophilicity of longer esters. However, the ester is cleaved off before the testosterone is able to be aromatised, making this a baseless claim. The only thing that matters is the relative injection frequency.

The average male produces around 7mg of testosterone per day (=49mg per week). You would have to inject 66mg of testosterone propionate (relatively short ester weight) per week to match that dose. However, that range is still far from being supraphysiological. You would have to inject 200mg+ to notice supraphysiological effects.

According to this study, injecting 600mg of testosterone whilst training 3 times per week can result in a ~6kg fat-free mass gain within 10 weeks whilst the placebo group gains merely ~2kg of fat-free mass.

#2: Boldenone is a steroid that you can add to your cycle to control your E2 levels. It doesn't cause hair loss, thus making it a better option compared to exemestane, which has the androgenic metabolite 17ß-Hydroxyexemestane, that will rape your hair. Non-steroidal aromatase inhibitors like anastrozole and letrozole are harsh on your lipids, making them unideal to use.

Oestradiol is crucial for most neurotransmitters like serotonin and GABA. To acutely treat an E2 crash, you can use the oral dianabol, which has the metabolite methyloestradiol, that is much stronger than regular oestradiol. Alternatively, you can use exogenous E2 or HCG, which would take a few days to work.

The optimal testosterone-to-boldenone ratio is completely individual and depends on your own aromatisation rate. For most people a ratio of 3:1 to 2:1 is ideal, but measuring your E2 levels on each dose will give you clarity. Boldenone also increases appetite in most individuals due to the increased red blood cell count.

#3: Trenbolone is highly androgenic (and obviously anabolic) meaning it will completely eviscerate your skin and hair if you aren't using the appropiate ancillaries. The synergy of tren is very high with E2 and GH; it is the best steroid for gaining muscle mass, whilst simultaneously dropping bodyfat.

The effects of trenbolone like nutrition partitioning and glucocorticoid receptor antagonism are dose-dependent like with any other pathway in the body, which means "microdosing tren" in the double digits is nonsense. Take a higher dose or go home.

#4: Growth hormone (GH), besides being anabolic if coupled with other compounds, is more of a quality of life drug. It improves REM sleep, synergises with tren and E2, improves joint, bone, and soft tissue health, with some recognised cognitive benefits, making it a favourable compound.

The first cycle:

Your first steroid cycle should consist of 500mg testosterone and 6-8IU of GH. It will be the first time you are experiencing supraphysiological effects of androgens and is more than enough in the beginning. The cycle should last 20-25+ weeks and should be followed by a cruising phase of a few months, ideally matching the cycle length. After the cruise you may start blasting again and titrating the dosage up according to your personal needs.

Intermediate steroid cycles:

Once you're at the point where you're blasting 700-800mg+ of testosterone, you should throw in boldenone following your personal test-to-bold ratio. Thereafter, following the test-to-bold ratio, increase doses accordingly. Alternatively, you may decrease the test to 500mg and throw in tren whilst titrating up to the maximum amount you want to run. This cycle is going to be way harsher on your blood markers and hair, but if you're using the correct ancillaries you are going to make the most gains you have ever made while recomp'ing.

---

To reduce and/or completely eliminate most side effects and cover all pathways steroids negatively impact, we're going to discuss a handful of ancillaries.

#1: Skin and hair

Dutasteride: nukes an enzyme (5α-reductase) that converts testosterone into the metabolite dihydrotestosterone. 5α-reductase interacts with other androgens like nandrolone, converting them into their 5α-reduced forms. It is also responsible for the synthesis of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of the GABAA receptor.

A lack of that neurosteroid is the proposed mechanism of the Post-Finasteride syndrome, which only affects 0.1% of individuals. If you want to stay on the safe side, test your brain's genotype (your GABAergic architecture) with a single dose of finasteride, which has a half-life of 6-8 hours, meaning all side effects would be resolved within 1-2 days.

DHT is primarely an intracrine hormone, meaning it exerts its effects in the tissue it is produced in. The tissues in question are mostly the skin, hair follicles, and the penis. DHT is responsible for upregulating sebaceous gland activity, miniaturising hair follicles, and growing the penis during puberty, respectively. I would only recommend using a 5α-reductase inhibitor during puberty, if you are blasting gear. Take atleast 2.5mg daily.

View attachment 4859548

RU-58841: a topical nonsteroidal anti-androgen that didn't pass clinical trials. Its purpose is to reduce the effects of androgens on your skin and scalp by antagonising the androgen receptor (AR). RU-58841 (1-2nM) has a lower binding affinity than testosterone (0.5-1nM) and DHT (0.2-0.3nM), but overpowers them by occupying the receptor site. Apply it daily.

I make my own DIY RU solution:

• 50mL glass dropper bottle
• 2-4g of RU58841 powder
• 5-8mL of DMSO
• Rest is pure ethanol

Isotretinoin: a retinoid that atrophies sebaceous glands i.e. reduces acne and is decent for anti-aging purposes. It is commonly prescribed by dermatologists for treating persistent cystic acne and is well-studied, with the most notable downsides being mild hepatotoxicity, dry lips and skin, and worsening of your lipid profile.

If you have done a few courses of isotretinoin, downregulation of the sebaceous glands tends to be permanent, meaning you won't get acne after coming off. Taking 10-20mg long-term is well tolerated, but I prefer the approach of reaching a specific cumulative dose over months and never having to worry about acne again.

#2: Blood pressure and left ventricular hypertrophy

Nebivolol: a highly selective ß1-adrenergic receptor blocker that is commonly used to treat high blood pressure (BP). It has vasodilatory proporties and reduces the heart rate. Side effects include hypotension and fatigue, which normally don't occur when used and dosed correctly. Take it outside of your workout window, because a high heart rate is ideal for training. Take up to 5mg daily, any higher than that and it loses its selectivity.

Telmisartan: an Angiotensin II receptor blocker that lowers your BP and is nephroprotective (=protects your kidneys) whilst countering aldosterone-induced bloat. Research suggests partial PPARγ agonistic effects including reducing inflammation, enhanced insulin sensitivity etc. Take 40-80mg daily.

Only combine both beta-blockers and ARBs if your blood pressure and heart rate is too high (Stage 1+ on one of the ancillaries).

View attachment 4859674

#3: Cholesterol

Statins: work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway. They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream. They cause a reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins. Statins also slightly activate PPARα via an overexpression of COX-2.

Statins have a ±10% risk of causing diabetes in men. They also seem to have a negative impact on mitochondrial health, which includes reduced coQ10 levels. You can counteract this by supplementing it additionally, which I personally do at high doses.

There are two major groups of statins: hydrophilic and lipophilic statins. Hydrophilic statins (e.g. rosuvasatin and pravastatin) don't cross the BBB and cause more inflammation, whereas lipohilic statins (e.g. pitavastatin, atorvastatin, and simvastatin) cross the BBB and cause less inflammation.

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile. A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks. Dosage: Take 1-4mg daily.

Rosuvastatin is just as good as seen below. You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.

View attachment 4867229

Ezetimibe: inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol. It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein. It doesn't affect the absorption of fat-soluble vitamins. Take 5-10mg daily.

Bemdedoic acid: an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins. Take 180mg daily.

Bempedoic acid significantly reduces LDL cholesterol levels according to this study.



SR9009: an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. SR9009 has multiple benefits like boosting mitochondrial activity, fat metabolism, improving your circadian rhythm, endurance, and inflammation, along with other benefits of you can see below. It also improves the lipid profile.


View attachment 4867256

#4: Oxidative stress and organ health

NAC: a precursor to L-glutathione, that reduces oxidative stress, protects the liver, and organs in general. Is frequently used in clinical settings. Take 2-3g daily, ~1g if you are using a liposomal formulation.

Injectable L-glutathione: as mentioned, a very strong antioxidant that reduces inflammatory markers like TNF-α and IL-6 directly. It is mainly mito-, hepato-, and neuroprotective, making it a nice all-rounder to keep your organs healthy on-cycle. It is also used for skin lightening. Inject 500mg every day.

TUDCA: mainly used as liver support, although NAC/L-glutathione would be more than enough. Liver support is only required on compounds like tren and 17α-alkylated (=orally bioavailable) steroids.

Retatrutide: an agonist of the GLP-1, GIP, and glucagon receptor. You can expect an inprovement in insulin sensitivity, increased energy expenditure, reduced inflammation, and appetite suppression, whilst experiencing only limited side effects like GI irritation and skin sensitivity. It is also a godsent drug to improve your lipid profile significantly, as seen in this study.



View attachment 4872339

#5: Neuroprotection (including modulation of serotonin and oxytocin)

Neurotoxicity mostly occurs on compounds like tren and if you have raped your E2 levels too hard, which you shouldn't since oestrogen is anabolic, keeps your joints healthy, and is neuroprotective. Contrary to popular belief, oxytocin doesn't appear to be impaired on trenbolone. Rather the opposite occurs.

Besides that, oxytocin doesn't appear to be the muh social hormone after all according to this study:



N-Acetyl Semax: modulates BDNF and neurotransmitters like dopamine and serotonin. The acetylation makes BBB penetration easier (it is normally advised to take semax intranasally to bypass the BBB) and causes a higher receptor saturation whilst prolonging the half-life. Dihexa and cerebrolysin may be used alternatively. However, NA-Semax alone will do the job. Taking higher dosages up to 1-2mg is fully tolerated.

Escitalopram: an SSRI. A pure SERT blocker with only minimal secondary receptor interactions and comes with many benefits like being anxiolytic, improving depression and OCD, all whilst being neuroprotective.

Vortioxetine: an even better SSRI that isn't only a SERT blocker, but also a serotonin receptor modulator. It increases BDNF, dopamine, and norepinephrine in the frontal cortex leading to improved neuroplasticity and overall cognition. It doesn't cause any emotional bluntness, but rather lifts you up, and has low sexual side effects.

Rasagiline: a MAO-B inhibitor, which means it nukes the enzyme that normally metabolises dopamine, phenethylamine, and some trace amines, causing an excess of availability. MAO-A stays intact, resulting in normal serotonin and norepinephrine levels. Rasagiline is also slightly mitoprotective due to reducing oxidative stress in dopaminergic neurons.

LIT-001: an agonist of the oxytocin receptor that is able to pass the BBB and doesn't interact with the vasopressin receptor (=agonism would cause bloat). At higher doses it can even be an antagonist of the vasopressin receptor.

#6: Suppression of HPG-axis

HMG and HCG: these two compounds, even moreso the latter, are all you need to keep your HPG-axis intact. HCG imitates LH, whereas HMG imitates FSH, both stimulating your testes. Inject 100-250IU of HCG every other day (EOD) and take a break every 4-5 months (in case you are permablasting) to reset desensitisation of the Leydig cells. Even for people that plan to blast the next few years, it is recommended to do a HCG cycle 1-2x per year.

View attachment 4860270

Taurine: has antioxidant properties. It protects Leydig cells by reducing ROS and improves mitochondrial function. It is naturally abundant in seminal fluid, which means supplementing taurine results in improved sperm quality. take 1-3g daily.

#7: Prolactin management

Liposomal Pyridoxal-5-Phosphat (P-5-P): a good option to control your prolactin levels and to prevent lactation on low to moderate doses of tren. This should be your go-to compound for prolactin management. It also assists the production of neurotransmitters like dopamine, serotonin, and GABA. It is also a cofactor in many enzymes, supporting various processes in the body. Neuropathy is from high dose pyridoxine, not P-5-P. I'd recommend taking 100-200mg daily.

Cabergoline: binds selectively to dopamine D2 receptors and has a long half-life of roughly 2-3 days. It is primarely used to reduce hyperprolactinemia. Cabergoline reduces GH and IGF-1 levels. Take 0.125-0.25mg every 3 days, but only if you are actively experiencing side effects on high dose tren.

#8: Other safety measures, habits, and general advice

• Donate blood to keep your haematocrit (and red blood cell count) low, especially on boldenone and tren.
• Get full blood work before, during, and after a blasting phase. This way you can verify whether your gear is dosed correctly, how certain blood markers are affected etc.
• Locked in with diet and training. If you aren't doing this, NGMI.
• Do cardio. It improves lipids, heart health, insulin sensitivity, and so much more. It is one of the core pillar "ancillaries" that keeps you healthy.
• Good sleep with melatonin, DSIP, dual orexin receptor antagonists, magnesium l-threonate, maintaining the same sleeping/waking up time. Only take benzos and other sedatives if completely required.
• Keep fat intake low, carbs and protein high. 200-300g protein is ideal daily.
• Stay below 15-20% all throughout the cycle. Start the cycle at a very low bodyfat %.
• In the very rare case that you end up getting puffy and sensitive nipples, use topical raloxifene.
• To decrease bloating on-cycle use amiloride

grey bolde is pretty ass primo mogs, kinda expensive tho

 

[bones>]

thanks

 

[zigeuner]

Natty lifting is cope. JFL at spending a decade training optimally to end up as looking like someone that has just ended his first cycle. If you're serious about Looksmaxing, you're going to take every shortcut to achieve your goal.

Why should I give a shit about roiding? A body halo is required for both female attention and male respect. If you have the body of a prepubescent boy, no one will take you seriously. You'll be the "friend", but never the guy she's looking for.

However, that doesn't mean a roided physique is able to compensate for a bad face. It is merely a multiplicator of your current looks level and adds few SMV points.

View attachment 4859439View attachment 4859449

After years of experience and research, the only three steroids you'll ever need are testosterone, boldenone, and trenbolone. Every other steroid, SARM, and prohormone is utter garbage and not worth it. Another compound that belongs into every stack is GH. Insulin isn't required for most people, but if you have a good source you might as well match the GH dose for optimal muscle accrual.

---

Spoiler: Scienceslop about other androgens

Every steroid is structurally derived from either testosterone, 19-nortestosterone, or dihydrotestosterone. These structural differences determine the interaction with the enzymes 5α-reductase and aromatase, the oestrogen and progesterone receptor, and other mechanisms of action.

View attachment 4866695

I will go over a few androgens.

Nandrolone: harsh on hair as it isn't able to be converted into a more tolerable metabolite (5α-dihydronandrolone) in androgenic tissues like skin when using using a 5α-reductase inhibitor. Redundant once you decide to use a topical anti-androgen like RU58841, as you could use stronger and better androgens instead. Nandrolone is also a ligand of the progesterone receptor.

17α-alkylated oral steroids: hepatotoxic in nature due to needing to be metabolised by the liver, which occurs independent of oral or injectable administration. Orals like Halotestin and Superdrol are known for acute strength gains and are used by powerlifters, whilst orals like Anavar are completely redundant.

DHT derivates: rape your hair follicles with the promise of looking drier temporarily. You can counteract this with RU58841, but as with nandrolone, you might as well just use trenbolone instead. They don't interact with aromatase and antagonise the oestrogen receptor, meaning they can be used to control E2 levels.

Exotic androgens: compounds like "The Clear", methyltrienolone, and norboletone are mostly rubbish. There aren't many studies and anecdotal evidence on them, which reduces our harm-reduction capabilities quite a bit. They are very rare and hard to synthesise, leading to these compounds being bunk in most cases.

#1: Testosterone is the main pillar of every steroid cycle and should be your main compound. It is a bioidentical hormone responsible for muscle accrual, bone remodelling, fat distribution, voice deepening, erythropoiesis, sexual wellness including libido, and mental drive. It undergoes 5α-reduction into dihydrotestosterone (DHT) and aromatises into oestradiol (E2). E2 is anabolic especially in conjunction with trenbolone, whereas DHT's existence is redundant.

Testosterone is typically administered with an ester that determines the pharmacokinetics of the compound. They most notably determine the half-life of the androgen. The ideal administration route is an intramuscular injection, but on TRT you may do subcutaneous injections for the sake of simplicity.

This is what you need for an injection:

• 22G needles for drawing the oil
• 25-27G (higher gauge -> smaller needle) needles to inject the oil
• Alcohol wipes
• 2-3mL syringes
• Optional: 29-31G needles for TRT

You can buy everything on Amazon or even in your local pharmacy for a total of 30usd. It is legal to buy injecting equipment. You prepare the injection by disinfecting the injection site and the top of the vial with an alcohol wipe. Ideal injection spots are the ventrogluteal, deltoid, and the vastus lateralis site.

View attachment 4866575

After preparing the injection site, you assemble the syringe by attaching the 22G needle to it and draw the oil. Then you add the 25-27G needle on top of the syringe and inject the oil into your preferred injection site (e.g. the ventrogluteal site). Aspirating (trying to draw blood with a needle) a needle is cope. However, it can get dangerous if you hit a major blood vessel and inject straight into it. This is extremely uncommon and chances are the needle will go through the blood vessel, which does eliminate any risks. Once you have pushed all of the oil in, throw the needle into a sharps container or into your regular rubbish bin and you're done. Here is also a video.

Contrary to popular belief, the added ester group doesn't have an impact on the pharmacodynamics of the steroid. It is argued that a longer ester is more anabolic, whereas a shorter one causes less aromatisation and concurrent bloat. A proposed mechanism for that is the increasing lipophilicity of longer esters. However, the ester is cleaved off before the testosterone is able to be aromatised, making this a baseless claim. The only thing that matters is the relative injection frequency.

The average male produces around 7mg of testosterone per day (=49mg per week). You would have to inject 66mg of testosterone propionate (relatively short ester weight) per week to match that dose. However, that range is still far from being supraphysiological. You would have to inject 200mg+ to notice supraphysiological effects.

According to this study, injecting 600mg of testosterone whilst training 3 times per week can result in a ~6kg fat-free mass gain within 10 weeks whilst the placebo group gains merely ~2kg of fat-free mass.

#2: Boldenone is a steroid that you can add to your cycle to control your E2 levels. It doesn't cause hair loss, thus making it a better option compared to exemestane, which has the androgenic metabolite 17ß-Hydroxyexemestane, that will rape your hair. Non-steroidal aromatase inhibitors like anastrozole and letrozole are harsh on your lipids, making them unideal to use.

Oestradiol is crucial for most neurotransmitters like serotonin and GABA. To acutely treat an E2 crash, you can use the oral dianabol, which has the metabolite methyloestradiol, that is much stronger than regular oestradiol. Alternatively, you can use exogenous E2 or HCG, which would take a few days to work.

The optimal testosterone-to-boldenone ratio is completely individual and depends on your own aromatisation rate. For most people a ratio of 3:1 to 2:1 is ideal, but measuring your E2 levels on each dose will give you clarity. Boldenone also increases appetite in most individuals due to the increased red blood cell count.

#3: Trenbolone is highly androgenic (and obviously anabolic) meaning it will completely eviscerate your skin and hair if you aren't using the appropiate ancillaries. The synergy of tren is very high with E2 and GH; it is the best steroid for gaining muscle mass, whilst simultaneously dropping bodyfat.

The effects of trenbolone like nutrition partitioning and glucocorticoid receptor antagonism are dose-dependent like with any other pathway in the body, which means "microdosing tren" in the double digits is nonsense. Take a higher dose or go home.

#4: Growth hormone (GH), besides being anabolic if coupled with other compounds, is more of a quality of life drug. It improves REM sleep, synergises with tren and E2, improves joint, bone, and soft tissue health, with some recognised cognitive benefits, making it a favourable compound.

The first cycle:

Your first steroid cycle should consist of 500mg testosterone and 6-8IU of GH. It will be the first time you are experiencing supraphysiological effects of androgens and is more than enough in the beginning. The cycle should last 20-25+ weeks and should be followed by a cruising phase of a few months, ideally matching the cycle length. After the cruise you may start blasting again and titrating the dosage up according to your personal needs.

Intermediate steroid cycles:

Once you're at the point where you're blasting 700-800mg+ of testosterone, you should throw in boldenone following your personal test-to-bold ratio. Thereafter, following the test-to-bold ratio, increase doses accordingly. Alternatively, you may decrease the test to 500mg and throw in tren whilst titrating up to the maximum amount you want to run. This cycle is going to be way harsher on your blood markers and hair, but if you're using the correct ancillaries you are going to make the most gains you have ever made while recomp'ing.

---

To reduce and/or completely eliminate most side effects and cover all pathways steroids negatively impact, we're going to discuss a handful of ancillaries.

#1: Skin and hair

Dutasteride: nukes an enzyme (5α-reductase) that converts testosterone into the metabolite dihydrotestosterone. 5α-reductase interacts with other androgens like nandrolone, converting them into their 5α-reduced forms. It is also responsible for the synthesis of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of the GABAA receptor.

A lack of that neurosteroid is the proposed mechanism of the Post-Finasteride syndrome, which only affects 0.1% of individuals. If you want to stay on the safe side, test your brain's genotype (your GABAergic architecture) with a single dose of finasteride, which has a half-life of 6-8 hours, meaning all side effects would be resolved within 1-2 days.

DHT is primarely an intracrine hormone, meaning it exerts its effects in the tissue it is produced in. The tissues in question are mostly the skin, hair follicles, and the penis. DHT is responsible for upregulating sebaceous gland activity, miniaturising hair follicles, and growing the penis during puberty, respectively. I would only recommend using a 5α-reductase inhibitor during puberty, if you are blasting gear. Take atleast 2.5mg daily.

View attachment 4859548

RU-58841: a topical nonsteroidal anti-androgen that didn't pass clinical trials. Its purpose is to reduce the effects of androgens on your skin and scalp by antagonising the androgen receptor (AR). RU-58841 (1-2nM) has a lower binding affinity than testosterone (0.5-1nM) and DHT (0.2-0.3nM), but overpowers them by occupying the receptor site. Apply it daily.

I make my own DIY RU solution:

• 50mL glass dropper bottle
• 2-4g of RU58841 powder
• 5-8mL of DMSO
• Rest is pure ethanol

Isotretinoin: a retinoid that atrophies sebaceous glands i.e. reduces acne and is decent for anti-aging purposes. It is commonly prescribed by dermatologists for treating persistent cystic acne and is well-studied, with the most notable downsides being mild hepatotoxicity, dry lips and skin, and worsening of your lipid profile.

If you have done a few courses of isotretinoin, downregulation of the sebaceous glands tends to be permanent, meaning you won't get acne after coming off. Taking 10-20mg long-term is well tolerated, but I prefer the approach of reaching a specific cumulative dose over months and never having to worry about acne again.

#2: Blood pressure and left ventricular hypertrophy

Nebivolol: a highly selective ß1-adrenergic receptor blocker that is commonly used to treat high blood pressure (BP). It has vasodilatory proporties and reduces the heart rate. Side effects include hypotension and fatigue, which normally don't occur when used and dosed correctly. Take it outside of your workout window, because a high heart rate is ideal for training. Take up to 5mg daily, any higher than that and it loses its selectivity.

Telmisartan: an Angiotensin II receptor blocker that lowers your BP and is nephroprotective (=protects your kidneys) whilst countering aldosterone-induced bloat. Research suggests partial PPARγ agonistic effects including reducing inflammation, enhanced insulin sensitivity etc. Take 40-80mg daily.

Only combine both beta-blockers and ARBs if your blood pressure and heart rate is too high (Stage 1+ on one of the ancillaries).

View attachment 4859674

#3: Cholesterol

Statins: work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway. They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream. They cause a reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins. Statins also slightly activate PPARα via an overexpression of COX-2.

Statins have a ±10% risk of causing diabetes in men. They also seem to have a negative impact on mitochondrial health, which includes reduced coQ10 levels. You can counteract this by supplementing it additionally, which I personally do at high doses.

There are two major groups of statins: hydrophilic and lipophilic statins. Hydrophilic statins (e.g. rosuvasatin and pravastatin) don't cross the BBB and cause more inflammation, whereas lipohilic statins (e.g. pitavastatin, atorvastatin, and simvastatin) cross the BBB and cause less inflammation.

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile. A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks. Dosage: Take 1-4mg daily.

Rosuvastatin is just as good as seen below. You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.

View attachment 4867229

Ezetimibe: inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol. It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein. It doesn't affect the absorption of fat-soluble vitamins. Take 5-10mg daily.

Bemdedoic acid: an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins. Take 180mg daily.

Bempedoic acid significantly reduces LDL cholesterol levels according to this study.



SR9009: an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. SR9009 has multiple benefits like boosting mitochondrial activity, fat metabolism, improving your circadian rhythm, endurance, and inflammation, along with other benefits of you can see below. It also improves the lipid profile.


View attachment 4867256

#4: Oxidative stress and organ health

NAC: a precursor to L-glutathione, that reduces oxidative stress, protects the liver, and organs in general. Is frequently used in clinical settings. Take 2-3g daily, ~1g if you are using a liposomal formulation.

Injectable L-glutathione: as mentioned, a very strong antioxidant that reduces inflammatory markers like TNF-α and IL-6 directly. It is mainly mito-, hepato-, and neuroprotective, making it a nice all-rounder to keep your organs healthy on-cycle. It is also used for skin lightening. Inject 500mg every day.

TUDCA: mainly used as liver support, although NAC/L-glutathione would be more than enough. Liver support is only required on compounds like tren and 17α-alkylated (=orally bioavailable) steroids.

Retatrutide: an agonist of the GLP-1, GIP, and glucagon receptor. You can expect an inprovement in insulin sensitivity, increased energy expenditure, reduced inflammation, and appetite suppression, whilst experiencing only limited side effects like GI irritation and skin sensitivity. It is also a godsent drug to improve your lipid profile significantly, as seen in this study.



View attachment 4872339

#5: Neuroprotection (including modulation of serotonin and oxytocin)

Neurotoxicity mostly occurs on compounds like tren and if you have raped your E2 levels too hard, which you shouldn't since oestrogen is anabolic, keeps your joints healthy, and is neuroprotective. Contrary to popular belief, oxytocin doesn't appear to be impaired on trenbolone. Rather the opposite occurs.

Besides that, oxytocin doesn't appear to be the muh social hormone after all according to this study:



N-Acetyl Semax: modulates BDNF and neurotransmitters like dopamine and serotonin. The acetylation makes BBB penetration easier (it is normally advised to take semax intranasally to bypass the BBB) and causes a higher receptor saturation whilst prolonging the half-life. Dihexa and cerebrolysin may be used alternatively. However, NA-Semax alone will do the job. Taking higher dosages up to 1-2mg is fully tolerated.

Escitalopram: an SSRI. A pure SERT blocker with only minimal secondary receptor interactions and comes with many benefits like being anxiolytic, improving depression and OCD, all whilst being neuroprotective.

Vortioxetine: an even better SSRI that isn't only a SERT blocker, but also a serotonin receptor modulator. It increases BDNF, dopamine, and norepinephrine in the frontal cortex leading to improved neuroplasticity and overall cognition. It doesn't cause any emotional bluntness, but rather lifts you up, and has low sexual side effects.

Rasagiline: a MAO-B inhibitor, which means it nukes the enzyme that normally metabolises dopamine, phenethylamine, and some trace amines, causing an excess of availability. MAO-A stays intact, resulting in normal serotonin and norepinephrine levels. Rasagiline is also slightly mitoprotective due to reducing oxidative stress in dopaminergic neurons.

LIT-001: an agonist of the oxytocin receptor that is able to pass the BBB and doesn't interact with the vasopressin receptor (=agonism would cause bloat). At higher doses it can even be an antagonist of the vasopressin receptor.

#6: Suppression of HPG-axis

HMG and HCG: these two compounds, even moreso the latter, are all you need to keep your HPG-axis intact. HCG imitates LH, whereas HMG imitates FSH, both stimulating your testes. Inject 100-250IU of HCG every other day (EOD) and take a break every 4-5 months (in case you are permablasting) to reset desensitisation of the Leydig cells. Even for people that plan to blast the next few years, it is recommended to do a HCG cycle 1-2x per year.

View attachment 4860270

Taurine: has antioxidant properties. It protects Leydig cells by reducing ROS and improves mitochondrial function. It is naturally abundant in seminal fluid, which means supplementing taurine results in improved sperm quality. take 1-3g daily.

#7: Prolactin management

Liposomal Pyridoxal-5-Phosphat (P-5-P): a good option to control your prolactin levels and to prevent lactation on low to moderate doses of tren. This should be your go-to compound for prolactin management. It also assists the production of neurotransmitters like dopamine, serotonin, and GABA. It is also a cofactor in many enzymes, supporting various processes in the body. Neuropathy is from high dose pyridoxine, not P-5-P. I'd recommend taking 100-200mg daily.

Cabergoline: binds selectively to dopamine D2 receptors and has a long half-life of roughly 2-3 days. It is primarely used to reduce hyperprolactinemia. Cabergoline reduces GH and IGF-1 levels. Take 0.125-0.25mg every 3 days, but only if you are actively experiencing side effects on high dose tren.

#8: Other safety measures, habits, and general advice

• Donate blood to keep your haematocrit (and red blood cell count) low, especially on boldenone and tren.
• Get full blood work before, during, and after a blasting phase. This way you can verify whether your gear is dosed correctly, how certain blood markers are affected etc.
• Locked in with diet and training. If you aren't doing this, NGMI.
• Do cardio. It improves lipids, heart health, insulin sensitivity, and so much more. It is one of the core pillar "ancillaries" that keeps you healthy.
• Good sleep with melatonin, DSIP, dual orexin receptor antagonists, magnesium l-threonate, maintaining the same sleeping/waking up time. Only take benzos and other sedatives if completely required.
• Keep fat intake low, carbs and protein high. 200-300g protein is ideal daily.
• Stay below 15-20% all throughout the cycle. Start the cycle at a very low bodyfat %.
• In the very rare case that you end up getting puffy and sensitive nipples, use topical raloxifene.
• To decrease bloating on-cycle use amiloride or eplerenone.

Where can you get topical raloxifene?

 

[kat.fcb]

I'm 17 too, here is how much 25 weeks of Test E 500mg and then Test E 200mg for another 25 weeks would cost. After the first 25 weeks I drop down to 5IUs of HGH daily.

50 weeks in total:

• Test E: $150
• HCG: $130
• Aromasin: $30
• HGH: $1,440
• Shipping: $50
• Total: $1,800
  
  Without HGH, it drops down significantly to $360.

1,800$ to ascend is pretty fair jfl

 

[infallible]

What about tren? What are your opinions on it?

he talks about it’s effects on your brain, i’d base it off your end goal tbh, incredible substance.

 

[849ta]

Natty lifting is cope. JFL at spending a decade training optimally to end up as looking like someone that has just ended his first cycle. If you're serious about Looksmaxing, you're going to take every shortcut to achieve your goal.

Why should I give a shit about roiding? A body halo is required for both female attention and male respect. If you have the body of a prepubescent boy, no one will take you seriously. You'll be the "friend", but never the guy she's looking for.

However, that doesn't mean a roided physique is able to compensate for a bad face. It is merely a multiplicator of your current looks level and adds few SMV points.

View attachment 4859439View attachment 4859449

After years of experience and research, the only three steroids you'll ever need are testosterone, boldenone, and trenbolone. Every other steroid, SARM, and prohormone is utter garbage and not worth it. Another compound that belongs into every stack is GH. Insulin isn't required for most people, but if you have a good source you might as well match the GH dose for optimal muscle accrual.

---

Spoiler: Scienceslop about other androgens

Every steroid is structurally derived from either testosterone, 19-nortestosterone, or dihydrotestosterone. These structural differences determine the interaction with the enzymes 5α-reductase and aromatase, the oestrogen and progesterone receptor, and other mechanisms of action.

View attachment 4866695

I will go over a few androgens.

Nandrolone: harsh on hair as it isn't able to be converted into a more tolerable metabolite (5α-dihydronandrolone) in androgenic tissues like skin when using using a 5α-reductase inhibitor. Redundant once you decide to use a topical anti-androgen like RU58841, as you could use stronger and better androgens instead. Nandrolone is also a ligand of the progesterone receptor.

17α-alkylated oral steroids: hepatotoxic in nature due to needing to be metabolised by the liver, which occurs independent of oral or injectable administration. Orals like Halotestin and Superdrol are known for acute strength gains and are used by powerlifters, whilst orals like Anavar are completely redundant.

DHT derivates: rape your hair follicles with the promise of looking drier temporarily. You can counteract this with RU58841, but as with nandrolone, you might as well just use trenbolone instead. They don't interact with aromatase and antagonise the oestrogen receptor, meaning they can be used to control E2 levels.

Exotic androgens: compounds like "The Clear", methyltrienolone, and norboletone are mostly rubbish. There aren't many studies and anecdotal evidence on them, which reduces our harm-reduction capabilities quite a bit. They are very rare and hard to synthesise, leading to these compounds being bunk in most cases.

#1: Testosterone is the main pillar of every steroid cycle and should be your main compound. It is a bioidentical hormone responsible for muscle accrual, bone remodelling, fat distribution, voice deepening, erythropoiesis, sexual wellness including libido, and mental drive. It undergoes 5α-reduction into dihydrotestosterone (DHT) and aromatises into oestradiol (E2). E2 is anabolic especially in conjunction with trenbolone, whereas DHT's existence is redundant.

Testosterone is typically administered with an ester that determines the pharmacokinetics of the compound. They most notably determine the half-life of the androgen. The ideal administration route is an intramuscular injection, but on TRT you may do subcutaneous injections for the sake of simplicity.

This is what you need for an injection:

• 22G needles for drawing the oil
• 25-27G (higher gauge -> smaller needle) needles to inject the oil
• Alcohol wipes
• 2-3mL syringes
• Optional: 29-31G needles for TRT

You can buy everything on Amazon or even in your local pharmacy for a total of 30usd. It is legal to buy injecting equipment. You prepare the injection by disinfecting the injection site and the top of the vial with an alcohol wipe. Ideal injection spots are the ventrogluteal, deltoid, and the vastus lateralis site.

View attachment 4866575

After preparing the injection site, you assemble the syringe by attaching the 22G needle to it and draw the oil. Then you add the 25-27G needle on top of the syringe and inject the oil into your preferred injection site (e.g. the ventrogluteal site). Aspirating (trying to draw blood with a needle) a needle is cope. However, it can get dangerous if you hit a major blood vessel and inject straight into it. This is extremely uncommon and chances are the needle will go through the blood vessel, which does eliminate any risks. Once you have pushed all of the oil in, throw the needle into a sharps container or into your regular rubbish bin and you're done. Here is also a video.

Contrary to popular belief, the added ester group doesn't have an impact on the pharmacodynamics of the steroid. It is argued that a longer ester is more anabolic, whereas a shorter one causes less aromatisation and concurrent bloat. A proposed mechanism for that is the increasing lipophilicity of longer esters. However, the ester is cleaved off before the testosterone is able to be aromatised, making this a baseless claim. The only thing that matters is the relative injection frequency.

The average male produces around 7mg of testosterone per day (=49mg per week). You would have to inject 66mg of testosterone propionate (relatively short ester weight) per week to match that dose. However, that range is still far from being supraphysiological. You would have to inject 200mg+ to notice supraphysiological effects.

According to this study, injecting 600mg of testosterone whilst training 3 times per week can result in a ~6kg fat-free mass gain within 10 weeks whilst the placebo group gains merely ~2kg of fat-free mass.

#2: Boldenone is a steroid that you can add to your cycle to control your E2 levels. It doesn't cause hair loss, thus making it a better option compared to exemestane, which has the androgenic metabolite 17ß-Hydroxyexemestane, that will rape your hair. Non-steroidal aromatase inhibitors like anastrozole and letrozole are harsh on your lipids, making them unideal to use.

Oestradiol is crucial for most neurotransmitters like serotonin and GABA. To acutely treat an E2 crash, you can use the oral dianabol, which has the metabolite methyloestradiol, that is much stronger than regular oestradiol. Alternatively, you can use exogenous E2 or HCG, which would take a few days to work.

The optimal testosterone-to-boldenone ratio is completely individual and depends on your own aromatisation rate. For most people a ratio of 3:1 to 2:1 is ideal, but measuring your E2 levels on each dose will give you clarity. Boldenone also increases appetite in most individuals due to the increased red blood cell count.

#3: Trenbolone is highly androgenic (and obviously anabolic) meaning it will completely eviscerate your skin and hair if you aren't using the appropiate ancillaries. The synergy of tren is very high with E2 and GH; it is the best steroid for gaining muscle mass, whilst simultaneously dropping bodyfat.

The effects of trenbolone like nutrition partitioning and glucocorticoid receptor antagonism are dose-dependent like with any other pathway in the body, which means "microdosing tren" in the double digits is nonsense. Take a higher dose or go home.

#4: Growth hormone (GH), besides being anabolic if coupled with other compounds, is more of a quality of life drug. It improves REM sleep, synergises with tren and E2, improves joint, bone, and soft tissue health, with some recognised cognitive benefits, making it a favourable compound.

The first cycle:

Your first steroid cycle should consist of 500mg testosterone and 6-8IU of GH. It will be the first time you are experiencing supraphysiological effects of androgens and is more than enough in the beginning. The cycle should last 20-25+ weeks and should be followed by a cruising phase of a few months, ideally matching the cycle length. After the cruise you may start blasting again and titrating the dosage up according to your personal needs.

Intermediate steroid cycles:

Once you're at the point where you're blasting 700-800mg+ of testosterone, you should throw in boldenone following your personal test-to-bold ratio. Thereafter, following the test-to-bold ratio, increase doses accordingly. Alternatively, you may decrease the test to 500mg and throw in tren whilst titrating up to the maximum amount you want to run. This cycle is going to be way harsher on your blood markers and hair, but if you're using the correct ancillaries you are going to make the most gains you have ever made while recomp'ing.

---

To reduce and/or completely eliminate most side effects and cover all pathways steroids negatively impact, we're going to discuss a handful of ancillaries.

#1: Skin and hair

Dutasteride: nukes an enzyme (5α-reductase) that converts testosterone into the metabolite dihydrotestosterone. 5α-reductase interacts with other androgens like nandrolone, converting them into their 5α-reduced forms. It is also responsible for the synthesis of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of the GABAA receptor.

A lack of that neurosteroid is the proposed mechanism of the Post-Finasteride syndrome, which only affects 0.1% of individuals. If you want to stay on the safe side, test your brain's genotype (your GABAergic architecture) with a single dose of finasteride, which has a half-life of 6-8 hours, meaning all side effects would be resolved within 1-2 days.

DHT is primarely an intracrine hormone, meaning it exerts its effects in the tissue it is produced in. The tissues in question are mostly the skin, hair follicles, and the penis. DHT is responsible for upregulating sebaceous gland activity, miniaturising hair follicles, and growing the penis during puberty, respectively. I would only recommend using a 5α-reductase inhibitor during puberty, if you are blasting gear. Take atleast 2.5mg daily.

View attachment 4859548

RU-58841: a topical nonsteroidal anti-androgen that didn't pass clinical trials. Its purpose is to reduce the effects of androgens on your skin and scalp by antagonising the androgen receptor (AR). RU-58841 (1-2nM) has a lower binding affinity than testosterone (0.5-1nM) and DHT (0.2-0.3nM), but overpowers them by occupying the receptor site. Apply it daily.

I make my own DIY RU solution:

• 50mL glass dropper bottle
• 2-4g of RU58841 powder
• 5-8mL of DMSO
• Rest is pure ethanol

Isotretinoin: a retinoid that atrophies sebaceous glands i.e. reduces acne and is decent for anti-aging purposes. It is commonly prescribed by dermatologists for treating persistent cystic acne and is well-studied, with the most notable downsides being mild hepatotoxicity, dry lips and skin, and worsening of your lipid profile.

If you have done a few courses of isotretinoin, downregulation of the sebaceous glands tends to be permanent, meaning you won't get acne after coming off. Taking 10-20mg long-term is well tolerated, but I prefer the approach of reaching a specific cumulative dose over months and never having to worry about acne again.

#2: Blood pressure and left ventricular hypertrophy

Nebivolol: a highly selective ß1-adrenergic receptor blocker that is commonly used to treat high blood pressure (BP). It has vasodilatory proporties and reduces the heart rate. Side effects include hypotension and fatigue, which normally don't occur when used and dosed correctly. Take it outside of your workout window, because a high heart rate is ideal for training. Take up to 5mg daily, any higher than that and it loses its selectivity.

Telmisartan: an Angiotensin II receptor blocker that lowers your BP and is nephroprotective (=protects your kidneys) whilst countering aldosterone-induced bloat. Research suggests partial PPARγ agonistic effects including reducing inflammation, enhanced insulin sensitivity etc. Take 40-80mg daily.

Only combine both beta-blockers and ARBs if your blood pressure and heart rate is too high (Stage 1+ on one of the ancillaries).

View attachment 4859674

#3: Cholesterol

Statins: work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway. They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream. They cause a reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins. Statins also slightly activate PPARα via an overexpression of COX-2.

Statins have a ±10% risk of causing diabetes in men. They also seem to have a negative impact on mitochondrial health, which includes reduced coQ10 levels. You can counteract this by supplementing it additionally, which I personally do at high doses.

There are two major groups of statins: hydrophilic and lipophilic statins. Hydrophilic statins (e.g. rosuvasatin and pravastatin) don't cross the BBB and cause more inflammation, whereas lipohilic statins (e.g. pitavastatin, atorvastatin, and simvastatin) cross the BBB and cause less inflammation.

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile. A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks. Dosage: Take 1-4mg daily.

Rosuvastatin is just as good as seen below. You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.

View attachment 4867229

Ezetimibe: inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol. It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein. It doesn't affect the absorption of fat-soluble vitamins. Take 5-10mg daily.

Bemdedoic acid: an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins. Take 180mg daily.

Bempedoic acid significantly reduces LDL cholesterol levels according to this study.



SR9009: an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. SR9009 has multiple benefits like boosting mitochondrial activity, fat metabolism, improving your circadian rhythm, endurance, and inflammation, along with other benefits of you can see below. It also improves the lipid profile.


View attachment 4867256

#4: Oxidative stress and organ health

NAC: a precursor to L-glutathione, that reduces oxidative stress, protects the liver, and organs in general. Is frequently used in clinical settings. Take 2-3g daily, ~1g if you are using a liposomal formulation.

Injectable L-glutathione: as mentioned, a very strong antioxidant that reduces inflammatory markers like TNF-α and IL-6 directly. It is mainly mito-, hepato-, and neuroprotective, making it a nice all-rounder to keep your organs healthy on-cycle. It is also used for skin lightening. Inject 500mg every day.

TUDCA: mainly used as liver support, although NAC/L-glutathione would be more than enough. Liver support is only required on compounds like tren and 17α-alkylated (=orally bioavailable) steroids.

Retatrutide: an agonist of the GLP-1, GIP, and glucagon receptor. You can expect an inprovement in insulin sensitivity, increased energy expenditure, reduced inflammation, and appetite suppression, whilst experiencing only limited side effects like GI irritation and skin sensitivity. It is also a godsent drug to improve your lipid profile significantly, as seen in this study.



View attachment 4872339

#5: Neuroprotection (including modulation of serotonin and oxytocin)

Neurotoxicity mostly occurs on compounds like tren and if you have raped your E2 levels too hard, which you shouldn't since oestrogen is anabolic, keeps your joints healthy, and is neuroprotective. Contrary to popular belief, oxytocin doesn't appear to be impaired on trenbolone. Rather the opposite occurs.

Besides that, oxytocin doesn't appear to be the muh social hormone after all according to this study:



N-Acetyl Semax: modulates BDNF and neurotransmitters like dopamine and serotonin. The acetylation makes BBB penetration easier (it is normally advised to take semax intranasally to bypass the BBB) and causes a higher receptor saturation whilst prolonging the half-life. Dihexa and cerebrolysin may be used alternatively. However, NA-Semax alone will do the job. Taking higher dosages up to 1-2mg is fully tolerated.

Escitalopram: an SSRI. A pure SERT blocker with only minimal secondary receptor interactions and comes with many benefits like being anxiolytic, improving depression and OCD, all whilst being neuroprotective.

Vortioxetine: an even better SSRI that isn't only a SERT blocker, but also a serotonin receptor modulator. It increases BDNF, dopamine, and norepinephrine in the frontal cortex leading to improved neuroplasticity and overall cognition. It doesn't cause any emotional bluntness, but rather lifts you up, and has low sexual side effects.

Rasagiline: a MAO-B inhibitor, which means it nukes the enzyme that normally metabolises dopamine, phenethylamine, and some trace amines, causing an excess of availability. MAO-A stays intact, resulting in normal serotonin and norepinephrine levels. Rasagiline is also slightly mitoprotective due to reducing oxidative stress in dopaminergic neurons.

LIT-001: an agonist of the oxytocin receptor that is able to pass the BBB and doesn't interact with the vasopressin receptor (=agonism would cause bloat). At higher doses it can even be an antagonist of the vasopressin receptor.

#6: Suppression of HPG-axis

HMG and HCG: these two compounds, even moreso the latter, are all you need to keep your HPG-axis intact. HCG imitates LH, whereas HMG imitates FSH, both stimulating your testes. Inject 100-250IU of HCG every other day (EOD) and take a break every 4-5 months (in case you are permablasting) to reset desensitisation of the Leydig cells. Even for people that plan to blast the next few years, it is recommended to do a HCG cycle 1-2x per year.

View attachment 4860270

Taurine: has antioxidant properties. It protects Leydig cells by reducing ROS and improves mitochondrial function. It is naturally abundant in seminal fluid, which means supplementing taurine results in improved sperm quality. take 1-3g daily.

#7: Prolactin management

Liposomal Pyridoxal-5-Phosphat (P-5-P): a good option to control your prolactin levels and to prevent lactation on low to moderate doses of tren. This should be your go-to compound for prolactin management. It also assists the production of neurotransmitters like dopamine, serotonin, and GABA. It is also a cofactor in many enzymes, supporting various processes in the body. Neuropathy is from high dose pyridoxine, not P-5-P. I'd recommend taking 100-200mg daily.

Cabergoline: binds selectively to dopamine D2 receptors and has a long half-life of roughly 2-3 days. It is primarely used to reduce hyperprolactinemia. Cabergoline reduces GH and IGF-1 levels. Take 0.125-0.25mg every 3 days, but only if you are actively experiencing side effects on high dose tren.

#8: Other safety measures, habits, and general advice

• Donate blood to keep your haematocrit (and red blood cell count) low, especially on boldenone and tren.
• Get full blood work before, during, and after a blasting phase. This way you can verify whether your gear is dosed correctly, how certain blood markers are affected etc.
• Locked in with diet and training. If you aren't doing this, NGMI.
• Do cardio. It improves lipids, heart health, insulin sensitivity, and so much more. It is one of the core pillar "ancillaries" that keeps you healthy.
• Good sleep with melatonin, DSIP, dual orexin receptor antagonists, magnesium l-threonate, maintaining the same sleeping/waking up time. Only take benzos and other sedatives if completely required.
• Keep fat intake low, carbs and protein high. 200-300g protein is ideal daily.
• Stay below 15-20% all throughout the cycle. Start the cycle at a very low bodyfat %.
• In the very rare case that you end up getting puffy and sensitive nipples, use topical raloxifene.
• To decrease bloating on-cycle use amiloride or eplerenone.

 

[tit]

Natty lifting is cope. JFL at spending a decade training optimally to end up as looking like someone that has just ended his first cycle. If you're serious about Looksmaxing, you're going to take every shortcut to achieve your goal.

Why should I give a shit about roiding? A body halo is required for both female attention and male respect. If you have the body of a prepubescent boy, no one will take you seriously. You'll be the "friend", but never the guy she's looking for.

However, that doesn't mean a roided physique is able to compensate for a bad face. It is merely a multiplicator of your current looks level and adds few SMV points.

View attachment 4859439View attachment 4859449

After years of experience and research, the only three steroids you'll ever need are testosterone, boldenone, and trenbolone. Every other steroid, SARM, and prohormone is utter garbage and not worth it. Another compound that belongs into every stack is GH. Insulin isn't required for most people, but if you have a good source you might as well match the GH dose for optimal muscle accrual.

---

Spoiler: Scienceslop about other androgens

Every steroid is structurally derived from either testosterone, 19-nortestosterone, or dihydrotestosterone. These structural differences determine the interaction with the enzymes 5α-reductase and aromatase, the oestrogen and progesterone receptor, and other mechanisms of action.

View attachment 4866695

I will go over a few androgens.

Nandrolone: harsh on hair as it isn't able to be converted into a more tolerable metabolite (5α-dihydronandrolone) in androgenic tissues like skin when using using a 5α-reductase inhibitor. Redundant once you decide to use a topical anti-androgen like RU58841, as you could use stronger and better androgens instead. Nandrolone is also a ligand of the progesterone receptor.

17α-alkylated oral steroids: hepatotoxic in nature due to needing to be metabolised by the liver, which occurs independent of oral or injectable administration. Orals like Halotestin and Superdrol are known for acute strength gains and are used by powerlifters, whilst orals like Anavar are completely redundant.

DHT derivates: rape your hair follicles with the promise of looking drier temporarily. You can counteract this with RU58841, but as with nandrolone, you might as well just use trenbolone instead. They don't interact with aromatase and antagonise the oestrogen receptor, meaning they can be used to control E2 levels.

Exotic androgens: compounds like "The Clear", methyltrienolone, and norboletone are mostly rubbish. There aren't many studies and anecdotal evidence on them, which reduces our harm-reduction capabilities quite a bit. They are very rare and hard to synthesise, leading to these compounds being bunk in most cases.

#1: Testosterone is the main pillar of every steroid cycle and should be your main compound. It is a bioidentical hormone responsible for muscle accrual, bone remodelling, fat distribution, voice deepening, erythropoiesis, sexual wellness including libido, and mental drive. It undergoes 5α-reduction into dihydrotestosterone (DHT) and aromatises into oestradiol (E2). E2 is anabolic especially in conjunction with trenbolone, whereas DHT's existence is redundant.

Testosterone is typically administered with an ester that determines the pharmacokinetics of the compound. They most notably determine the half-life of the androgen. The ideal administration route is an intramuscular injection, but on TRT you may do subcutaneous injections for the sake of simplicity.

This is what you need for an injection:

• 22G needles for drawing the oil
• 25-27G (higher gauge -> smaller needle) needles to inject the oil
• Alcohol wipes
• 2-3mL syringes
• Optional: 29-31G needles for TRT

You can buy everything on Amazon or even in your local pharmacy for a total of 30usd. It is legal to buy injecting equipment. You prepare the injection by disinfecting the injection site and the top of the vial with an alcohol wipe. Ideal injection spots are the ventrogluteal, deltoid, and the vastus lateralis site.

View attachment 4866575

After preparing the injection site, you assemble the syringe by attaching the 22G needle to it and draw the oil. Then you add the 25-27G needle on top of the syringe and inject the oil into your preferred injection site (e.g. the ventrogluteal site). Aspirating (trying to draw blood with a needle) a needle is cope. However, it can get dangerous if you hit a major blood vessel and inject straight into it. This is extremely uncommon and chances are the needle will go through the blood vessel, which does eliminate any risks. Once you have pushed all of the oil in, throw the needle into a sharps container or into your regular rubbish bin and you're done. Here is also a video.

Contrary to popular belief, the added ester group doesn't have an impact on the pharmacodynamics of the steroid. It is argued that a longer ester is more anabolic, whereas a shorter one causes less aromatisation and concurrent bloat. A proposed mechanism for that is the increasing lipophilicity of longer esters. However, the ester is cleaved off before the testosterone is able to be aromatised, making this a baseless claim. The only thing that matters is the relative injection frequency.

The average male produces around 7mg of testosterone per day (=49mg per week). You would have to inject 66mg of testosterone propionate (relatively short ester weight) per week to match that dose. However, that range is still far from being supraphysiological. You would have to inject 200mg+ to notice supraphysiological effects.

According to this study, injecting 600mg of testosterone whilst training 3 times per week can result in a ~6kg fat-free mass gain within 10 weeks whilst the placebo group gains merely ~2kg of fat-free mass.

#2: Boldenone is a steroid that you can add to your cycle to control your E2 levels. It doesn't cause hair loss, thus making it a better option compared to exemestane, which has the androgenic metabolite 17ß-Hydroxyexemestane, that will rape your hair. Non-steroidal aromatase inhibitors like anastrozole and letrozole are harsh on your lipids, making them unideal to use.

Oestradiol is crucial for most neurotransmitters like serotonin and GABA. To acutely treat an E2 crash, you can use the oral dianabol, which has the metabolite methyloestradiol, that is much stronger than regular oestradiol. Alternatively, you can use exogenous E2 or HCG, which would take a few days to work.

The optimal testosterone-to-boldenone ratio is completely individual and depends on your own aromatisation rate. For most people a ratio of 3:1 to 2:1 is ideal, but measuring your E2 levels on each dose will give you clarity. Boldenone also increases appetite in most individuals due to the increased red blood cell count.

#3: Trenbolone is highly androgenic (and obviously anabolic) meaning it will completely eviscerate your skin and hair if you aren't using the appropiate ancillaries. The synergy of tren is very high with E2 and GH; it is the best steroid for gaining muscle mass, whilst simultaneously dropping bodyfat.

The effects of trenbolone like nutrition partitioning and glucocorticoid receptor antagonism are dose-dependent like with any other pathway in the body, which means "microdosing tren" in the double digits is nonsense. Take a higher dose or go home.

#4: Growth hormone (GH), besides being anabolic if coupled with other compounds, is more of a quality of life drug. It improves REM sleep, synergises with tren and E2, improves joint, bone, and soft tissue health, with some recognised cognitive benefits, making it a favourable compound.

The first cycle:

Your first steroid cycle should consist of 500mg testosterone and 6-8IU of GH. It will be the first time you are experiencing supraphysiological effects of androgens and is more than enough in the beginning. The cycle should last 20-25+ weeks and should be followed by a cruising phase of a few months, ideally matching the cycle length. After the cruise you may start blasting again and titrating the dosage up according to your personal needs.

Intermediate steroid cycles:

Once you're at the point where you're blasting 700-800mg+ of testosterone, you should throw in boldenone following your personal test-to-bold ratio. Thereafter, following the test-to-bold ratio, increase doses accordingly. Alternatively, you may decrease the test to 500mg and throw in tren whilst titrating up to the maximum amount you want to run. This cycle is going to be way harsher on your blood markers and hair, but if you're using the correct ancillaries you are going to make the most gains you have ever made while recomp'ing.

---

To reduce and/or completely eliminate most side effects and cover all pathways steroids negatively impact, we're going to discuss a handful of ancillaries.

#1: Skin and hair

Dutasteride: nukes an enzyme (5α-reductase) that converts testosterone into the metabolite dihydrotestosterone. 5α-reductase interacts with other androgens like nandrolone, converting them into their 5α-reduced forms. It is also responsible for the synthesis of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of the GABAA receptor.

A lack of that neurosteroid is the proposed mechanism of the Post-Finasteride syndrome, which only affects 0.1% of individuals. If you want to stay on the safe side, test your brain's genotype (your GABAergic architecture) with a single dose of finasteride, which has a half-life of 6-8 hours, meaning all side effects would be resolved within 1-2 days.

DHT is primarely an intracrine hormone, meaning it exerts its effects in the tissue it is produced in. The tissues in question are mostly the skin, hair follicles, and the penis. DHT is responsible for upregulating sebaceous gland activity, miniaturising hair follicles, and growing the penis during puberty, respectively. I would only recommend using a 5α-reductase inhibitor during puberty, if you are blasting gear. Take atleast 2.5mg daily.

View attachment 4859548

RU-58841: a topical nonsteroidal anti-androgen that didn't pass clinical trials. Its purpose is to reduce the effects of androgens on your skin and scalp by antagonising the androgen receptor (AR). RU-58841 (1-2nM) has a lower binding affinity than testosterone (0.5-1nM) and DHT (0.2-0.3nM), but overpowers them by occupying the receptor site. Apply it daily.

I make my own DIY RU solution:

• 50mL glass dropper bottle
• 2-4g of RU58841 powder
• 5-8mL of DMSO
• Rest is pure ethanol

Isotretinoin: a retinoid that atrophies sebaceous glands i.e. reduces acne and is decent for anti-aging purposes. It is commonly prescribed by dermatologists for treating persistent cystic acne and is well-studied, with the most notable downsides being mild hepatotoxicity, dry lips and skin, and worsening of your lipid profile.

If you have done a few courses of isotretinoin, downregulation of the sebaceous glands tends to be permanent, meaning you won't get acne after coming off. Taking 10-20mg long-term is well tolerated, but I prefer the approach of reaching a specific cumulative dose over months and never having to worry about acne again.

#2: Blood pressure and left ventricular hypertrophy

Nebivolol: a highly selective ß1-adrenergic receptor blocker that is commonly used to treat high blood pressure (BP). It has vasodilatory proporties and reduces the heart rate. Side effects include hypotension and fatigue, which normally don't occur when used and dosed correctly. Take it outside of your workout window, because a high heart rate is ideal for training. Take up to 5mg daily, any higher than that and it loses its selectivity.

Telmisartan: an Angiotensin II receptor blocker that lowers your BP and is nephroprotective (=protects your kidneys) whilst countering aldosterone-induced bloat. Research suggests partial PPARγ agonistic effects including reducing inflammation, enhanced insulin sensitivity etc. Take 40-80mg daily.

Only combine both beta-blockers and ARBs if your blood pressure and heart rate is too high (Stage 1+ on one of the ancillaries).

View attachment 4859674

#3: Cholesterol

Statins: work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway. They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream. They cause a reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins. Statins also slightly activate PPARα via an overexpression of COX-2.

Statins have a ±10% risk of causing diabetes in men. They also seem to have a negative impact on mitochondrial health, which includes reduced coQ10 levels. You can counteract this by supplementing it additionally, which I personally do at high doses.

There are two major groups of statins: hydrophilic and lipophilic statins. Hydrophilic statins (e.g. rosuvasatin and pravastatin) don't cross the BBB and cause more inflammation, whereas lipohilic statins (e.g. pitavastatin, atorvastatin, and simvastatin) cross the BBB and cause less inflammation.

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile. A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks. Dosage: Take 1-4mg daily.

Rosuvastatin is just as good as seen below. You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.

View attachment 4867229

Ezetimibe: inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol. It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein. It doesn't affect the absorption of fat-soluble vitamins. Take 5-10mg daily.

Bemdedoic acid: an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins. Take 180mg daily.

Bempedoic acid significantly reduces LDL cholesterol levels according to this study.



SR9009: an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. SR9009 has multiple benefits like boosting mitochondrial activity, fat metabolism, improving your circadian rhythm, endurance, and inflammation, along with other benefits of you can see below. It also improves the lipid profile.


View attachment 4867256

#4: Oxidative stress and organ health

NAC: a precursor to L-glutathione, that reduces oxidative stress, protects the liver, and organs in general. Is frequently used in clinical settings. Take 2-3g daily, ~1g if you are using a liposomal formulation.

Injectable L-glutathione: as mentioned, a very strong antioxidant that reduces inflammatory markers like TNF-α and IL-6 directly. It is mainly mito-, hepato-, and neuroprotective, making it a nice all-rounder to keep your organs healthy on-cycle. It is also used for skin lightening. Inject 500mg every day.

TUDCA: mainly used as liver support, although NAC/L-glutathione would be more than enough. Liver support is only required on compounds like tren and 17α-alkylated (=orally bioavailable) steroids.

Retatrutide: an agonist of the GLP-1, GIP, and glucagon receptor. You can expect an inprovement in insulin sensitivity, increased energy expenditure, reduced inflammation, and appetite suppression, whilst experiencing only limited side effects like GI irritation and skin sensitivity. It is also a godsent drug to improve your lipid profile significantly, as seen in this study.



View attachment 4872339

#5: Neuroprotection (including modulation of serotonin and oxytocin)

Neurotoxicity mostly occurs on compounds like tren and if you have raped your E2 levels too hard, which you shouldn't since oestrogen is anabolic, keeps your joints healthy, and is neuroprotective. Contrary to popular belief, oxytocin doesn't appear to be impaired on trenbolone. Rather the opposite occurs.

Besides that, oxytocin doesn't appear to be the muh social hormone after all according to this study:



N-Acetyl Semax: modulates BDNF and neurotransmitters like dopamine and serotonin. The acetylation makes BBB penetration easier (it is normally advised to take semax intranasally to bypass the BBB) and causes a higher receptor saturation whilst prolonging the half-life. Dihexa and cerebrolysin may be used alternatively. However, NA-Semax alone will do the job. Taking higher dosages up to 1-2mg is fully tolerated.

Escitalopram: an SSRI. A pure SERT blocker with only minimal secondary receptor interactions and comes with many benefits like being anxiolytic, improving depression and OCD, all whilst being neuroprotective.

Vortioxetine: an even better SSRI that isn't only a SERT blocker, but also a serotonin receptor modulator. It increases BDNF, dopamine, and norepinephrine in the frontal cortex leading to improved neuroplasticity and overall cognition. It doesn't cause any emotional bluntness, but rather lifts you up, and has low sexual side effects.

Rasagiline: a MAO-B inhibitor, which means it nukes the enzyme that normally metabolises dopamine, phenethylamine, and some trace amines, causing an excess of availability. MAO-A stays intact, resulting in normal serotonin and norepinephrine levels. Rasagiline is also slightly mitoprotective due to reducing oxidative stress in dopaminergic neurons.

LIT-001: an agonist of the oxytocin receptor that is able to pass the BBB and doesn't interact with the vasopressin receptor (=agonism would cause bloat). At higher doses it can even be an antagonist of the vasopressin receptor.

#6: Suppression of HPG-axis

HMG and HCG: these two compounds, even moreso the latter, are all you need to keep your HPG-axis intact. HCG imitates LH, whereas HMG imitates FSH, both stimulating your testes. Inject 100-250IU of HCG every other day (EOD) and take a break every 4-5 months (in case you are permablasting) to reset desensitisation of the Leydig cells. Even for people that plan to blast the next few years, it is recommended to do a HCG cycle 1-2x per year.

View attachment 4860270

Taurine: has antioxidant properties. It protects Leydig cells by reducing ROS and improves mitochondrial function. It is naturally abundant in seminal fluid, which means supplementing taurine results in improved sperm quality. take 1-3g daily.

#7: Prolactin management

Liposomal Pyridoxal-5-Phosphat (P-5-P): a good option to control your prolactin levels and to prevent lactation on low to moderate doses of tren. This should be your go-to compound for prolactin management. It also assists the production of neurotransmitters like dopamine, serotonin, and GABA. It is also a cofactor in many enzymes, supporting various processes in the body. Neuropathy is from high dose pyridoxine, not P-5-P. I'd recommend taking 100-200mg daily.

Cabergoline: binds selectively to dopamine D2 receptors and has a long half-life of roughly 2-3 days. It is primarely used to reduce hyperprolactinemia. Cabergoline reduces GH and IGF-1 levels. Take 0.125-0.25mg every 3 days, but only if you are actively experiencing side effects on high dose tren.

#8: Other safety measures, habits, and general advice

• Donate blood to keep your haematocrit (and red blood cell count) low, especially on boldenone and tren.
• Get full blood work before, during, and after a blasting phase. This way you can verify whether your gear is dosed correctly, how certain blood markers are affected etc.
• Locked in with diet and training. If you aren't doing this, NGMI.
• Do cardio. It improves lipids, heart health, insulin sensitivity, and so much more. It is one of the core pillar "ancillaries" that keeps you healthy.
• Good sleep with melatonin, DSIP, dual orexin receptor antagonists, magnesium l-threonate, maintaining the same sleeping/waking up time. Only take benzos and other sedatives if completely required.
• Keep fat intake low, carbs and protein high. 200-300g protein is ideal daily.
• Stay below 15-20% all throughout the cycle. Start the cycle at a very low bodyfat %.
• In the very rare case that you end up getting puffy and sensitive nipples, use topical raloxifene.
• To decrease bloating on-cycle use amiloride or eplerenone.

Read everything other than the health side management, great thread bhai. Gonna do tren cycle for the summer inshallah. Need to cop some ru as well. If I take tren and don't get a slay, I will give up on soft maxing and probably just die or something.

 

[megahandsomegoat]

Natty lifting is cope. JFL at spending a decade training optimally to end up as looking like someone that has just ended his first cycle. If you're serious about Looksmaxing, you're going to take every shortcut to achieve your goal.

Why should I give a shit about roiding? A body halo is required for both female attention and male respect. If you have the body of a prepubescent boy, no one will take you seriously. You'll be the "friend", but never the guy she's looking for.

However, that doesn't mean a roided physique is able to compensate for a bad face. It is merely a multiplicator of your current looks level and adds few SMV points.

View attachment 4859439View attachment 4859449

After years of experience and research, the only three steroids you'll ever need are testosterone, boldenone, and trenbolone. Every other steroid, SARM, and prohormone is utter garbage and not worth it. Another compound that belongs into every stack is GH. Insulin isn't required for most people, but if you have a good source you might as well match the GH dose for optimal muscle accrual.

---

Spoiler: Scienceslop about other androgens

Every steroid is structurally derived from either testosterone, 19-nortestosterone, or dihydrotestosterone. These structural differences determine the interaction with the enzymes 5α-reductase and aromatase, the oestrogen and progesterone receptor, and other mechanisms of action.

View attachment 4866695

I will go over a few androgens.

Nandrolone: harsh on hair as it isn't able to be converted into a more tolerable metabolite (5α-dihydronandrolone) in androgenic tissues like skin when using using a 5α-reductase inhibitor. Redundant once you decide to use a topical anti-androgen like RU58841, as you could use stronger and better androgens instead. Nandrolone is also a ligand of the progesterone receptor.

17α-alkylated oral steroids: hepatotoxic in nature due to needing to be metabolised by the liver, which occurs independent of oral or injectable administration. Orals like Halotestin and Superdrol are known for acute strength gains and are used by powerlifters, whilst orals like Anavar are completely redundant.

DHT derivates: rape your hair follicles with the promise of looking drier temporarily. You can counteract this with RU58841, but as with nandrolone, you might as well just use trenbolone instead. They don't interact with aromatase and antagonise the oestrogen receptor, meaning they can be used to control E2 levels.

Exotic androgens: compounds like "The Clear", methyltrienolone, and norboletone are mostly rubbish. There aren't many studies and anecdotal evidence on them, which reduces our harm-reduction capabilities quite a bit. They are very rare and hard to synthesise, leading to these compounds being bunk in most cases.

#1: Testosterone is the main pillar of every steroid cycle and should be your main compound. It is a bioidentical hormone responsible for muscle accrual, bone remodelling, fat distribution, voice deepening, erythropoiesis, sexual wellness including libido, and mental drive. It undergoes 5α-reduction into dihydrotestosterone (DHT) and aromatises into oestradiol (E2). E2 is anabolic especially in conjunction with trenbolone, whereas DHT's existence is redundant.

Testosterone is typically administered with an ester that determines the pharmacokinetics of the compound. They most notably determine the half-life of the androgen. The ideal administration route is an intramuscular injection, but on TRT you may do subcutaneous injections for the sake of simplicity.

This is what you need for an injection:

• 22G needles for drawing the oil
• 25-27G (higher gauge -> smaller needle) needles to inject the oil
• Alcohol wipes
• 2-3mL syringes
• Optional: 29-31G needles for TRT

You can buy everything on Amazon or even in your local pharmacy for a total of 30usd. It is legal to buy injecting equipment. You prepare the injection by disinfecting the injection site and the top of the vial with an alcohol wipe. Ideal injection spots are the ventrogluteal, deltoid, and the vastus lateralis site.

View attachment 4866575

After preparing the injection site, you assemble the syringe by attaching the 22G needle to it and draw the oil. Then you add the 25-27G needle on top of the syringe and inject the oil into your preferred injection site (e.g. the ventrogluteal site). Aspirating (trying to draw blood with a needle) a needle is cope. However, it can get dangerous if you hit a major blood vessel and inject straight into it. This is extremely uncommon and chances are the needle will go through the blood vessel, which does eliminate any risks. Once you have pushed all of the oil in, throw the needle into a sharps container or into your regular rubbish bin and you're done. Here is also a video.

Contrary to popular belief, the added ester group doesn't have an impact on the pharmacodynamics of the steroid. It is argued that a longer ester is more anabolic, whereas a shorter one causes less aromatisation and concurrent bloat. A proposed mechanism for that is the increasing lipophilicity of longer esters. However, the ester is cleaved off before the testosterone is able to be aromatised, making this a baseless claim. The only thing that matters is the relative injection frequency.

The average male produces around 7mg of testosterone per day (=49mg per week). You would have to inject 66mg of testosterone propionate (relatively short ester weight) per week to match that dose. However, that range is still far from being supraphysiological. You would have to inject 200mg+ to notice supraphysiological effects.

According to this study, injecting 600mg of testosterone whilst training 3 times per week can result in a ~6kg fat-free mass gain within 10 weeks whilst the placebo group gains merely ~2kg of fat-free mass.

#2: Boldenone is a steroid that you can add to your cycle to control your E2 levels. It doesn't cause hair loss, thus making it a better option compared to exemestane, which has the androgenic metabolite 17ß-Hydroxyexemestane, that will rape your hair. Non-steroidal aromatase inhibitors like anastrozole and letrozole are harsh on your lipids, making them unideal to use.

Oestradiol is crucial for most neurotransmitters like serotonin and GABA. To acutely treat an E2 crash, you can use the oral dianabol, which has the metabolite methyloestradiol, that is much stronger than regular oestradiol. Alternatively, you can use exogenous E2 or HCG, which would take a few days to work.

The optimal testosterone-to-boldenone ratio is completely individual and depends on your own aromatisation rate. For most people a ratio of 3:1 to 2:1 is ideal, but measuring your E2 levels on each dose will give you clarity. Boldenone also increases appetite in most individuals due to the increased red blood cell count.

#3: Trenbolone is highly androgenic (and obviously anabolic) meaning it will completely eviscerate your skin and hair if you aren't using the appropiate ancillaries. The synergy of tren is very high with E2 and GH; it is the best steroid for gaining muscle mass, whilst simultaneously dropping bodyfat.

The effects of trenbolone like nutrition partitioning and glucocorticoid receptor antagonism are dose-dependent like with any other pathway in the body, which means "microdosing tren" in the double digits is nonsense. Take a higher dose or go home.

#4: Growth hormone (GH), besides being anabolic if coupled with other compounds, is more of a quality of life drug. It improves REM sleep, synergises with tren and E2, improves joint, bone, and soft tissue health, with some recognised cognitive benefits, making it a favourable compound.

The first cycle:

Your first steroid cycle should consist of 500mg testosterone and 6-8IU of GH. It will be the first time you are experiencing supraphysiological effects of androgens and is more than enough in the beginning. The cycle should last 20-25+ weeks and should be followed by a cruising phase of a few months, ideally matching the cycle length. After the cruise you may start blasting again and titrating the dosage up according to your personal needs.

Intermediate steroid cycles:

Once you're at the point where you're blasting 700-800mg+ of testosterone, you should throw in boldenone following your personal test-to-bold ratio. Thereafter, following the test-to-bold ratio, increase doses accordingly. Alternatively, you may decrease the test to 500mg and throw in tren whilst titrating up to the maximum amount you want to run. This cycle is going to be way harsher on your blood markers and hair, but if you're using the correct ancillaries you are going to make the most gains you have ever made while recomp'ing.

---

To reduce and/or completely eliminate most side effects and cover all pathways steroids negatively impact, we're going to discuss a handful of ancillaries.

#1: Skin and hair

Dutasteride: nukes an enzyme (5α-reductase) that converts testosterone into the metabolite dihydrotestosterone. 5α-reductase interacts with other androgens like nandrolone, converting them into their 5α-reduced forms. It is also responsible for the synthesis of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of the GABAA receptor.

A lack of that neurosteroid is the proposed mechanism of the Post-Finasteride syndrome, which only affects 0.1% of individuals. If you want to stay on the safe side, test your brain's genotype (your GABAergic architecture) with a single dose of finasteride, which has a half-life of 6-8 hours, meaning all side effects would be resolved within 1-2 days.

DHT is primarely an intracrine hormone, meaning it exerts its effects in the tissue it is produced in. The tissues in question are mostly the skin, hair follicles, and the penis. DHT is responsible for upregulating sebaceous gland activity, miniaturising hair follicles, and growing the penis during puberty, respectively. I would only recommend using a 5α-reductase inhibitor during puberty, if you are blasting gear. Take atleast 2.5mg daily.

View attachment 4859548

RU-58841: a topical nonsteroidal anti-androgen that didn't pass clinical trials. Its purpose is to reduce the effects of androgens on your skin and scalp by antagonising the androgen receptor (AR). RU-58841 (1-2nM) has a lower binding affinity than testosterone (0.5-1nM) and DHT (0.2-0.3nM), but overpowers them by occupying the receptor site. Apply it daily.

I make my own DIY RU solution:

• 50mL glass dropper bottle
• 2-4g of RU58841 powder
• 5-8mL of DMSO
• Rest is pure ethanol

Isotretinoin: a retinoid that atrophies sebaceous glands i.e. reduces acne and is decent for anti-aging purposes. It is commonly prescribed by dermatologists for treating persistent cystic acne and is well-studied, with the most notable downsides being mild hepatotoxicity, dry lips and skin, and worsening of your lipid profile.

If you have done a few courses of isotretinoin, downregulation of the sebaceous glands tends to be permanent, meaning you won't get acne after coming off. Taking 10-20mg long-term is well tolerated, but I prefer the approach of reaching a specific cumulative dose over months and never having to worry about acne again.

#2: Blood pressure and left ventricular hypertrophy

Nebivolol: a highly selective ß1-adrenergic receptor blocker that is commonly used to treat high blood pressure (BP). It has vasodilatory proporties and reduces the heart rate. Side effects include hypotension and fatigue, which normally don't occur when used and dosed correctly. Take it outside of your workout window, because a high heart rate is ideal for training. Take up to 5mg daily, any higher than that and it loses its selectivity.

Telmisartan: an Angiotensin II receptor blocker that lowers your BP and is nephroprotective (=protects your kidneys) whilst countering aldosterone-induced bloat. Research suggests partial PPARγ agonistic effects including reducing inflammation, enhanced insulin sensitivity etc. Take 40-80mg daily.

Only combine both beta-blockers and ARBs if your blood pressure and heart rate is too high (Stage 1+ on one of the ancillaries).

View attachment 4859674

#3: Cholesterol

Statins: work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway. They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream. They cause a reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins. Statins also slightly activate PPARα via an overexpression of COX-2.

Statins have a ±10% risk of causing diabetes in men. They also seem to have a negative impact on mitochondrial health, which includes reduced coQ10 levels. You can counteract this by supplementing it additionally, which I personally do at high doses.

There are two major groups of statins: hydrophilic and lipophilic statins. Hydrophilic statins (e.g. rosuvasatin and pravastatin) don't cross the BBB and cause more inflammation, whereas lipohilic statins (e.g. pitavastatin, atorvastatin, and simvastatin) cross the BBB and cause less inflammation.

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile. A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks. Dosage: Take 1-4mg daily.

Rosuvastatin is just as good as seen below. You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.

View attachment 4867229

Ezetimibe: inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol. It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein. It doesn't affect the absorption of fat-soluble vitamins. Take 5-10mg daily.

Bemdedoic acid: an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins. Take 180mg daily.

Bempedoic acid significantly reduces LDL cholesterol levels according to this study.



SR9009: an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. SR9009 has multiple benefits like boosting mitochondrial activity, fat metabolism, improving your circadian rhythm, endurance, and inflammation, along with other benefits of you can see below. It also improves the lipid profile.


View attachment 4867256

#4: Oxidative stress and organ health

NAC: a precursor to L-glutathione, that reduces oxidative stress, protects the liver, and organs in general. Is frequently used in clinical settings. Take 2-3g daily, ~1g if you are using a liposomal formulation.

Injectable L-glutathione: as mentioned, a very strong antioxidant that reduces inflammatory markers like TNF-α and IL-6 directly. It is mainly mito-, hepato-, and neuroprotective, making it a nice all-rounder to keep your organs healthy on-cycle. It is also used for skin lightening. Inject 500mg every day.

TUDCA: mainly used as liver support, although NAC/L-glutathione would be more than enough. Liver support is only required on compounds like tren and 17α-alkylated (=orally bioavailable) steroids.

Retatrutide: an agonist of the GLP-1, GIP, and glucagon receptor. You can expect an inprovement in insulin sensitivity, increased energy expenditure, reduced inflammation, and appetite suppression, whilst experiencing only limited side effects like GI irritation and skin sensitivity. It is also a godsent drug to improve your lipid profile significantly, as seen in this study.



View attachment 4872339

#5: Neuroprotection (including modulation of serotonin and oxytocin)

Neurotoxicity mostly occurs on compounds like tren and if you have raped your E2 levels too hard, which you shouldn't since oestrogen is anabolic, keeps your joints healthy, and is neuroprotective. Contrary to popular belief, oxytocin doesn't appear to be impaired on trenbolone. Rather the opposite occurs.

Besides that, oxytocin doesn't appear to be the muh social hormone after all according to this study:



N-Acetyl Semax: modulates BDNF and neurotransmitters like dopamine and serotonin. The acetylation makes BBB penetration easier (it is normally advised to take semax intranasally to bypass the BBB) and causes a higher receptor saturation whilst prolonging the half-life. Dihexa and cerebrolysin may be used alternatively. However, NA-Semax alone will do the job. Taking higher dosages up to 1-2mg is fully tolerated.

Escitalopram: an SSRI. A pure SERT blocker with only minimal secondary receptor interactions and comes with many benefits like being anxiolytic, improving depression and OCD, all whilst being neuroprotective.

Vortioxetine: an even better SSRI that isn't only a SERT blocker, but also a serotonin receptor modulator. It increases BDNF, dopamine, and norepinephrine in the frontal cortex leading to improved neuroplasticity and overall cognition. It doesn't cause any emotional bluntness, but rather lifts you up, and has low sexual side effects.

Rasagiline: a MAO-B inhibitor, which means it nukes the enzyme that normally metabolises dopamine, phenethylamine, and some trace amines, causing an excess of availability. MAO-A stays intact, resulting in normal serotonin and norepinephrine levels. Rasagiline is also slightly mitoprotective due to reducing oxidative stress in dopaminergic neurons.

LIT-001: an agonist of the oxytocin receptor that is able to pass the BBB and doesn't interact with the vasopressin receptor (=agonism would cause bloat). At higher doses it can even be an antagonist of the vasopressin receptor.

#6: Suppression of HPG-axis

HMG and HCG: these two compounds, even moreso the latter, are all you need to keep your HPG-axis intact. HCG imitates LH, whereas HMG imitates FSH, both stimulating your testes. Inject 100-250IU of HCG every other day (EOD) and take a break every 4-5 months (in case you are permablasting) to reset desensitisation of the Leydig cells. Even for people that plan to blast the next few years, it is recommended to do a HCG cycle 1-2x per year.

View attachment 4860270

Taurine: has antioxidant properties. It protects Leydig cells by reducing ROS and improves mitochondrial function. It is naturally abundant in seminal fluid, which means supplementing taurine results in improved sperm quality. take 1-3g daily.

#7: Prolactin management

Liposomal Pyridoxal-5-Phosphat (P-5-P): a good option to control your prolactin levels and to prevent lactation on low to moderate doses of tren. This should be your go-to compound for prolactin management. It also assists the production of neurotransmitters like dopamine, serotonin, and GABA. It is also a cofactor in many enzymes, supporting various processes in the body. Neuropathy is from high dose pyridoxine, not P-5-P. I'd recommend taking 100-200mg daily.

Cabergoline: binds selectively to dopamine D2 receptors and has a long half-life of roughly 2-3 days. It is primarely used to reduce hyperprolactinemia. Cabergoline reduces GH and IGF-1 levels. Take 0.125-0.25mg every 3 days, but only if you are actively experiencing side effects on high dose tren.

#8: Other safety measures, habits, and general advice

• Donate blood to keep your haematocrit (and red blood cell count) low, especially on boldenone and tren.
• Get full blood work before, during, and after a blasting phase. This way you can verify whether your gear is dosed correctly, how certain blood markers are affected etc.
• Locked in with diet and training. If you aren't doing this, NGMI.
• Do cardio. It improves lipids, heart health, insulin sensitivity, and so much more. It is one of the core pillar "ancillaries" that keeps you healthy.
• Good sleep with melatonin, DSIP, dual orexin receptor antagonists, magnesium l-threonate, maintaining the same sleeping/waking up time. Only take benzos and other sedatives if completely required.
• Keep fat intake low, carbs and protein high. 200-300g protein is ideal daily.
• Stay below 15-20% all throughout the cycle. Start the cycle at a very low bodyfat %.
• In the very rare case that you end up getting puffy and sensitive nipples, use topical raloxifene.
• To decrease bloating on-cycle use amiloride or eplerenone.

Where can I get test?? I can’t find it anywhere does anyone have a source please

 

[patrikos.psl]

bookmarking this shit nigga

 

[kktsk]

so WHAT is cruising and how to do it

 

[kullancı1998572619]

just used test tren based on this thread ı just turned gay nigga wtf

 

[Itsnotover77]

Natty lifting is cope. JFL at spending a decade training optimally to end up as looking like someone that has just ended his first cycle. If you're serious about Looksmaxing, you're going to take every shortcut to achieve your goal.

Why should I give a shit about roiding? A body halo is required for both female attention and male respect. If you have the body of a prepubescent boy, no one will take you seriously. You'll be the "friend", but never the guy she's looking for.

However, that doesn't mean a roided physique is able to compensate for a bad face. It is merely a multiplicator of your current looks level and adds few SMV points.

View attachment 4859439View attachment 4859449

After years of experience and research, the only three steroids you'll ever need are testosterone, boldenone, and trenbolone. Every other steroid, SARM, and prohormone is utter garbage and not worth it. Another compound that belongs into every stack is GH. Insulin isn't required for most people, but if you have a good source you might as well match the GH dose for optimal muscle accrual.

---

Spoiler: Scienceslop about other androgens

Every steroid is structurally derived from either testosterone, 19-nortestosterone, or dihydrotestosterone. These structural differences determine the interaction with the enzymes 5α-reductase and aromatase, the oestrogen and progesterone receptor, and other mechanisms of action.

View attachment 4866695

I will go over a few androgens.

Nandrolone: harsh on hair as it isn't able to be converted into a more tolerable metabolite (5α-dihydronandrolone) in androgenic tissues like skin when using using a 5α-reductase inhibitor. Redundant once you decide to use a topical anti-androgen like RU58841, as you could use stronger and better androgens instead. Nandrolone is also a ligand of the progesterone receptor.

17α-alkylated oral steroids: hepatotoxic in nature due to needing to be metabolised by the liver, which occurs independent of oral or injectable administration. Orals like Halotestin and Superdrol are known for acute strength gains and are used by powerlifters, whilst orals like Anavar are completely redundant.

DHT derivates: rape your hair follicles with the promise of looking drier temporarily. You can counteract this with RU58841, but as with nandrolone, you might as well just use trenbolone instead. They don't interact with aromatase and antagonise the oestrogen receptor, meaning they can be used to control E2 levels.

Exotic androgens: compounds like "The Clear", methyltrienolone, and norboletone are mostly rubbish. There aren't many studies and anecdotal evidence on them, which reduces our harm-reduction capabilities quite a bit. They are very rare and hard to synthesise, leading to these compounds being bunk in most cases.

#1: Testosterone is the main pillar of every steroid cycle and should be your main compound. It is a bioidentical hormone responsible for muscle accrual, bone remodelling, fat distribution, voice deepening, erythropoiesis, sexual wellness including libido, and mental drive. It undergoes 5α-reduction into dihydrotestosterone (DHT) and aromatises into oestradiol (E2). E2 is anabolic especially in conjunction with trenbolone, whereas DHT's existence is redundant.

Testosterone is typically administered with an ester that determines the pharmacokinetics of the compound. They most notably determine the half-life of the androgen. The ideal administration route is an intramuscular injection, but on TRT you may do subcutaneous injections for the sake of simplicity.

This is what you need for an injection:

• 22G needles for drawing the oil
• 25-27G (higher gauge -> smaller needle) needles to inject the oil
• Alcohol wipes
• 2-3mL syringes
• Optional: 29-31G needles for TRT

You can buy everything on Amazon or even in your local pharmacy for a total of 30usd. It is legal to buy injecting equipment. You prepare the injection by disinfecting the injection site and the top of the vial with an alcohol wipe. Ideal injection spots are the ventrogluteal, deltoid, and the vastus lateralis site.

View attachment 4866575

After preparing the injection site, you assemble the syringe by attaching the 22G needle to it and draw the oil. Then you add the 25-27G needle on top of the syringe and inject the oil into your preferred injection site (e.g. the ventrogluteal site). Aspirating (trying to draw blood with a needle) a needle is cope. However, it can get dangerous if you hit a major blood vessel and inject straight into it. This is extremely uncommon and chances are the needle will go through the blood vessel, which does eliminate any risks. Once you have pushed all of the oil in, throw the needle into a sharps container or into your regular rubbish bin and you're done. Here is also a video.

Contrary to popular belief, the added ester group doesn't have an impact on the pharmacodynamics of the steroid. It is argued that a longer ester is more anabolic, whereas a shorter one causes less aromatisation and concurrent bloat. A proposed mechanism for that is the increasing lipophilicity of longer esters. However, the ester is cleaved off before the testosterone is able to be aromatised, making this a baseless claim. The only thing that matters is the relative injection frequency.

The average male produces around 7mg of testosterone per day (=49mg per week). You would have to inject 66mg of testosterone propionate (relatively short ester weight) per week to match that dose. However, that range is still far from being supraphysiological. You would have to inject 200mg+ to notice supraphysiological effects.

According to this study, injecting 600mg of testosterone whilst training 3 times per week can result in a ~6kg fat-free mass gain within 10 weeks whilst the placebo group gains merely ~2kg of fat-free mass.

#2: Boldenone is a steroid that you can add to your cycle to control your E2 levels. It doesn't cause hair loss, thus making it a better option compared to exemestane, which has the androgenic metabolite 17ß-Hydroxyexemestane, that will rape your hair. Non-steroidal aromatase inhibitors like anastrozole and letrozole are harsh on your lipids, making them unideal to use.

Oestradiol is crucial for most neurotransmitters like serotonin and GABA. To acutely treat an E2 crash, you can use the oral dianabol, which has the metabolite methyloestradiol, that is much stronger than regular oestradiol. Alternatively, you can use exogenous E2 or HCG, which would take a few days to work.

The optimal testosterone-to-boldenone ratio is completely individual and depends on your own aromatisation rate. For most people a ratio of 3:1 to 2:1 is ideal, but measuring your E2 levels on each dose will give you clarity. Boldenone also increases appetite in most individuals due to the increased red blood cell count.

#3: Trenbolone is highly androgenic (and obviously anabolic) meaning it will completely eviscerate your skin and hair if you aren't using the appropiate ancillaries. The synergy of tren is very high with E2 and GH; it is the best steroid for gaining muscle mass, whilst simultaneously dropping bodyfat.

The effects of trenbolone like nutrition partitioning and glucocorticoid receptor antagonism are dose-dependent like with any other pathway in the body, which means "microdosing tren" in the double digits is nonsense. Take a higher dose or go home.

#4: Growth hormone (GH), besides being anabolic if coupled with other compounds, is more of a quality of life drug. It improves REM sleep, synergises with tren and E2, improves joint, bone, and soft tissue health, with some recognised cognitive benefits, making it a favourable compound.

The first cycle:

Your first steroid cycle should consist of 500mg testosterone and 6-8IU of GH. It will be the first time you are experiencing supraphysiological effects of androgens and is more than enough in the beginning. The cycle should last 20-25+ weeks and should be followed by a cruising phase of a few months, ideally matching the cycle length. After the cruise you may start blasting again and titrating the dosage up according to your personal needs.

Intermediate steroid cycles:

Once you're at the point where you're blasting 700-800mg+ of testosterone, you should throw in boldenone following your personal test-to-bold ratio. Thereafter, following the test-to-bold ratio, increase doses accordingly. Alternatively, you may decrease the test to 500mg and throw in tren whilst titrating up to the maximum amount you want to run. This cycle is going to be way harsher on your blood markers and hair, but if you're using the correct ancillaries you are going to make the most gains you have ever made while recomp'ing.

---

To reduce and/or completely eliminate most side effects and cover all pathways steroids negatively impact, we're going to discuss a handful of ancillaries.

#1: Skin and hair

Dutasteride: nukes an enzyme (5α-reductase) that converts testosterone into the metabolite dihydrotestosterone. 5α-reductase interacts with other androgens like nandrolone, converting them into their 5α-reduced forms. It is also responsible for the synthesis of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of the GABAA receptor.

A lack of that neurosteroid is the proposed mechanism of the Post-Finasteride syndrome, which only affects 0.1% of individuals. If you want to stay on the safe side, test your brain's genotype (your GABAergic architecture) with a single dose of finasteride, which has a half-life of 6-8 hours, meaning all side effects would be resolved within 1-2 days.

DHT is primarely an intracrine hormone, meaning it exerts its effects in the tissue it is produced in. The tissues in question are mostly the skin, hair follicles, and the penis. DHT is responsible for upregulating sebaceous gland activity, miniaturising hair follicles, and growing the penis during puberty, respectively. I would only recommend using a 5α-reductase inhibitor during puberty, if you are blasting gear. Take atleast 2.5mg daily.

View attachment 4859548

RU-58841: a topical nonsteroidal anti-androgen that didn't pass clinical trials. Its purpose is to reduce the effects of androgens on your skin and scalp by antagonising the androgen receptor (AR). RU-58841 (1-2nM) has a lower binding affinity than testosterone (0.5-1nM) and DHT (0.2-0.3nM), but overpowers them by occupying the receptor site. Apply it daily.

I make my own DIY RU solution:

• 50mL glass dropper bottle
• 2-4g of RU58841 powder
• 5-8mL of DMSO
• Rest is pure ethanol

Isotretinoin: a retinoid that atrophies sebaceous glands i.e. reduces acne and is decent for anti-aging purposes. It is commonly prescribed by dermatologists for treating persistent cystic acne and is well-studied, with the most notable downsides being mild hepatotoxicity, dry lips and skin, and worsening of your lipid profile.

If you have done a few courses of isotretinoin, downregulation of the sebaceous glands tends to be permanent, meaning you won't get acne after coming off. Taking 10-20mg long-term is well tolerated, but I prefer the approach of reaching a specific cumulative dose over months and never having to worry about acne again.

#2: Blood pressure and left ventricular hypertrophy

Nebivolol: a highly selective ß1-adrenergic receptor blocker that is commonly used to treat high blood pressure (BP). It has vasodilatory proporties and reduces the heart rate. Side effects include hypotension and fatigue, which normally don't occur when used and dosed correctly. Take it outside of your workout window, because a high heart rate is ideal for training. Take up to 5mg daily, any higher than that and it loses its selectivity.

Telmisartan: an Angiotensin II receptor blocker that lowers your BP and is nephroprotective (=protects your kidneys) whilst countering aldosterone-induced bloat. Research suggests partial PPARγ agonistic effects including reducing inflammation, enhanced insulin sensitivity etc. Take 40-80mg daily.

Only combine both beta-blockers and ARBs if your blood pressure and heart rate is too high (Stage 1+ on one of the ancillaries).

View attachment 4859674

#3: Cholesterol

Statins: work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway. They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream. They cause a reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins. Statins also slightly activate PPARα via an overexpression of COX-2.

Statins have a ±10% risk of causing diabetes in men. They also seem to have a negative impact on mitochondrial health, which includes reduced coQ10 levels. You can counteract this by supplementing it additionally, which I personally do at high doses.

There are two major groups of statins: hydrophilic and lipophilic statins. Hydrophilic statins (e.g. rosuvasatin and pravastatin) don't cross the BBB and cause more inflammation, whereas lipohilic statins (e.g. pitavastatin, atorvastatin, and simvastatin) cross the BBB and cause less inflammation.

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile. A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks. Dosage: Take 1-4mg daily.

Rosuvastatin is just as good as seen below. You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.

View attachment 4867229

Ezetimibe: inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol. It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein. It doesn't affect the absorption of fat-soluble vitamins. Take 5-10mg daily.

Bemdedoic acid: an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins. Take 180mg daily.

Bempedoic acid significantly reduces LDL cholesterol levels according to this study.



SR9009: an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. SR9009 has multiple benefits like boosting mitochondrial activity, fat metabolism, improving your circadian rhythm, endurance, and inflammation, along with other benefits of you can see below. It also improves the lipid profile.


View attachment 4867256

#4: Oxidative stress and organ health

NAC: a precursor to L-glutathione, that reduces oxidative stress, protects the liver, and organs in general. Is frequently used in clinical settings. Take 2-3g daily, ~1g if you are using a liposomal formulation.

Injectable L-glutathione: as mentioned, a very strong antioxidant that reduces inflammatory markers like TNF-α and IL-6 directly. It is mainly mito-, hepato-, and neuroprotective, making it a nice all-rounder to keep your organs healthy on-cycle. It is also used for skin lightening. Inject 500mg every day.

TUDCA: mainly used as liver support, although NAC/L-glutathione would be more than enough. Liver support is only required on compounds like tren and 17α-alkylated (=orally bioavailable) steroids.

Retatrutide: an agonist of the GLP-1, GIP, and glucagon receptor. You can expect an inprovement in insulin sensitivity, increased energy expenditure, reduced inflammation, and appetite suppression, whilst experiencing only limited side effects like GI irritation and skin sensitivity. It is also a godsent drug to improve your lipid profile significantly, as seen in this study.



View attachment 4872339

#5: Neuroprotection (including modulation of serotonin and oxytocin)

Neurotoxicity mostly occurs on compounds like tren and if you have raped your E2 levels too hard, which you shouldn't since oestrogen is anabolic, keeps your joints healthy, and is neuroprotective. Contrary to popular belief, oxytocin doesn't appear to be impaired on trenbolone. Rather the opposite occurs.

Besides that, oxytocin doesn't appear to be the muh social hormone after all according to this study:



N-Acetyl Semax: modulates BDNF and neurotransmitters like dopamine and serotonin. The acetylation makes BBB penetration easier (it is normally advised to take semax intranasally to bypass the BBB) and causes a higher receptor saturation whilst prolonging the half-life. Dihexa and cerebrolysin may be used alternatively. However, NA-Semax alone will do the job. Taking higher dosages up to 1-2mg is fully tolerated.

Escitalopram: an SSRI. A pure SERT blocker with only minimal secondary receptor interactions and comes with many benefits like being anxiolytic, improving depression and OCD, all whilst being neuroprotective.

Vortioxetine: an even better SSRI that isn't only a SERT blocker, but also a serotonin receptor modulator. It increases BDNF, dopamine, and norepinephrine in the frontal cortex leading to improved neuroplasticity and overall cognition. It doesn't cause any emotional bluntness, but rather lifts you up, and has low sexual side effects.

Rasagiline: a MAO-B inhibitor, which means it nukes the enzyme that normally metabolises dopamine, phenethylamine, and some trace amines, causing an excess of availability. MAO-A stays intact, resulting in normal serotonin and norepinephrine levels. Rasagiline is also slightly mitoprotective due to reducing oxidative stress in dopaminergic neurons.

LIT-001: an agonist of the oxytocin receptor that is able to pass the BBB and doesn't interact with the vasopressin receptor (=agonism would cause bloat). At higher doses it can even be an antagonist of the vasopressin receptor.

#6: Suppression of HPG-axis

HMG and HCG: these two compounds, even moreso the latter, are all you need to keep your HPG-axis intact. HCG imitates LH, whereas HMG imitates FSH, both stimulating your testes. Inject 100-250IU of HCG every other day (EOD) and take a break every 4-5 months (in case you are permablasting) to reset desensitisation of the Leydig cells. Even for people that plan to blast the next few years, it is recommended to do a HCG cycle 1-2x per year.

View attachment 4860270

Taurine: has antioxidant properties. It protects Leydig cells by reducing ROS and improves mitochondrial function. It is naturally abundant in seminal fluid, which means supplementing taurine results in improved sperm quality. take 1-3g daily.

#7: Prolactin management

Liposomal Pyridoxal-5-Phosphat (P-5-P): a good option to control your prolactin levels and to prevent lactation on low to moderate doses of tren. This should be your go-to compound for prolactin management. It also assists the production of neurotransmitters like dopamine, serotonin, and GABA. It is also a cofactor in many enzymes, supporting various processes in the body. Neuropathy is from high dose pyridoxine, not P-5-P. I'd recommend taking 100-200mg daily.

Cabergoline: binds selectively to dopamine D2 receptors and has a long half-life of roughly 2-3 days. It is primarely used to reduce hyperprolactinemia. Cabergoline reduces GH and IGF-1 levels. Take 0.125-0.25mg every 3 days, but only if you are actively experiencing side effects on high dose tren.

#8: Other safety measures, habits, and general advice

• Donate blood to keep your haematocrit (and red blood cell count) low, especially on boldenone and tren.
• Get full blood work before, during, and after a blasting phase. This way you can verify whether your gear is dosed correctly, how certain blood markers are affected etc.
• Locked in with diet and training. If you aren't doing this, NGMI.
• Do cardio. It improves lipids, heart health, insulin sensitivity, and so much more. It is one of the core pillar "ancillaries" that keeps you healthy.
• Good sleep with melatonin, DSIP, dual orexin receptor antagonists, magnesium l-threonate, maintaining the same sleeping/waking up time. Only take benzos and other sedatives if completely required.
• Keep fat intake low, carbs and protein high. 200-300g protein is ideal daily.
• Stay below 15-20% all throughout the cycle. Start the cycle at a very low bodyfat %.
• In the very rare case that you end up getting puffy and sensitive nipples, use topical raloxifene.
• To decrease bloating on-cycle use amiloride or eplerenone.

500MG FOR THE FIRST CYCLE???

 

[TfImOn?]

Mirin really high iq. Im saving it till I moneymaxxed and can hop on
Did you hop on yet?

I mean it's pretty cheap tho just to start w the basics.

 

[SteveRogers]

Great thread but if you want to reliably retain reproductive ability without HCG/HMG, avoid acne etc. then simple low-moderate dosage 4-6 week dbol cycles are far superior.
After 6 weeks your androgen sensitivity is nuked to shit, it only takes 2 weeks to resensitise, so simply rinse and repeat.
The water weight stuff is highly mythical, just don’t slam ridiculous amounts of salt and carbs, but absolutely carb up pre workout in order to maximise MUR obviously.
Dbol is obviously never faked, it’s cheap, it’s what all the old school guys were on, and they all safely had kids on repeat, they also didn’t look watery (in the face), and (for the most part) lived very long, acne free lives…
Imo every looksmaxxer needs to be on Reta, mt2 and dbol (or other hair safe roids, dbol is the most hair safe roid btw, anavar will have all the benefits of dbol but will Norwood you to shit), non negotiable.
As a side piece I’d imagine most are already doing microneedling followed by topical GHK Cu application and monthly skin boosters, if not, honestly volcel.
Also a good idea for great thread creating users like @SlayerJonas , make a thread about PLLA fillers, they’re essentially HA fillers that a) don’t cause bone resorption b) act like volume inducing threads - they create their own collagen matrix instead of having a foreign body in your own skin c) can be used to enhance FRAME - I am looking into either getting an injector or DIY myself, to add a good inch or two to my side delts, it can also act like PMMA site enchancement (similar to synthol) which literally gives you permanent fascia stretching so your muscle literally permanently expands… but PMMA kills you (RIP Rich Piana) it’s injecting straight micro plastics, this stuff makes your own collagen build around it and dissolves itself like a simple sugar would (PDO).
You can also do this in places like calves too obviously.
I think this could be a ground breaking fix to UEE too btw.

 

[mtnuglyboy]

very happy to see a fellow test eq tren enjoyer, every roid does have a use case tho ; ) esp orals like anadrol when it comes to breaking plateaus

Since you're recommending taking 80mg of Telmisartan, take double or a little higher. 160mg+ for partial PPAR gamma agonism (loads of benefits literally amazing). Telmi is a ppar pan ligand higher doses gets you benefits other PPAR agonism. 80mg is max saturation so no BP drop or potassium serum increase.

5mg eze= 0.8 10mg eze. So to save money use 5mg

also mention something like aspirin next time since it is eq we are dealing with here

currently on 81mg should i up when i hop on tren and test and eq?

 

[Faustum]

good thread, reminds me of the good bb ones, nostalgic as fuck

Micro-dosing Tren 75-100mg a week worth it? Im already on a 580mg/week Test base and 4 IU's of HGH.

 

[fraudster#1]

Micro-dosing Tren 75-100mg a week worth it? Im already on a 580mg/week Test base and 4 IU's of HGH.

thats not a microdose range
microdose is ~40 mg wkly

 

[Faustum]

thats not a microdose range
microdose is ~40 mg wkly

I guess it differs person to person.

I'll stick with 75 and run a full vial.

Let's hope I don't turn into faggot or have horrible insomnia

 

[Lucasegoliftson]

currently on 81mg should i up when i hop on tren and test and eq?

nah just stick to 81mg aspirin
up it if u need based on bloodwork
u can experiment with higher doses (300-500mg) preworkout

 

[Aloof]

nah just stick to 81mg aspirin
up it if u need based on bloodwork
u can experiment with higher doses (300-500mg) preworkout

Are you da real Lucasegolifts?

If you are but don’t want to say it just follow me

 

[Lucasegoliftson]

Are you da real Lucasegolifts?

If you are but don’t want to say it just follow me

@lucasegolifts is the real one, he adopted me

 

[richoffline]

Natty lifting is cope. JFL at spending a decade training optimally to end up as looking like someone that has just ended his first cycle. If you're serious about Looksmaxing, you're going to take every shortcut to achieve your goal.

Why should I give a shit about roiding? A body halo is required for both female attention and male respect. If you have the body of a prepubescent boy, no one will take you seriously. You'll be the "friend", but never the guy she's looking for.

However, that doesn't mean a roided physique is able to compensate for a bad face. It is merely a multiplicator of your current looks level and adds few SMV points.

View attachment 4859439View attachment 4859449

After years of experience and research, the only three steroids you'll ever need are testosterone, boldenone, and trenbolone. Every other steroid, SARM, and prohormone is utter garbage and not worth it. Another compound that belongs into every stack is GH. Insulin isn't required for most people, but if you have a good source you might as well match the GH dose for optimal muscle accrual.

---

Spoiler: Scienceslop about other androgens

Every steroid is structurally derived from either testosterone, 19-nortestosterone, or dihydrotestosterone. These structural differences determine the interaction with the enzymes 5α-reductase and aromatase, the oestrogen and progesterone receptor, and other mechanisms of action.

View attachment 4866695

I will go over a few androgens.

Nandrolone: harsh on hair as it isn't able to be converted into a more tolerable metabolite (5α-dihydronandrolone) in androgenic tissues like skin when using using a 5α-reductase inhibitor. Redundant once you decide to use a topical anti-androgen like RU58841, as you could use stronger and better androgens instead. Nandrolone is also a ligand of the progesterone receptor.

17α-alkylated oral steroids: hepatotoxic in nature due to needing to be metabolised by the liver, which occurs independent of oral or injectable administration. Orals like Halotestin and Superdrol are known for acute strength gains and are used by powerlifters, whilst orals like Anavar are completely redundant.

DHT derivates: rape your hair follicles with the promise of looking drier temporarily. You can counteract this with RU58841, but as with nandrolone, you might as well just use trenbolone instead. They don't interact with aromatase and antagonise the oestrogen receptor, meaning they can be used to control E2 levels.

Exotic androgens: compounds like "The Clear", methyltrienolone, and norboletone are mostly rubbish. There aren't many studies and anecdotal evidence on them, which reduces our harm-reduction capabilities quite a bit. They are very rare and hard to synthesise, leading to these compounds being bunk in most cases.

#1: Testosterone is the main pillar of every steroid cycle and should be your main compound. It is a bioidentical hormone responsible for muscle accrual, bone remodelling, fat distribution, voice deepening, erythropoiesis, sexual wellness including libido, and mental drive. It undergoes 5α-reduction into dihydrotestosterone (DHT) and aromatises into oestradiol (E2). E2 is anabolic especially in conjunction with trenbolone, whereas DHT's existence is redundant.

Testosterone is typically administered with an ester that determines the pharmacokinetics of the compound. They most notably determine the half-life of the androgen. The ideal administration route is an intramuscular injection, but on TRT you may do subcutaneous injections for the sake of simplicity.

This is what you need for an injection:

• 22G needles for drawing the oil
• 25-27G (higher gauge -> smaller needle) needles to inject the oil
• Alcohol wipes
• 2-3mL syringes
• Optional: 29-31G needles for TRT

You can buy everything on Amazon or even in your local pharmacy for a total of 30usd. It is legal to buy injecting equipment. You prepare the injection by disinfecting the injection site and the top of the vial with an alcohol wipe. Ideal injection spots are the ventrogluteal, deltoid, and the vastus lateralis site.

View attachment 4866575

After preparing the injection site, you assemble the syringe by attaching the 22G needle to it and draw the oil. Then you add the 25-27G needle on top of the syringe and inject the oil into your preferred injection site (e.g. the ventrogluteal site). Aspirating (trying to draw blood with a needle) a needle is cope. However, it can get dangerous if you hit a major blood vessel and inject straight into it. This is extremely uncommon and chances are the needle will go through the blood vessel, which does eliminate any risks. Once you have pushed all of the oil in, throw the needle into a sharps container or into your regular rubbish bin and you're done. Here is also a video.

Contrary to popular belief, the added ester group doesn't have an impact on the pharmacodynamics of the steroid. It is argued that a longer ester is more anabolic, whereas a shorter one causes less aromatisation and concurrent bloat. A proposed mechanism for that is the increasing lipophilicity of longer esters. However, the ester is cleaved off before the testosterone is able to be aromatised, making this a baseless claim. The only thing that matters is the relative injection frequency.

The average male produces around 7mg of testosterone per day (=49mg per week). You would have to inject 66mg of testosterone propionate (relatively short ester weight) per week to match that dose. However, that range is still far from being supraphysiological. You would have to inject 200mg+ to notice supraphysiological effects.

According to this study, injecting 600mg of testosterone whilst training 3 times per week can result in a ~6kg fat-free mass gain within 10 weeks whilst the placebo group gains merely ~2kg of fat-free mass.

#2: Boldenone is a steroid that you can add to your cycle to control your E2 levels. It doesn't cause hair loss, thus making it a better option compared to exemestane, which has the androgenic metabolite 17ß-Hydroxyexemestane, that will rape your hair. Non-steroidal aromatase inhibitors like anastrozole and letrozole are harsh on your lipids, making them unideal to use.

Oestradiol is crucial for most neurotransmitters like serotonin and GABA. To acutely treat an E2 crash, you can use the oral dianabol, which has the metabolite methyloestradiol, that is much stronger than regular oestradiol. Alternatively, you can use exogenous E2 or HCG, which would take a few days to work.

The optimal testosterone-to-boldenone ratio is completely individual and depends on your own aromatisation rate. For most people a ratio of 3:1 to 2:1 is ideal, but measuring your E2 levels on each dose will give you clarity. Boldenone also increases appetite in most individuals due to the increased red blood cell count.

#3: Trenbolone is highly androgenic (and obviously anabolic) meaning it will completely eviscerate your skin and hair if you aren't using the appropiate ancillaries. The synergy of tren is very high with E2 and GH; it is the best steroid for gaining muscle mass, whilst simultaneously dropping bodyfat.

The effects of trenbolone like nutrition partitioning and glucocorticoid receptor antagonism are dose-dependent like with any other pathway in the body, which means "microdosing tren" in the double digits is nonsense. Take a higher dose or go home.

#4: Growth hormone (GH), besides being anabolic if coupled with other compounds, is more of a quality of life drug. It improves REM sleep, synergises with tren and E2, improves joint, bone, and soft tissue health, with some recognised cognitive benefits, making it a favourable compound.

The first cycle:

Your first steroid cycle should consist of 500mg testosterone and 6-8IU of GH. It will be the first time you are experiencing supraphysiological effects of androgens and is more than enough in the beginning. The cycle should last 20-25+ weeks and should be followed by a cruising phase of a few months, ideally matching the cycle length. After the cruise you may start blasting again and titrating the dosage up according to your personal needs.

Intermediate steroid cycles:

Once you're at the point where you're blasting 700-800mg+ of testosterone, you should throw in boldenone following your personal test-to-bold ratio. Thereafter, following the test-to-bold ratio, increase doses accordingly. Alternatively, you may decrease the test to 500mg and throw in tren whilst titrating up to the maximum amount you want to run. This cycle is going to be way harsher on your blood markers and hair, but if you're using the correct ancillaries you are going to make the most gains you have ever made while recomp'ing.

---

To reduce and/or completely eliminate most side effects and cover all pathways steroids negatively impact, we're going to discuss a handful of ancillaries.

#1: Skin and hair

Dutasteride: nukes an enzyme (5α-reductase) that converts testosterone into the metabolite dihydrotestosterone. 5α-reductase interacts with other androgens like nandrolone, converting them into their 5α-reduced forms. It is also responsible for the synthesis of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of the GABAA receptor.

A lack of that neurosteroid is the proposed mechanism of the Post-Finasteride syndrome, which only affects 0.1% of individuals. If you want to stay on the safe side, test your brain's genotype (your GABAergic architecture) with a single dose of finasteride, which has a half-life of 6-8 hours, meaning all side effects would be resolved within 1-2 days.

DHT is primarely an intracrine hormone, meaning it exerts its effects in the tissue it is produced in. The tissues in question are mostly the skin, hair follicles, and the penis. DHT is responsible for upregulating sebaceous gland activity, miniaturising hair follicles, and growing the penis during puberty, respectively. I would only recommend using a 5α-reductase inhibitor during puberty, if you are blasting gear. Take atleast 2.5mg daily.

View attachment 4859548

RU-58841: a topical nonsteroidal anti-androgen that didn't pass clinical trials. Its purpose is to reduce the effects of androgens on your skin and scalp by antagonising the androgen receptor (AR). RU-58841 (1-2nM) has a lower binding affinity than testosterone (0.5-1nM) and DHT (0.2-0.3nM), but overpowers them by occupying the receptor site. Apply it daily.

I make my own DIY RU solution:

• 50mL glass dropper bottle
• 2-4g of RU58841 powder
• 5-8mL of DMSO
• Rest is pure ethanol

Isotretinoin: a retinoid that atrophies sebaceous glands i.e. reduces acne and is decent for anti-aging purposes. It is commonly prescribed by dermatologists for treating persistent cystic acne and is well-studied, with the most notable downsides being mild hepatotoxicity, dry lips and skin, and worsening of your lipid profile.

If you have done a few courses of isotretinoin, downregulation of the sebaceous glands tends to be permanent, meaning you won't get acne after coming off. Taking 10-20mg long-term is well tolerated, but I prefer the approach of reaching a specific cumulative dose over months and never having to worry about acne again.

#2: Blood pressure and left ventricular hypertrophy

Nebivolol: a highly selective ß1-adrenergic receptor blocker that is commonly used to treat high blood pressure (BP). It has vasodilatory proporties and reduces the heart rate. Side effects include hypotension and fatigue, which normally don't occur when used and dosed correctly. Take it outside of your workout window, because a high heart rate is ideal for training. Take up to 5mg daily, any higher than that and it loses its selectivity.

Telmisartan: an Angiotensin II receptor blocker that lowers your BP and is nephroprotective (=protects your kidneys) whilst countering aldosterone-induced bloat. Research suggests partial PPARγ agonistic effects including reducing inflammation, enhanced insulin sensitivity etc. Take 40-80mg daily.

Only combine both beta-blockers and ARBs if your blood pressure and heart rate is too high (Stage 1+ on one of the ancillaries).

View attachment 4859674

#3: Cholesterol

Statins: work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway. They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream. They cause a reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins. Statins also slightly activate PPARα via an overexpression of COX-2.

Statins have a ±10% risk of causing diabetes in men. They also seem to have a negative impact on mitochondrial health, which includes reduced coQ10 levels. You can counteract this by supplementing it additionally, which I personally do at high doses.

There are two major groups of statins: hydrophilic and lipophilic statins. Hydrophilic statins (e.g. rosuvasatin and pravastatin) don't cross the BBB and cause more inflammation, whereas lipohilic statins (e.g. pitavastatin, atorvastatin, and simvastatin) cross the BBB and cause less inflammation.

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile. A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks. Dosage: Take 1-4mg daily.

Rosuvastatin is just as good as seen below. You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.

View attachment 4867229

Ezetimibe: inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol. It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein. It doesn't affect the absorption of fat-soluble vitamins. Take 5-10mg daily.

Bemdedoic acid: an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins. Take 180mg daily.

Bempedoic acid significantly reduces LDL cholesterol levels according to this study.



SR9009: an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. SR9009 has multiple benefits like boosting mitochondrial activity, fat metabolism, improving your circadian rhythm, endurance, and inflammation, along with other benefits of you can see below. It also improves the lipid profile.


View attachment 4867256

#4: Oxidative stress and organ health

NAC: a precursor to L-glutathione, that reduces oxidative stress, protects the liver, and organs in general. Is frequently used in clinical settings. Take 2-3g daily, ~1g if you are using a liposomal formulation.

Injectable L-glutathione: as mentioned, a very strong antioxidant that reduces inflammatory markers like TNF-α and IL-6 directly. It is mainly mito-, hepato-, and neuroprotective, making it a nice all-rounder to keep your organs healthy on-cycle. It is also used for skin lightening. Inject 500mg every day.

TUDCA: mainly used as liver support, although NAC/L-glutathione would be more than enough. Liver support is only required on compounds like tren and 17α-alkylated (=orally bioavailable) steroids.

Retatrutide: an agonist of the GLP-1, GIP, and glucagon receptor. You can expect an inprovement in insulin sensitivity, increased energy expenditure, reduced inflammation, and appetite suppression, whilst experiencing only limited side effects like GI irritation and skin sensitivity. It is also a godsent drug to improve your lipid profile significantly, as seen in this study.



View attachment 4872339

#5: Neuroprotection (including modulation of serotonin and oxytocin)

Neurotoxicity mostly occurs on compounds like tren and if you have raped your E2 levels too hard, which you shouldn't since oestrogen is anabolic, keeps your joints healthy, and is neuroprotective. Contrary to popular belief, oxytocin doesn't appear to be impaired on trenbolone. Rather the opposite occurs.

Besides that, oxytocin doesn't appear to be the muh social hormone after all according to this study:



N-Acetyl Semax: modulates BDNF and neurotransmitters like dopamine and serotonin. The acetylation makes BBB penetration easier (it is normally advised to take semax intranasally to bypass the BBB) and causes a higher receptor saturation whilst prolonging the half-life. Dihexa and cerebrolysin may be used alternatively. However, NA-Semax alone will do the job. Taking higher dosages up to 1-2mg is fully tolerated.

Escitalopram: an SSRI. A pure SERT blocker with only minimal secondary receptor interactions and comes with many benefits like being anxiolytic, improving depression and OCD, all whilst being neuroprotective.

Vortioxetine: an even better SSRI that isn't only a SERT blocker, but also a serotonin receptor modulator. It increases BDNF, dopamine, and norepinephrine in the frontal cortex leading to improved neuroplasticity and overall cognition. It doesn't cause any emotional bluntness, but rather lifts you up, and has low sexual side effects.

Rasagiline: a MAO-B inhibitor, which means it nukes the enzyme that normally metabolises dopamine, phenethylamine, and some trace amines, causing an excess of availability. MAO-A stays intact, resulting in normal serotonin and norepinephrine levels. Rasagiline is also slightly mitoprotective due to reducing oxidative stress in dopaminergic neurons.

LIT-001: an agonist of the oxytocin receptor that is able to pass the BBB and doesn't interact with the vasopressin receptor (=agonism would cause bloat). At higher doses it can even be an antagonist of the vasopressin receptor.

#6: Suppression of HPG-axis

HMG and HCG: these two compounds, even moreso the latter, are all you need to keep your HPG-axis intact. HCG imitates LH, whereas HMG imitates FSH, both stimulating your testes. Inject 100-250IU of HCG every other day (EOD) and take a break every 4-5 months (in case you are permablasting) to reset desensitisation of the Leydig cells. Even for people that plan to blast the next few years, it is recommended to do a HCG cycle 1-2x per year.

View attachment 4860270

Taurine: has antioxidant properties. It protects Leydig cells by reducing ROS and improves mitochondrial function. It is naturally abundant in seminal fluid, which means supplementing taurine results in improved sperm quality. take 1-3g daily.

#7: Prolactin management

Liposomal Pyridoxal-5-Phosphat (P-5-P): a good option to control your prolactin levels and to prevent lactation on low to moderate doses of tren. This should be your go-to compound for prolactin management. It also assists the production of neurotransmitters like dopamine, serotonin, and GABA. It is also a cofactor in many enzymes, supporting various processes in the body. Neuropathy is from high dose pyridoxine, not P-5-P. I'd recommend taking 100-200mg daily.

Cabergoline: binds selectively to dopamine D2 receptors and has a long half-life of roughly 2-3 days. It is primarely used to reduce hyperprolactinemia. Cabergoline reduces GH and IGF-1 levels. Take 0.125-0.25mg every 3 days, but only if you are actively experiencing side effects on high dose tren.

#8: Other safety measures, habits, and general advice

• Donate blood to keep your haematocrit (and red blood cell count) low, especially on boldenone and tren.
• Get full blood work before, during, and after a blasting phase. This way you can verify whether your gear is dosed correctly, how certain blood markers are affected etc.
• Locked in with diet and training. If you aren't doing this, NGMI.
• Do cardio. It improves lipids, heart health, insulin sensitivity, and so much more. It is one of the core pillar "ancillaries" that keeps you healthy.
• Good sleep with melatonin, DSIP, dual orexin receptor antagonists, magnesium l-threonate, maintaining the same sleeping/waking up time. Only take benzos and other sedatives if completely required.
• Keep fat intake low, carbs and protein high. 200-300g protein is ideal daily.
• Stay below 15-20% all throughout the cycle. Start the cycle at a very low bodyfat %.
• In the very rare case that you end up getting puffy and sensitive nipples, use topical raloxifene.
• To decrease bloating on-cycle use amiloride or eplerenone.

thank you truly

 

[Deleted member 330894]

excellent tioico

 

[lilAskeladen]

very high iq, gonna help me alot on my next cycle

 

[hexum.dnd]

Dnr

 

[rqzuoo]

where do you source ru powder?

 

[pelocils]

Natty lifting is cope. JFL at spending a decade training optimally to end up as looking like someone that has just ended his first cycle. If you're serious about Looksmaxing, you're going to take every shortcut to achieve your goal.

Why should I give a shit about roiding? A body halo is required for both female attention and male respect. If you have the body of a prepubescent boy, no one will take you seriously. You'll be the "friend", but never the guy she's looking for.

However, that doesn't mean a roided physique is able to compensate for a bad face. It is merely a multiplicator of your current looks level and adds few SMV points.

View attachment 4859439View attachment 4859449

After years of experience and research, the only three steroids you'll ever need are testosterone, boldenone, and trenbolone. Every other steroid, SARM, and prohormone is utter garbage and not worth it. Another compound that belongs into every stack is GH. Insulin isn't required for most people, but if you have a good source you might as well match the GH dose for optimal muscle accrual.

---

Spoiler: Scienceslop about other androgens

Every steroid is structurally derived from either testosterone, 19-nortestosterone, or dihydrotestosterone. These structural differences determine the interaction with the enzymes 5α-reductase and aromatase, the oestrogen and progesterone receptor, and other mechanisms of action.

View attachment 4866695

I will go over a few androgens.

Nandrolone: harsh on hair as it isn't able to be converted into a more tolerable metabolite (5α-dihydronandrolone) in androgenic tissues like skin when using using a 5α-reductase inhibitor. Redundant once you decide to use a topical anti-androgen like RU58841, as you could use stronger and better androgens instead. Nandrolone is also a ligand of the progesterone receptor.

17α-alkylated oral steroids: hepatotoxic in nature due to needing to be metabolised by the liver, which occurs independent of oral or injectable administration. Orals like Halotestin and Superdrol are known for acute strength gains and are used by powerlifters, whilst orals like Anavar are completely redundant.

DHT derivates: rape your hair follicles with the promise of looking drier temporarily. You can counteract this with RU58841, but as with nandrolone, you might as well just use trenbolone instead. They don't interact with aromatase and antagonise the oestrogen receptor, meaning they can be used to control E2 levels.

Exotic androgens: compounds like "The Clear", methyltrienolone, and norboletone are mostly rubbish. There aren't many studies and anecdotal evidence on them, which reduces our harm-reduction capabilities quite a bit. They are very rare and hard to synthesise, leading to these compounds being bunk in most cases.

#1: Testosterone is the main pillar of every steroid cycle and should be your main compound. It is a bioidentical hormone responsible for muscle accrual, bone remodelling, fat distribution, voice deepening, erythropoiesis, sexual wellness including libido, and mental drive. It undergoes 5α-reduction into dihydrotestosterone (DHT) and aromatises into oestradiol (E2). E2 is anabolic especially in conjunction with trenbolone, whereas DHT's existence is redundant.

Testosterone is typically administered with an ester that determines the pharmacokinetics of the compound. They most notably determine the half-life of the androgen. The ideal administration route is an intramuscular injection, but on TRT you may do subcutaneous injections for the sake of simplicity.

This is what you need for an injection:

• 22G needles for drawing the oil
• 25-27G (higher gauge -> smaller needle) needles to inject the oil
• Alcohol wipes
• 2-3mL syringes
• Optional: 29-31G needles for TRT

You can buy everything on Amazon or even in your local pharmacy for a total of 30usd. It is legal to buy injecting equipment. You prepare the injection by disinfecting the injection site and the top of the vial with an alcohol wipe. Ideal injection spots are the ventrogluteal, deltoid, and the vastus lateralis site.

View attachment 4866575

After preparing the injection site, you assemble the syringe by attaching the 22G needle to it and draw the oil. Then you add the 25-27G needle on top of the syringe and inject the oil into your preferred injection site (e.g. the ventrogluteal site). Aspirating (trying to draw blood with a needle) a needle is cope. However, it can get dangerous if you hit a major blood vessel and inject straight into it. This is extremely uncommon and chances are the needle will go through the blood vessel, which does eliminate any risks. Once you have pushed all of the oil in, throw the needle into a sharps container or into your regular rubbish bin and you're done. Here is also a video.

Contrary to popular belief, the added ester group doesn't have an impact on the pharmacodynamics of the steroid. It is argued that a longer ester is more anabolic, whereas a shorter one causes less aromatisation and concurrent bloat. A proposed mechanism for that is the increasing lipophilicity of longer esters. However, the ester is cleaved off before the testosterone is able to be aromatised, making this a baseless claim. The only thing that matters is the relative injection frequency.

The average male produces around 7mg of testosterone per day (=49mg per week). You would have to inject 66mg of testosterone propionate (relatively short ester weight) per week to match that dose. However, that range is still far from being supraphysiological. You would have to inject 200mg+ to notice supraphysiological effects.

According to this study, injecting 600mg of testosterone whilst training 3 times per week can result in a ~6kg fat-free mass gain within 10 weeks whilst the placebo group gains merely ~2kg of fat-free mass.

#2: Boldenone is a steroid that you can add to your cycle to control your E2 levels. It doesn't cause hair loss, thus making it a better option compared to exemestane, which has the androgenic metabolite 17ß-Hydroxyexemestane, that will rape your hair. Non-steroidal aromatase inhibitors like anastrozole and letrozole are harsh on your lipids, making them unideal to use.

Oestradiol is crucial for most neurotransmitters like serotonin and GABA. To acutely treat an E2 crash, you can use the oral dianabol, which has the metabolite methyloestradiol, that is much stronger than regular oestradiol. Alternatively, you can use exogenous E2 or HCG, which would take a few days to work.

The optimal testosterone-to-boldenone ratio is completely individual and depends on your own aromatisation rate. For most people a ratio of 3:1 to 2:1 is ideal, but measuring your E2 levels on each dose will give you clarity. Boldenone also increases appetite in most individuals due to the increased red blood cell count.

#3: Trenbolone is highly androgenic (and obviously anabolic) meaning it will completely eviscerate your skin and hair if you aren't using the appropiate ancillaries. The synergy of tren is very high with E2 and GH; it is the best steroid for gaining muscle mass, whilst simultaneously dropping bodyfat.

The effects of trenbolone like nutrition partitioning and glucocorticoid receptor antagonism are dose-dependent like with any other pathway in the body, which means "microdosing tren" in the double digits is nonsense. Take a higher dose or go home.

#4: Growth hormone (GH), besides being anabolic if coupled with other compounds, is more of a quality of life drug. It improves REM sleep, synergises with tren and E2, improves joint, bone, and soft tissue health, with some recognised cognitive benefits, making it a favourable compound.

The first cycle:

Your first steroid cycle should consist of 500mg testosterone and 6-8IU of GH. It will be the first time you are experiencing supraphysiological effects of androgens and is more than enough in the beginning. The cycle should last 20-25+ weeks and should be followed by a cruising phase of a few months, ideally matching the cycle length. After the cruise you may start blasting again and titrating the dosage up according to your personal needs.

Intermediate steroid cycles:

Once you're at the point where you're blasting 700-800mg+ of testosterone, you should throw in boldenone following your personal test-to-bold ratio. Thereafter, following the test-to-bold ratio, increase doses accordingly. Alternatively, you may decrease the test to 500mg and throw in tren whilst titrating up to the maximum amount you want to run. This cycle is going to be way harsher on your blood markers and hair, but if you're using the correct ancillaries you are going to make the most gains you have ever made while recomp'ing.

---

To reduce and/or completely eliminate most side effects and cover all pathways steroids negatively impact, we're going to discuss a handful of ancillaries.

#1: Skin and hair

Dutasteride: nukes an enzyme (5α-reductase) that converts testosterone into the metabolite dihydrotestosterone. 5α-reductase interacts with other androgens like nandrolone, converting them into their 5α-reduced forms. It is also responsible for the synthesis of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of the GABAA receptor.

A lack of that neurosteroid is the proposed mechanism of the Post-Finasteride syndrome, which only affects 0.1% of individuals. If you want to stay on the safe side, test your brain's genotype (your GABAergic architecture) with a single dose of finasteride, which has a half-life of 6-8 hours, meaning all side effects would be resolved within 1-2 days.

DHT is primarely an intracrine hormone, meaning it exerts its effects in the tissue it is produced in. The tissues in question are mostly the skin, hair follicles, and the penis. DHT is responsible for upregulating sebaceous gland activity, miniaturising hair follicles, and growing the penis during puberty, respectively. I would only recommend using a 5α-reductase inhibitor during puberty, if you are blasting gear. Take atleast 2.5mg daily.

View attachment 4859548

RU-58841: a topical nonsteroidal anti-androgen that didn't pass clinical trials. Its purpose is to reduce the effects of androgens on your skin and scalp by antagonising the androgen receptor (AR). RU-58841 (1-2nM) has a lower binding affinity than testosterone (0.5-1nM) and DHT (0.2-0.3nM), but overpowers them by occupying the receptor site. Apply it daily.

I make my own DIY RU solution:

• 50mL glass dropper bottle
• 2-4g of RU58841 powder
• 5-8mL of DMSO
• Rest is pure ethanol

Isotretinoin: a retinoid that atrophies sebaceous glands i.e. reduces acne and is decent for anti-aging purposes. It is commonly prescribed by dermatologists for treating persistent cystic acne and is well-studied, with the most notable downsides being mild hepatotoxicity, dry lips and skin, and worsening of your lipid profile.

If you have done a few courses of isotretinoin, downregulation of the sebaceous glands tends to be permanent, meaning you won't get acne after coming off. Taking 10-20mg long-term is well tolerated, but I prefer the approach of reaching a specific cumulative dose over months and never having to worry about acne again.

#2: Blood pressure and left ventricular hypertrophy

Nebivolol: a highly selective ß1-adrenergic receptor blocker that is commonly used to treat high blood pressure (BP). It has vasodilatory proporties and reduces the heart rate. Side effects include hypotension and fatigue, which normally don't occur when used and dosed correctly. Take it outside of your workout window, because a high heart rate is ideal for training. Take up to 5mg daily, any higher than that and it loses its selectivity.

Telmisartan: an Angiotensin II receptor blocker that lowers your BP and is nephroprotective (=protects your kidneys) whilst countering aldosterone-induced bloat. Research suggests partial PPARγ agonistic effects including reducing inflammation, enhanced insulin sensitivity etc. Take 40-80mg daily.

Only combine both beta-blockers and ARBs if your blood pressure and heart rate is too high (Stage 1+ on one of the ancillaries).

View attachment 4859674

#3: Cholesterol

Statins: work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway. They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream. They cause a reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins. Statins also slightly activate PPARα via an overexpression of COX-2.

Statins have a ±10% risk of causing diabetes in men. They also seem to have a negative impact on mitochondrial health, which includes reduced coQ10 levels. You can counteract this by supplementing it additionally, which I personally do at high doses.

There are two major groups of statins: hydrophilic and lipophilic statins. Hydrophilic statins (e.g. rosuvasatin and pravastatin) don't cross the BBB and cause more inflammation, whereas lipohilic statins (e.g. pitavastatin, atorvastatin, and simvastatin) cross the BBB and cause less inflammation.

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile. A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks. Dosage: Take 1-4mg daily.

Rosuvastatin is just as good as seen below. You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.

View attachment 4867229

Ezetimibe: inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol. It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein. It doesn't affect the absorption of fat-soluble vitamins. Take 5-10mg daily.

Bemdedoic acid: an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins. Take 180mg daily.

Bempedoic acid significantly reduces LDL cholesterol levels according to this study.



SR9009: an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. SR9009 has multiple benefits like boosting mitochondrial activity, fat metabolism, improving your circadian rhythm, endurance, and inflammation, along with other benefits of you can see below. It also improves the lipid profile.


View attachment 4867256

#4: Oxidative stress and organ health

NAC: a precursor to L-glutathione, that reduces oxidative stress, protects the liver, and organs in general. Is frequently used in clinical settings. Take 2-3g daily, ~1g if you are using a liposomal formulation.

Injectable L-glutathione: as mentioned, a very strong antioxidant that reduces inflammatory markers like TNF-α and IL-6 directly. It is mainly mito-, hepato-, and neuroprotective, making it a nice all-rounder to keep your organs healthy on-cycle. It is also used for skin lightening. Inject 500mg every day.

TUDCA: mainly used as liver support, although NAC/L-glutathione would be more than enough. Liver support is only required on compounds like tren and 17α-alkylated (=orally bioavailable) steroids.

Retatrutide: an agonist of the GLP-1, GIP, and glucagon receptor. You can expect an inprovement in insulin sensitivity, increased energy expenditure, reduced inflammation, and appetite suppression, whilst experiencing only limited side effects like GI irritation and skin sensitivity. It is also a godsent drug to improve your lipid profile significantly, as seen in this study.



View attachment 4872339

#5: Neuroprotection (including modulation of serotonin and oxytocin)

Neurotoxicity mostly occurs on compounds like tren and if you have raped your E2 levels too hard, which you shouldn't since oestrogen is anabolic, keeps your joints healthy, and is neuroprotective. Contrary to popular belief, oxytocin doesn't appear to be impaired on trenbolone. Rather the opposite occurs.

Besides that, oxytocin doesn't appear to be the muh social hormone after all according to this study:



N-Acetyl Semax: modulates BDNF and neurotransmitters like dopamine and serotonin. The acetylation makes BBB penetration easier (it is normally advised to take semax intranasally to bypass the BBB) and causes a higher receptor saturation whilst prolonging the half-life. Dihexa and cerebrolysin may be used alternatively. However, NA-Semax alone will do the job. Taking higher dosages up to 1-2mg is fully tolerated.

Escitalopram: an SSRI. A pure SERT blocker with only minimal secondary receptor interactions and comes with many benefits like being anxiolytic, improving depression and OCD, all whilst being neuroprotective.

Vortioxetine: an even better SSRI that isn't only a SERT blocker, but also a serotonin receptor modulator. It increases BDNF, dopamine, and norepinephrine in the frontal cortex leading to improved neuroplasticity and overall cognition. It doesn't cause any emotional bluntness, but rather lifts you up, and has low sexual side effects.

Rasagiline: a MAO-B inhibitor, which means it nukes the enzyme that normally metabolises dopamine, phenethylamine, and some trace amines, causing an excess of availability. MAO-A stays intact, resulting in normal serotonin and norepinephrine levels. Rasagiline is also slightly mitoprotective due to reducing oxidative stress in dopaminergic neurons.

LIT-001: an agonist of the oxytocin receptor that is able to pass the BBB and doesn't interact with the vasopressin receptor (=agonism would cause bloat). At higher doses it can even be an antagonist of the vasopressin receptor.

#6: Suppression of HPG-axis

HMG and HCG: these two compounds, even moreso the latter, are all you need to keep your HPG-axis intact. HCG imitates LH, whereas HMG imitates FSH, both stimulating your testes. Inject 100-250IU of HCG every other day (EOD) and take a break every 4-5 months (in case you are permablasting) to reset desensitisation of the Leydig cells. Even for people that plan to blast the next few years, it is recommended to do a HCG cycle 1-2x per year.

View attachment 4860270

Taurine: has antioxidant properties. It protects Leydig cells by reducing ROS and improves mitochondrial function. It is naturally abundant in seminal fluid, which means supplementing taurine results in improved sperm quality. take 1-3g daily.

#7: Prolactin management

Liposomal Pyridoxal-5-Phosphat (P-5-P): a good option to control your prolactin levels and to prevent lactation on low to moderate doses of tren. This should be your go-to compound for prolactin management. It also assists the production of neurotransmitters like dopamine, serotonin, and GABA. It is also a cofactor in many enzymes, supporting various processes in the body. Neuropathy is from high dose pyridoxine, not P-5-P. I'd recommend taking 100-200mg daily.

Cabergoline: binds selectively to dopamine D2 receptors and has a long half-life of roughly 2-3 days. It is primarely used to reduce hyperprolactinemia. Cabergoline reduces GH and IGF-1 levels. Take 0.125-0.25mg every 3 days, but only if you are actively experiencing side effects on high dose tren.

#8: Other safety measures, habits, and general advice

• Donate blood to keep your haematocrit (and red blood cell count) low, especially on boldenone and tren.
• Get full blood work before, during, and after a blasting phase. This way you can verify whether your gear is dosed correctly, how certain blood markers are affected etc.
• Locked in with diet and training. If you aren't doing this, NGMI.
• Do cardio. It improves lipids, heart health, insulin sensitivity, and so much more. It is one of the core pillar "ancillaries" that keeps you healthy.
• Good sleep with melatonin, DSIP, dual orexin receptor antagonists, magnesium l-threonate, maintaining the same sleeping/waking up time. Only take benzos and other sedatives if completely required.
• Keep fat intake low, carbs and protein high. 200-300g protein is ideal daily.
• Stay below 15-20% all throughout the cycle. Start the cycle at a very low bodyfat %.
• In the very rare case that you end up getting puffy and sensitive nipples, use topical raloxifene.
• To decrease bloating on-cycle use amiloride or eplerenone.

Natty lifting is cope. JFL at spending a decade training optimally to end up as looking like someone that has just ended his first cycle. If you're serious about Looksmaxing, you're going to take every shortcut to achieve your goal.

Why should I give a shit about roiding? A body halo is required for both female attention and male respect. If you have the body of a prepubescent boy, no one will take you seriously. You'll be the "friend", but never the guy she's looking for.

However, that doesn't mean a roided physique is able to compensate for a bad face. It is merely a multiplicator of your current looks level and adds few SMV points.

View attachment 4859439View attachment 4859449

After years of experience and research, the only three steroids you'll ever need are testosterone, boldenone, and trenbolone. Every other steroid, SARM, and prohormone is utter garbage and not worth it. Another compound that belongs into every stack is GH. Insulin isn't required for most people, but if you have a good source you might as well match the GH dose for optimal muscle accrual.

---

Spoiler: Scienceslop about other androgens

Every steroid is structurally derived from either testosterone, 19-nortestosterone, or dihydrotestosterone. These structural differences determine the interaction with the enzymes 5α-reductase and aromatase, the oestrogen and progesterone receptor, and other mechanisms of action.

View attachment 4866695

I will go over a few androgens.

Nandrolone: harsh on hair as it isn't able to be converted into a more tolerable metabolite (5α-dihydronandrolone) in androgenic tissues like skin when using using a 5α-reductase inhibitor. Redundant once you decide to use a topical anti-androgen like RU58841, as you could use stronger and better androgens instead. Nandrolone is also a ligand of the progesterone receptor.

17α-alkylated oral steroids: hepatotoxic in nature due to needing to be metabolised by the liver, which occurs independent of oral or injectable administration. Orals like Halotestin and Superdrol are known for acute strength gains and are used by powerlifters, whilst orals like Anavar are completely redundant.

DHT derivates: rape your hair follicles with the promise of looking drier temporarily. You can counteract this with RU58841, but as with nandrolone, you might as well just use trenbolone instead. They don't interact with aromatase and antagonise the oestrogen receptor, meaning they can be used to control E2 levels.

Exotic androgens: compounds like "The Clear", methyltrienolone, and norboletone are mostly rubbish. There aren't many studies and anecdotal evidence on them, which reduces our harm-reduction capabilities quite a bit. They are very rare and hard to synthesise, leading to these compounds being bunk in most cases.

#1: Testosterone is the main pillar of every steroid cycle and should be your main compound. It is a bioidentical hormone responsible for muscle accrual, bone remodelling, fat distribution, voice deepening, erythropoiesis, sexual wellness including libido, and mental drive. It undergoes 5α-reduction into dihydrotestosterone (DHT) and aromatises into oestradiol (E2). E2 is anabolic especially in conjunction with trenbolone, whereas DHT's existence is redundant.

Testosterone is typically administered with an ester that determines the pharmacokinetics of the compound. They most notably determine the half-life of the androgen. The ideal administration route is an intramuscular injection, but on TRT you may do subcutaneous injections for the sake of simplicity.

This is what you need for an injection:

• 22G needles for drawing the oil
• 25-27G (higher gauge -> smaller needle) needles to inject the oil
• Alcohol wipes
• 2-3mL syringes
• Optional: 29-31G needles for TRT

You can buy everything on Amazon or even in your local pharmacy for a total of 30usd. It is legal to buy injecting equipment. You prepare the injection by disinfecting the injection site and the top of the vial with an alcohol wipe. Ideal injection spots are the ventrogluteal, deltoid, and the vastus lateralis site.

View attachment 4866575

After preparing the injection site, you assemble the syringe by attaching the 22G needle to it and draw the oil. Then you add the 25-27G needle on top of the syringe and inject the oil into your preferred injection site (e.g. the ventrogluteal site). Aspirating (trying to draw blood with a needle) a needle is cope. However, it can get dangerous if you hit a major blood vessel and inject straight into it. This is extremely uncommon and chances are the needle will go through the blood vessel, which does eliminate any risks. Once you have pushed all of the oil in, throw the needle into a sharps container or into your regular rubbish bin and you're done. Here is also a video.

Contrary to popular belief, the added ester group doesn't have an impact on the pharmacodynamics of the steroid. It is argued that a longer ester is more anabolic, whereas a shorter one causes less aromatisation and concurrent bloat. A proposed mechanism for that is the increasing lipophilicity of longer esters. However, the ester is cleaved off before the testosterone is able to be aromatised, making this a baseless claim. The only thing that matters is the relative injection frequency.

The average male produces around 7mg of testosterone per day (=49mg per week). You would have to inject 66mg of testosterone propionate (relatively short ester weight) per week to match that dose. However, that range is still far from being supraphysiological. You would have to inject 200mg+ to notice supraphysiological effects.

According to this study, injecting 600mg of testosterone whilst training 3 times per week can result in a ~6kg fat-free mass gain within 10 weeks whilst the placebo group gains merely ~2kg of fat-free mass.

#2: Boldenone is a steroid that you can add to your cycle to control your E2 levels. It doesn't cause hair loss, thus making it a better option compared to exemestane, which has the androgenic metabolite 17ß-Hydroxyexemestane, that will rape your hair. Non-steroidal aromatase inhibitors like anastrozole and letrozole are harsh on your lipids, making them unideal to use.

Oestradiol is crucial for most neurotransmitters like serotonin and GABA. To acutely treat an E2 crash, you can use the oral dianabol, which has the metabolite methyloestradiol, that is much stronger than regular oestradiol. Alternatively, you can use exogenous E2 or HCG, which would take a few days to work.

The optimal testosterone-to-boldenone ratio is completely individual and depends on your own aromatisation rate. For most people a ratio of 3:1 to 2:1 is ideal, but measuring your E2 levels on each dose will give you clarity. Boldenone also increases appetite in most individuals due to the increased red blood cell count.

#3: Trenbolone is highly androgenic (and obviously anabolic) meaning it will completely eviscerate your skin and hair if you aren't using the appropiate ancillaries. The synergy of tren is very high with E2 and GH; it is the best steroid for gaining muscle mass, whilst simultaneously dropping bodyfat.

The effects of trenbolone like nutrition partitioning and glucocorticoid receptor antagonism are dose-dependent like with any other pathway in the body, which means "microdosing tren" in the double digits is nonsense. Take a higher dose or go home.

#4: Growth hormone (GH), besides being anabolic if coupled with other compounds, is more of a quality of life drug. It improves REM sleep, synergises with tren and E2, improves joint, bone, and soft tissue health, with some recognised cognitive benefits, making it a favourable compound.

The first cycle:

Your first steroid cycle should consist of 500mg testosterone and 6-8IU of GH. It will be the first time you are experiencing supraphysiological effects of androgens and is more than enough in the beginning. The cycle should last 20-25+ weeks and should be followed by a cruising phase of a few months, ideally matching the cycle length. After the cruise you may start blasting again and titrating the dosage up according to your personal needs.

Intermediate steroid cycles:

Once you're at the point where you're blasting 700-800mg+ of testosterone, you should throw in boldenone following your personal test-to-bold ratio. Thereafter, following the test-to-bold ratio, increase doses accordingly. Alternatively, you may decrease the test to 500mg and throw in tren whilst titrating up to the maximum amount you want to run. This cycle is going to be way harsher on your blood markers and hair, but if you're using the correct ancillaries you are going to make the most gains you have ever made while recomp'ing.

---

To reduce and/or completely eliminate most side effects and cover all pathways steroids negatively impact, we're going to discuss a handful of ancillaries.

#1: Skin and hair

Dutasteride: nukes an enzyme (5α-reductase) that converts testosterone into the metabolite dihydrotestosterone. 5α-reductase interacts with other androgens like nandrolone, converting them into their 5α-reduced forms. It is also responsible for the synthesis of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of the GABAA receptor.

A lack of that neurosteroid is the proposed mechanism of the Post-Finasteride syndrome, which only affects 0.1% of individuals. If you want to stay on the safe side, test your brain's genotype (your GABAergic architecture) with a single dose of finasteride, which has a half-life of 6-8 hours, meaning all side effects would be resolved within 1-2 days.

DHT is primarely an intracrine hormone, meaning it exerts its effects in the tissue it is produced in. The tissues in question are mostly the skin, hair follicles, and the penis. DHT is responsible for upregulating sebaceous gland activity, miniaturising hair follicles, and growing the penis during puberty, respectively. I would only recommend using a 5α-reductase inhibitor during puberty, if you are blasting gear. Take atleast 2.5mg daily.

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RU-58841: a topical nonsteroidal anti-androgen that didn't pass clinical trials. Its purpose is to reduce the effects of androgens on your skin and scalp by antagonising the androgen receptor (AR). RU-58841 (1-2nM) has a lower binding affinity than testosterone (0.5-1nM) and DHT (0.2-0.3nM), but overpowers them by occupying the receptor site. Apply it daily.

I make my own DIY RU solution:

• 50mL glass dropper bottle
• 2-4g of RU58841 powder
• 5-8mL of DMSO
• Rest is pure ethanol

Isotretinoin: a retinoid that atrophies sebaceous glands i.e. reduces acne and is decent for anti-aging purposes. It is commonly prescribed by dermatologists for treating persistent cystic acne and is well-studied, with the most notable downsides being mild hepatotoxicity, dry lips and skin, and worsening of your lipid profile.

If you have done a few courses of isotretinoin, downregulation of the sebaceous glands tends to be permanent, meaning you won't get acne after coming off. Taking 10-20mg long-term is well tolerated, but I prefer the approach of reaching a specific cumulative dose over months and never having to worry about acne again.

#2: Blood pressure and left ventricular hypertrophy

Nebivolol: a highly selective ß1-adrenergic receptor blocker that is commonly used to treat high blood pressure (BP). It has vasodilatory proporties and reduces the heart rate. Side effects include hypotension and fatigue, which normally don't occur when used and dosed correctly. Take it outside of your workout window, because a high heart rate is ideal for training. Take up to 5mg daily, any higher than that and it loses its selectivity.

Telmisartan: an Angiotensin II receptor blocker that lowers your BP and is nephroprotective (=protects your kidneys) whilst countering aldosterone-induced bloat. Research suggests partial PPARγ agonistic effects including reducing inflammation, enhanced insulin sensitivity etc. Take 40-80mg daily.

Only combine both beta-blockers and ARBs if your blood pressure and heart rate is too high (Stage 1+ on one of the ancillaries).

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#3: Cholesterol

Statins: work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway. They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream. They cause a reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins. Statins also slightly activate PPARα via an overexpression of COX-2.

Statins have a ±10% risk of causing diabetes in men. They also seem to have a negative impact on mitochondrial health, which includes reduced coQ10 levels. You can counteract this by supplementing it additionally, which I personally do at high doses.

There are two major groups of statins: hydrophilic and lipophilic statins. Hydrophilic statins (e.g. rosuvasatin and pravastatin) don't cross the BBB and cause more inflammation, whereas lipohilic statins (e.g. pitavastatin, atorvastatin, and simvastatin) cross the BBB and cause less inflammation.

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile. A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks. Dosage: Take 1-4mg daily.

Rosuvastatin is just as good as seen below. You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.

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Ezetimibe: inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol. It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein. It doesn't affect the absorption of fat-soluble vitamins. Take 5-10mg daily.

Bemdedoic acid: an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins. Take 180mg daily.

Bempedoic acid significantly reduces LDL cholesterol levels according to this study.



SR9009: an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. SR9009 has multiple benefits like boosting mitochondrial activity, fat metabolism, improving your circadian rhythm, endurance, and inflammation, along with other benefits of you can see below. It also improves the lipid profile.


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#4: Oxidative stress and organ health

NAC: a precursor to L-glutathione, that reduces oxidative stress, protects the liver, and organs in general. Is frequently used in clinical settings. Take 2-3g daily, ~1g if you are using a liposomal formulation.

Injectable L-glutathione: as mentioned, a very strong antioxidant that reduces inflammatory markers like TNF-α and IL-6 directly. It is mainly mito-, hepato-, and neuroprotective, making it a nice all-rounder to keep your organs healthy on-cycle. It is also used for skin lightening. Inject 500mg every day.

TUDCA: mainly used as liver support, although NAC/L-glutathione would be more than enough. Liver support is only required on compounds like tren and 17α-alkylated (=orally bioavailable) steroids.

Retatrutide: an agonist of the GLP-1, GIP, and glucagon receptor. You can expect an inprovement in insulin sensitivity, increased energy expenditure, reduced inflammation, and appetite suppression, whilst experiencing only limited side effects like GI irritation and skin sensitivity. It is also a godsent drug to improve your lipid profile significantly, as seen in this study.



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#5: Neuroprotection (including modulation of serotonin and oxytocin)

Neurotoxicity mostly occurs on compounds like tren and if you have raped your E2 levels too hard, which you shouldn't since oestrogen is anabolic, keeps your joints healthy, and is neuroprotective. Contrary to popular belief, oxytocin doesn't appear to be impaired on trenbolone. Rather the opposite occurs.

Besides that, oxytocin doesn't appear to be the muh social hormone after all according to this study:



N-Acetyl Semax: modulates BDNF and neurotransmitters like dopamine and serotonin. The acetylation makes BBB penetration easier (it is normally advised to take semax intranasally to bypass the BBB) and causes a higher receptor saturation whilst prolonging the half-life. Dihexa and cerebrolysin may be used alternatively. However, NA-Semax alone will do the job. Taking higher dosages up to 1-2mg is fully tolerated.

Escitalopram: an SSRI. A pure SERT blocker with only minimal secondary receptor interactions and comes with many benefits like being anxiolytic, improving depression and OCD, all whilst being neuroprotective.

Vortioxetine: an even better SSRI that isn't only a SERT blocker, but also a serotonin receptor modulator. It increases BDNF, dopamine, and norepinephrine in the frontal cortex leading to improved neuroplasticity and overall cognition. It doesn't cause any emotional bluntness, but rather lifts you up, and has low sexual side effects.

Rasagiline: a MAO-B inhibitor, which means it nukes the enzyme that normally metabolises dopamine, phenethylamine, and some trace amines, causing an excess of availability. MAO-A stays intact, resulting in normal serotonin and norepinephrine levels. Rasagiline is also slightly mitoprotective due to reducing oxidative stress in dopaminergic neurons.

LIT-001: an agonist of the oxytocin receptor that is able to pass the BBB and doesn't interact with the vasopressin receptor (=agonism would cause bloat). At higher doses it can even be an antagonist of the vasopressin receptor.

#6: Suppression of HPG-axis

HMG and HCG: these two compounds, even moreso the latter, are all you need to keep your HPG-axis intact. HCG imitates LH, whereas HMG imitates FSH, both stimulating your testes. Inject 100-250IU of HCG every other day (EOD) and take a break every 4-5 months (in case you are permablasting) to reset desensitisation of the Leydig cells. Even for people that plan to blast the next few years, it is recommended to do a HCG cycle 1-2x per year.

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Taurine: has antioxidant properties. It protects Leydig cells by reducing ROS and improves mitochondrial function. It is naturally abundant in seminal fluid, which means supplementing taurine results in improved sperm quality. take 1-3g daily.

#7: Prolactin management

Liposomal Pyridoxal-5-Phosphat (P-5-P): a good option to control your prolactin levels and to prevent lactation on low to moderate doses of tren. This should be your go-to compound for prolactin management. It also assists the production of neurotransmitters like dopamine, serotonin, and GABA. It is also a cofactor in many enzymes, supporting various processes in the body. Neuropathy is from high dose pyridoxine, not P-5-P. I'd recommend taking 100-200mg daily.

Cabergoline: binds selectively to dopamine D2 receptors and has a long half-life of roughly 2-3 days. It is primarely used to reduce hyperprolactinemia. Cabergoline reduces GH and IGF-1 levels. Take 0.125-0.25mg every 3 days, but only if you are actively experiencing side effects on high dose tren.

#8: Other safety measures, habits, and general advice

• Donate blood to keep your haematocrit (and red blood cell count) low, especially on boldenone and tren.
• Get full blood work before, during, and after a blasting phase. This way you can verify whether your gear is dosed correctly, how certain blood markers are affected etc.
• Locked in with diet and training. If you aren't doing this, NGMI.
• Do cardio. It improves lipids, heart health, insulin sensitivity, and so much more. It is one of the core pillar "ancillaries" that keeps you healthy.
• Good sleep with melatonin, DSIP, dual orexin receptor antagonists, magnesium l-threonate, maintaining the same sleeping/waking up time. Only take benzos and other sedatives if completely required.
• Keep fat intake low, carbs and protein high. 200-300g protein is ideal daily.
• Stay below 15-20% all throughout the cycle. Start the cycle at a very low bodyfat %.
• In the very rare case that you end up getting puffy and sensitive nipples, use topical raloxifene.
• To decrease bloating on-cycle use amiloride or eplerenone.

holy

 

[Penguino12]

I thought about getting on roids but tbh I see more cons to this than pros. Keep in mind just getting on roids will not get you to that aesthetic levels which those youtubers, influencers have. Some might have potential, but most do not as genetics have huge role in this. There are so many side effects which add up more expenses, even testosterone enanthate cycle for up to 20-25 weeks is quite expensive (well in my country it is, idk in others) + buying syringes and other stuff to fight the side-effects. There are so many what ifs and it is pretty much gamble, if you stop the cycle and end up having TRT deficiency for the rest of your life and having to spend MORE money to regulate this. Also internet is such a ball of illusion, when you see those chad face card aesthetic roidmaxxed fellas, you gotta keep in mind that they got top tier face card. If you just roidmaxx you might even further ruin your looks and also damage your health. Rather than spending that much money on roidmaxx, just invest it in surgery if you have a major flaw on your face and grind hard for 2+ years to achieve decent body. Roids not worth it especally if you have not reached your full potentional and you are hopping on roids with your delusional ass thinking you will be like David Laid

 

[Penguino12]

I am not here to preach normie cuck shit, I am just trying to show the other side of this shit and to be real as possible. As nothing is like butterflies in the sky. Btw lifes not only about fucking girls and lifting weights, think about having family and kids. Or do you choose to stay on looksmax arc and develop permanent mental illness? Eventually you will be needing kids to have different kind of happiness in your life