Running RU58841 without 5-ar inhibitors?

[Deleted member 2268]

Would this be an effective way to combat hairloss? I am currently running 0.5 mg Dutasteride but am curious if coming off it and just running RU would make any difference?

 

[Deleted member 23017]

Yes

 

[Deleted member 2268]

Yes

You think RU alone is just as effective as Dut?

 

[Deleted member 23017]

You think RU alone is just as effective as Dut?

Only if it gets absorbed. If so, actually more effective.

 

[Deleted member 2268]

Only if it gets absorbed. If so, actually more effective.

Well the only way to increase absorption is to dermaroll but this is not safe with RU

 

[Deleted member 23017]

Well the only way to increase absorption is to dermaroll but this is not safe with RU

Everybody GTFIH we have found Sherlock Holmes in the flesh!

 

[Deleted member 2268]

Everybody GTFIH we have found Sherlock Holmes in the flesh!

Alright dumbass was just asking what you meant by absorption

 

[Anasurimbor]

it is speculated that frontal scalp is sensitive to dht and testosterone. Can explain why i experienced full regrowth over there.
But crown is pure dht area an on ru i didnt experience regrow there. only With added dermarolling it finally started to also regrow.

in terms of dht fin/dut> ru although in hair density studies ru>>>>fin. So eventually its going to depend on your receptor sensitivity. If your hair loss is mild/moderate- ru prolly is gonna nuff. If its hardcore speed- you gonna need both ru and fin/dut

 

[Deleted member 2268]

it is speculated that frontal scalp is sensitive to dht and testosterone. Can explain why i experienced full regrowth over there.
But crown is pure dht area an on ru i didnt experience regrow there. only With added dermarolling it finally started to also regrow.

in terms of dht fin/dut> ru although in hair density studies ru>>>>fin. So eventually its going to depend on your receptor sensitivity. If your hair loss is mild/moderate- ru prolly is gonna nuff. If its hardcore speed- you gonna need both ru and fin/dut

Minox is good for crown

 

[makeme183]

it is speculated that frontal scalp is sensitive to dht and testosterone. Can explain why i experienced full regrowth over there.
But crown is pure dht area an on ru i didnt experience regrow there.

this is obvious
RU has more affinity for AR than test , but DHT has more affinity to AR than RU
which means RU will only work if your balding is due to test
crown balding is also due to estrogen(explains why older men are bald even with lower levels of T/DHT)

 

[Deleted member 2268]

this is obvious
RU has more affinity for AR than test , but DHT has more affinity to AR than RU
which means RU will only work if your balding is due to test
crown balding is also due to estrogen(explains why older men are bald even with lower levels of T/DHT)

Any proof that DHT has more binding affinity than ru

 

[makeme183]

Any proof that DHT has more binding affinity than ru

I read it in a pubmed article on RU
just google it , its well known

 

[Deleted member 2268]

I read it in a pubmed article on RU
just google it , its well known

Do steroids like Anavar cause a spike in scalp dht? Is dht active on the scalp?

 

[makeme183]

Do steroids like Anavar cause a spike in scalp dht?

I have no idea about this

Is dht active on the scalp?

there are 2 types of DHT
1.scalp DHT - produced by hair follicles/skin on the scalp
2.serum DHT - produced by prostate and liver

serum DHT is the bigger culprit for hairloss, which is reduced by oral fin
topical fin can't reduce it,so its cope

 

[Tallooksmaxxer]

RU has more affinity for AR than test , but DHT has more affinity to AR than RU
which means RU will only work if your balding is due to test

The binding affinity alone is not the absolute way to determine if its effective against another hormone or not.
Concentration is also important too, hence thats why ru58841 still works despite having a binding affinity lower than DHT.