SEX HORMONES QUESTION HIGH IQ MFS GTFIH

Endocrinology

Endocrinology

Iron
Joined
Jan 31, 2026
Posts
218
Reputation
143
Why is fertility not kept when running test cycles (250-500) with hcg and rFSH because all stimulis: (Leydig cells sertolli cells, High testicular serum testosterone) are met. I know it is kept for long periods of time but why not indefinitely? I heard it was because of pulsation but could you guys give more nuance?
 
  • +1
Reactions: Jimcel
Solution
Jimcel
hCG + rFSH preserves fertility on 250-500mg testosterone cycles for long periods (often 1–2+ years) by restoring high intratesticular testosterone and supporting Sertoli cells.

It is not indefinite mainly because natural LH/FSH is pulsatile; continuous hCG causes gradual Leydig cell desensitization and less efficient signaling than natural pulses. Supraphysiological T and individual factors can also contribute to slow decline over time. Regular semen analysis is key.

Mark as solution by clicking the checkmark on right :feelsautistic:
hCG + rFSH preserves fertility on 250-500mg testosterone cycles for long periods (often 1–2+ years) by restoring high intratesticular testosterone and supporting Sertoli cells.

It is not indefinite mainly because natural LH/FSH is pulsatile; continuous hCG causes gradual Leydig cell desensitization and less efficient signaling than natural pulses. Supraphysiological T and individual factors can also contribute to slow decline over time. Regular semen analysis is key.

Mark as solution by clicking the checkmark on right :feelsautistic:
 
  • +1
Reactions: TotallyAGrey, foidrepeller271 and Endocrinology
Solution
Thanks G, I think I am going to run a cycle coming school year (september 2026- september 2027) and do semen analysis. I will keep you guys updated because there really arent many guys doin this regement because most are iqlets.
 
  • +1
Reactions: Jimcel
hCG + rFSH preserves fertility on 250-500mg testosterone cycles for long periods (often 1–2+ years) by restoring high intratesticular testosterone and supporting Sertoli cells.

It is not indefinite mainly because natural LH/FSH is pulsatile; continuous hCG causes gradual Leydig cell desensitization and less efficient signaling than natural pulses. Supraphysiological T and individual factors can also contribute to slow decline over time. Regular semen analysis is key.

Mark as solution by clicking the checkmark on right :feelsautistic:W
wait if repeated stimulus is the reason it doesn't work, why cant we have an LH and FSH pump just like diabetes pumps work? this would grant you high test ( as long as it isn't enough to cause scaring of the testicular cells) and fertility.
 
  • +1
Reactions: Jimcel
wait if repeated stimulus is the reason it doesn't work, why cant we have an LH and FSH pump just like diabetes pumps work? this would grant you high test ( as long as it isn't enough to cause scaring of the testicular cells) and fertility.
mainly for medical infertility—not high-dose exogenous testosterone use.
 
mainly for medical infertility—not high-dose exogenous testosterone use.
A lot of studies do point out the amount of testosterone we can tolerate before testicular atrophy accurs is quite high. So I think it could be viable even above trt dosages.
 

Similar threads

Goyr67aper
Replies
19
Views
121
timfa
T
xqovr
Replies
9
Views
61
Antonlord7
Antonlord7
ccwb
Replies
30
Views
110
pio
pio
ccwb
Replies
5
Views
58
ccwb
ccwb
teddy101
Replies
7
Views
44
teddy101
teddy101

Users who are viewing this thread

Back
Top