shitposting/random memes megathread (NSFW)

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"Ratting at the border again, aint you?"

PuertoRicanFest2022%20-%206.jpeg
 
92


ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Search:
PopulationGroupSample SizeRef AlleleAlt Allele

PopulationGroupSample SizeRef AlleleAlt Allele
Total Global260224A=0.958259G=0.041741
European Sub222722A=0.992744G=0.007256
African Sub8216A=0.9853G=0.0147
African Others Sub280A=1.000G=0.000
African American Sub7936A=0.9848G=0.0152
Asian Sub6686A=0.1084G=0.8916
East Asian Sub4796A=0.0842G=0.9158
 
23


93


One was from my grandfather.

  • Frequency
  • Variant Details
  • Clinical Significance
  • HGVS
  • Submissions
  • History
  • Publications
  • Flanks


ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.


PopulationGroupSample SizeRef AlleleAlt Allele

PopulationGroupSample SizeRef AlleleAlt Allele
Total Global11572G=0.70930A=0.00000, C=0.29070
European Sub9024G=0.6417A=0.0000, C=0.3583
African Sub2010G=0.9866A=0.0000, C=0.0134
African Others Sub86G=0.99A=0.00, C=0.01
African American Sub1924G=0.9865A=0.0000, C=0.0135
Asian Sub4G=0.0A=0.0, C=1.0
East Asian Sub2G=0.0A=0.0, C=1.0
 
We'll review our SNPs, given the polygenicity of IQ and make a detailed comparison of the variants uncommon in Africans.

rs6042314
 
nfjdjekcirjwkfhrkdhebrjrjrhekejehrkfbdhdurjrhdodhdbfjdjdjdhdjdjdhdjsjdjdodhfjdjdkwjhsndndndjdhdhdhdhdbfndndnd
 
jfkdjdjdjdjdjdjdjenenwjwkejendkdkdndndndbcnfhd
 
nfiglfjddkxhdudhd
 
oing to kill mysef
 
thats it tjats it just like that
 
alright time to offmyself fr
 
tailored blue and white lab-created
 
i am going to bed now
 
alright bru it wasn t tht deep
 

A genome-wide association study for extremely high intelligence​


We used a case-control genome-wide association (GWA) design with cases consisting of 1238 individuals from the top 0.0003 (~170 mean IQ) of the population distribution of intelligence and 8172 unselected population-based controls. The single-nucleotide polymorphism heritability for the extreme IQ trait was 0.33 (0.02), which is the highest so far for a cognitive phenotype, and significant genome-wide genetic correlations of 0.78 were observed with educational attainment and 0.86 with population IQ. Three variants in locus ADAM12 achieved genome-wide significance, although they did not replicate with published GWA analyses of normal-range IQ or educational attainment. A genome-wide polygenic score constructed from the GWA results accounted for 1.6% of the variance of intelligence in the normal range in an unselected sample of 3414 individuals, which is comparable to the variance explained by GWA studies of intelligence with substantially larger sample sizes. The gene family plexins, members of which are mutated in several monogenic neurodevelopmental disorders, was significantly enriched for associations with high IQ. This study shows the utility of extreme trait selection for genetic study of intelligence and suggests that extremely high intelligence is continuous genetically with normal-range intelligence in the population.
 
Ancestral Pride:

Sou Quechua
 

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