What is Sodium Deoxycholate?
Sodium deoxycholate(SD) is the sodium salt of deoxycholic acid, which is a secondary bile acid derived from cholic acid. Used cosmetically for lipolysis and fat reduction treatments.
How is it used?
The primary route of administration is through subcutaneous injections, but if we are going to be using it at home the injection experience and arterial knowledge of the average person is not sufficient enough to avoid hitting an artery and causing permanent damage, especially in fragile areas like the face.
How could we use it topically?
Hypothetically, SD could be applied topically to the skin post microneedling treatment in order to spot reduce fat cells.
This assumption is based off of the recent study (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226838/) where a microneedle patch holding a β3 adrenergic receptor agonist was applied to mice to spot reduce fat. The result was positive.
“Mice were dissected for further investigation. For MN-administered mice, the total BAT organ weight increased (+35.94%), eWAT (epididymal WAT, −42.85%) and iWAT (inguinal WAT, −42.31%) decreased . In addition, the histology of adipose tissue analysis showed a significant reduction in lipid content and adipocyte size in WAT.”
For context White Adipose Tissue(WAT) stores and releases lipids while Brown Adipose Tissue(BAT) uses lipids to fuel thermogenesis.
Temporarily putting aside the incredible implications of this drug(CL-316243), we can take advantage of the knowledge that with microneedling we can deliver drugs down into the hypodermis(fat cells).
Example of Procedure using this
**The gel would be composed of 2.5% to 5% final concentration sodium deoxycholate diluted with distilled water/deionized water and glycerin to thicken it. The % is just a guess as what might be effective
In “Action of sodium deoxycholate on subcutaneous human tissue: local and systemic effects”(https://pubmed.ncbi.nlm.nih.gov/17300603/) there was no systemic effects detected after SD injection so we can assume there is a high chance that there will not be systematic effects with topical delivery but assumptions are frequently wrong and medicine is a unpredictable field.
Predicted Side effects -
Disclaimer: I am not encouraging the usage of sodium deoxycholate for at home local fat reduction but am providing a summary of the current knowledge available for educational purposes.
Sodium deoxycholate(SD) is the sodium salt of deoxycholic acid, which is a secondary bile acid derived from cholic acid. Used cosmetically for lipolysis and fat reduction treatments.
How is it used?
The primary route of administration is through subcutaneous injections, but if we are going to be using it at home the injection experience and arterial knowledge of the average person is not sufficient enough to avoid hitting an artery and causing permanent damage, especially in fragile areas like the face.
How could we use it topically?
Hypothetically, SD could be applied topically to the skin post microneedling treatment in order to spot reduce fat cells.
This assumption is based off of the recent study (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226838/) where a microneedle patch holding a β3 adrenergic receptor agonist was applied to mice to spot reduce fat. The result was positive.
“Mice were dissected for further investigation. For MN-administered mice, the total BAT organ weight increased (+35.94%), eWAT (epididymal WAT, −42.85%) and iWAT (inguinal WAT, −42.31%) decreased . In addition, the histology of adipose tissue analysis showed a significant reduction in lipid content and adipocyte size in WAT.”
For context White Adipose Tissue(WAT) stores and releases lipids while Brown Adipose Tissue(BAT) uses lipids to fuel thermogenesis.
Temporarily putting aside the incredible implications of this drug(CL-316243), we can take advantage of the knowledge that with microneedling we can deliver drugs down into the hypodermis(fat cells).
Example of Procedure using this
- Microneedling treatment in area with unwanted fat cells
- Application of sodium deoxycholate gel**.
- Waiting
**The gel would be composed of 2.5% to 5% final concentration sodium deoxycholate diluted with distilled water/deionized water and glycerin to thicken it. The % is just a guess as what might be effective
In “Action of sodium deoxycholate on subcutaneous human tissue: local and systemic effects”(https://pubmed.ncbi.nlm.nih.gov/17300603/) there was no systemic effects detected after SD injection so we can assume there is a high chance that there will not be systematic effects with topical delivery but assumptions are frequently wrong and medicine is a unpredictable field.
Predicted Side effects -
- Inflammation on applied site.
- Swelling on applied site.
- Reddening of site.
- Localized heat on application site.
Disclaimer: I am not encouraging the usage of sodium deoxycholate for at home local fat reduction but am providing a summary of the current knowledge available for educational purposes.
