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https://www.frontiersin.org/articles/10.3389/fcell.2019.00270/full
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iPSCs yamanaka factors with auxiliary bio printing can be used to turn any cell into growth plate chondrocytes in vitro, the only problem is finding out a way to do it in vivo effectively without any collateral damage around the region.
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Pluripotent stem cells are developmental progenitors of all adult tissues. Therefore, in theory, they must be intrinsically capable to form both, phenotypically stable articular cartilage and hypertrophic mineralizing cartilage
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Induced pluripotent stem cells (iPSCs) can be reprogramed from any nucleated cell and expanded in culture without losing differentiation capacity (Yama a et al., 2018). Thus, unlimited cell quantities are available from minimally or non-invasive sources, which makes iPSCs highly attractive for cartilage regeneration.
iPSCs yamanaka factors with auxiliary bio printing can be used to turn any cell into growth plate chondrocytes in vitro, the only problem is finding out a way to do it in vivo effectively without any collateral damage around the region.