critpanda
Silence Jew
- Joined
- Jul 11, 2025
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Ever wake up feeling bloated, or shredding/starvemaxxing and want to eat something nice and not blow up the next day? People are fear mongering diuretics and pushing cope debloat powder or vitamin megadoses.
One off diuretics are completely safe if you are hydrated! Take them for events, when you want to slay etc.
Think of it like this: your body has buffers. Electrolytes like potassium and magnesium are not just floating in the blood they’re stored in cells and bone. A one time diuretic dose will push some out in urine, so serum levels dip a bit, but unless your already severely deficient the drop is temporary and usually not enough to trigger dangerous consequences like arrhythmias
You might see a tiny, transient dip in serum K+/Mg2+, usually not enough to trigger arrhythmia in a healthy person. Symptoms, if any, are usually just mild weakness or twinges.
Hyponatremia usually requires either excess water intake or multiple doses, because the body can compensate with a single dose. If has a negligible effect unless they’re already very low on sodium or overhydrate immediately.
So how do you take lasix safely?
Drink water normally, don’t overhydrate.
Relenish potassium and magnesium before dosing again. Make sure your diet isn’t deficient. Electrolyte dips peak within a few hours of the dose, then gradually normalize as the body rebalances. You don’t need to pre-load electrolytes for one dose, but avoiding extreme deficits (very low K+ diet, dehydration, heavy sweating) helps.
Lasix acutely lowers plasma volume causing RAAS to retain sodium and water. The aldosterone rebound can be mitigated with a selective aldosterone antagonist such as eplerenone to block aldosterone at the mineralocorticoid receptor to reduce post diuretic sodium retention and potassium wasting.
Lasix flushes potassium out; Eplerenone keeps it in. Eplerenone will not blunt acute urine output or the “weight/fluid loss” from Lasix. It prevents the later potassium drop and partially reduces sodium retention after the initial diuresis.
Administer 25-50mg 3-6 hours post lasix after initial volume drop and peak diuresis but before aldosterone peaks. This allows you to blunt the rebound without interfering with the acute diuretic effect. Optionally repeat at 24h if you get a second RAAS surge.
Diuretic effect peaks within 1–3 hours
Aldosterone rebound starts ~3–6 hours peaks ~6–24 hours.
Eplerenone is timed ~3–6 hours after Lasix to blunt the rebound, not before the diuresis.
One off diuretics are completely safe if you are hydrated! Take them for events, when you want to slay etc.
Think of it like this: your body has buffers. Electrolytes like potassium and magnesium are not just floating in the blood they’re stored in cells and bone. A one time diuretic dose will push some out in urine, so serum levels dip a bit, but unless your already severely deficient the drop is temporary and usually not enough to trigger dangerous consequences like arrhythmias
You might see a tiny, transient dip in serum K+/Mg2+, usually not enough to trigger arrhythmia in a healthy person. Symptoms, if any, are usually just mild weakness or twinges.
Hyponatremia usually requires either excess water intake or multiple doses, because the body can compensate with a single dose. If has a negligible effect unless they’re already very low on sodium or overhydrate immediately.
So how do you take lasix safely?
Drink water normally, don’t overhydrate.
Relenish potassium and magnesium before dosing again. Make sure your diet isn’t deficient. Electrolyte dips peak within a few hours of the dose, then gradually normalize as the body rebalances. You don’t need to pre-load electrolytes for one dose, but avoiding extreme deficits (very low K+ diet, dehydration, heavy sweating) helps.
Lasix acutely lowers plasma volume causing RAAS to retain sodium and water. The aldosterone rebound can be mitigated with a selective aldosterone antagonist such as eplerenone to block aldosterone at the mineralocorticoid receptor to reduce post diuretic sodium retention and potassium wasting.
Lasix flushes potassium out; Eplerenone keeps it in. Eplerenone will not blunt acute urine output or the “weight/fluid loss” from Lasix. It prevents the later potassium drop and partially reduces sodium retention after the initial diuresis.
Administer 25-50mg 3-6 hours post lasix after initial volume drop and peak diuresis but before aldosterone peaks. This allows you to blunt the rebound without interfering with the acute diuretic effect. Optionally repeat at 24h if you get a second RAAS surge.
Diuretic effect peaks within 1–3 hours
Aldosterone rebound starts ~3–6 hours peaks ~6–24 hours.
Eplerenone is timed ~3–6 hours after Lasix to blunt the rebound, not before the diuresis.
that would bloat you
