Studies on GH timing and IGF-1 release

[LegitUser]

Anyone have links to studies comparing time and frequency of GH (eg 6iu once vs 3iu twice daily) and what the IGF-1 levels are for that?

 

[Laidcel]

Inject the 6 ius all at once right before bed.

 

[LegitUser]

Ok so the time of injection dosent matter but what about splitting the dose?

Effect of timing of growth hormone administration on plasma growth-hormone-binding activity, insulin-like growth factor-I and growth in children with a subnormal spontaneous secretion of growth hormone - PubMed

Since normal pulsatile growth-hormone (GH) secretion displays a major and consistent surge during sleep, we studied the effect of timing of GH supplementation on plasma GH-binding protein activity (GH-BP), insulin-like growth factor-I (IGF-I) and growth. 34 prepubertal subjects (28 boys, 6...

pubmed.ncbi.nlm.nih.gov

GH was administered either at 8.00-10.00 h (M group), 14.00-16.00 h (AN group) or 19.00-21.00 h (NT group). Height velocity, IGF-I and GH-BP were determined prior to and after 6 and 12 months on GH therapy in the three groups. There was no significant difference between the three groups in the growth response, IGF-I and GH-BP increase, all of which increased significantly during GH therapy. Although GH levels after the injection decline to preinjection levels after 10 h, the changes induced by GH therapy, as reflected in IGF-I and GH-BP, last in the circulation long enough to prevent fluctuations in its action. The similarity of IGF-I and of GH-BP levels in the three treatment groups might explain the similar growth effects of the 3 protocols.

 

[org3cel.RR]

Anyone have links to studies comparing time and frequency of GH (eg 6iu once vs 3iu twice daily) and what the IGF-1 levels are for that?

Inject at least 10 IUS before bed depending on your weight